ATE72584T1 - Homogenes testsystem fuer spezifische polynukleotide und kit dafuer. - Google Patents

Homogenes testsystem fuer spezifische polynukleotide und kit dafuer.

Info

Publication number
ATE72584T1
ATE72584T1 AT86306860T AT86306860T ATE72584T1 AT E72584 T1 ATE72584 T1 AT E72584T1 AT 86306860 T AT86306860 T AT 86306860T AT 86306860 T AT86306860 T AT 86306860T AT E72584 T1 ATE72584 T1 AT E72584T1
Authority
AT
Austria
Prior art keywords
reagent
analyte
sample
rendering
reagents
Prior art date
Application number
AT86306860T
Other languages
English (en)
Inventor
Nurith Kurn
Chander Bahl
Edwin F Ullman
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25098095&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE72584(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Syntex Inc filed Critical Syntex Inc
Application granted granted Critical
Publication of ATE72584T1 publication Critical patent/ATE72584T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701Specific hybridization probes
    • C12Q1/705Specific hybridization probes for herpetoviridae, e.g. herpes simplex, varicella zoster
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6832Enhancement of hybridisation reaction
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/81Packaged device or kit
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/807Apparatus included in process claim, e.g. physical support structures
    • Y10S436/808Automated or kit

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT86306860T 1985-09-06 1986-09-05 Homogenes testsystem fuer spezifische polynukleotide und kit dafuer. ATE72584T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/773,386 US4868104A (en) 1985-09-06 1985-09-06 Homogeneous assay for specific polynucleotides
EP86306860A EP0224995B2 (de) 1985-09-06 1986-09-05 Homogenes Testsystem für spezifische Polynukleotide und Kit dafür

Publications (1)

Publication Number Publication Date
ATE72584T1 true ATE72584T1 (de) 1992-02-15

Family

ID=25098095

Family Applications (1)

Application Number Title Priority Date Filing Date
AT86306860T ATE72584T1 (de) 1985-09-06 1986-09-05 Homogenes testsystem fuer spezifische polynukleotide und kit dafuer.

Country Status (7)

Country Link
US (1) US4868104A (de)
EP (1) EP0224995B2 (de)
JP (1) JPH07121238B2 (de)
AT (1) ATE72584T1 (de)
AU (1) AU597592B2 (de)
CA (1) CA1272940A (de)
DE (1) DE3683897D1 (de)

Families Citing this family (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4994368A (en) 1987-07-23 1991-02-19 Syntex (U.S.A.) Inc. Amplification method for polynucleotide assays
EP0310361A3 (de) * 1987-09-30 1989-05-24 Beckman Instruments, Inc. Aus drei Verzahnungen bestehendes Konjugat und Verfahren zu seiner Verwendung
US5196351A (en) * 1987-09-30 1993-03-23 Beckman Instruments, Inc. Bidentate conjugate and method of use thereof
US5002867A (en) * 1988-04-25 1991-03-26 Macevicz Stephen C Nucleic acid sequence determination by multiple mixed oligonucleotide probes
US5817797A (en) * 1988-06-01 1998-10-06 The United States Of America As Represented By The Department Of Health And Human Services Sequencing DNA; a modification of the polymerase chain reaction
US5185243A (en) * 1988-08-25 1993-02-09 Syntex (U.S.A.) Inc. Method for detection of specific nucleic acid sequences
JP3021036B2 (ja) * 1989-02-13 2000-03-15 ジェネコ・ピーティーワイ・リミテッド 核酸配列又はその中の変化の検出
US5856092A (en) * 1989-02-13 1999-01-05 Geneco Pty Ltd Detection of a nucleic acid sequence or a change therein
US6040138A (en) * 1995-09-15 2000-03-21 Affymetrix, Inc. Expression monitoring by hybridization to high density oligonucleotide arrays
BR9106345A (pt) 1990-04-16 1993-04-20 Univ Pennsylvania Composicoes de sacarideos,processos e aparelhos para sua sintese
US5180674A (en) 1990-04-16 1993-01-19 The Trustees Of The University Of Pennsylvania Saccharide compositions, methods and apparatus for their synthesis
CA2040896C (en) * 1990-04-20 2002-01-29 Edwin F. Ullman Double receptor polynucleotide assay method
US5595891A (en) * 1990-07-19 1997-01-21 Behringwerke Ag Method for producing a polynucleotide for use in single primer amplification
US5439793A (en) * 1990-07-19 1995-08-08 Syntex (U.S.A.) Inc. Method for producing a polynucleotide having an intramolecularly base-paired structure
JPH04120732A (ja) * 1990-09-12 1992-04-21 Hitachi Ltd 固体素子及びその製造方法
US5173562A (en) * 1990-10-29 1992-12-22 Chisso America Inc. Liquid crystal polymer composition containing bisphenol A in combination with 4,4'-thiodiphenol
US6518051B1 (en) 1991-04-11 2003-02-11 The Trustees Of The University Of Pennsylvania Saccharide compositions, methods and apparatus for their synthesis
CA2080305A1 (en) 1991-10-11 1993-04-12 Linda M. Western Method for producing a polynucleotide for use in single primer amplification and phosphorothioate-containing oligonucleotides as primers in nucleic acid amplification
US5543292A (en) * 1992-06-16 1996-08-06 Hitachi, Ltd. Process for the measurement of nucleic acids
US5747352A (en) * 1994-05-23 1998-05-05 Beckman Instruments, Inc. Reagents and methods for the rapid and quantitative assay of pharmacological agents
US5807522A (en) * 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
US7378236B1 (en) 1994-06-17 2008-05-27 The Board Of Trustees Of The Leland Stanford Junior University Method for analyzing gene expression patterns
US7323298B1 (en) 1994-06-17 2008-01-29 The Board Of Trustees Of The Leland Stanford Junior University Microarray for determining the relative abundances of polynuceotide sequences
US8236493B2 (en) 1994-10-21 2012-08-07 Affymetrix, Inc. Methods of enzymatic discrimination enhancement and surface-bound double-stranded DNA
US5882867A (en) * 1995-06-07 1999-03-16 Dade Behring Marburg Gmbh Detection of nucleic acids by formation of template-dependent product
US5981180A (en) * 1995-10-11 1999-11-09 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and methods
WO1997014028A2 (en) 1995-10-11 1997-04-17 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and method
US5736330A (en) * 1995-10-11 1998-04-07 Luminex Corporation Method and compositions for flow cytometric determination of DNA sequences
DE69637518D1 (de) * 1995-12-22 2008-06-19 Dade Behring Marburg Gmbh Homogene vervielfältigung und nachweis von nukleinsäuren
EP0880598A4 (de) 1996-01-23 2005-02-23 Affymetrix Inc Verfahren zur analyse von nukleinsäure
DK1179600T3 (da) * 1996-06-04 2005-09-05 Univ Utah Res Found Overvågning af hybridisering under PCR
DE69725118T2 (de) * 1996-07-18 2004-07-08 Dade Behring Marburg Gmbh Reagentien für tests für mycophenolsäure
JP3706895B2 (ja) 1996-07-18 2005-10-19 ベーリングウエルケ、アクティエンゲゼルシャフト リガンド検定用試薬
US7098320B1 (en) 1996-07-29 2006-08-29 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6984491B2 (en) 1996-07-29 2006-01-10 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6361944B1 (en) 1996-07-29 2002-03-26 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US7169556B2 (en) 1996-07-29 2007-01-30 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6506564B1 (en) 1996-07-29 2003-01-14 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6582921B2 (en) * 1996-07-29 2003-06-24 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses thereof
US6750016B2 (en) * 1996-07-29 2004-06-15 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6449562B1 (en) 1996-10-10 2002-09-10 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and method
US6974669B2 (en) 2000-03-28 2005-12-13 Nanosphere, Inc. Bio-barcodes based on oligonucleotide-modified nanoparticles
US20050037397A1 (en) * 2001-03-28 2005-02-17 Nanosphere, Inc. Bio-barcode based detection of target analytes
US5929049A (en) * 1997-08-08 1999-07-27 Dade Behring Marburg Gmbh Polysaccharide conjugates of biomolecules
US6365346B1 (en) 1998-02-18 2002-04-02 Dade Behring Inc. Quantitative determination of nucleic acid amplification products
US6153442A (en) * 1998-05-20 2000-11-28 Dade Behring Inc. Reagents and methods for specific binding assays
US6303325B1 (en) 1998-05-29 2001-10-16 Dade Behring Inc. Method for detecting analytes
DE69936534T2 (de) 1998-11-30 2008-03-13 Nanosphere, Inc., Northbrook Nanopartikel mit polymerschalen
WO2000034521A1 (en) * 1998-12-08 2000-06-15 Boston Probes, Inc. Methods, kits and compositions for the identification of nucleic acids electrostatically bound to matrices
EP1165787A2 (de) 1999-03-31 2002-01-02 The University of North Carolina at Chapel Hill Cullin regulatoren roc1 und roc2, dafür kodierende dna, und methoden zur ihrer verwendug
US7101989B1 (en) 1999-07-09 2006-09-05 University Of North Carolina At Chapel Hill DsrA protein and polynucleotides encoding the same
EP1294930B1 (de) * 2000-01-13 2011-03-30 Nanosphere, Inc. Nanopartikel an denen oligonukleotide gebunden sind und deren verwendungen
AU2001276870B2 (en) * 2000-07-11 2006-07-20 Northwestern University Method of detection by enhancement of silver staining
US20060040286A1 (en) * 2001-03-28 2006-02-23 Nanosphere, Inc. Bio-barcode based detection of target analytes
US20030113740A1 (en) * 2001-04-26 2003-06-19 Mirkin Chad A. Oligonucleotide-modified ROMP polymers and co-polymers
US7147687B2 (en) * 2001-05-25 2006-12-12 Nanosphere, Inc. Non-alloying core shell nanoparticles
AU2002239726A1 (en) * 2001-05-25 2002-12-09 Northwestern University Non-alloying core shell nanoparticles
US20040161741A1 (en) * 2001-06-30 2004-08-19 Elazar Rabani Novel compositions and processes for analyte detection, quantification and amplification
US9777312B2 (en) * 2001-06-30 2017-10-03 Enzo Life Sciences, Inc. Dual polarity analysis of nucleic acids
US9261460B2 (en) 2002-03-12 2016-02-16 Enzo Life Sciences, Inc. Real-time nucleic acid detection processes and compositions
EP1466015B1 (de) 2001-11-09 2008-08-06 Nanosphere, Inc. Biokonjugat-nanopartikelsonden
US9575070B2 (en) * 2001-12-04 2017-02-21 Wayne State University Neoepitope detection of disease using protein arrays
US7674632B1 (en) * 2001-12-10 2010-03-09 Zeus Scientific, Inc Method and composition for homogeneous multiplexed microparticle-based assay
US9353405B2 (en) 2002-03-12 2016-05-31 Enzo Life Sciences, Inc. Optimized real time nucleic acid detection processes
US20030211488A1 (en) * 2002-05-07 2003-11-13 Northwestern University Nanoparticle probs with Raman spectrocopic fingerprints for analyte detection
JP2005532456A (ja) * 2002-07-02 2005-10-27 ナノスフェアー インコーポレイテッド ナノ粒子ポリアニオン複合物ならびに分析物の検出における同複合物の用途
WO2004026109A2 (en) * 2002-09-20 2004-04-01 Wayne State University Molecular targets of cancer and aging
JP2007524347A (ja) * 2003-02-27 2007-08-30 ナノスフェアー インコーポレイテッド マイクロアレイ形式のアッセイにおける、万能ナノ粒子プローブを用いた標識不要の遺伝子発現プロファイリング
KR20070121853A (ko) 2003-03-31 2007-12-27 에프. 호프만-라 로슈 아게 일본 뇌염 바이러스 혈청군의 구성원을 포함하는, 특정플라비바이러스 검출용 조성물 및 방법
US20050250094A1 (en) * 2003-05-30 2005-11-10 Nanosphere, Inc. Method for detecting analytes based on evanescent illumination and scatter-based detection of nanoparticle probe complexes
US20050039420A1 (en) * 2003-07-31 2005-02-24 Albritton Charles Wade Fluid sensing in a drip tray
US7195919B2 (en) * 2003-12-19 2007-03-27 Beckman Coulter, Inc. Hematology controls for reticulocytes and nucleated red blood cells
US8101431B2 (en) 2004-02-27 2012-01-24 Board Of Regents, The University Of Texas System Integration of fluids and reagents into self-contained cartridges containing sensor elements and reagent delivery systems
EP1771583A2 (de) * 2004-07-26 2007-04-11 Nanosphere, Inc. Verfahren zur unterscheidung von methicillin-resistentem s. aureus von methicillin-sensitivem s. aureus in einer mischkultur
AU2006309284B2 (en) 2005-05-31 2012-08-02 Board Of Regents, The University Of Texas System Methods and compositions related to determination and use of white blood cell counts
WO2007002567A2 (en) * 2005-06-23 2007-01-04 Nanosphere, Inc. Selective isolation and concentration of nucleic acids from complex samples
DE602006018477D1 (de) * 2005-08-19 2011-01-05 Nanosphere Inc Dna und antikörpern sowie verwendungen davon
GB0605302D0 (en) * 2006-03-16 2006-04-26 Akubio Ltd Improvements in or relating to coating surfaces
US9487828B2 (en) 2012-05-10 2016-11-08 The General Hospital Corporation Methods for determining a nucleotide sequence contiguous to a known target nucleotide sequence
JP7016215B2 (ja) 2014-01-27 2022-02-04 ザ ジェネラル ホスピタル コーポレイション 配列決定のために核酸を調製する方法
WO2018053362A1 (en) 2016-09-15 2018-03-22 ArcherDX, Inc. Methods of nucleic acid sample preparation
EP3512965B1 (de) 2016-09-15 2024-03-13 ArcherDX, LLC Verfahren zur herstellung von nukleinsäuren zur analyse von zellfreier dna

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4193983A (en) * 1978-05-16 1980-03-18 Syva Company Labeled liposome particle compositions and immunoassays therewith
NL7807532A (nl) * 1978-07-13 1980-01-15 Akzo Nv Metaal-immunotest.
CA1190838A (en) * 1981-07-17 1985-07-23 Cavit Akin Homogeneous nucleic acid hybridization diagnostics by non-radiative energy transfer
FI63596C (fi) * 1981-10-16 1983-07-11 Orion Yhtymae Oy Mikrobdiagnostiskt foerfarande som grundar sig pao skiktshybridisering av nukleinsyror och vid foerfarandet anvaenda kombinationer av reagenser
US4522922A (en) * 1982-04-16 1985-06-11 Jose Carro Soluble assay
CA1222680A (en) * 1983-07-05 1987-06-09 Nanibhushan Dattagupta Testing dna samples for particular nucleotide sequences
US4623627A (en) * 1983-08-19 1986-11-18 Cetus Corporation Monoclonal antibody having specificity for the double-stranded conformation of native DNA and diagnostic methods using same
EP0139489A3 (de) * 1983-09-26 1988-01-13 Ortho Diagnostic Systems Inc. Sandwichhybridisierungsverfahren zum Nachweis von Nukleinsäuren
US4599303A (en) * 1983-12-12 1986-07-08 Hri Associates, Inc. Nucleic acid hybridization assay employing probes crosslinkable to target sequences
DE3586689T2 (de) * 1984-02-28 1993-04-08 Ortho Diagnostic Systems Inc Diagnose von genmissbildungen durch restriktionskarte-analysierung unter anwendung eines sandwichhybridisierungsformats.
GB8405437D0 (en) * 1984-03-01 1984-04-04 Amersham Int Plc Detecting polynucleotide sequences
US4749647A (en) * 1984-06-22 1988-06-07 Genetic Systems Corporation Polymerization-induced separation assay using recognition pairs
US4563417A (en) * 1984-08-31 1986-01-07 Miles Laboratories, Inc. Nucleic acid hybridization assay employing antibodies to intercalation complexes
US4820630A (en) * 1984-11-23 1989-04-11 Digene Diagnostics, Incorporated Assay for nucleic acid sequences, particularly genetic lesions, using interactive labels
US4751177A (en) * 1985-06-13 1988-06-14 Amgen Methods and kits for performing nucleic acid hybridization assays

Also Published As

Publication number Publication date
EP0224995B2 (de) 1995-11-08
JPH07121238B2 (ja) 1995-12-25
EP0224995A1 (de) 1987-06-10
US4868104A (en) 1989-09-19
DE3683897D1 (de) 1992-03-26
EP0224995B1 (de) 1992-02-12
AU6236486A (en) 1987-03-12
CA1272940A (en) 1990-08-21
JPS62103570A (ja) 1987-05-14
AU597592B2 (en) 1990-06-07

Similar Documents

Publication Publication Date Title
ATE72584T1 (de) Homogenes testsystem fuer spezifische polynukleotide und kit dafuer.
Kourkine et al. High-throughput, high-sensitivity genetic mutation detection by tandem single-strand conformation polymorphism/heteroduplex analysis capillary array electrophoresis
DE60042623D1 (de) Polynukleotidmatrix-basiertes Verfahren zur Identifizierung von Mikroorganismen
ATE54028T1 (de) Hybridisierungstest fuer nukleinsaeure mittels anwendung von nachweisbaren antihybridantik¯rpern.
ES8609473A1 (es) Un metodo para detectar material genetico objetivo
WO2001059161A3 (en) Analyte assays employing universal arrays
EP1709203A2 (de) Verbesserung von polynukleotid-ligationsreaktionen
AU1082492A (en) Diagnostic assays using nucleic acid probes
ES2061411A6 (es) Un metodo cuantitativo para la determinacion de moleculas de acido nucleico
ES8607560A1 (es) Un metodo para detectar una secuencia nucleotidica deteminada en una muestra
ES8607557A1 (es) Un metodo para detectar una secuencia polinuscleotidica determinada en un medio a ensayar
EP0128018A3 (en) Molecular genetic probe, and method of forming same, assay technique and kit using said molecular genetic probe
EP0843019A3 (de) Verfahren zur Bestimmung einer spezifischen Nukleinsäuresequenz, und ein Reagenz für diesen Zweck
Chia et al. Direct detection of PCR products for HLA class II typing
KR870009032A (ko) 핵산을 함유하는 시료중의 미생물의 검출
JP2000125900A5 (de)
KR102531590B1 (ko) 절단효소 인식부위의 미러링 결합에 의한 표적핵산의 검출 방법 및 핵산 검출용 조성물
Sutherland Enzymes in modern assay systems.
RU98108399A (ru) Набор для определения наличия или отсутствия нуклеотидной последовательности аналита-мишени (аналита-мишени) или, по меньшей мере, двух различных нуклеотидных последовательностей аналитов-мишеней (аналитов-мишеней) в образце материала (варианты), способ определения наличия или отсутствия нуклеотидной последовательности мишени (аналита-мишени) или, по меньшей мере, двух нуклеотидных последовательностей-мишеней (аналитов-мишеней) в образце материала (варианты) и способ количественного определения нуклеотидной последовательности-мишени (аналита-мишени) или, по меньшей мере, двух нуклеотидных последовательностей-мишеней (аналитов-мишеней) в образце материала (варианты)

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties