ATE82137T1 - Verbesserung des eindringens in die haut durch verwendung von mischungen der freien base mit dem sauren additionssalz von wirkstoffen. - Google Patents

Verbesserung des eindringens in die haut durch verwendung von mischungen der freien base mit dem sauren additionssalz von wirkstoffen.

Info

Publication number
ATE82137T1
ATE82137T1 AT88121046T AT88121046T ATE82137T1 AT E82137 T1 ATE82137 T1 AT E82137T1 AT 88121046 T AT88121046 T AT 88121046T AT 88121046 T AT88121046 T AT 88121046T AT E82137 T1 ATE82137 T1 AT E82137T1
Authority
AT
Austria
Prior art keywords
free base
skin penetration
acid addition
addition salt
mixtures
Prior art date
Application number
AT88121046T
Other languages
German (de)
English (en)
Inventor
Dinesh C Patel
Yunik Chang
Original Assignee
Theratech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Theratech Inc filed Critical Theratech Inc
Application granted granted Critical
Publication of ATE82137T1 publication Critical patent/ATE82137T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
AT88121046T 1987-12-21 1988-12-15 Verbesserung des eindringens in die haut durch verwendung von mischungen der freien base mit dem sauren additionssalz von wirkstoffen. ATE82137T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/136,115 US4888354A (en) 1987-12-21 1987-12-21 Skin penetration enhancement using free base and acid addition salt combinations of active agents
EP88121046A EP0321870B1 (en) 1987-12-21 1988-12-15 Skin penetration enhancement using free base and acid addition salt combinations of active agents

Publications (1)

Publication Number Publication Date
ATE82137T1 true ATE82137T1 (de) 1992-11-15

Family

ID=22471370

Family Applications (1)

Application Number Title Priority Date Filing Date
AT88121046T ATE82137T1 (de) 1987-12-21 1988-12-15 Verbesserung des eindringens in die haut durch verwendung von mischungen der freien base mit dem sauren additionssalz von wirkstoffen.

Country Status (9)

Country Link
US (1) US4888354A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP0321870B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JP2856407B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KR (1) KR970007898B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (1) ATE82137T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA1332713C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE3875931T2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES2052682T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GR (1) GR3006499T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (93)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5446070A (en) * 1991-02-27 1995-08-29 Nover Pharmaceuticals, Inc. Compositions and methods for topical administration of pharmaceutically active agents
US5234957A (en) * 1991-02-27 1993-08-10 Noven Pharmaceuticals, Inc. Compositions and methods for topical administration of pharmaceutically active agents
US4975271A (en) * 1988-12-19 1990-12-04 Vipont Pharmaceutical, Inc. Muscosal delivery systems for treatment of periodontal disease
EP0387751B1 (en) * 1989-03-15 1994-06-08 Nitto Denko Corporation Medicated plasters
US5246949A (en) * 1989-12-06 1993-09-21 Sansho Co., Ltd. Preparation for endermism containing dopamine derivatives
JPH03236317A (ja) * 1989-12-06 1991-10-22 Sansei Seiyaku Kk ドパミン誘導体含有経皮用製剤
CA2056405A1 (en) * 1990-04-06 1991-10-07 Mitsumasa Shino Solid oral preparation containing catechol compound
US5433950A (en) * 1990-05-07 1995-07-18 Schering-Plough Healthcare Products, Inc. Flexible collodion compositions
US5332576A (en) * 1991-02-27 1994-07-26 Noven Pharmaceuticals, Inc. Compositions and methods for topical administration of pharmaceutically active agents
WO1993000113A1 (en) * 1991-06-21 1993-01-07 Victor Patrick Davidson A composition for treating a soft tissue injury
US5470874A (en) * 1994-10-14 1995-11-28 Lerner; Sheldon Ascorbic acid and proanthocyanidine composition for topical application to human skin
US5618557A (en) * 1994-11-22 1997-04-08 E.R. Squibb & Sons, Inc. Prophylactic treatment of allergic contact dermatitis
GB9504265D0 (en) * 1995-03-03 1995-04-19 Medeva Plc Corticosteroid-containing pharmaceutical composition
US5990179A (en) * 1995-04-28 1999-11-23 Alza Corporation Composition and method of enhancing electrotransport agent delivery
SE9601528D0 (sv) 1996-04-23 1996-04-23 Pharmacia Ab Transdermally administered dextromethorphan as antitissue agent
US6512010B1 (en) * 1996-07-15 2003-01-28 Alza Corporation Formulations for the administration of fluoxetine
WO1998018417A1 (en) * 1996-10-30 1998-05-07 Theratech, Inc. Fatty acid esters of lactic acid salts as permeation enhancers
US6203817B1 (en) 1997-02-19 2001-03-20 Alza Corporation Reduction of skin reactions caused by transdermal drug delivery
AUPO983897A0 (en) 1997-10-17 1997-11-06 Soltec Research Pty Ltd Topical antifungal composition
US6030374A (en) * 1998-05-29 2000-02-29 Mcdaniel; David H. Ultrasound enhancement of percutaneous drug absorption
US6398753B2 (en) 1998-04-03 2002-06-04 Mcdaniel David H. Ultrasound enhancement of percutaneous drug absorption
AUPP310798A0 (en) 1998-04-22 1998-05-14 Soltec Research Pty Ltd Vehicle system for a composition comprising a piperidinopyrimidine derivative
US6265412B1 (en) * 1998-05-26 2001-07-24 Taisho Pharmaceutical Co., Ltd. Minoxidil compositions for external use
US7004933B2 (en) 1998-05-29 2006-02-28 Light Bioscience L.L.C. Ultrasound enhancement of percutaneous drug absorption
US6699497B1 (en) 1998-07-24 2004-03-02 Alza Corporation Formulations for the transdermal administration of fenoldopam
US6676655B2 (en) 1998-11-30 2004-01-13 Light Bioscience L.L.C. Low intensity light therapy for the manipulation of fibroblast, and fibroblast-derived mammalian cells and collagen
US6936044B2 (en) * 1998-11-30 2005-08-30 Light Bioscience, Llc Method and apparatus for the stimulation of hair growth
US9192780B2 (en) 1998-11-30 2015-11-24 L'oreal Low intensity light therapy for treatment of retinal, macular, and visual pathway disorders
US6663659B2 (en) 2000-01-13 2003-12-16 Mcdaniel David H. Method and apparatus for the photomodulation of living cells
US6283956B1 (en) 1998-11-30 2001-09-04 David H. McDaniels Reduction, elimination, or stimulation of hair growth
US20060212025A1 (en) * 1998-11-30 2006-09-21 Light Bioscience, Llc Method and apparatus for acne treatment
US6887260B1 (en) * 1998-11-30 2005-05-03 Light Bioscience, Llc Method and apparatus for acne treatment
EP1449527A3 (en) * 1998-12-07 2004-09-08 Elan Pharma International Limited Transdermal patch for administering a volatile liquid drug
US6974588B1 (en) 1999-12-07 2005-12-13 Elan Pharma International Limited Transdermal patch for delivering volatile liquid drugs
US7179483B2 (en) 2000-04-26 2007-02-20 Watson Pharmaceuticals, Inc. Compositions and methods for transdermal oxybutynin therapy
WO2002096374A2 (en) 2001-05-31 2002-12-05 Upsher-Smith Laboratories, Inc. Dermatological compositions and methods comprising alpha-hydroxy acids or derivatives
US20030060422A1 (en) 2001-08-31 2003-03-27 Balaji Venkataraman Tannate compositions and methods of treatment
US20190328679A1 (en) 2001-10-12 2019-10-31 Aquestive Therapeutics, Inc. Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions
US10285910B2 (en) 2001-10-12 2019-05-14 Aquestive Therapeutics, Inc. Sublingual and buccal film compositions
US8765167B2 (en) 2001-10-12 2014-07-01 Monosol Rx, Llc Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions
US7357891B2 (en) 2001-10-12 2008-04-15 Monosol Rx, Llc Process for making an ingestible film
US8900498B2 (en) 2001-10-12 2014-12-02 Monosol Rx, Llc Process for manufacturing a resulting multi-layer pharmaceutical film
US20110033542A1 (en) 2009-08-07 2011-02-10 Monosol Rx, Llc Sublingual and buccal film compositions
US20070281003A1 (en) 2001-10-12 2007-12-06 Fuisz Richard C Polymer-Based Films and Drug Delivery Systems Made Therefrom
US7666337B2 (en) 2002-04-11 2010-02-23 Monosol Rx, Llc Polyethylene oxide-based films and drug delivery systems made therefrom
US8900497B2 (en) 2001-10-12 2014-12-02 Monosol Rx, Llc Process for making a film having a substantially uniform distribution of components
US8603514B2 (en) * 2002-04-11 2013-12-10 Monosol Rx, Llc Uniform films for rapid dissolve dosage form incorporating taste-masking compositions
US11207805B2 (en) 2001-10-12 2021-12-28 Aquestive Therapeutics, Inc. Process for manufacturing a resulting pharmaceutical film
US7425292B2 (en) 2001-10-12 2008-09-16 Monosol Rx, Llc Thin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom
US7910641B2 (en) 2001-10-12 2011-03-22 Monosol Rx, Llc PH modulated films for delivery of actives
US8663687B2 (en) 2001-10-12 2014-03-04 Monosol Rx, Llc Film compositions for delivery of actives
US8758733B2 (en) 2002-02-04 2014-06-24 Allergan, Inc. Topical treatment for chemotherapy induced eyelash loss or hypotrichosis using prostamide F2 alpha agonists
US7351404B2 (en) 2002-02-04 2008-04-01 Allergan, Inc. Method of enhancing hair growth
US9216183B2 (en) 2002-02-04 2015-12-22 Allergan, Inc. Topical treatment for chemotherapy induced eyelash loss or hypotrichosis using prostamide F2 alpha agonists
US7022342B2 (en) 2002-03-28 2006-04-04 Andrx Corporation, Inc. Controlled release oral dosage form of beta-adrenergic blocking agents
US8017150B2 (en) 2002-04-11 2011-09-13 Monosol Rx, Llc Polyethylene oxide-based films and drug delivery systems made therefrom
US9561182B2 (en) 2003-08-22 2017-02-07 Cure Pharmaceutical Corporation Edible films for administration of medicaments to animals, methods for their manufacture and methods for their use for the treatment of animals
CN1784184A (zh) 2003-04-10 2006-06-07 光生物科学有限责任公司 调节细胞增殖以及基因表达的光调节方法以及装置
US20040258742A1 (en) * 2003-04-11 2004-12-23 Van Osdol William Woodson Transdermal administration of N-(2,5-disubstituted phenyl)-N'-(3-substituted phenyl)-N'-methyl guanidines
CA2533129A1 (en) * 2003-07-31 2005-02-10 Light Bioscience, Llc System and method for the photodynamic treatment of burns, wounds, and related skin disorders
US20080020028A1 (en) * 2003-08-20 2008-01-24 Euro-Celtique S.A. Transdermal dosage form comprising an active agent and a salt and a free-base form of an adverse agent
JP2007520285A (ja) * 2004-02-06 2007-07-26 バロレ，ダニエル 哺乳類組織の治療方法及び装置
US7718674B2 (en) 2004-09-27 2010-05-18 Bridge Pharma, Inc. Methods of relieving neuropathic pain with the S-isomer of 2-{2[N-(2-indanyl)-N-phenylamino]ethyl}piperidine
US8501818B2 (en) * 2005-03-14 2013-08-06 Ceptaris Therapeutics, Inc. Stabilized compositions of alkylating agents and methods of using same
US7872050B2 (en) * 2005-03-14 2011-01-18 Yaupon Therapeutics Inc. Stabilized compositions of volatile alkylating agents and methods of using thereof
US20110039943A1 (en) * 2005-03-14 2011-02-17 Robert Alonso Methods for treating skin disorders with topical nitrogen mustard compositions
US20060216350A1 (en) * 2005-03-24 2006-09-28 Dow Gordon J Ganglionic blocking agents for the treatment of epithelial diseases
WO2007033152A2 (en) * 2005-09-12 2007-03-22 Conor Medsystems, Inc. Composition, system and method for modulating release kinetics in implantable drug delivery devices by modifying drug solubility
KR20080081175A (ko) * 2005-12-19 2008-09-08 코멘티스, 인코포레이티드 안구 투여를 위한 국소 메카밀라민 제형 및 그것의 사용
AU2007207503A1 (en) * 2006-01-20 2007-07-26 Monosol Rx, Llc Film bandage for mucosal administration of actives
US7592458B2 (en) 2006-07-21 2009-09-22 Wright George E Dermal anesthetic compounds and pharmaceutical compositions for inducing local anesthesia and mitigating neuropathic pain
EP2063864A4 (en) 2006-09-20 2012-03-14 Monosol Rx Llc EDIBLE WATER-SOLUBLE FILM CONTAINING FLAVOR-REDUCING AGENT
US20080081829A1 (en) * 2006-09-28 2008-04-03 Med Institute, Inc Medical Device Including an Anesthetic and Method of Preparation Thereof
EP2068968A2 (en) * 2006-09-28 2009-06-17 Med Institute, Inc. Medical devices incorporating a bioactive and methods of preparing such devices
US20080082038A1 (en) * 2006-09-28 2008-04-03 Vance Products Incorporated, D/B/A/ Cook Urological Incorporated Medical Device including a Bioactive in a Non-ionic and an Ionic Form and Methods of Preparation Thereof
ES2962777T3 (es) * 2007-11-15 2024-03-21 Amgen Inc Formulación acuosa de anticuerpos estabilizada por antioxidantes para la administración parenteral
FR2926721B1 (fr) * 2008-01-30 2011-07-22 Philippe Perovitch Forme galenique pour l'adminsitration par voie trans-muqueuse de triptans
LT2273876T (lt) * 2008-03-27 2019-05-27 Helsinn Healthcare Sa Stabilizuotos alkilinimo medžiagų kompozicijos ir jų panaudojimo būdai
US7943187B2 (en) * 2008-05-23 2011-05-17 Bakr Rabie Paeoniflorin preparations and uses thereof for fat reduction
US20100204335A1 (en) * 2008-12-01 2010-08-12 Allergan, Inc. Kit and composition for eyelash growth
US8475832B2 (en) 2009-08-07 2013-07-02 Rb Pharmaceuticals Limited Sublingual and buccal film compositions
EP2498783B1 (en) 2009-11-09 2018-08-22 Allergan, Inc. Compositions and methods for stimulating hair growth
US9149484B2 (en) 2009-11-09 2015-10-06 Allergan, Inc. Compositions and methods for stimulating hair growth
WO2011156711A1 (en) 2010-06-10 2011-12-15 Schobel Alexander M Nanoparticle film delivery systems
US9149959B2 (en) 2010-10-22 2015-10-06 Monosol Rx, Llc Manufacturing of small film strips
US20120129789A1 (en) 2010-11-18 2012-05-24 Steven Yoelin Compositions and methods for hair growth
WO2013172838A1 (en) 2012-05-17 2013-11-21 Steven Yoelin Compositions and methods for hair growth
US8859616B2 (en) 2011-01-21 2014-10-14 Allergan, Inc. Compounds and methods for enhancing hair growth
AU2014242317B2 (en) * 2013-03-14 2018-12-20 Allergan, Inc. Topical compositions comprising bimatoprost and methods for stimulating hair growth therewith
US9587235B2 (en) 2013-03-15 2017-03-07 Atyr Pharma, Inc. Histidyl-tRNA synthetase-Fc conjugates
KR20190005199A (ko) 2016-05-05 2019-01-15 어퀘스티브 테라퓨틱스, 아이엔씨. 강화된 전달 에프네프린 조성물
US11273131B2 (en) 2016-05-05 2022-03-15 Aquestive Therapeutics, Inc. Pharmaceutical compositions with enhanced permeation
CN118908900B (zh) * 2024-10-10 2025-01-28 山东则正医药技术有限公司 一种米诺地尔乳酸盐晶型及其制备方法和应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL300886A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1962-11-23
CA1165240A (en) * 1980-07-09 1984-04-10 The Procter & Gamble Company Penetrating topical pharmaceutical compositions
US4537776A (en) * 1983-06-21 1985-08-27 The Procter & Gamble Company Penetrating topical pharmaceutical compositions containing N-(2-hydroxyethyl) pyrrolidone
US4731384A (en) * 1983-07-01 1988-03-15 Troponwerke Gmbh & Co, Kg Etofenamate formulation
US4600708A (en) * 1985-07-19 1986-07-15 American Home Products Corporation Propranolol hydrochloride liquid formulations
ES2042564T3 (es) * 1986-06-13 1993-12-16 Procter & Gamble Composiciones por via topica penetrantes mejoradas para aumentar el crecimiento del cabello.

Also Published As

Publication number Publication date
DE3875931T2 (de) 1993-03-25
EP0321870A1 (en) 1989-06-28
EP0321870B1 (en) 1992-11-11
JPH02104516A (ja) 1990-04-17
GR3006499T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1993-06-21
KR970007898B1 (ko) 1997-05-17
KR890009374A (ko) 1989-08-01
ES2052682T3 (es) 1994-07-16
US4888354A (en) 1989-12-19
JP2856407B2 (ja) 1999-02-10
CA1332713C (en) 1994-10-25
DE3875931D1 (de) 1992-12-17

Similar Documents

Publication Publication Date Title
ATE82137T1 (de) Verbesserung des eindringens in die haut durch verwendung von mischungen der freien base mit dem sauren additionssalz von wirkstoffen.
GB8630721D0 (en) Cosmetic compositions
GB1367841A (en) Cosmetic compositions for counteracting the greasy appearance of the head of hair and of the skin and for counteracting dandruff
UA19303A (uk) Спосіб одержаhhя похідhих 2-аhіліhопіримідиhу
ES8603271A1 (es) Un metodo de producir una composicion de interleuquina-2
ES2033434T3 (es) Composicion cosmetica.
DE3176215D1 (en) Non-yellowing topical pharmaceutical composition
FR2647342B1 (fr) Composition cosmetique s'opposant au vieillissement de la peau
ES436648A1 (es) Un procedimiento para la preparacion de compuestos tienilo ytietilo.
GB2210556B (en) The use of 15-keto-16-halo-prostaglandins in cathartic compositions
DK0631772T3 (da) Retinoidholdig sammensætning
JO1610B1 (en) Tetrahydimidimidose compounds (1,4) benzodiazepine-2 thyonath anti-viral and anti-viral
NO178054C (no) Tannpleiemiddel
ES8700054A1 (es) Procedimiento de obtencion de germicidas a base de acidos clorhidrico y fosforico.
GB1130566A (en) Dentifrice
ZA873928B (en) Topical methotrexate preparation for the treatment of hyperproliferative epithelial disease
DE3870236D1 (de) Haar-anregungs-, anti-schuppen- und anti-seborrhoee-zusammensetzung fuer topische anwendung.
ES451160A1 (es) Procedimiento para la obtencion de cromenos.
IT8521528A0 (it) Composizioni farmaceutiche e cosmetiche contenenti come ingrediente attivo diidrossi-1,8fenil-10 antrone-9, e procedimentodi preparazione dell'ingrediente attivo.
GB1532550A (en) Agent for preventing cold turbidity in beer
DE68905796D1 (de) Chromoglycinsaeure-natriumsalz enthaltende aerosolzubereitungen.
GB1264509A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GB1328169A (en) Benzamide compounds and methods for their production
ATE17188T1 (de) Pharmazeutisches praeparat zum steigern der keratinogenese und reduzieren von seborrhoea der gesichts- und kopfhaut.
JPS5799516A (en) Hair tonic

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee