ATE75225T1 - Verfahren zur herstellung von 1-phenyl-2-diethylaminocarbonyl-2-phthalimidomethyl-cyclopropan z. - Google Patents
Verfahren zur herstellung von 1-phenyl-2-diethylaminocarbonyl-2-phthalimidomethyl-cyclopropan z.Info
- Publication number
- ATE75225T1 ATE75225T1 AT89403659T AT89403659T ATE75225T1 AT E75225 T1 ATE75225 T1 AT E75225T1 AT 89403659 T AT89403659 T AT 89403659T AT 89403659 T AT89403659 T AT 89403659T AT E75225 T1 ATE75225 T1 AT E75225T1
- Authority
- AT
- Austria
- Prior art keywords
- phenyl
- diethylaminocarbonyl
- preparation
- cyclopropan
- phthalimidomethyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8817326A FR2640972B1 (de) | 1988-12-28 | 1988-12-28 | |
| EP89403659A EP0377381B1 (de) | 1988-12-28 | 1989-12-27 | Verfahren zur Herstellung von 1-Phenyl-2-diethyl-aminocarbonyl-2-phthalimidomethyl-cyclopropan Z |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE75225T1 true ATE75225T1 (de) | 1992-05-15 |
Family
ID=9373531
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT89403659T ATE75225T1 (de) | 1988-12-28 | 1989-12-27 | Verfahren zur herstellung von 1-phenyl-2-diethylaminocarbonyl-2-phthalimidomethyl-cyclopropan z. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5034541A (de) |
| EP (1) | EP0377381B1 (de) |
| JP (1) | JP2964041B2 (de) |
| AT (1) | ATE75225T1 (de) |
| BR (1) | BR1100117A (de) |
| CA (1) | CA2006464C (de) |
| DE (1) | DE68901334D1 (de) |
| ES (1) | ES2032671T3 (de) |
| FR (1) | FR2640972B1 (de) |
| GR (1) | GR3004813T3 (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2752732B1 (fr) * | 1996-08-28 | 1998-11-20 | Pf Medicament | Forme galenique a liberation prolongee de milnacipran |
| US6635675B2 (en) | 2001-11-05 | 2003-10-21 | Cypress Bioscience, Inc. | Method of treating chronic fatigue syndrome |
| US6602911B2 (en) | 2001-11-05 | 2003-08-05 | Cypress Bioscience, Inc. | Methods of treating fibromyalgia |
| EP1767522B1 (de) * | 2004-06-25 | 2013-01-16 | Sumitomo Chemical Company, Limited | Verfahren zur herstellung von (z)-1-phenyl-1-diethylaminocarbonyl-2-hydroxymethylcyclopropan |
| JP4828863B2 (ja) | 2005-01-28 | 2011-11-30 | 住友化学株式会社 | （ｚ）−１−フェニル−１−（ｎ，ｎ−ジエチルアミノカルボニル）−２−フタルイミドメチルシクロプロパンの製造方法 |
| EP1894565B1 (de) | 2005-06-10 | 2013-10-30 | Pierre Fabre Médicament S.A. | Stabilisierte milnacipran-formulierung |
| KR100772244B1 (ko) | 2005-07-20 | 2007-11-01 | 안국약품 주식회사 | 밀나시프란염산염의 제조방법 |
| US7994220B2 (en) * | 2005-09-28 | 2011-08-09 | Cypress Bioscience, Inc. | Milnacipran for the long-term treatment of fibromyalgia syndrome |
| US20080319083A1 (en) * | 2006-01-27 | 2008-12-25 | Asahi Kasei Pharma Corporation | Medicine for transnasal administration |
| FR2941454B1 (fr) | 2009-01-29 | 2011-04-01 | Pf Medicament | Proced de synthese du (1s,2r)-milnacipran |
| WO2011158249A1 (en) * | 2010-06-16 | 2011-12-22 | Glenmark Generics Limited | Process for preparation of milnacipran intermediate and its use in preparation of pure milnacipran |
| EP2699539B1 (de) | 2011-04-21 | 2019-03-06 | Emory University | Cyclopropylderivate und verfahren zu ihrer verwendung |
| WO2014009767A1 (en) | 2012-07-07 | 2014-01-16 | Micro Labs Limited | An improved process for the preparation of 1-aryl 2-aminomethyl cyclopropane carboxyamide (z) derivatives, their isomers and salts |
| WO2014203277A2 (en) * | 2013-06-19 | 2014-12-24 | Msn Laboratories Private Limited | Process for the preparation of (1s,2r)-2-(aminomethyl)-n,n-diethyl-1-phenylcyclopropanearboxamide hydrochloride |
| EP3230258B1 (de) | 2014-11-04 | 2019-06-26 | Química Sintética, S.A. | Verfahren zur herstellung von (1s,2r)-milnacipran |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2508033A1 (fr) * | 1981-06-23 | 1982-12-24 | Fabre Sa Pierre | Aryl-1 aminomethyl-2 cyclopropanes carboxylates (z), leur preparation et leur application en tant que medicaments utiles dans le traitement d'algies diverses |
| FR2581059B1 (fr) * | 1985-04-25 | 1988-04-22 | Pf Medicament | Procede de preparation du chlorhydrate de phenyl-1 diethyl amino carbonyl-1 aminomethyl-2 cyclopropane (z) |
| FR2581060B1 (fr) * | 1985-04-25 | 1988-07-01 | Pf Medicament | Procede industriel d'obtention du midalcipran |
-
1988
- 1988-12-28 FR FR8817326A patent/FR2640972B1/fr not_active Expired - Lifetime
-
1989
- 1989-12-21 CA CA002006464A patent/CA2006464C/fr not_active Expired - Lifetime
- 1989-12-27 EP EP89403659A patent/EP0377381B1/de not_active Expired - Lifetime
- 1989-12-27 ES ES198989403659T patent/ES2032671T3/es not_active Expired - Lifetime
- 1989-12-27 US US07/457,352 patent/US5034541A/en not_active Expired - Lifetime
- 1989-12-27 JP JP1345050A patent/JP2964041B2/ja not_active Expired - Lifetime
- 1989-12-27 DE DE8989403659T patent/DE68901334D1/de not_active Expired - Lifetime
- 1989-12-27 AT AT89403659T patent/ATE75225T1/de not_active IP Right Cessation
-
1992
- 1992-06-04 GR GR920401157T patent/GR3004813T3/el unknown
-
1996
- 1996-12-30 BR BR1100117-8A patent/BR1100117A/pt active Search and Examination
Also Published As
| Publication number | Publication date |
|---|---|
| BR1100117A (pt) | 1999-12-07 |
| ES2032671T3 (es) | 1993-02-16 |
| EP0377381A1 (de) | 1990-07-11 |
| JPH02262558A (ja) | 1990-10-25 |
| FR2640972A1 (de) | 1990-06-29 |
| CA2006464A1 (fr) | 1990-06-28 |
| JP2964041B2 (ja) | 1999-10-18 |
| FR2640972B1 (de) | 1991-04-19 |
| DE68901334D1 (de) | 1992-05-27 |
| EP0377381B1 (de) | 1992-04-22 |
| CA2006464C (fr) | 1999-06-15 |
| GR3004813T3 (de) | 1993-04-28 |
| US5034541A (en) | 1991-07-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| EELA | Cancelled due to lapse of time |