ATE556709T1 - Pharmazeutische zusammensetzungen aus levobupivacain in der form freier basen oder pharmazeutischer verträglichen salzen und deren verwendung - Google Patents

Pharmazeutische zusammensetzungen aus levobupivacain in der form freier basen oder pharmazeutischer verträglichen salzen und deren verwendung

Info

Publication number
ATE556709T1
ATE556709T1 AT01916779T AT01916779T ATE556709T1 AT E556709 T1 ATE556709 T1 AT E556709T1 AT 01916779 T AT01916779 T AT 01916779T AT 01916779 T AT01916779 T AT 01916779T AT E556709 T1 ATE556709 T1 AT E556709T1
Authority
AT
Austria
Prior art keywords
levobupivacain
pharmaceutically acceptable
pharmaceutical compositions
acceptable salts
free bases
Prior art date
Application number
AT01916779T
Other languages
English (en)
Inventor
Roberto Takashi Sudo
Prazeres Barbalho Simonetti Maria Dos
Valter Freire Torres Russo
Souza Russo Elisa Mannochio De
Original Assignee
Cristalia Prod Quimicos Farm
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cristalia Prod Quimicos Farm filed Critical Cristalia Prod Quimicos Farm
Application granted granted Critical
Publication of ATE556709T1 publication Critical patent/ATE556709T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Anesthesiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
AT01916779T 2000-04-06 2001-04-05 Pharmazeutische zusammensetzungen aus levobupivacain in der form freier basen oder pharmazeutischer verträglichen salzen und deren verwendung ATE556709T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
BR0002246-2A BR0002246A (pt) 2000-04-06 2000-04-06 Processo de obtenção dos enantiÈmeros da bupivacaìna racêmica, processo de obtenção de composições farmacêuticas a base de levobupivacaìna: composições farmacêuticas a base de levobupivacaìna formuladas nas formas básicas ou sais farmaceuticamente aceitáveis e utilização das composições farmacêuticas a base de levobupivacaìna formuladas nas formas básicas ou sais farmaceuticamente aceitáveis
PCT/BR2001/000040 WO2001076599A1 (en) 2000-04-06 2001-04-05 Process of making racemic bupivacaine's enantiomers, levobupivacaine's pharmaceutical compositions, levobupivacaine's pharmaceutical compositions formulated on its free base form or its pharmaceutical acceptable salts and use of levobupivacaine's pharmaceutical compositions formulated on its free base form

Publications (1)

Publication Number Publication Date
ATE556709T1 true ATE556709T1 (de) 2012-05-15

Family

ID=37515791

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01916779T ATE556709T1 (de) 2000-04-06 2001-04-05 Pharmazeutische zusammensetzungen aus levobupivacain in der form freier basen oder pharmazeutischer verträglichen salzen und deren verwendung

Country Status (7)

Country Link
US (3) US20040024021A1 (de)
EP (1) EP1276480B1 (de)
AR (1) AR029906A1 (de)
AT (1) ATE556709T1 (de)
AU (1) AU4397501A (de)
BR (1) BR0002246A (de)
WO (1) WO2001076599A1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040001889A1 (en) 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
CN101797221B (zh) 2002-12-13 2013-06-12 杜雷科特公司 包含高粘度液体载体材料的口服递药系统
AU2005287175B2 (en) 2004-09-17 2011-12-01 Durect Corporation Sustained local anesthetic composition containing preferably a sugar ester such as SAIB
US20060270708A1 (en) * 2005-05-25 2006-11-30 Navinta Llc Novel process for preparation of isotonic aqueous injection of ropivacaine
US20070027105A1 (en) 2005-07-26 2007-02-01 Alza Corporation Peroxide removal from drug delivery vehicle
WO2007123405A1 (en) * 2006-04-25 2007-11-01 Dishman Pharmaceuticals And Chemicals Ltd. Ropivacaine hydrochloride anhydrate and the preparation thereof
EP2117521B1 (de) 2006-11-03 2012-06-27 Durect Corporation Transdermale abgabesysteme mit bupivacain
JP2011506319A (ja) 2007-12-06 2011-03-03 デュレクト コーポレーション 疼痛、関節炎症状、または慢性疾患に伴う炎症の治療に有用な方法
US20100260844A1 (en) 2008-11-03 2010-10-14 Scicinski Jan J Oral pharmaceutical dosage forms
JP2016515523A (ja) 2013-03-15 2016-05-30 デュレクト コーポレーション 溶解変動性を低減させるためのレオロジー改質剤を有する組成物
CN105315196A (zh) * 2015-11-28 2016-02-10 山东齐都药业有限公司 一种高纯度盐酸左布比卡因精制方法
AU2017292791B2 (en) 2016-07-06 2023-05-25 Orient Pharma Co., Ltd. Oral dosage form with drug composition, barrier layer and drug layer
CN106866501B (zh) * 2017-04-11 2019-09-20 山东百诺医药股份有限公司 一种盐酸左布比卡因的制备方法
CN107098849B (zh) * 2017-04-11 2019-09-20 山东百诺医药股份有限公司 一种盐酸左布比卡因的制备方法
CN109734654A (zh) * 2019-02-26 2019-05-10 南京亿华药业有限公司 一种盐酸左布比卡因的制备方法
CN110530992B (zh) * 2019-08-30 2022-05-10 珠海润都制药股份有限公司 一种盐酸左布比卡因注射液光学异构体的检验方法
EP4087554A4 (de) 2020-01-10 2024-01-17 Pacira Pharmaceuticals, Inc. Behandlung von schmerzen durch subarachnoidale verabreichung von liposomalen anästhetischen zusammensetzungen mit verzögerter freisetzung
WO2021141959A1 (en) 2020-01-10 2021-07-15 Pacira Pharmaceuticals, Inc. Treatment of pain by administration of sustained-release liposomal anesthetic compositions
CA3167217A1 (en) 2020-01-13 2021-07-22 Durect Corporation Sustained release drug delivery systems with reduced impurities and related methods
US11918688B2 (en) 2021-01-11 2024-03-05 Pacira Pharmaceuticals, Inc. Treatment of hip pain with sustained-release liposomal anesthetic compositions
CA3203561A1 (en) 2021-01-12 2022-07-21 Adrian Neil Verity Sustained release drug delivery systems and related methods
EP4308084A4 (de) 2021-03-19 2025-04-23 Pacira Pharmaceuticals, Inc. Behandlung von schmerzen bei pädiatrischen patienten durch verabreichung liposomaler anästhesiezusammensetzungen mit verzögerter freisetzung
US12226610B2 (en) 2022-11-03 2025-02-18 Pacira Pharmaceuticals, Inc. Treatment of pain associated with total knee arthroplasty with sustained-release liposomal anesthetic compositions
US11918565B1 (en) 2022-11-03 2024-03-05 Pacira Pharmaceuticals, Inc. Treatment of post-operative pain via sciatic nerve block with sustained-release liposomal anesthetic compositions

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE431092B (sv) * 1979-07-10 1984-01-16 Thuresson Af Ekenstam Bo Terapeutiskt aktiva, substituerade piperidinkarboxianilider
US5849763A (en) * 1993-10-13 1998-12-15 Darwin Discovery Limited Use of levobupivacaine as an anesthetic agent
DK0723445T3 (da) * 1993-10-13 1997-10-06 Chiroscience Ltd Analgetisk middel samt anvendelse deraf
GB9321061D0 (en) 1993-10-13 1993-12-01 Chiroscience Ltd Analgestic agent and its use
US5786484A (en) * 1994-09-23 1998-07-28 Chiroscience Limited Racemization and asymmetric transformation processes used in the manufacture of levobupivacaine and analogues thereof
CA2200355C (en) * 1994-10-25 2007-03-06 Marianne Langston Crystallisation of levobupivacaine and analogues thereof
GB9501071D0 (en) * 1995-01-18 1995-03-08 Chiroscience Ltd Racemisation
ATE239474T1 (de) * 1997-07-22 2003-05-15 Darwin Discovery Ltd Verwendung von levobupivacain
WO2002067896A1 (en) 2001-02-23 2002-09-06 Virginia Commonwealth University Ibutilide and methanesulfonamide for local anesthetics

Also Published As

Publication number Publication date
WO2001076599A8 (en) 2004-12-09
US20040024021A1 (en) 2004-02-05
AU4397501A (en) 2001-10-23
US20050239831A1 (en) 2005-10-27
WO2001076599A1 (en) 2001-10-18
US20070249681A1 (en) 2007-10-25
WO2001076599B1 (en) 2002-03-21
BR0002246A (pt) 2003-04-15
EP1276480A4 (de) 2003-07-16
EP1276480A1 (de) 2003-01-22
US7700629B2 (en) 2010-04-20
EP1276480B1 (de) 2012-05-09
AR029906A1 (es) 2003-07-23

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