ATE63123T1 - Reinigung von synthetischen oligomeren. - Google Patents

Reinigung von synthetischen oligomeren.

Info

Publication number
ATE63123T1
ATE63123T1 AT86104250T AT86104250T ATE63123T1 AT E63123 T1 ATE63123 T1 AT E63123T1 AT 86104250 T AT86104250 T AT 86104250T AT 86104250 T AT86104250 T AT 86104250T AT E63123 T1 ATE63123 T1 AT E63123T1
Authority
AT
Austria
Prior art keywords
gps
addn
oligomers
terminal blocking
monomers
Prior art date
Application number
AT86104250T
Other languages
English (en)
Inventor
Michael S Urdea
Thomas Horn
Original Assignee
Chiron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiron Corp filed Critical Chiron Corp
Application granted granted Critical
Publication of ATE63123T1 publication Critical patent/ATE63123T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C07F9/2404—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/2408—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic of hydroxyalkyl compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Luminescent Compositions (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Treatments Of Macromolecular Shaped Articles (AREA)
AT86104250T 1985-03-28 1986-03-27 Reinigung von synthetischen oligomeren. ATE63123T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US71720685A 1985-03-28 1985-03-28
EP86104250A EP0196101B1 (de) 1985-03-28 1986-03-27 Reinigung von synthetischen Oligomeren

Publications (1)

Publication Number Publication Date
ATE63123T1 true ATE63123T1 (de) 1991-05-15

Family

ID=24881128

Family Applications (2)

Application Number Title Priority Date Filing Date
AT86104250T ATE63123T1 (de) 1985-03-28 1986-03-27 Reinigung von synthetischen oligomeren.
AT90112795T ATE126518T1 (de) 1985-03-28 1986-03-27 0,0'-dicyanoethyl-phosphoramidite, verfahren zu deren herstellung und ihre verwendung in phosphorylierungsreaktionen.

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT90112795T ATE126518T1 (de) 1985-03-28 1986-03-27 0,0'-dicyanoethyl-phosphoramidite, verfahren zu deren herstellung und ihre verwendung in phosphorylierungsreaktionen.

Country Status (5)

Country Link
EP (2) EP0398391B1 (de)
JP (2) JPH0829090B2 (de)
AT (2) ATE63123T1 (de)
CA (1) CA1293938C (de)
DE (2) DE3678988D1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3433649A1 (de) * 1984-09-13 1986-03-20 Gesellschaft für Biotechnologische Forschung mbH (GBF), 3300 Braunschweig Verfahren zur aufreinigung synthetischer oligonucleotide
US5118605A (en) * 1984-10-16 1992-06-02 Chiron Corporation Polynucleotide determination with selectable cleavage sites
DE3507881A1 (de) * 1985-03-06 1986-09-11 Hoechst Ag, 6230 Frankfurt Verfahren und mittel zur phosphorylierung
FR2596761B1 (fr) * 1986-04-08 1988-05-20 Commissariat Energie Atomique Derives de nucleosides et leur utilisation pour la synthese d'oligonucleotides
US5204456A (en) * 1986-04-08 1993-04-20 Commissariat A L'energie Atomique Derivatives of nucleosides and their use for the synthesis of oligonucleotides
US5071974A (en) * 1986-10-31 1991-12-10 Amoco Corporation Compositions and methods for the synthesis of oligonucleotides having 5'-phosphorylated termini
US5262530A (en) 1988-12-21 1993-11-16 Applied Biosystems, Inc. Automated system for polynucleotide synthesis and purification
US5049656A (en) * 1988-12-21 1991-09-17 Board Of Regents Of The University Of Nebraska Sequential peptide and oligonucleotide syntheses using immunoaffinity techniques
US5047524A (en) * 1988-12-21 1991-09-10 Applied Biosystems, Inc. Automated system for polynucleotide synthesis and purification
GB9021625D0 (en) * 1990-10-04 1990-11-21 Ici Plc Synthesis of oligonucleotides
WO1992020697A1 (en) * 1991-05-10 1992-11-26 Hybridon, Inc. 3'-end blocked oligonucleotides
US5516664A (en) * 1992-12-23 1996-05-14 Hyman; Edward D. Enzymatic synthesis of repeat regions of oligonucleotides
US6965041B1 (en) 1999-03-24 2005-11-15 The United States Of America As Represented By The Department Of Health And Human Services N-acylphosphoramidites and their use in oligonucleotide synthesis
WO2003048179A2 (en) 2001-12-03 2003-06-12 The Government Of The United States Of America, Represented By The Secretary Of The Department Of Health And Human Services Thermolabile hydroxyl protecting groups and methods of use
WO2006065751A2 (en) 2004-12-13 2006-06-22 Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Cpg oligonucleotide prodrugs, compositions thereof and associated therapeutic methods

Also Published As

Publication number Publication date
EP0398391B1 (de) 1995-08-16
EP0196101B1 (de) 1991-05-02
JPH0867686A (ja) 1996-03-12
DE3678988D1 (de) 1991-06-06
CA1293938C (en) 1992-01-07
JP2801564B2 (ja) 1998-09-21
JPH0829090B2 (ja) 1996-03-27
DE3650371D1 (de) 1995-09-21
ATE126518T1 (de) 1995-09-15
DE3650371T2 (de) 1996-03-07
EP0196101A3 (en) 1988-01-07
JPS6219096A (ja) 1987-01-27
EP0398391A1 (de) 1990-11-22
EP0196101A2 (de) 1986-10-01

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee