ATE79262T1 - Arzneimittelemulsion. - Google Patents
Arzneimittelemulsion.Info
- Publication number
- ATE79262T1 ATE79262T1 AT88305718T AT88305718T ATE79262T1 AT E79262 T1 ATE79262 T1 AT E79262T1 AT 88305718 T AT88305718 T AT 88305718T AT 88305718 T AT88305718 T AT 88305718T AT E79262 T1 ATE79262 T1 AT E79262T1
- Authority
- AT
- Austria
- Prior art keywords
- drug
- solvent
- emulsion
- mixing
- oil
- Prior art date
Links
- 239000000839 emulsion Substances 0.000 title abstract 3
- 229940079593 drug Drugs 0.000 abstract 6
- 239000003814 drug Substances 0.000 abstract 6
- 239000006184 cosolvent Substances 0.000 abstract 3
- 239000004094 surface-active agent Substances 0.000 abstract 2
- APKFDSVGJQXUKY-KKGHZKTASA-N Amphotericin-B Natural products O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1C=CC=CC=CC=CC=CC=CC=C[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-KKGHZKTASA-N 0.000 abstract 1
- APKFDSVGJQXUKY-INPOYWNPSA-N amphotericin B Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-INPOYWNPSA-N 0.000 abstract 1
- 229960003942 amphotericin b Drugs 0.000 abstract 1
- 230000000843 anti-fungal effect Effects 0.000 abstract 1
- 229940121375 antifungal agent Drugs 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000007764 o/w emulsion Substances 0.000 abstract 1
- 150000004291 polyenes Chemical class 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 230000001988 toxicity Effects 0.000 abstract 1
- 231100000419 toxicity Toxicity 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1277—Preparation processes; Proliposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Dispersion Chemistry (AREA)
- Biophysics (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB878714652A GB8714652D0 (en) | 1987-06-23 | 1987-06-23 | Drug emulsion |
| EP88305718A EP0296845B1 (de) | 1987-06-23 | 1988-06-22 | Arzneimittelemulsion |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE79262T1 true ATE79262T1 (de) | 1992-08-15 |
Family
ID=10619376
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT88305718T ATE79262T1 (de) | 1987-06-23 | 1988-06-22 | Arzneimittelemulsion. |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP0296845B1 (de) |
| AT (1) | ATE79262T1 (de) |
| AU (1) | AU1957388A (de) |
| DE (1) | DE3873641T2 (de) |
| GB (1) | GB8714652D0 (de) |
| WO (1) | WO1988010116A1 (de) |
| ZA (1) | ZA884513B (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6406713B1 (en) | 1987-03-05 | 2002-06-18 | The Liposome Company, Inc. | Methods of preparing low-toxicity drug-lipid complexes |
| US5616334A (en) * | 1987-03-05 | 1997-04-01 | The Liposome Company, Inc. | Low toxicity drug-lipid systems |
| GB8919172D0 (en) * | 1989-08-23 | 1989-10-04 | Univ Nottingham | Useful composition |
| DE69027941T2 (de) * | 1989-11-27 | 1997-01-23 | Nippon Shinyaku Co Ltd | Fettemulsion |
| US5534502A (en) * | 1990-11-06 | 1996-07-09 | Nippon Shinyaku Co. Ltd. | Process for producing fat emulsion |
| EP0556392A4 (de) * | 1990-11-06 | 1994-03-17 | Nippon Shinyaku Co Ltd | Verfahren zur produktion einer fettemulsion. |
| US6447806B1 (en) | 1999-02-25 | 2002-09-10 | Novartis Ag | Pharmaceutical compositions comprised of stabilized peptide particles |
| IN188843B (de) * | 2000-06-22 | 2002-11-09 | Vinod Daftary Gautam Dr | |
| DE10036871A1 (de) * | 2000-07-28 | 2002-02-14 | Pharmasol Gmbh | Dispersionen zur Formulierung wenig oder schwer löslicher Wirkstoffe |
| US20080124387A1 (en) * | 2006-11-27 | 2008-05-29 | Kapac, Llc | Methods and formulations for enhancing the absorption and decreasing the absorption variability of orally administered drugs, vitamins and nutrients |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0065513B1 (de) * | 1980-11-27 | 1985-09-18 | CHINOIN Gyogyszer és Vegyészeti Termékek Gyára RT. | Antimykotische synergitische arzneimittelzusammensetzungen und verfahren zu deren herstellung |
| WO1984001693A1 (en) * | 1982-11-08 | 1984-05-10 | Wrigley W M Jun Co | Anhydrous chewing gum |
| US4707470A (en) * | 1985-05-17 | 1987-11-17 | Smithkline Beckman Corporation | Polyene antibiotic emulsion formulation |
| IL78929A0 (en) * | 1985-07-29 | 1986-09-30 | Abbott Lab | Microemulsion compositions for parenteral administration |
| US4784845A (en) * | 1985-09-16 | 1988-11-15 | American Cyanamid Company | Emulsion compostions for the parenteral administration of sparingly water soluble ionizable hydrophobic drugs |
-
1987
- 1987-06-23 GB GB878714652A patent/GB8714652D0/en active Pending
-
1988
- 1988-06-22 DE DE8888305718T patent/DE3873641T2/de not_active Expired - Fee Related
- 1988-06-22 WO PCT/GB1988/000486 patent/WO1988010116A1/en not_active Ceased
- 1988-06-22 AT AT88305718T patent/ATE79262T1/de not_active IP Right Cessation
- 1988-06-22 EP EP88305718A patent/EP0296845B1/de not_active Expired - Lifetime
- 1988-06-22 AU AU19573/88A patent/AU1957388A/en not_active Abandoned
- 1988-06-23 ZA ZA884513A patent/ZA884513B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GB8714652D0 (en) | 1987-07-29 |
| DE3873641D1 (de) | 1992-09-17 |
| EP0296845B1 (de) | 1992-08-12 |
| ZA884513B (en) | 1989-03-29 |
| AU1957388A (en) | 1989-01-19 |
| WO1988010116A1 (en) | 1988-12-29 |
| DE3873641T2 (de) | 1993-02-11 |
| EP0296845A1 (de) | 1988-12-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee | ||
| RZN | Patent revoked |