ATE55246T1 - Stabilisierte spergualin enthaltende arzneimittel mit krebshemmender und immunomodulierender wirkung. - Google Patents

Stabilisierte spergualin enthaltende arzneimittel mit krebshemmender und immunomodulierender wirkung.

Info

Publication number
ATE55246T1
ATE55246T1 AT85116670T AT85116670T ATE55246T1 AT E55246 T1 ATE55246 T1 AT E55246T1 AT 85116670 T AT85116670 T AT 85116670T AT 85116670 T AT85116670 T AT 85116670T AT E55246 T1 ATE55246 T1 AT E55246T1
Authority
AT
Austria
Prior art keywords
stabilized
cancer
spergualin
medicinal products
containing medicinal
Prior art date
Application number
AT85116670T
Other languages
English (en)
Inventor
Hamao Prof Umezawa
Shintaro Suzuki
Takaaki Okuma
Fumihiro Sato
Teruya Nakamura
Original Assignee
Microbial Chem Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbial Chem Res Found filed Critical Microbial Chem Res Found
Application granted granted Critical
Publication of ATE55246T1 publication Critical patent/ATE55246T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
AT85116670T 1985-01-14 1985-12-31 Stabilisierte spergualin enthaltende arzneimittel mit krebshemmender und immunomodulierender wirkung. ATE55246T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP60003351A JPS61165322A (ja) 1985-01-14 1985-01-14 スパガリン類の注射用凍結乾燥製剤
EP85116670A EP0188821B1 (de) 1985-01-14 1985-12-31 Stabilisierte Spergualin enthaltende Arzneimittel mit krebshemmender und immunomodulierender Wirkung

Publications (1)

Publication Number Publication Date
ATE55246T1 true ATE55246T1 (de) 1990-08-15

Family

ID=11554927

Family Applications (1)

Application Number Title Priority Date Filing Date
AT85116670T ATE55246T1 (de) 1985-01-14 1985-12-31 Stabilisierte spergualin enthaltende arzneimittel mit krebshemmender und immunomodulierender wirkung.

Country Status (10)

Country Link
US (2) US4710517A (de)
EP (1) EP0188821B1 (de)
JP (1) JPS61165322A (de)
KR (1) KR920003331B1 (de)
CN (1) CN1010279B (de)
AT (1) ATE55246T1 (de)
AU (1) AU589939B2 (de)
CA (1) CA1263316A (de)
DE (1) DE3579146D1 (de)
IE (1) IE58220B1 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61129119A (ja) * 1984-11-13 1986-06-17 Microbial Chem Res Found 新規免疫抑制剤
EP0241797B1 (de) * 1986-04-04 1991-06-12 Microbial Chemistry Research Foundation Spergualinähnliche Verbindungen und ihr Herstellungsverfahren
FR2622104B1 (fr) * 1987-10-22 1990-03-30 Bioetica Sa Procede de stabilisation de phases lamellaires lipidiques hydratees, par ex. de liposomes, composition de phases lamellaires lipidiques hydratees, par ex. des liposomes, stabilisees par un emploi d'un support stabilisant a base d'atelocollagene et de glycosaminoglycannes et utilisation en pharmacie ou en cosmetologie
CA1330650C (fr) * 1987-10-22 1994-07-12 Alain Huc Procede de stabilisation de phases lamellaires lipidiques hydratees, par exemple de liposomes, composition de phases lamellaires lipidiques hydratees, par exemple des liposomes, stabilisees par un emploi d'un support stabilisant a base d'atelocollagene et de glycosaminoglycannes, et utilisation en pharmacie ou en ...
GR1000597B (el) * 1988-01-19 1992-08-26 Judah Moses Folkman Παραγοντας αναστολης αναπτυξης και χρηση του.
US5019562A (en) * 1988-01-19 1991-05-28 The Trustees Of The University Of Pennsylvania/Childrens Hospital Corporation Growth inhibiting agent and the use thereof
US5637575A (en) * 1988-01-19 1997-06-10 The Trustees Of The University Of Pennsylvania Methods of inhibiting restenosis
US5760015A (en) * 1988-01-19 1998-06-02 The Trustees Of The University Of Pennsylvania Cyclodextrin compounds and methods of making and use thereof
AU626538B2 (en) * 1988-01-19 1992-08-06 Moses Judah Folkman Growth inhibiting agent and the use thereof
US5658894A (en) * 1989-04-23 1997-08-19 The Trustees Of The University Of Pennsylvania Compositions for inhibiting restenosis
US5002756A (en) * 1988-04-04 1991-03-26 Zaidanhojin Biseibutsu Kagakukenkyukai Method for relieving radiogenic or drug-induced side effects
ATE78156T1 (de) * 1988-12-02 1992-08-15 Coletica Stabilisierung von hydratierten lamellaren phasen.
WO1990012029A1 (en) * 1989-04-11 1990-10-18 Immunobiology Research Institute, Inc. Lyophilized peptide formulations
US5441944A (en) * 1989-04-23 1995-08-15 The Trustees Of The University Of Pennsylvania Substituted cyclodextrin sulfates and their uses as growth modulating agents
US5446030A (en) * 1991-09-19 1995-08-29 Weisz; Paul B. Prevention of hemolysis
US5424301A (en) * 1993-02-01 1995-06-13 Warner-Lambert Company Starch stabilized o-substituted tetrahydropyridine oxime cholinergic agents
BR9405858A (pt) * 1993-03-31 1995-12-12 Univ Pennsylvania Processos de afetar o crescimento de tecido vivo em mamiferos compostos e composiçÕes para os mesmos
US5505715A (en) * 1994-02-25 1996-04-09 Bristol-Myers Squibb Company Iontophoretic transdermal delivery of deoxyspergualin compounds
CA2183917A1 (en) * 1995-09-26 1997-03-27 Xuebao Wang Preparation of optically active (s)-(-) and (r)-(+)- deoxyspergualin and novel intermediates thereof
WO1997039761A1 (en) 1996-04-19 1997-10-30 Alpha Therapeutic Corporation A process for viral inactivation of lyophilized blood proteins
AU750207B2 (en) * 1997-06-13 2002-07-11 Cydex Pharmaceuticals, Inc. Polar drug or prodrug compositions with extended shelf-life storage and a method of making thereof
DE19932157A1 (de) * 1999-07-13 2001-01-18 Pharmasol Gmbh Verfahren zur schonenden Herstellung von hochfeinen Mikropartikeln und Nanopartikeln
BR0112417A (pt) * 2000-07-13 2003-07-01 Daiichi Seiyaku Co Composições farmacêuticas contendo composto dds
US20020146409A1 (en) * 2001-01-30 2002-10-10 Herring Steven W. Methods for stabilizing lyophilized blood proteins
TWI232102B (en) 2001-07-17 2005-05-11 Shionogi & Co A pharmaceutical formulation for injection

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54157818A (en) * 1978-06-02 1979-12-13 Tokyo Tanabe Co Injectionable preparation of chlorethylnitrosourea compound
JPS5748957A (en) * 1980-09-08 1982-03-20 Microbial Chem Res Found Novel antibiotic bmg 162-af2, its preparation and carcinostatic agent comprising it as active ingredient
JPS57185254A (en) * 1981-05-11 1982-11-15 Microbial Chem Res Found Novel carcinostatic substances and their preparation
JPS5862152A (ja) * 1981-10-08 1983-04-13 Microbial Chem Res Found Ｎ−〔４−（３−アミノプロピル）アミノブチル〕−２−（ω−グアニジノ脂肪酸アミド）−２−ヒドロキシエタンアミドおよびその誘導体ならびにその製造法
JPS58198455A (ja) * 1982-05-17 1983-11-18 Microbial Chem Res Found （−）−１５−デオキシスパガリンおよびその製造法並びにその中間体
JPS5942356A (ja) * 1982-09-02 1984-03-08 Microbial Chem Res Found スパガリン関連化合物およびその製造法
US4525299A (en) * 1983-05-10 1985-06-25 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai (-)-15-Deoxyspergualin, process for the preparation thereof, and intermediate of the same
JPS60185758A (ja) * 1984-03-02 1985-09-21 Microbial Chem Res Found フエニレン基を有するスパガリン関連化合物およびその製造法

Also Published As

Publication number Publication date
CN1010279B (zh) 1990-11-07
CA1263316A (en) 1989-11-28
AU5222486A (en) 1986-07-17
US4710517A (en) 1987-12-01
US4876244A (en) 1989-10-24
IE58220B1 (en) 1993-08-11
EP0188821A3 (en) 1987-08-12
DE3579146D1 (de) 1990-09-13
AU589939B2 (en) 1989-10-26
JPS61165322A (ja) 1986-07-26
IE860089L (en) 1986-07-14
EP0188821B1 (de) 1990-08-08
KR920003331B1 (ko) 1992-04-27
CN86100157A (zh) 1986-08-27
KR860005636A (ko) 1986-08-11
EP0188821A2 (de) 1986-07-30
JPH0413325B2 (de) 1992-03-09

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