ATE551364T1 - NON-NATURAL RECOMBINANT GELATINS WITH ADVANCED FUNCTIONALITY - Google Patents

NON-NATURAL RECOMBINANT GELATINS WITH ADVANCED FUNCTIONALITY

Info

Publication number
ATE551364T1
ATE551364T1 AT08741615T AT08741615T ATE551364T1 AT E551364 T1 ATE551364 T1 AT E551364T1 AT 08741615 T AT08741615 T AT 08741615T AT 08741615 T AT08741615 T AT 08741615T AT E551364 T1 ATE551364 T1 AT E551364T1
Authority
AT
Austria
Prior art keywords
recombinant gelatins
advanced functionality
natural recombinant
gelatins
natural
Prior art date
Application number
AT08741615T
Other languages
German (de)
Inventor
Boer Arjo De
Urk Hendrik Van
Asten Peter Van
Jan Bouwstra
Original Assignee
Fujifilm Mfg Europe Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP07102839A external-priority patent/EP1961414A1/en
Priority claimed from EP07102838A external-priority patent/EP1961411A1/en
Application filed by Fujifilm Mfg Europe Bv filed Critical Fujifilm Mfg Europe Bv
Application granted granted Critical
Publication of ATE551364T1 publication Critical patent/ATE551364T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2531/00—Microcarriers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins

Abstract

The invention concerns recombinant gelatin monomers and recombinant gelatins comprising or consisting of multimers of the monomers. The recombinant gelatins can be produced with enhanced stability.
AT08741615T 2007-02-21 2008-02-21 NON-NATURAL RECOMBINANT GELATINS WITH ADVANCED FUNCTIONALITY ATE551364T1 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
EP07102839A EP1961414A1 (en) 2007-02-21 2007-02-21 A controlled release composition comprising a recombinant gelatin
EP07102838A EP1961411A1 (en) 2007-02-21 2007-02-21 A controlled release composition
EP07116189 2007-09-12
EP07116193 2007-09-12
EP08100556 2008-01-16
PCT/NL2008/050104 WO2008103044A1 (en) 2007-02-21 2008-02-21 Non-natural recombinant gelatins with enhanced functionality

Publications (1)

Publication Number Publication Date
ATE551364T1 true ATE551364T1 (en) 2012-04-15

Family

ID=39503383

Family Applications (2)

Application Number Title Priority Date Filing Date
AT08712629T ATE554103T1 (en) 2007-02-21 2008-02-21 RECOMBINANT GELATIN CONTAINING RGD
AT08741615T ATE551364T1 (en) 2007-02-21 2008-02-21 NON-NATURAL RECOMBINANT GELATINS WITH ADVANCED FUNCTIONALITY

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT08712629T ATE554103T1 (en) 2007-02-21 2008-02-21 RECOMBINANT GELATIN CONTAINING RGD

Country Status (5)

Country Link
US (5) US8198047B2 (en)
EP (4) EP2121749B1 (en)
JP (4) JP5349335B2 (en)
AT (2) ATE554103T1 (en)
WO (4) WO2008103042A1 (en)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE554103T1 (en) * 2007-02-21 2012-05-15 Fujifilm Mfg Europe Bv RECOMBINANT GELATIN CONTAINING RGD
US20100273215A1 (en) * 2007-12-21 2010-10-28 Anna Cornelia Hendrika Van Hautum Secretion Yield of a Protein of Interest by in vivo Proteolytic Processing of a Multimeric Precursor
WO2009126031A1 (en) * 2008-04-10 2009-10-15 Fujifilm Manufacturing Europe B.V. Recombinant protein enriched in a heparin binding site and/or a heparan sulfate binding site
US20110106243A1 (en) * 2008-07-04 2011-05-05 Elisabeth Marianna Wilhelmina Maria Van Dongen Coating Method for Medical Devices
EP2344593A2 (en) * 2008-10-02 2011-07-20 Fujifilm Manufacturing Europe BV Antimicrobial coating
US8263133B2 (en) * 2009-02-18 2012-09-11 The Regents Of The University Of California Multivalent clustering targeting strategy for drug carriers
JP5752033B2 (en) * 2009-05-07 2015-07-22 富士フイルム株式会社 Angiogenesis inducer containing genetically modified gelatin
US8877158B2 (en) 2009-06-12 2014-11-04 Fujifilm Corporation Targeting agent to newly formed blood vessels
WO2010147109A1 (en) * 2009-06-15 2010-12-23 富士フイルム株式会社 Angiogenesis inducer comprising genetically modified gelatin and basic fibroblast growth factor
WO2011013792A1 (en) 2009-07-30 2011-02-03 富士フイルム株式会社 Kidney imaging agent comprising genetically modified gelatin
WO2011013791A1 (en) * 2009-07-30 2011-02-03 富士フイルム株式会社 Kidney-targeting drug delivery agent comprising genetically modified gelatin
US8987204B2 (en) 2009-09-04 2015-03-24 Fujifilm Coporation Bone regeneration agent comprising gelatin
EP2502939B1 (en) * 2009-11-19 2016-01-27 Zhejiang University Nonnatural collagen-like protein and use thereof
GB0921460D0 (en) 2009-12-08 2010-01-20 Fujifilm Mfg Europe Bv Anti-fibrotic hydrogel compositions
US8961929B2 (en) * 2010-01-08 2015-02-24 Fujifilm Corporation Targeting agent for tumor site
WO2011108517A1 (en) 2010-03-01 2011-09-09 富士フイルム株式会社 Cell structure comprising cells and macromolecular blocks having biocompatibility
EP2543398B1 (en) * 2010-03-02 2019-10-16 FUJIFILM Corporation Cell support and bone regeneration material
GB201008404D0 (en) * 2010-05-20 2010-07-07 Fujifilm Mfg Europe Bv Hemostatic compositions
GB201014388D0 (en) 2010-08-31 2010-10-13 Fujifilm Mfg Europe Bv Biocompatible compositions for tissue augmentation
GB201018044D0 (en) 2010-10-26 2010-12-08 Fujifilm Mfg Europe Bv Non-natural gelatin-like proteins with enhanced functionality
JP5847418B2 (en) 2011-03-30 2016-01-20 富士フイルム株式会社 Cell adhesion protein
US20120263681A1 (en) 2011-04-12 2012-10-18 Fujifilm Corporation Composition comprising cell and biocompatible polymer
JP2012244909A (en) * 2011-05-25 2012-12-13 Nagoya City Univ Method for producing recombinant protein, and method for introducing protein
JP5876787B2 (en) * 2011-08-31 2016-03-02 富士フイルム株式会社 Cell structure for cell transplantation and cell assembly for cell transplantation
JP5990298B2 (en) * 2011-08-31 2016-09-14 富士フイルム株式会社 Cell structure for cell transplantation and cell assembly for cell transplantation
JP5808631B2 (en) * 2011-09-29 2015-11-10 富士フイルム株式会社 Angiogenic scaffold and method for producing blood vessel for regenerative medicine
GB201119173D0 (en) 2011-11-07 2011-12-21 Fujifilm Mfg Europe Bv Porous tissue scaffolds
GB201119182D0 (en) 2011-11-07 2011-12-21 Fujifilm Mfg Europe Bv Porous tissue scaffolds
EP2826494B1 (en) 2012-03-12 2021-01-06 Fujifilm Corporation Method for producing tissue repair material
JP5992529B2 (en) 2012-09-26 2016-09-14 富士フイルム株式会社 Polypeptide, scaffold composition, cartilage tissue repair composition, chondrocyte culture composition and glycosaminoglycan production promoting composition
EP2949347B1 (en) * 2013-01-25 2021-06-16 FUJIFILM Corporation Artificial dermis for transplantation and method for producing same
CN107033383B (en) 2013-02-27 2020-07-24 富士胶片株式会社 Method for producing porous body of biocompatible polymer
ES2711672T3 (en) 2013-03-12 2019-05-06 Fujifilm Corp Material repair material
GB201304947D0 (en) * 2013-03-18 2013-05-01 Cass Anthony E G Biomimetic collagen
CN105611950A (en) 2013-09-25 2016-05-25 富士胶片株式会社 Method for producing biocompatible macromolecular porous body, biocompatible macromolecular porous body, biocompatible macromolecular block and cell structure
JP6455862B2 (en) 2015-06-25 2019-01-23 学校法人早稲田大学 Polymerized peptide and gel having collagen-like structure
KR102015738B1 (en) 2015-09-11 2019-08-28 후지필름 가부시키가이샤 Gelatinous Structure Manufacturing Method, and Gelatinous Structure Manufacturing System
JP6694512B2 (en) 2015-12-30 2020-05-13 フジフィルム セルラー ダイナミクス，インコーポレイテッド Microtissue formation using stem cell-derived human hepatocytes
JP6820912B2 (en) * 2016-03-28 2021-01-27 富士フイルム株式会社 Preparations, preparation parts and methods for manufacturing them
JPWO2017170342A1 (en) * 2016-03-29 2019-01-17 富士フイルム株式会社 Cell sheet embedding agent, cell sheet-containing composition and kit
WO2017170343A1 (en) * 2016-03-29 2017-10-05 富士フイルム株式会社 Laminate body containing cell sheet, heart disease therapeutic agent and film for cell sheet lamination
EP3460050B1 (en) * 2016-05-19 2021-11-03 FUJIFILM Corporation Cell culturing method, culture medium, and culture medium kit
KR102204763B1 (en) 2016-05-30 2021-01-19 후지필름 가부시키가이샤 Calcium phosphate molded body manufacturing method, calcium phosphate molded body and material for implantation
JP6637598B2 (en) 2016-06-08 2020-01-29 富士フイルム株式会社 Method for producing gelatin molded article and gelatin molded article
EP3590952A4 (en) * 2017-03-02 2020-03-11 Fujifilm Corporation Embedding agent for cell mass or cell structure, and cell mass- or cell structure-containing composition and kit
WO2018169061A1 (en) 2017-03-16 2018-09-20 富士フイルム株式会社 Method for separating megakaryocytes and platelets and instrument for separating megakaryocytes and platelets
EP3597731B1 (en) 2017-03-17 2022-06-29 FUJIFILM Corporation Method for producing cell structures
EP3623466A4 (en) * 2017-05-12 2020-08-12 FUJIFILM Corporation Method for producing mesenchymal stem cells, and application thereof
JP6903295B2 (en) 2017-06-30 2021-07-14 富士フイルム株式会社 Lysosomal storage disease treatment agent
WO2019044990A1 (en) 2017-08-30 2019-03-07 富士フイルム株式会社 Cell transplantation device and method for manufacturing same
EP3677289A4 (en) 2017-08-30 2020-08-26 FUJIFILM Corporation Angiogenic agent and method for producing same
KR102476632B1 (en) * 2017-11-06 2022-12-09 후지필름 가부시키가이샤 Materials for pearl farming and compositions for coating
WO2019093468A1 (en) 2017-11-10 2019-05-16 富士フイルム株式会社 Method for producing insulin-producing cells from mesenchymal stem cells, insulin-producing cells, cell structure, and pharmaceutical composition
EP3747475A4 (en) * 2018-01-30 2021-06-02 FUJIFILM Corporation Fibrin composition, base material for regenerative medicine, method for producing fibrin composition, and kit
EP3848063A4 (en) 2018-09-03 2021-10-27 FUJIFILM Corporation Gel formation kit, gel, and gel production method
JP6906713B2 (en) * 2018-10-12 2021-07-21 富士フイルム株式会社 Pearl farming material, enucleation method and pearl farming material composition
JP7385664B2 (en) 2019-07-26 2023-11-22 富士フイルム株式会社 living body transplant material
WO2021039610A1 (en) 2019-08-23 2021-03-04 富士フイルム株式会社 Composition comprising microcapsule and cell structure
WO2021241409A1 (en) 2020-05-25 2021-12-02 富士フイルム株式会社 Composition, sheet-shaped molded body, artificial leather, and sheet-shaped molded body production method
GB2596525A (en) * 2020-06-26 2022-01-05 Fujifilm Corp Modified gelatins
CN117098967A (en) 2021-03-24 2023-11-21 富士胶片株式会社 Heating treatment device and method for producing heating treated product
EP4300022A1 (en) 2021-03-26 2024-01-03 FUJIFILM Corporation Freeze-drying container
EP4299482A1 (en) 2021-03-26 2024-01-03 FUJIFILM Corporation Powder supply device
WO2022210204A1 (en) 2021-03-31 2022-10-06 富士フイルム株式会社 Crushing method, polymer block manufacturing method, and crushing device
WO2023013596A1 (en) 2021-08-02 2023-02-09 株式会社Rainbow Method for storing or transporting stem cells in unfrozen state
WO2023053710A1 (en) 2021-09-30 2023-04-06 富士フイルム株式会社 Tissue restorative material kit and tissue restoration method

Family Cites Families (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US68013A (en) * 1867-08-20 Es ait t aeeaft
US106410A (en) * 1870-08-16 William f
US147501A (en) * 1874-02-17 Improvement in eooklnq-stoves
US114078A (en) * 1871-04-25 Improvement in valves and steam-chests for engines
US113910A (en) * 1871-04-18 Improvement in door-locks
US24361A (en) * 1859-06-07 Jacob j
US274957A (en) * 1883-04-03 Punch for nut-machines
US167446A (en) * 1875-09-07 Improvement in refrigerators
US4034A (en) * 1845-05-07 Improvement in machines for breaking and cleaning hemp
US9580A (en) * 1853-02-08 Improvement in gas-meters
US241032A (en) * 1881-05-03 Machine for making curved lead pipe
US190153A (en) * 1877-05-01 Improvement in processes of making shoes
US64074A (en) * 1867-04-23 Thesraphic oo
US143568A (en) * 1873-10-14 Improvement in stays for ships sails
US204551A (en) * 1878-06-04 Improvement in bee-hives
US251719A (en) * 1882-01-03 Crucible
US24346A (en) * 1859-06-07 Lock attachment
US28243A (en) * 1860-05-08 williams
US147690A (en) * 1874-02-17 Improvement in belt-fastenings
US107666A (en) * 1870-09-27 Improvement in rollers for sewing-machines
US237663A (en) * 1881-02-08 Hydrocarbon-gas generator
US229264A (en) * 1880-06-29 Recovering soda from spent liquors after treating vegetable fiber
US196496A (en) * 1877-10-23 Improvement in elevator-cups
US121609A (en) * 1871-12-05 Improvement in tremolos for reed organs
US7991A (en) * 1851-03-18 Of beehives
US58703A (en) * 1866-10-09 Improved mop-head
US31501A (en) * 1861-02-19 Fracture apparatus
US208141A (en) * 1878-09-17 Improvement in harvester guard-fingers
US119170A (en) * 1871-09-19 Improvement in harvester-cutters
US177492A (en) * 1876-05-16 Improvement in anchors
US4855134A (en) * 1983-10-14 1989-08-08 Sumitomo Pharmaceuticals Company, Limited Sustained-release preparation
IL78826A (en) 1986-05-19 1991-05-12 Yissum Res Dev Co Precursor composition for the preparation of a biodegradable implant for the sustained release of an active material and such implants prepared therefrom
US5514581A (en) 1986-11-04 1996-05-07 Protein Polymer Technologies, Inc. Functional recombinantly prepared synthetic protein polymer
US5002769A (en) * 1987-03-13 1991-03-26 Yissum Research Development Company Of The Hebrew University Of Jerusalem Compositions for the sustained-release of chlorhexidine
US4994388A (en) 1988-04-15 1991-02-19 Solohill Engineering, Inc. Collagen-coated polystyrene microcarrier beads
EP0406357B1 (en) * 1988-11-09 1998-01-07 Protein Polymer Technologies, Inc. Functional recombinantly prepared synthetic protein polymer
IL95500A (en) * 1989-09-11 1997-03-18 Matrix Pharma ANTI-PROLIFERATIVE COMPOSITIONS CONTAINING TGF-b PROTEIN IN A VISCOUS MATRIX AND THEIR USE
DE69233300T2 (en) * 1991-11-12 2004-11-25 Protein Polymer Technologies, Inc., San Diego Collagen-like protein polymers with high molecular weights
DE4140192C2 (en) * 1991-12-05 1996-02-29 Alfatec Pharma Gmbh Sol-controlled gelatin-based thermocolloid matrix for peroral sustained release forms
DE4210334A1 (en) 1992-03-30 1993-10-07 Stoess & Co Gelatine Biodegradable, water-resistant polymer material
IL105529A0 (en) * 1992-05-01 1993-08-18 Amgen Inc Collagen-containing sponges as drug delivery for proteins
US5512474A (en) 1992-05-29 1996-04-30 Bsi Corporation Cell culture support containing a cell adhesion factor and a positively-charged molecule
JP3639593B2 (en) 1993-05-31 2005-04-20 科研製薬株式会社 Cross-linked gelatin gel preparation containing basic fibroblast growth factor
IL109539A0 (en) 1994-05-03 1994-08-26 Yissum Res Dev Co Substained-release pharmaceutical system for the delivery of antioxidants
WO1998055161A1 (en) 1997-06-03 1998-12-10 Innogenetics N.V. New medicaments based on polymers composed of methacrylamide-modified gelatin
US6342250B1 (en) 1997-09-25 2002-01-29 Gel-Del Technologies, Inc. Drug delivery devices comprising biodegradable protein for the controlled release of pharmacologically active agents and method of making the drug delivery devices
NL1007908C2 (en) * 1997-12-24 1999-06-25 Fuji Photo Film Bv Silver halide emulsions with recombinant collagen suitable for photographic administration and their preparation.
US6150081A (en) 1997-12-24 2000-11-21 Fuji Photo Film B.V. Silver halide emulsions with recombinant collagen suitable for photographic application and also the preparation thereof
US7662409B2 (en) * 1998-09-25 2010-02-16 Gel-Del Technologies, Inc. Protein matrix materials, devices and methods of making and using thereof
US20050147690A1 (en) 1998-09-25 2005-07-07 Masters David B. Biocompatible protein particles, particle devices and methods thereof
US20030007991A1 (en) 1998-09-25 2003-01-09 Masters David B. Devices including protein matrix materials and methods of making and using thereof
EP1014176B1 (en) 1998-12-23 2009-04-29 FUJIFILM Manufacturing Europe B.V. Silver halide emulsions containing recombinant gelatin-like proteins
CN1309737C (en) * 1999-11-12 2007-04-11 法布罗根股份有限公司 Recombinant gelatins
US6992172B1 (en) 1999-11-12 2006-01-31 Fibrogen, Inc. Recombinant gelatins
US20030118598A1 (en) 2000-02-08 2003-06-26 Allergan, Inc. Clostridial toxin pharmaceutical compositions
EP1238675A1 (en) 2001-03-06 2002-09-11 Fuji Photo Film B.V. Recombinant gelatin-like proteins for use as plasma expanders
US20060024346A1 (en) * 2004-07-29 2006-02-02 Brody Richard S Stabilization of biologically active proteins with mixtures of polysaccharides and amino acid based compounds
US7067150B2 (en) * 2002-04-16 2006-06-27 Scepter Holdings, Inc. Delivery systems for functional ingredients
US20070196496A1 (en) 2002-04-16 2007-08-23 Michael Farber Delivery systems for functional ingredients
JP4723862B2 (en) 2002-12-23 2011-07-13 フジフィルム マニュファクチャリング ユーロプ ビー．ブイ． Method for coating a cell culture support
WO2004078120A2 (en) 2003-02-28 2004-09-16 Fibrogen, Inc. Collagen compositions and biomaterials
JP4459543B2 (en) 2003-03-17 2010-04-28 株式会社メドジェル Sustained release hydrogel formulation
EP1875924B1 (en) 2003-03-28 2010-04-28 FUJIFILM Manufacturing Europe B.V. RGD-enriched gelatine-like proteins for prevention of platelet aggregation
US20050058703A1 (en) 2003-08-01 2005-03-17 Chang Robert C. Gelatin capsules
US20060204511A1 (en) 2003-08-05 2006-09-14 Bouwstra Jan B Use of recombinant or synthetic gelatin as stabiliser in vaccines
US20070031501A1 (en) 2003-08-05 2007-02-08 Andries Van Es Use of recombinant or synthetic gelatin-like proteins as stabiliser in lyophilized pharmaceutical compositions
JP2007518811A (en) * 2004-01-23 2007-07-12 カリフォルニア インスティチュート オブ テクノロジー Engineered proteins and methods of making and using
JP2005211477A (en) 2004-01-30 2005-08-11 Gunze Ltd Support for regenerative medicine
WO2005079879A1 (en) 2004-02-25 2005-09-01 Ihara & Company Ltd. Collagen gel and process for producing the same
US20070190153A1 (en) 2004-03-05 2007-08-16 Jonathan Farber Delivery systems for non-steroidal anti-inflammatory drugs (nsaids)
EP1773415A1 (en) 2004-06-30 2007-04-18 Covalon Technologies Inc. Non-adhesive hydrogels
US20060024361A1 (en) 2004-07-28 2006-02-02 Isa Odidi Disintegrant assisted controlled release technology
CA2581328A1 (en) 2004-09-21 2006-03-30 Massachusetts Institute Of Technology Gradient scaffolding and methods of producing the same
AU2005289311B2 (en) * 2004-09-30 2011-03-03 Covalon Technologies Inc. Non-adhesive elastic gelatin matrices
JP5133708B2 (en) 2005-02-23 2013-01-30 フジフィルム マニュファクチャリング ユーロプ ビー．ブイ． Non-glycosylated recombinant collagen-like polypeptide
EP1863466B1 (en) 2005-03-03 2017-08-09 Takasago International Corporation (USA) Synergistic salivation components
EP1801122A1 (en) 2005-12-23 2007-06-27 FUJIFILM Manufacturing Europe B.V. Recombinant gelatin particles for cell adhesion
ATE554103T1 (en) * 2007-02-21 2012-05-15 Fujifilm Mfg Europe Bv RECOMBINANT GELATIN CONTAINING RGD

Also Published As

Publication number Publication date
US8198047B2 (en) 2012-06-12
JP5548984B2 (en) 2014-07-16
US8349589B2 (en) 2013-01-08
EP2112997B1 (en) 2012-08-01
WO2008103044A1 (en) 2008-08-28
JP2010519293A (en) 2010-06-03
WO2008103041A8 (en) 2009-07-23
JP2010518833A (en) 2010-06-03
US8173776B1 (en) 2012-05-08
US8349588B2 (en) 2013-01-08
WO2008103042A1 (en) 2008-08-28
EP2121749B1 (en) 2013-07-03
WO2008103044A8 (en) 2010-03-04
WO2008103043A1 (en) 2008-08-28
US20120107372A1 (en) 2012-05-03
JP5349335B2 (en) 2013-11-20
US20100119574A1 (en) 2010-05-13
US8158756B2 (en) 2012-04-17
JP2010519251A (en) 2010-06-03
EP2112999B1 (en) 2012-03-28
EP2121749A1 (en) 2009-11-25
US20100105618A1 (en) 2010-04-29
EP2112998B1 (en) 2012-04-18
US20100075902A1 (en) 2010-03-25
ATE554103T1 (en) 2012-05-15
WO2008103042A8 (en) 2009-07-23
JP5548983B2 (en) 2014-07-16
WO2008103043A8 (en) 2009-07-23
EP2112998A1 (en) 2009-11-04
WO2008103041A1 (en) 2008-08-28
US20100062531A1 (en) 2010-03-11
EP2112999A1 (en) 2009-11-04
EP2112997A1 (en) 2009-11-04
JP2010519252A (en) 2010-06-03
JP5349336B2 (en) 2013-11-20

Similar Documents

Publication Publication Date Title
ATE551364T1 (en) NON-NATURAL RECOMBINANT GELATINS WITH ADVANCED FUNCTIONALITY
BR112013010834A2 (en) modified factor ix polypeptides and uses thereof
CY1122101T1 (en) MODIFIED RELAXIN POLYPEPTIDES AND USES THEREOF
DK3454871T3 (en) MANIPULATED NATURAL KILLER CELLS AND APPLICATIONS THEREOF
DK3280433T3 (en) THE NOVO BINING DOMAIN CONTAINING POLYPEPTIDES AND USES THEREOF
EA201170242A1 (en) MODIFIED BULL POLYPEPTIDES G-CSF AND THEIR APPLICATION
UY34570A (en) COMBINATIONS OF INHIBITING COMPOUNDS OF THE NS5A PROTEIN IN THE HEPATITIS C VIRUS
EP3789506A4 (en) Prunus mume pendulous trait snp molecular markers and use thereof
DE602005021328D1 (en) FLASH SPUNVLIES WITH IMPROVED BREATHABILITY
UY3722Q (en) STOVE
ATE447414T1 (en) USE OF ACTIVATED POLYMERS TO SEPARATE PROTEIN AND POLYPEPTIDE MULTIMERS
BRPI1008941A2 (en) Polynucleotide and polypeptide sequence and methods thereof.
DK3532059T3 (en) COMBINATION THERAPY WITH BROMDOMAIN AND EXTRA TERMINAL PROTEIN INHIBITOR
MX2015014808A (en) Road marking.
EA201290541A1 (en) MODIFIED BULL SOMATOTROPINE POLYPEPTIDES AND THEIR APPLICATION
DE102010017275B8 (en) Side lighting projection lens and headlights with the same
DK3630798T3 (en) Engineered aldolase polypeptides and their applications in the synthesis of beta-hydroxy-alpha-amino acids
CL2018001208A1 (en) Stimulus sensitive adhesives
DK3488144T3 (en) Electric light and assembly thereof
DK2032708T3 (en) Recombinant novirhab viruses and their applications
ITTV20080022A1 (en) ROAD REFLECTOR WITH HEATING AND ALARMS.
IT201900024226A1 (en) LAMP AND CORRESPONDING PROCEDURE
DK3760915T3 (en) Public light mast for the provision of decorative and / or informative lighting
UA40430S (en) CHILDREN'S VEST WITH REFLECTIVE ELEMENTS
ES1230515Y (en) MUNECA WITH INCORPORATED GYROSCOPE