ATE74751T1 - Oestradiol-implantat und verfahren zu seiner herstellung. - Google Patents

Oestradiol-implantat und verfahren zu seiner herstellung.

Info

Publication number
ATE74751T1
ATE74751T1 AT87111218T AT87111218T ATE74751T1 AT E74751 T1 ATE74751 T1 AT E74751T1 AT 87111218 T AT87111218 T AT 87111218T AT 87111218 T AT87111218 T AT 87111218T AT E74751 T1 ATE74751 T1 AT E74751T1
Authority
AT
Austria
Prior art keywords
oestradiol
implant
manufacture
time
extended periods
Prior art date
Application number
AT87111218T
Other languages
English (en)
Inventor
Mimi Yih-Pei Chou Schaaf
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Application granted granted Critical
Publication of ATE74751T1 publication Critical patent/ATE74751T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A61K9/204—Polyesters, e.g. poly(lactide-co-glycolide)

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
  • Prostheses (AREA)
  • Materials For Medical Uses (AREA)
AT87111218T 1986-08-11 1987-08-04 Oestradiol-implantat und verfahren zu seiner herstellung. ATE74751T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/895,415 US4758435A (en) 1986-08-11 1986-08-11 Estradiol implant composition and method for preparation
EP87111218A EP0257369B1 (de) 1986-08-11 1987-08-04 Östradiol-Implantat und Verfahren zu seiner Herstellung

Publications (1)

Publication Number Publication Date
ATE74751T1 true ATE74751T1 (de) 1992-05-15

Family

ID=25404471

Family Applications (1)

Application Number Title Priority Date Filing Date
AT87111218T ATE74751T1 (de) 1986-08-11 1987-08-04 Oestradiol-implantat und verfahren zu seiner herstellung.

Country Status (10)

Country Link
US (1) US4758435A (de)
EP (1) EP0257369B1 (de)
AT (1) ATE74751T1 (de)
AU (1) AU599406B2 (de)
CA (1) CA1297020C (de)
DE (1) DE3778244D1 (de)
ES (1) ES2031096T3 (de)
GR (1) GR3004370T3 (de)
NZ (1) NZ221390A (de)
ZA (1) ZA875897B (de)

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US4846844A (en) * 1987-08-31 1989-07-11 Eli Lilly And Company Antimicrobial coated implants
DE3734223A1 (de) * 1987-10-09 1989-04-20 Boehringer Ingelheim Kg Implantierbares, biologisch abbaubares wirkstofffreigabesystem
US5250584A (en) * 1988-08-31 1993-10-05 G-C Dental Industrial Corp. Periodontium-regenerative materials
FR2654337B1 (fr) * 1989-11-15 1994-08-05 Roussel Uclaf Nouvelles microspheres injectables biodegradables procede de preparation et suspensions injectables les renfermant.
US5198220A (en) * 1989-11-17 1993-03-30 The Procter & Gamble Company Sustained release compositions for treating periodontal disease
US5350580A (en) * 1990-03-05 1994-09-27 Minnesota Mining And Manufacturing Company Device and method for extended delivery of pharmacologically active agents to the ear
EP0447719B1 (de) * 1990-03-05 1993-11-03 Minnesota Mining And Manufacturing Company Vorrichtung zur verzögerten Abgabe von pharmakologisch aktiven Verbindungen ins Ohr
US5288496A (en) * 1990-05-15 1994-02-22 Stolle Research & Development Corporation Growth promoters for animals
US5643595A (en) * 1992-11-24 1997-07-01 Alkermes Controlled Therapeutics Inc. Ii Growth promoters for animals
US20020111603A1 (en) 1996-12-02 2002-08-15 Societe De Conseils De Recherches Et D'application Device for local administration of solid or semi-solid formulations and delayed-release formulations for proposal parental administration and preparation process
FR2756493B1 (fr) * 1996-12-02 2001-04-13 Delab Dispositif d'administration locale de formulations solides ou semi-solides
DE19744135C1 (de) * 1997-09-29 1999-03-25 Schering Ag Beschichtete medizinische Implantate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Restenoseprophylaxe
US6022554A (en) * 1997-12-15 2000-02-08 American Home Products Corporation Polymeric microporous film coated subcutaneous implant
ES2359973T3 (es) 1998-03-19 2011-05-30 MERCK SHARP & DOHME CORP. Composiciones poliméricas líquidas para la liberación controlada de sustancias bioactivas.
FR2770134B1 (fr) * 1998-10-28 2002-06-07 Delab Formulations solides ou semi-solides pour administration locale
US7767708B2 (en) * 1998-11-04 2010-08-03 Schering-Plough Animal Health Corp. Growth stimulant compositions
US6498153B1 (en) 1998-12-31 2002-12-24 Akzo Nobel N.V. Extended release growth promoting two component composition
US6787342B2 (en) 2000-02-16 2004-09-07 Merial Limited Paste formulations
US6953586B1 (en) * 2000-06-08 2005-10-11 Ivy Animal Health, Inc. Growth promoting pharmaceutical implant
WO2007011708A2 (en) 2005-07-15 2007-01-25 Micell Technologies, Inc. Stent with polymer coating containing amorphous rapamycin
JP5756588B2 (ja) 2005-07-15 2015-07-29 ミセル テクノロジーズ、インコーポレイテッド 制御されたモルホロジーの薬剤粉末を含むポリマーコーティング
US8362086B2 (en) 2005-08-19 2013-01-29 Merial Limited Long acting injectable formulations
CA2996768C (en) 2006-04-26 2020-12-08 Micell Technologies, Inc. Coatings containing multiple drugs
JP5419699B2 (ja) * 2006-10-31 2014-02-19 エボニック コーポレイション 球状化されたポリマー粒子
JP5603598B2 (ja) 2007-01-08 2014-10-08 ミセル テクノロジーズ、インコーポレイテッド 生物分解層を有するステント
US11426494B2 (en) 2007-01-08 2022-08-30 MT Acquisition Holdings LLC Stents having biodegradable layers
US9433516B2 (en) 2007-04-17 2016-09-06 Micell Technologies, Inc. Stents having controlled elution
BRPI0910969B8 (pt) 2008-04-17 2021-06-22 Micell Technologies Inc dispositivo
EP2278999B1 (de) 2008-04-21 2025-01-29 Dompé farmaceutici S.p.A. Ohrbehandlungsformulierungen zur behandlung von ohrenerkrankungen und -leiden
AU2009270695A1 (en) 2008-07-17 2010-01-21 Ap Pharma Methods for enhancing the stability of polyorthoesters and their formulations
WO2011009096A1 (en) 2009-07-16 2011-01-20 Micell Technologies, Inc. Drug delivery medical device
EP2313122B1 (de) 2008-07-17 2019-03-06 Micell Technologies, Inc. Medizinische wirkstofffreisetzungsvorrichtung
US8784870B2 (en) * 2008-07-21 2014-07-22 Otonomy, Inc. Controlled release compositions for modulating free-radical induced damage and methods of use thereof
JP5421366B2 (ja) 2008-07-21 2014-02-19 オトノミ―，インク． 制御放出性の耳の構造体調節および生来の免疫システム調節化合物および耳の障害の処置のための方法
EP2413847A4 (de) 2009-04-01 2013-11-27 Micell Technologies Inc Beschichtete stents
EP2531140B1 (de) 2010-02-02 2017-11-01 Micell Technologies, Inc. Stent und stenteinsatzsystem mit verbesserter einsetzbarkeit
WO2011133655A1 (en) 2010-04-22 2011-10-27 Micell Technologies, Inc. Stents and other devices having extracellular matrix coating
CA2804035A1 (en) * 2010-06-30 2012-01-05 Evonik Degussa Corporation Implant processing methods for thermally labile and other bioactive agents and implants prepared from same
EP2593039B1 (de) 2010-07-16 2022-11-30 Micell Technologies, Inc. Medizinische wirkstofffreisetzungsvorrichtung
WO2013012689A1 (en) 2011-07-15 2013-01-24 Micell Technologies, Inc. Drug delivery medical device
US10188772B2 (en) 2011-10-18 2019-01-29 Micell Technologies, Inc. Drug delivery medical device
WO2013082373A1 (en) * 2011-12-02 2013-06-06 Merial Limited Long-acting injectable moxidectin formulations and novel moxidectin crystal forms
JP6330024B2 (ja) 2013-03-12 2018-05-23 マイセル・テクノロジーズ，インコーポレイテッド 生体吸収性バイオメディカルインプラント
JP2016519965A (ja) 2013-05-15 2016-07-11 マイセル・テクノロジーズ，インコーポレイテッド 生体吸収性バイオメディカルインプラント
US10226419B2 (en) 2014-09-08 2019-03-12 ProMed Pharma, LLC Methods for manufacturing implants
EP3328898B8 (de) 2015-07-28 2024-04-10 6452728 Canada Corp. Trkb- oder trkc-agonisten-zusammensetzungen und verfahren zur behandlung von erkrankungen des ohrs
CN109689027A (zh) 2016-06-29 2019-04-26 奥德纳米有限公司 甘油三酯耳用制剂及其用途
LT3737233T (lt) 2018-01-09 2025-11-25 Augimo faktoriaus preparatai ausims
US20230355542A1 (en) * 2022-05-04 2023-11-09 Yasin Oduk Drug-eluting device with genetic and chemical therapeutics for treating or preventing vascular access dysfunctions

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) * 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
CA1076480A (en) * 1975-04-28 1980-04-29 John S. Kent Inert core implant pellet
US4191741A (en) * 1978-09-22 1980-03-04 Eli Lilly And Company Removable drug implant
US4293539A (en) * 1979-09-12 1981-10-06 Eli Lilly And Company Controlled release formulations and method of treatment
DK119884A (da) * 1983-03-18 1984-09-19 Lilly Co Eli Fast, cylindrisk, subkutan implantation og dens anvendelse
CA1256638A (en) * 1984-07-06 1989-06-27 Motoaki Tanaka Polymer and its production

Also Published As

Publication number Publication date
US4758435A (en) 1988-07-19
DE3778244D1 (de) 1992-05-21
GR3004370T3 (de) 1993-03-31
ES2031096T3 (es) 1992-12-01
AU7672487A (en) 1988-02-18
NZ221390A (en) 1990-10-26
ZA875897B (en) 1988-05-25
EP0257369B1 (de) 1992-04-15
EP0257369A1 (de) 1988-03-02
AU599406B2 (en) 1990-07-19
CA1297020C (en) 1992-03-10

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee