ATE69233T1 - (2,2-bis(aminomethyl)-1,3-propandiol-n,n'>plati - komplexe. - Google Patents

(2,2-bis(aminomethyl)-1,3-propandiol-n,n'>plati - komplexe.

Info

Publication number
ATE69233T1
ATE69233T1 AT87101030T AT87101030T ATE69233T1 AT E69233 T1 ATE69233 T1 AT E69233T1 AT 87101030 T AT87101030 T AT 87101030T AT 87101030 T AT87101030 T AT 87101030T AT E69233 T1 ATE69233 T1 AT E69233T1
Authority
AT
Austria
Prior art keywords
plati
aminomethyl
propanediol
complexes
bis
Prior art date
Application number
AT87101030T
Other languages
English (en)
Inventor
Child Ralph Grassing
Panayota Bitha
Joseph John Hlavka
Yang-I Lin
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Application granted granted Critical
Publication of ATE69233T1 publication Critical patent/ATE69233T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0086—Platinum compounds
    • C07F15/0093—Platinum compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F17/00—Metallocenes
    • C07F17/02—Metallocenes of metals of Groups 8, 9 or 10 of the Periodic Table
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Metal Extraction Processes (AREA)
AT87101030T 1986-01-31 1987-01-26 (2,2-bis(aminomethyl)-1,3-propandiol-n,n'>plati - komplexe. ATE69233T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/825,023 US4760157A (en) 1986-01-31 1986-01-31 (2,2,-bis(aminomethyl)-1,3-propanediol-N,N')platinum complexes
EP87101030A EP0231847B1 (de) 1986-01-31 1987-01-26 [2,2-Bis(aminomethyl)-1,3-propandiol-N,N']platin-Komplexe

Publications (1)

Publication Number Publication Date
ATE69233T1 true ATE69233T1 (de) 1991-11-15

Family

ID=25242935

Family Applications (1)

Application Number Title Priority Date Filing Date
AT87101030T ATE69233T1 (de) 1986-01-31 1987-01-26 (2,2-bis(aminomethyl)-1,3-propandiol-n,n'>plati - komplexe.

Country Status (17)

Country Link
US (2) US4760157A (de)
EP (1) EP0231847B1 (de)
JP (1) JPS62246589A (de)
KR (1) KR900003513B1 (de)
AT (1) ATE69233T1 (de)
AU (1) AU593319B2 (de)
CA (1) CA1268775A (de)
DE (1) DE3774286D1 (de)
DK (1) DK50687A (de)
ES (1) ES2037670T3 (de)
FI (1) FI84485C (de)
GR (1) GR3003068T3 (de)
HU (1) HU197754B (de)
NO (1) NO870397L (de)
NZ (1) NZ219095A (de)
PH (1) PH24452A (de)
ZA (1) ZA87714B (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4737589A (en) * 1985-08-27 1988-04-12 Nippon Kayaku Kabushiki Kaisha Platinum Complexes
US5384127A (en) * 1985-10-18 1995-01-24 Board Of Regents, The University Of Texas System Stable liposomal formulations of lipophilic platinum compounds
US5117022A (en) * 1985-10-18 1992-05-26 The Board Of Regents, The University Of Texas System Hydrophobic cis-platinum complexes efficiently incorporated into liposomes
US5041581A (en) * 1985-10-18 1991-08-20 The University Of Texas System Board Of Regents Hydrophobic cis-platinum complexes efficiently incorporated into liposomes
DE3630497A1 (de) * 1986-09-08 1988-03-10 Behringwerke Ag Cis-platin-komplexe, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische mittel
JPS63203692A (ja) * 1987-02-19 1988-08-23 Nippon Kayaku Co Ltd 新規白金錯体
US4870070A (en) * 1987-08-10 1989-09-26 American Cyanamid Company Water soluble platinum complexes of novel malonate derivatives
AT390065B (de) * 1987-10-08 1990-03-12 Behringwerke Ag Cis-platin-komplexe, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische mittel
US5434256A (en) * 1988-11-22 1995-07-18 Board Of Regents, The University Of Texas System Diamine platinum complexes as antitumor agents
US5041578A (en) * 1988-11-22 1991-08-20 Board Of Regents, The University Of Texas System Water soluble 1,2-diaminocyclohexane platinum (IV) complexes as antitumor agents
US5393909A (en) * 1988-11-22 1995-02-28 Board Of Regents, The University Of Texas System Diamine platinum complexes as antitumor agents
US5130450A (en) * 1990-04-25 1992-07-14 Nippon Kayaku Kabushiki Kaisha Platinum complexes
US5922689A (en) * 1995-09-11 1999-07-13 Unitech Pharmaceuticals, Inc. Cisplatin analogs for cancer treatment
US6133317A (en) * 1995-11-15 2000-10-17 Hart; Francis J. Oxalic acid or oxalate composition and method of treatment
US6133318A (en) 1995-11-15 2000-10-17 Hart; Francis J. Oxalic acid or oxalate compositions and methods for bacterial, viral, and other diseases or conditions
US5843475A (en) 1996-12-06 1998-12-01 Board Of Regents, The University Of Texas System Delivery and activation through liposome incorporation of diaminocyclohexane platinum (II) complexes
US7160908B2 (en) * 2003-03-04 2007-01-09 Unitech Pharmaceuticals, Inc. Dynamic anticancer platinum compounds

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH605550A5 (de) * 1972-06-08 1978-09-29 Research Corp
GB2019399A (en) * 1978-04-04 1979-10-31 Johnson Matthey Co Ltd Compositions Containing Platinum
NL7807334A (nl) * 1978-07-06 1980-01-08 Tno Platina-diaminecomplexen, werkwijze voor het bereiden daarvan, werkwijze voor het bereiden van een genees- middel met toepassing van een dergelijk platina-dia- minecomplex voor de behandeling van kanker, alsmede al- dus verkregen gevormd geneesmiddel.
NL8204067A (nl) * 1982-10-21 1984-05-16 Tno Platina-diaminecomplexen, werkwijze voor het bereiden daarvan, werkwijze voor het bereiden van een geneesmiddel met toepassing van een dergelijk platinadiaminecomplex voor de behandeling van kanker, alsmede aldus verkregen gevormd geneesmiddel.
NL181434C (nl) * 1980-01-03 1987-08-17 Tno Platina(iv)-diamine-complexen, alsmede hun bereiding en toepassing.
US4500465A (en) * 1982-06-28 1985-02-19 Engelhard Corporation Solubilized platinum (II) complexes
US4587331A (en) * 1984-12-17 1986-05-06 American Cyanamid Company Platinum complexes of polyhydroxylated alkylamines and 2-polyhydroxylated alkyl-1,2-diaminoethanes
US4808730A (en) * 1987-06-23 1989-02-28 American Cyanamid Company Synthesis of cisplatin analogs

Also Published As

Publication number Publication date
AU593319B2 (en) 1990-02-08
CA1268775A (en) 1990-05-08
KR870007190A (ko) 1987-08-17
HU197754B (en) 1989-05-29
EP0231847A3 (en) 1988-03-23
FI870415L (fi) 1987-08-01
DK50687D0 (da) 1987-01-30
ES2037670T3 (es) 1993-07-01
NO870397L (no) 1987-08-03
EP0231847B1 (de) 1991-11-06
AU6816687A (en) 1987-08-06
ZA87714B (en) 1987-09-30
PH24452A (en) 1990-06-25
DE3774286D1 (de) 1991-12-12
US4760157A (en) 1988-07-26
HUT44267A (en) 1988-02-29
US4900756A (en) 1990-02-13
EP0231847A2 (de) 1987-08-12
JPS62246589A (ja) 1987-10-27
FI870415A0 (fi) 1987-01-30
NO870397D0 (no) 1987-01-30
FI84485B (fi) 1991-08-30
KR900003513B1 (ko) 1990-05-21
GR3003068T3 (en) 1993-02-17
DK50687A (da) 1987-08-01
FI84485C (fi) 1991-12-10
NZ219095A (en) 1990-07-26

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee