ATE74751T1 - Oestradiol-implantat und verfahren zu seiner herstellung. - Google Patents

Oestradiol-implantat und verfahren zu seiner herstellung.

Info

Publication number
ATE74751T1
ATE74751T1 AT87111218T AT87111218T ATE74751T1 AT E74751 T1 ATE74751 T1 AT E74751T1 AT 87111218 T AT87111218 T AT 87111218T AT 87111218 T AT87111218 T AT 87111218T AT E74751 T1 ATE74751 T1 AT E74751T1
Authority
AT
Austria
Prior art keywords
oestradiol
implant
manufacture
time
extended periods
Prior art date
Application number
AT87111218T
Other languages
German (de)
English (en)
Inventor
Mimi Yih-Pei Chou Schaaf
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Application granted granted Critical
Publication of ATE74751T1 publication Critical patent/ATE74751T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A61K9/204—Polyesters, e.g. poly(lactide-co-glycolide)

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
  • Prostheses (AREA)
  • Materials For Medical Uses (AREA)
AT87111218T 1986-08-11 1987-08-04 Oestradiol-implantat und verfahren zu seiner herstellung. ATE74751T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/895,415 US4758435A (en) 1986-08-11 1986-08-11 Estradiol implant composition and method for preparation
EP87111218A EP0257369B1 (en) 1986-08-11 1987-08-04 Improved estradiol implant composition and method for preparation

Publications (1)

Publication Number Publication Date
ATE74751T1 true ATE74751T1 (de) 1992-05-15

Family

ID=25404471

Family Applications (1)

Application Number Title Priority Date Filing Date
AT87111218T ATE74751T1 (de) 1986-08-11 1987-08-04 Oestradiol-implantat und verfahren zu seiner herstellung.

Country Status (10)

Country Link
US (1) US4758435A (enExample)
EP (1) EP0257369B1 (enExample)
AT (1) ATE74751T1 (enExample)
AU (1) AU599406B2 (enExample)
CA (1) CA1297020C (enExample)
DE (1) DE3778244D1 (enExample)
ES (1) ES2031096T3 (enExample)
GR (1) GR3004370T3 (enExample)
NZ (1) NZ221390A (enExample)
ZA (1) ZA875897B (enExample)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4846844A (en) * 1987-08-31 1989-07-11 Eli Lilly And Company Antimicrobial coated implants
DE3734223A1 (de) * 1987-10-09 1989-04-20 Boehringer Ingelheim Kg Implantierbares, biologisch abbaubares wirkstofffreigabesystem
US5250584A (en) * 1988-08-31 1993-10-05 G-C Dental Industrial Corp. Periodontium-regenerative materials
FR2654337B1 (fr) * 1989-11-15 1994-08-05 Roussel Uclaf Nouvelles microspheres injectables biodegradables procede de preparation et suspensions injectables les renfermant.
US5198220A (en) * 1989-11-17 1993-03-30 The Procter & Gamble Company Sustained release compositions for treating periodontal disease
EP0447719B1 (en) * 1990-03-05 1993-11-03 Minnesota Mining And Manufacturing Company Device for extended delivery of pharmacologically active agents to the ear
US5350580A (en) * 1990-03-05 1994-09-27 Minnesota Mining And Manufacturing Company Device and method for extended delivery of pharmacologically active agents to the ear
US5288496A (en) * 1990-05-15 1994-02-22 Stolle Research & Development Corporation Growth promoters for animals
US5686092A (en) * 1992-11-24 1997-11-11 Alkermes Controlled Therapeutics Inc. Ii Growth promoters for animals
US20020111603A1 (en) 1996-12-02 2002-08-15 Societe De Conseils De Recherches Et D'application Device for local administration of solid or semi-solid formulations and delayed-release formulations for proposal parental administration and preparation process
FR2756493B1 (fr) * 1996-12-02 2001-04-13 Delab Dispositif d'administration locale de formulations solides ou semi-solides
DE19744135C1 (de) * 1997-09-29 1999-03-25 Schering Ag Beschichtete medizinische Implantate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Restenoseprophylaxe
US6022554A (en) * 1997-12-15 2000-02-08 American Home Products Corporation Polymeric microporous film coated subcutaneous implant
ES2359973T3 (es) 1998-03-19 2011-05-30 MERCK SHARP & DOHME CORP. Composiciones poliméricas líquidas para la liberación controlada de sustancias bioactivas.
FR2770134B1 (fr) * 1998-10-28 2002-06-07 Delab Formulations solides ou semi-solides pour administration locale
US7767708B2 (en) * 1998-11-04 2010-08-03 Schering-Plough Animal Health Corp. Growth stimulant compositions
US6498153B1 (en) 1998-12-31 2002-12-24 Akzo Nobel N.V. Extended release growth promoting two component composition
US6787342B2 (en) 2000-02-16 2004-09-07 Merial Limited Paste formulations
US6953586B1 (en) * 2000-06-08 2005-10-11 Ivy Animal Health, Inc. Growth promoting pharmaceutical implant
WO2007011707A2 (en) 2005-07-15 2007-01-25 Micell Technologies, Inc. Polymer coatings containing drug powder of controlled morphology
WO2007011708A2 (en) 2005-07-15 2007-01-25 Micell Technologies, Inc. Stent with polymer coating containing amorphous rapamycin
US8362086B2 (en) 2005-08-19 2013-01-29 Merial Limited Long acting injectable formulations
AU2007243268B2 (en) 2006-04-26 2013-06-13 Micell Technologies, Inc. Coatings containing multiple drugs
CA2667890C (en) * 2006-10-31 2015-01-27 Surmodics Pharmaceuticals, Inc. Spheronized polymer particles
US11426494B2 (en) 2007-01-08 2022-08-30 MT Acquisition Holdings LLC Stents having biodegradable layers
CA2679712C (en) 2007-01-08 2016-11-15 Micell Technologies, Inc. Stents having biodegradable layers
SG192524A1 (en) 2008-04-17 2013-08-30 Micell Technologies Inc Stents having bioabsorbable layers
KR20160029870A (ko) 2008-04-21 2016-03-15 오토노미, 인코포레이티드 귀 질환 및 병태를 치료하기 위한 귀 조제물
WO2010009335A1 (en) 2008-07-17 2010-01-21 Micell Technologies, Inc. Drug delivery medical device
US9510856B2 (en) 2008-07-17 2016-12-06 Micell Technologies, Inc. Drug delivery medical device
MX2011000629A (es) 2008-07-17 2011-04-26 Merial Ltd Formulaciones analgesicas inyectables de larga duracion para animales.
WO2010011605A2 (en) 2008-07-21 2010-01-28 Otonomy, Inc. Controlled-release otic structure modulating and innate immune system modulating compositions and methods for the treatment of otic disorders
US8784870B2 (en) * 2008-07-21 2014-07-22 Otonomy, Inc. Controlled release compositions for modulating free-radical induced damage and methods of use thereof
US9981072B2 (en) 2009-04-01 2018-05-29 Micell Technologies, Inc. Coated stents
EP2419058B1 (en) 2009-04-17 2018-02-28 Micell Technologies, Inc. Stents having controlled elution
EP2531140B1 (en) 2010-02-02 2017-11-01 Micell Technologies, Inc. Stent and stent delivery system with improved deliverability
US10232092B2 (en) 2010-04-22 2019-03-19 Micell Technologies, Inc. Stents and other devices having extracellular matrix coating
AU2011271500A1 (en) * 2010-06-30 2013-02-14 Evonik Corporation Implant processing methods for thermally labile and other bioactive agents and implants prepared from same
CA2805631C (en) 2010-07-16 2018-07-31 Micell Technologies, Inc. Drug delivery medical device
US10117972B2 (en) 2011-07-15 2018-11-06 Micell Technologies, Inc. Drug delivery medical device
US10188772B2 (en) 2011-10-18 2019-01-29 Micell Technologies, Inc. Drug delivery medical device
CA3082432C (en) * 2011-12-02 2023-01-03 Boehringer Ingelheim Animal Health USA Inc. Long-acting injectable moxidectin formulations and novel moxidectin crystal forms
CA2905419C (en) 2013-03-12 2020-04-28 Micell Technologies, Inc. Bioabsorbable biomedical implants
CA2912387C (en) 2013-05-15 2019-04-16 Micell Technologies, Inc. Bioabsorbable biomedical implants
US10226419B2 (en) 2014-09-08 2019-03-12 ProMed Pharma, LLC Methods for manufacturing implants
CA2993645A1 (en) 2015-07-28 2017-02-02 Otonomy, Inc. Trkb or trkc agonist compositions and methods for the treatment of otic conditions
CN109689027A (zh) 2016-06-29 2019-04-26 奥德纳米有限公司 甘油三酯耳用制剂及其用途
SI3737233T1 (sl) 2018-01-09 2025-10-30 Dompé Farmaceutici S.P.A. Ušesne formulacije z rastnimi faktorji
US20230355542A1 (en) * 2022-05-04 2023-11-09 Yasin Oduk Drug-eluting device with genetic and chemical therapeutics for treating or preventing vascular access dysfunctions

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) * 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
CA1076480A (en) * 1975-04-28 1980-04-29 John S. Kent Inert core implant pellet
US4191741A (en) * 1978-09-22 1980-03-04 Eli Lilly And Company Removable drug implant
US4293539A (en) * 1979-09-12 1981-10-06 Eli Lilly And Company Controlled release formulations and method of treatment
DK119884A (da) * 1983-03-18 1984-09-19 Lilly Co Eli Fast, cylindrisk, subkutan implantation og dens anvendelse
CA1236641A (en) * 1984-07-06 1988-05-10 Motoaki Tanaka Copolymer of lactic acid and glycolic acid and method for producing same

Also Published As

Publication number Publication date
AU7672487A (en) 1988-02-18
AU599406B2 (en) 1990-07-19
GR3004370T3 (enExample) 1993-03-31
DE3778244D1 (de) 1992-05-21
EP0257369A1 (en) 1988-03-02
CA1297020C (en) 1992-03-10
ES2031096T3 (es) 1992-12-01
US4758435A (en) 1988-07-19
ZA875897B (en) 1988-05-25
EP0257369B1 (en) 1992-04-15
NZ221390A (en) 1990-10-26

Similar Documents

Publication Publication Date Title
ATE74751T1 (de) Oestradiol-implantat und verfahren zu seiner herstellung.
DE68920975D1 (de) Den unangenehmen Geschmack verdeckende Zusammensetzungen und Verfahren zu ihrer Herstellung.
ATE89161T1 (de) Zubereitungen mit verzoegerter freisetzung sowie deren herstellung.
CA2011637A1 (en) Compositions for the sustained-release of chlorhexidine
IL78826A (en) Precursor composition for the preparation of a biodegradable implant for the sustained release of an active material and such implants prepared therefrom
DE68923819D1 (de) Verwendung von gamma-Hydroxy-Buttersäuresalzen zur Herstellung von pharmazeutischen Zusammensetzungen zur Verwendung bei der Behandlung von Alkoholismus und die hergestellten Zusammensetzungen.
CA2029046A1 (en) Sustained release compositions for treating periodontal disease
DE69030874D1 (de) Nichtresorbierbares Zweiphasen-Hornhautimplantat und Verfahren zu seiner Herstellung
HUT58058A (en) Insecticidal composition and process for producing its active ingredient, 1-phenylimidazole derivatives
HUT52083A (en) Herbicidal compositions comprising cyclohexenone oxymetres as active ingredient and process for producing the active ingredients
ATE173578T1 (de) Implantierbare formkörper zur verabreichung von wirkstoffen an pflanzen
DE69011985D1 (de) Medizinisches Material, Verfahren zu seiner Herstellung und medizinisches Gerät, in dem dieses Material verwendet wird.
ATE74487T1 (de) Verfahren zur herstellung und verwendung fester, pflanzenwirksamer zusammensetzungen.
ATE100095T1 (de) 2,2-dimethylchromenderivate, verfahren zur herstellung und diese enthaltende pharmazeutische zusammenstellungen.
HUT46508A (en) Insecticidal compositions comprising 6-member heterocyclic derivatives of n'-substituted-n,n'-diacylhydrazine and process for producing the active ingredients
DK0443848T3 (da) Nyt antiulcermiddel
HUT54358A (en) Process for producing substituted 1,3,5-triazinetrione derivatives and medical compositions comprising such compounds as active ingredient
HUT54289A (en) Fungicidal compositions comprising guanidine derivatives as active ingredient and process for producing the active ingredients
GB8603964D0 (en) Compositions
DE69314463D1 (de) Hautregenerierende kosmetische zusammensetzung
HUT63306A (en) Insecticidal compositions comprising guanide derivatives as active ingredient and process for producing the active ingredient
HUT46323A (en) Compositions against pestiferous insects and process for producing compositions against zooparasites and comprising milbemycin derivatives as active ingredient and for producing the active ingredients
DE3850044D1 (de) Azelastin-Embonat, Verfahren zu seiner Herstellung und pharmazeutische Zubereitungen, die als Wirkstoff Azelastin-Embonat enthalten.
HUT46641A (en) Fungicides comprising propargyl-oxy-benzene derivatives as active ingredient and process for producing the active ingredients
HUT46881A (en) Herbicides comprising cyclohexane-1,3,5-triones as active ingredient and process for producing the active ingredients

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee