ATE538212T1 - Assays für modulatoren der parkin-aktivität mithilfe neuartiger substrate - Google Patents
Assays für modulatoren der parkin-aktivität mithilfe neuartiger substrateInfo
- Publication number
- ATE538212T1 ATE538212T1 AT08728753T AT08728753T ATE538212T1 AT E538212 T1 ATE538212 T1 AT E538212T1 AT 08728753 T AT08728753 T AT 08728753T AT 08728753 T AT08728753 T AT 08728753T AT E538212 T1 ATE538212 T1 AT E538212T1
- Authority
- AT
- Austria
- Prior art keywords
- modulators
- assay
- parkin
- novel substrates
- parkin activity
- Prior art date
Links
- 230000000694 effects Effects 0.000 title abstract 3
- 238000003556 assay Methods 0.000 title abstract 2
- 239000000758 substrate Substances 0.000 title 1
- 102000045222 parkin Human genes 0.000 abstract 3
- 101000619542 Homo sapiens E3 ubiquitin-protein ligase parkin Proteins 0.000 abstract 2
- 230000034512 ubiquitination Effects 0.000 abstract 2
- 238000010798 ubiquitination Methods 0.000 abstract 2
- 108010022579 ATP dependent 26S protease Proteins 0.000 abstract 1
- 102000004903 Troponin Human genes 0.000 abstract 1
- 108090001027 Troponin Proteins 0.000 abstract 1
- 238000000423 cell based assay Methods 0.000 abstract 1
- 238000000099 in vitro assay Methods 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 108700007244 parkin Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/25—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving enzymes not classifiable in groups C12Q1/26 - C12Q1/66
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/9015—Ligases (6)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/10—Screening for compounds of potential therapeutic value involving cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2835—Movement disorders, e.g. Parkinson, Huntington, Tourette
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US89894707P | 2007-01-31 | 2007-01-31 | |
| PCT/US2008/052700 WO2008095126A2 (en) | 2007-01-31 | 2008-01-31 | Assays for modulators of parkin activity using novel substrates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE538212T1 true ATE538212T1 (de) | 2012-01-15 |
Family
ID=39645491
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT08728753T ATE538212T1 (de) | 2007-01-31 | 2008-01-31 | Assays für modulatoren der parkin-aktivität mithilfe neuartiger substrate |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7790365B2 (https=) |
| EP (1) | EP2115159B1 (https=) |
| JP (2) | JP5329434B2 (https=) |
| AT (1) | ATE538212T1 (https=) |
| CA (1) | CA2677231C (https=) |
| WO (1) | WO2008095126A2 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2115159B1 (en) | 2007-01-31 | 2011-12-21 | Elan Pharma International Limited | Assays for modulators of parkin activity using novel substrates |
| JP2010527614A (ja) * | 2007-05-21 | 2010-08-19 | エラン・フアルマ・インターナシヨナル・リミテツド | パーキン基質およびアッセイ |
| US20090226946A1 (en) * | 2008-01-31 | 2009-09-10 | Elan Pharmaceuticals, Inc. | Thermal Denaturation Screening Assay to Identify Candidate Compounds for Prevention and Treatment of Parkinson's Disease |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA975137A (en) * | 1969-04-08 | 1975-09-30 | Howard K. Rae | Deuterium-hydrogen monothermal exchange |
| AU2299999A (en) | 1998-02-09 | 1999-08-23 | Yoshikuni Mizuno | Dnas or genes participating in parkinson's disease |
| US20040247586A1 (en) * | 2003-03-05 | 2004-12-09 | Asa Abeliovich | Parkin-associated complex for protecting post-mitotic neurons from excitotoxicity and uses thereof |
| EP2115159B1 (en) | 2007-01-31 | 2011-12-21 | Elan Pharma International Limited | Assays for modulators of parkin activity using novel substrates |
| JP2010527614A (ja) * | 2007-05-21 | 2010-08-19 | エラン・フアルマ・インターナシヨナル・リミテツド | パーキン基質およびアッセイ |
-
2008
- 2008-01-31 EP EP08728753A patent/EP2115159B1/en active Active
- 2008-01-31 CA CA2677231A patent/CA2677231C/en not_active Expired - Fee Related
- 2008-01-31 WO PCT/US2008/052700 patent/WO2008095126A2/en not_active Ceased
- 2008-01-31 US US12/024,032 patent/US7790365B2/en not_active Expired - Fee Related
- 2008-01-31 AT AT08728753T patent/ATE538212T1/de active
- 2008-01-31 JP JP2009548455A patent/JP5329434B2/ja not_active Expired - Fee Related
-
2013
- 2013-06-05 JP JP2013118678A patent/JP2013215198A/ja not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| JP5329434B2 (ja) | 2013-10-30 |
| EP2115159A2 (en) | 2009-11-11 |
| WO2008095126A3 (en) | 2008-12-31 |
| CA2677231A1 (en) | 2008-08-07 |
| US7790365B2 (en) | 2010-09-07 |
| US20080293089A1 (en) | 2008-11-27 |
| EP2115159B1 (en) | 2011-12-21 |
| WO2008095126A2 (en) | 2008-08-07 |
| CA2677231C (en) | 2015-11-24 |
| JP2010517535A (ja) | 2010-05-27 |
| JP2013215198A (ja) | 2013-10-24 |
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