ATE63560T1 - Bestimmte phosphonsaeuren und derivate. - Google Patents
Bestimmte phosphonsaeuren und derivate.Info
- Publication number
- ATE63560T1 ATE63560T1 AT86810219T AT86810219T ATE63560T1 AT E63560 T1 ATE63560 T1 AT E63560T1 AT 86810219 T AT86810219 T AT 86810219T AT 86810219 T AT86810219 T AT 86810219T AT E63560 T1 ATE63560 T1 AT E63560T1
- Authority
- AT
- Austria
- Prior art keywords
- carbon
- carboxy
- compounds
- heterocyclic ring
- direct bond
- Prior art date
Links
- 150000003009 phosphonic acids Chemical class 0.000 title 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- -1 2-carboxypyrrolidinyl Chemical group 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 102000018899 Glutamate Receptors Human genes 0.000 abstract 1
- 108010027915 Glutamate Receptors Proteins 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- HOKKHZGPKSLGJE-GSVOUGTGSA-N N-Methyl-D-aspartic acid Chemical compound CN[C@@H](C(O)=O)CC(O)=O HOKKHZGPKSLGJE-GSVOUGTGSA-N 0.000 abstract 1
- 208000012902 Nervous system disease Diseases 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 125000002837 carbocyclic group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 239000011203 carbon fibre reinforced carbon Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- ABLZXFCXXLZCGV-UHFFFAOYSA-N phosphonic acid group Chemical group P(O)(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/60—Quinoline or hydrogenated quinoline ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/58—Pyridine rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/59—Hydrogenated pyridine rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Detergent Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73810285A | 1985-05-24 | 1985-05-24 | |
| EP86810219A EP0203891B1 (de) | 1985-05-24 | 1986-05-20 | Bestimmte Phosphonsäuren und Derivate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE63560T1 true ATE63560T1 (de) | 1991-06-15 |
Family
ID=24966580
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT86810219T ATE63560T1 (de) | 1985-05-24 | 1986-05-20 | Bestimmte phosphonsaeuren und derivate. |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP0203891B1 (de) |
| JP (1) | JPH0653752B2 (de) |
| KR (1) | KR940010292B1 (de) |
| AT (1) | ATE63560T1 (de) |
| AU (1) | AU593553B2 (de) |
| CA (1) | CA1312331C (de) |
| CY (1) | CY1769A (de) |
| DD (1) | DD261164A5 (de) |
| DE (1) | DE3679236D1 (de) |
| DK (1) | DK167811B1 (de) |
| ES (1) | ES8707250A1 (de) |
| FI (1) | FI84356C (de) |
| GR (1) | GR861337B (de) |
| HK (1) | HK9994A (de) |
| HU (1) | HU204058B (de) |
| IE (1) | IE58440B1 (de) |
| IL (1) | IL78866A0 (de) |
| NO (1) | NO170807C (de) |
| NZ (1) | NZ216282A (de) |
| PH (1) | PH23848A (de) |
| PT (1) | PT82626B (de) |
| ZA (1) | ZA863826B (de) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4906621A (en) * | 1985-05-24 | 1990-03-06 | Ciba-Geigy Corporation | Certain 2-carboxypiperidyl-alkylene phosphonic acids and esters thereof useful for the treatment of disorders responsive to N-methyl-D-aspartate receptor blockade |
| US5057506A (en) * | 1985-05-24 | 1991-10-15 | Ciba-Geigy Corporation | Certain phosphonic acids and derivatives useful for the treatment of disorders responsive to N-methyl-D-aspartate receptor blockade |
| IL84492A0 (en) * | 1986-11-21 | 1988-04-29 | Ciba Geigy Ag | Unsaturated phosphonic acids and derivatives |
| US5175153A (en) * | 1987-11-30 | 1992-12-29 | Warner-Lambert Company | Substituted alpha-amino acids having pharmaceutical activity |
| US4968678A (en) * | 1988-02-19 | 1990-11-06 | Eli Lilly And Company | Tetrazole excitatory amino acid receptor antagonists |
| DE68905845T2 (de) * | 1988-02-19 | 1993-08-05 | Lilly Co Eli | Tetrazolverbindungen als antagonisten der excitatorischen aminosaeurerezeptoren. |
| US5177240A (en) * | 1988-10-21 | 1993-01-05 | G. D. Searle & Co. | O-phosphono(alkyl)-n-sulfonyl-phenyl-alanine derivatives useful as intermediates for preparation of phosphono-hydroisoquinolines |
| CA2000901A1 (en) * | 1988-10-21 | 1990-04-21 | Alexis A. Cordi | Phosphono-hydroisoquinoline compounds useful in reducing neurotoxic injury |
| US4997821A (en) * | 1988-10-21 | 1991-03-05 | Cordi Alexis A | Phosphono-hydroisoquinoline compounds useful in reducing neurotoxic injury |
| US5231102A (en) * | 1989-03-08 | 1993-07-27 | Merck Sharp & Dohme, Ltd. | Tetrahydroquinoline derivatives useful for neurodegenerative disorders |
| EP0386839B1 (de) * | 1989-03-08 | 1997-01-15 | Merck Sharp & Dohme Ltd. | Tetrahydroquinolin-Derivate, verwendbar bei neurodegenerativen Krankheiten |
| US5238958A (en) * | 1990-02-26 | 1993-08-24 | Warner-Lambert Company | Substituted α-amino acids having selected acidic moieties for use as excitatory amino acid antagonists in pharmaceuticals |
| US5194430A (en) * | 1990-05-17 | 1993-03-16 | Merrell Dow Pharmaceuticals Inc. | Heterocyclic-nmda antagonists |
| US5118675A (en) * | 1991-02-15 | 1992-06-02 | American Home Products Corporation | Quinoxaline phosphono-amino acids |
| US5124319A (en) * | 1991-10-11 | 1992-06-23 | American Home Products Corporation | Benzimidazole phosphono-amino acids |
| US5260286A (en) * | 1992-10-16 | 1993-11-09 | Japan Tobacco, Inc. | 2-piperidinecarboxylic acid derivatives useful as NMDA receptor antagonists |
| WO1999033846A2 (en) * | 1997-12-31 | 1999-07-08 | The University Of Kansas | Water soluble prodrugs of secondary and tertiary amine containing drugs and methods of making thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2104079B (en) | 1981-08-14 | 1985-08-21 | London Polytech | New aminoacid isomers, their production and their medicinal use |
-
1986
- 1986-04-30 PH PH33727A patent/PH23848A/en unknown
- 1986-05-19 FI FI862093A patent/FI84356C/fi not_active IP Right Cessation
- 1986-05-20 AT AT86810219T patent/ATE63560T1/de not_active IP Right Cessation
- 1986-05-20 DE DE8686810219T patent/DE3679236D1/de not_active Expired - Lifetime
- 1986-05-20 EP EP86810219A patent/EP0203891B1/de not_active Expired - Lifetime
- 1986-05-21 IL IL78866A patent/IL78866A0/xx not_active IP Right Cessation
- 1986-05-22 GR GR861337A patent/GR861337B/el unknown
- 1986-05-22 CA CA000509709A patent/CA1312331C/en not_active Expired - Fee Related
- 1986-05-22 PT PT82626A patent/PT82626B/pt not_active IP Right Cessation
- 1986-05-22 ZA ZA863826A patent/ZA863826B/xx unknown
- 1986-05-23 KR KR1019860004043A patent/KR940010292B1/ko not_active IP Right Cessation
- 1986-05-23 IE IE137286A patent/IE58440B1/en not_active IP Right Cessation
- 1986-05-23 AU AU57846/86A patent/AU593553B2/en not_active Ceased
- 1986-05-23 DK DK242786A patent/DK167811B1/da not_active IP Right Cessation
- 1986-05-23 ES ES555291A patent/ES8707250A1/es not_active Expired
- 1986-05-23 HU HU862195A patent/HU204058B/hu not_active IP Right Cessation
- 1986-05-23 NO NO862064A patent/NO170807C/no unknown
- 1986-05-23 NZ NZ216282A patent/NZ216282A/xx unknown
- 1986-05-23 DD DD86290535A patent/DD261164A5/de not_active IP Right Cessation
- 1986-05-24 JP JP61120050A patent/JPH0653752B2/ja not_active Expired - Lifetime
-
1994
- 1994-02-02 HK HK99/94A patent/HK9994A/xx not_active IP Right Cessation
-
1995
- 1995-10-20 CY CY176995A patent/CY1769A/xx unknown
Also Published As
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| Publication | Publication Date | Title |
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| ATE63560T1 (de) | Bestimmte phosphonsaeuren und derivate. | |
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| DE68914225D1 (de) | 3-Oxiranbenzoesäuren und Derivate. | |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |