JP5329434B2 - 新規基質を使用したパーキン活性のモジュレーターのアッセイ方法 - Google Patents

新規基質を使用したパーキン活性のモジュレーターのアッセイ方法 Download PDF

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JP5329434B2
JP5329434B2 JP2009548455A JP2009548455A JP5329434B2 JP 5329434 B2 JP5329434 B2 JP 5329434B2 JP 2009548455 A JP2009548455 A JP 2009548455A JP 2009548455 A JP2009548455 A JP 2009548455A JP 5329434 B2 JP5329434 B2 JP 5329434B2
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parkin
protein
activity
ubiquitination
test agent
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Japanese (ja)
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JP2010517535A5 (https=
JP2010517535A (ja
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ジヨンストン,ジエニフアー・エイ
ゴールドバーグ,アルフレツド
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エラン・フアルマ・インターナシヨナル・リミテツド
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/25Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving enzymes not classifiable in groups C12Q1/26 - C12Q1/66
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90Enzymes; Proenzymes
    • G01N2333/9015Ligases (6)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value
    • G01N2500/02Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value
    • G01N2500/10Screening for compounds of potential therapeutic value involving cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/28Neurological disorders
    • G01N2800/2835Movement disorders, e.g. Parkinson, Huntington, Tourette

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2009548455A 2007-01-31 2008-01-31 新規基質を使用したパーキン活性のモジュレーターのアッセイ方法 Expired - Fee Related JP5329434B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US89894707P 2007-01-31 2007-01-31
US60/898,947 2007-01-31
PCT/US2008/052700 WO2008095126A2 (en) 2007-01-31 2008-01-31 Assays for modulators of parkin activity using novel substrates

Related Child Applications (1)

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JP2013118678A Division JP2013215198A (ja) 2007-01-31 2013-06-05 新規基質を使用したパーキン活性のモジュレーターのアッセイ方法

Publications (3)

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JP2010517535A JP2010517535A (ja) 2010-05-27
JP2010517535A5 JP2010517535A5 (https=) 2011-03-31
JP5329434B2 true JP5329434B2 (ja) 2013-10-30

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JP2009548455A Expired - Fee Related JP5329434B2 (ja) 2007-01-31 2008-01-31 新規基質を使用したパーキン活性のモジュレーターのアッセイ方法
JP2013118678A Ceased JP2013215198A (ja) 2007-01-31 2013-06-05 新規基質を使用したパーキン活性のモジュレーターのアッセイ方法

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JP2013118678A Ceased JP2013215198A (ja) 2007-01-31 2013-06-05 新規基質を使用したパーキン活性のモジュレーターのアッセイ方法

Country Status (6)

Country Link
US (1) US7790365B2 (https=)
EP (1) EP2115159B1 (https=)
JP (2) JP5329434B2 (https=)
AT (1) ATE538212T1 (https=)
CA (1) CA2677231C (https=)
WO (1) WO2008095126A2 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2115159B1 (en) 2007-01-31 2011-12-21 Elan Pharma International Limited Assays for modulators of parkin activity using novel substrates
JP2010527614A (ja) * 2007-05-21 2010-08-19 エラン・フアルマ・インターナシヨナル・リミテツド パーキン基質およびアッセイ
US20090226946A1 (en) * 2008-01-31 2009-09-10 Elan Pharmaceuticals, Inc. Thermal Denaturation Screening Assay to Identify Candidate Compounds for Prevention and Treatment of Parkinson's Disease

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA975137A (en) * 1969-04-08 1975-09-30 Howard K. Rae Deuterium-hydrogen monothermal exchange
AU2299999A (en) 1998-02-09 1999-08-23 Yoshikuni Mizuno Dnas or genes participating in parkinson's disease
US20040247586A1 (en) * 2003-03-05 2004-12-09 Asa Abeliovich Parkin-associated complex for protecting post-mitotic neurons from excitotoxicity and uses thereof
EP2115159B1 (en) 2007-01-31 2011-12-21 Elan Pharma International Limited Assays for modulators of parkin activity using novel substrates
JP2010527614A (ja) * 2007-05-21 2010-08-19 エラン・フアルマ・インターナシヨナル・リミテツド パーキン基質およびアッセイ

Also Published As

Publication number Publication date
EP2115159A2 (en) 2009-11-11
WO2008095126A3 (en) 2008-12-31
CA2677231A1 (en) 2008-08-07
US7790365B2 (en) 2010-09-07
US20080293089A1 (en) 2008-11-27
EP2115159B1 (en) 2011-12-21
WO2008095126A2 (en) 2008-08-07
ATE538212T1 (de) 2012-01-15
CA2677231C (en) 2015-11-24
JP2010517535A (ja) 2010-05-27
JP2013215198A (ja) 2013-10-24

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