ATE553764T1 - Zusammensetzungen und verfahren zur identifizierung von inhibitoren einer retrovirusinfektion - Google Patents

Zusammensetzungen und verfahren zur identifizierung von inhibitoren einer retrovirusinfektion

Info

Publication number
ATE553764T1
ATE553764T1 AT08830668T AT08830668T ATE553764T1 AT E553764 T1 ATE553764 T1 AT E553764T1 AT 08830668 T AT08830668 T AT 08830668T AT 08830668 T AT08830668 T AT 08830668T AT E553764 T1 ATE553764 T1 AT E553764T1
Authority
AT
Austria
Prior art keywords
methods
trna
inhibitors
nucleic acid
stem loop
Prior art date
Application number
AT08830668T
Other languages
English (en)
Inventor
Richard Guenther
Original Assignee
Trana Discovery
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Trana Discovery filed Critical Trana Discovery
Application granted granted Critical
Publication of ATE553764T1 publication Critical patent/ATE553764T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/702—Specific hybridization probes for retroviruses
    • C12Q1/703—Viruses associated with AIDS
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/99—Enzyme inactivation by chemical treatment
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • AIDS & HIV (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT08830668T 2007-09-14 2008-09-12 Zusammensetzungen und verfahren zur identifizierung von inhibitoren einer retrovirusinfektion ATE553764T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US97259507P 2007-09-14 2007-09-14
US8009208P 2008-07-11 2008-07-11
PCT/US2008/076210 WO2009036299A2 (en) 2007-09-14 2008-09-12 Compositions and methods for the identification of inhibitors of retroviral infection

Publications (1)

Publication Number Publication Date
ATE553764T1 true ATE553764T1 (de) 2012-05-15

Family

ID=40452844

Family Applications (1)

Application Number Title Priority Date Filing Date
AT08830668T ATE553764T1 (de) 2007-09-14 2008-09-12 Zusammensetzungen und verfahren zur identifizierung von inhibitoren einer retrovirusinfektion

Country Status (7)

Country Link
US (4) US20110033850A1 (de)
EP (2) EP2201118B1 (de)
CN (2) CN101854938B (de)
AT (1) ATE553764T1 (de)
AU (2) AU2008301890A1 (de)
CA (2) CA2699370A1 (de)
WO (2) WO2009036299A2 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008064304A2 (en) 2006-11-22 2008-05-29 Trana Discovery, Inc. Compositions and methods for the identification of inhibitors of protein synthesis
ATE553764T1 (de) * 2007-09-14 2012-05-15 Trana Discovery Zusammensetzungen und verfahren zur identifizierung von inhibitoren einer retrovirusinfektion
EP2342339A4 (de) * 2008-09-29 2012-06-06 Trana Discovery Inc Screening-verfahren zur identifizierung spezifischer staphylococcus aureus-inhibitoren
WO2010111718A2 (en) * 2009-03-13 2010-09-30 Trana Discovery Antiviral compounds and methods of use thereof
US9173886B2 (en) * 2010-03-12 2015-11-03 Trana Discovery, Inc. Antiviral compounds and methods of use thereof
WO2012079032A2 (en) * 2010-12-09 2012-06-14 Trana Discovery, Inc. Compositions and methods of treating drug-resistant retroviral infections
US9682100B2 (en) * 2015-01-26 2017-06-20 International Business Machines Corporation Cationic polyamines for treatment of viruses
CN109517877B (zh) * 2018-10-15 2021-07-20 北京大学 筛选m6A去修饰酶抑制剂的核苷酸底物、试剂盒和方法
CN112852824B (zh) * 2021-02-08 2023-05-23 中国农业科学院哈尔滨兽医研究所（中国动物卫生与流行病学中心哈尔滨分中心） 特异性识别fpv的核酸适配体

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0533838T3 (da) * 1990-06-11 1998-02-23 Nexstar Pharmaceuticals Inc Nukleinsyreligander
GB9016973D0 (en) * 1990-08-02 1990-09-19 Medical Res Council Viral growth inhibition
US5786145A (en) * 1990-09-20 1998-07-28 Medical Research Council Oligonucleotide competitors for binding of HIV RRE to REV protein and assays for screening inhibitors of this binding
US6446032B1 (en) * 1990-09-21 2002-09-03 Massachusetts Institute Of Technology Designing compounds specifically inhibiting ribonucleic acid by binding to the minor groove
US5358862A (en) * 1991-08-30 1994-10-25 Research Development Foundation Synthetic TRNAS
US5821052A (en) * 1992-04-16 1998-10-13 University Of Medicine And Dentistry Of New Jersey Control of the synthesis of proteins by anitisense RNA-tRNA complex
DE69434931T2 (de) * 1993-04-02 2007-11-22 Rigel Pharmaceuticals, Inc., South San Francisco Methode zur selektiven inaktivierung der viralen replication
US6824976B1 (en) * 1993-04-02 2004-11-30 Rigel Pharmaceuticals, Inc. Method for selective inactivation of viral replication
US5750394A (en) * 1994-05-20 1998-05-12 The Mount Sinai Medical Center Identification and use of antiviral compounds that inhibit interaction of host cell proteins and viral proteins required for viral replication
US5712096A (en) * 1994-08-23 1998-01-27 University Of Massachusetts Medical Center Oligoribonucleotide assays for novel antibiotics
GB9505438D0 (en) * 1995-03-17 1995-05-03 Sod Conseils Rech Applic Antisense oligonucleotides
US5593835A (en) * 1995-05-12 1997-01-14 President And Fellows Of Harvard College Methods and kits for RNA binding compounds
US6503703B1 (en) * 1995-05-19 2003-01-07 Mount Sinai School Of Medicine Of New York University Identification and use of antiviral compounds that inhibit interaction of host cell proteins and viral proteins required for viral replication
US5843655A (en) * 1995-09-18 1998-12-01 Affymetrix, Inc. Methods for testing oligonucleotide arrays
US6461845B1 (en) * 1995-09-27 2002-10-08 Emory University Recombinant hepatitis C virus RNA replicase
US6004749A (en) * 1996-07-31 1999-12-21 Message Pharmaceuticals Method for identifying compounds affecting RNA/RNA binding protein interactions
US6107029A (en) * 1996-07-31 2000-08-22 Message Pharmaceticals, Inc. Universal method for detecting interactions between RNA molecules and RNA binding proteins
US6448059B1 (en) * 1996-09-13 2002-09-10 Thomas Jefferson University Methods and composition for inhibition of tRNA activities
US5783985A (en) * 1997-04-25 1998-07-21 Littelfuse, Inc. Compressible body for fuse
US6355790B1 (en) * 1997-06-03 2002-03-12 University Of Rochester Inhibition of HIV replication using a mutated transfer RNA primer
US6156029A (en) * 1997-11-25 2000-12-05 Eclipse Surgical Technologies, Inc. Selective treatment of endocardial/myocardial boundary
US6846625B1 (en) * 1998-01-09 2005-01-25 Cubist Pharmaceuticals, Inc. Method for identifying validated target and assay combination for drug development
US6475726B1 (en) * 1998-01-09 2002-11-05 Cubist Pharmaceuticals, Inc. Method for identifying validated target and assay combinations for drug development
AU2225199A (en) * 1998-01-14 1999-08-02 Human Gene Therapy Research Institute Human suppressor trna oligonucleotides and methods of use for same
US6461815B1 (en) * 1998-05-22 2002-10-08 North Carolina State University Antibacterial agents and methods of screening for the same
US6605709B1 (en) * 1999-04-09 2003-08-12 Genome Therapeutics Corporation Nucleic acid and amino acid sequences relating to Proteus mirabilis for diagnostics and therapeutics
DE60042338D1 (de) * 1999-10-04 2009-07-16 Univ New Jersey Med TAR RNA bindende Peptide
KR20020064915A (ko) * 1999-11-29 2002-08-10 에이브이아이 바이오파마 인코포레이티드 안티센스 항박테리아 방법 및 조성물
US20020001804A1 (en) * 2000-02-25 2002-01-03 Wayne Mitchell Genomic analysis of tRNA gene sets
CA2401019A1 (en) * 2000-02-25 2001-08-30 Tao Biosciences, Llc Genomic analysis of trna gene sets
US6808876B1 (en) * 2000-05-02 2004-10-26 Immusol, Inc. Cellular regulators of infectious agents and methods of use
CN1137999C (zh) * 2000-07-04 2004-02-11 清华大学 集成式微阵列装置
SE0003002D0 (sv) * 2000-08-22 2000-08-22 Primert Ab New sequences
WO2002044349A2 (en) * 2000-11-28 2002-06-06 Mcgill University INCORPORATION AND PRIMING FUNCTION OF tRNALYS IN HIV AND RELATED VIRUSES
US20040219545A1 (en) * 2001-04-13 2004-11-04 Rando Robert F. Methods for identifying small molecules that bind specific rna structural motifs
WO2002083837A1 (en) * 2001-04-11 2002-10-24 Ptc Therapeutics, Inc. Methods for identifying small molecules that bind specific rna structural motifs
US20030143558A1 (en) * 2001-05-25 2003-07-31 Tao Biosciences, Llc Methods for attenuation of virulence in bacteria
US20050026145A1 (en) * 2001-07-24 2005-02-03 Pang Phillip S. Computational method for predicting intramolecular and intermolecular biopolymer interactions
US20030143247A1 (en) * 2002-01-30 2003-07-31 Robertson Hugh D. Antiviral compositions and methods for identification and use
FR2851577A1 (fr) * 2003-02-20 2004-08-27 Centre Nat Rech Scient Procede de criblage de composes inhibiteurs de l'initiation de la retrotranscription de l'arn de virus vih-1 et moyens de mise en oeuvre du procede
US20050136395A1 (en) * 2003-05-08 2005-06-23 Affymetrix, Inc Methods for genetic analysis of SARS virus
US20050239102A1 (en) * 2003-10-31 2005-10-27 Verdine Gregory L Nucleic acid binding oligonucleotides
CA2467312A1 (en) * 2004-05-14 2005-11-14 Lawrence Kleiman Inhibition of the trnalys3-primed initiation of reverse transcription in hiv-1 by apobec3g
US7361465B2 (en) * 2004-09-07 2008-04-22 Applera Corporation Methods and compositions for tailing and amplifying RNA
WO2008064304A2 (en) * 2006-11-22 2008-05-29 Trana Discovery, Inc. Compositions and methods for the identification of inhibitors of protein synthesis
ATE553764T1 (de) * 2007-09-14 2012-05-15 Trana Discovery Zusammensetzungen und verfahren zur identifizierung von inhibitoren einer retrovirusinfektion
EP2342339A4 (de) * 2008-09-29 2012-06-06 Trana Discovery Inc Screening-verfahren zur identifizierung spezifischer staphylococcus aureus-inhibitoren

Also Published As

Publication number Publication date
WO2009038666A3 (en) 2009-05-14
EP2201118B1 (de) 2012-04-18
EP2197455A2 (de) 2010-06-23
WO2009036299A2 (en) 2009-03-19
CA2699859A1 (en) 2009-03-26
US20110033850A1 (en) 2011-02-10
EP2201118A4 (de) 2010-10-20
US9677143B2 (en) 2017-06-13
CN101854938A (zh) 2010-10-06
EP2197455A4 (de) 2010-10-20
US20160222473A1 (en) 2016-08-04
AU2008298712A1 (en) 2009-03-19
EP2201118A2 (de) 2010-06-30
AU2008301890A1 (en) 2009-03-26
US9249473B2 (en) 2016-02-02
CN101854938B (zh) 2013-06-12
WO2009036299A3 (en) 2009-05-07
WO2009038666A2 (en) 2009-03-26
US20140121124A1 (en) 2014-05-01
CN101855351A (zh) 2010-10-06
US20100291032A1 (en) 2010-11-18
CA2699370A1 (en) 2009-03-19

Similar Documents

Publication Publication Date Title
ATE553764T1 (de) Zusammensetzungen und verfahren zur identifizierung von inhibitoren einer retrovirusinfektion
ATE388961T1 (de) Verfahren zur identifikation von inhibitoren
MX2021002181A (es) Inhibicion de la integrina alfa v beta 6.
BRPI0720525B8 (pt) inibidores de mapk/erk quinase
EA201892489A1 (ru) Число мишеней для мультиплексной оптимизированной амплификации с несоответствиями (moma)
EA201000915A1 (ru) Ингибиторы пролилгидроксилазы
BR112012033091A2 (pt) método de cimentação, e, composição de cimento
BRPI0713446A2 (pt) inibidores prolila hidroxilase
EA200870185A1 (ru) Комбинации ингибиторов ang2 и vegf
BRPI0906104B8 (pt) derivado de ácido peptonucleico, composição farmacêutica contendo uma quantidade terapeuticamente eficaz do derivado de ácido peptonucleico, método de utilização do derivado de ácido peptonucleico e composto
BRPI0418639B8 (pt) compostos inibidores de dipeptidil peptidase, assim como composição farmacêutica contendo os mesmos
EA201000920A1 (ru) Ингибиторы пролилгидроксилазы
ATE449097T1 (de) Pyridoä2,3-düpyrimidin-2,4-diamin-verbindungen als ptpib-hemmer
ATE551433T1 (de) Verfahren und produkte zum erfassen von nukleinsäurezielen
BR112014003693A2 (pt) amino quinazolinas como inibidores de quinase
EA201490450A1 (ru) Новые ингибиторы ферментов
WO2008064304A3 (en) Compositions and methods for the identification of inhibitors of protein synthesis
BRPI0919236A8 (pt) Terapêutica e vacinas de combinação de gas
BR112014021993A2 (pt) detecção da variação de nucleotídeo em sequência de ácido nucleico alvo através de ensaio de clivagem e extensão de pto
AU2021269176A8 (en) Single domain antibodies binding to SARS-CoV-2 spike protein
EA200970407A1 (ru) Ингибиторы киназ mapk/erk
BR112022017724A2 (pt) Inibidores de egfr, kras, braf e outros alvos e uso dos mesmos
ATE538216T1 (de) Nukleinsäureverstärkung mithilfe eines reversibel modifizierten oligonukleotids
DK2005190T3 (da) Inhibering af gasc1
BR112013026150A2 (pt) composição imunogênica compreendendo um peptídeo antigênico da fórmula (i), peptídeo antigênico da fórmula (i), método para detectar e/ou quantificar anticorpos e kit para detectar e/ou quantificar anticorpos