ATE527228T1 - Verfahren zur herstellung von beta-santalol und derivaten davon - Google Patents

Verfahren zur herstellung von beta-santalol und derivaten davon

Info

Publication number
ATE527228T1
ATE527228T1 AT09750238T AT09750238T ATE527228T1 AT E527228 T1 ATE527228 T1 AT E527228T1 AT 09750238 T AT09750238 T AT 09750238T AT 09750238 T AT09750238 T AT 09750238T AT E527228 T1 ATE527228 T1 AT E527228T1
Authority
AT
Austria
Prior art keywords
santalol
derivatives
producing beta
group
compound
Prior art date
Application number
AT09750238T
Other languages
German (de)
English (en)
Inventor
Charles Fehr
Magali Vuagnoux
Original Assignee
Firmenich & Cie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Firmenich & Cie filed Critical Firmenich & Cie
Application granted granted Critical
Publication of ATE527228T1 publication Critical patent/ATE527228T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/05—Alcohols containing rings other than six-membered aromatic rings
    • C07C33/14—Alcohols containing rings other than six-membered aromatic rings containing six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/147—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of carboxylic acids or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/36—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal
    • C07C29/38—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/30—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with halogen containing compounds, e.g. hypohalogenation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C07C45/511—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups
    • C07C45/512—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups the singly bound functional group being a free hydroxyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/62—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by hydrogenation of carbon-to-carbon double or triple bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
    • C07C45/74—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups combined with dehydration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
    • C07C45/75—Reactions with formaldehyde
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/28—Preparation of carboxylic acid esters by modifying the hydroxylic moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/283—Preparation of carboxylic acid esters by modifying the hydroxylic moiety of the ester, such modification not being an introduction of an ester group by hydrogenation of unsaturated carbon-to-carbon bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
    • C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
    • C07C2602/42—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing seven carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Catalysts (AREA)
AT09750238T 2008-05-20 2009-05-18 Verfahren zur herstellung von beta-santalol und derivaten davon ATE527228T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08104028 2008-05-20
PCT/IB2009/052048 WO2009141781A1 (en) 2008-05-20 2009-05-18 Process for the preparation of beta-santalol and derivatives thereof

Publications (1)

Publication Number Publication Date
ATE527228T1 true ATE527228T1 (de) 2011-10-15

Family

ID=39885154

Family Applications (1)

Application Number Title Priority Date Filing Date
AT09750238T ATE527228T1 (de) 2008-05-20 2009-05-18 Verfahren zur herstellung von beta-santalol und derivaten davon

Country Status (8)

Country Link
US (2) US7902393B2 (enExample)
EP (2) EP2282985B1 (enExample)
JP (2) JP5550637B2 (enExample)
CN (1) CN102036941B (enExample)
AT (1) ATE527228T1 (enExample)
ES (2) ES2372911T3 (enExample)
IL (2) IL209363A (enExample)
WO (1) WO2009141781A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8822733B2 (en) 2011-02-16 2014-09-02 Firmenich Sa Intermediates for the preparation of beta-santalol
BR112013028052A2 (pt) 2011-06-30 2017-06-27 Firmenich & Cie processo para a preparação de beta-santalol
MX2013013256A (es) * 2011-06-30 2013-12-16 Firmenich & Cie Proceso para la preparacion de beta-santalol.
CN105705478B (zh) * 2013-11-11 2018-10-12 弗门尼舍有限公司 具有木质气味的化合物
US9958504B2 (en) 2014-06-20 2018-05-01 Duracell U.S. Operations, Inc. Primary alkaline battery with integrated in-cell resistances
WO2016087179A1 (en) * 2014-12-02 2016-06-09 Firmenich Sa Intermediates and process for the preparation of sandalwood oil building blocks
CN117843453A (zh) * 2022-09-30 2024-04-09 中国科学院大连化学物理研究所 一种2-亚龙脑烯基丁醇的制备方法
EP4678622A1 (en) 2024-07-07 2026-01-14 Studiengesellschaft Kohle gGmbH Process for preparing an enantiomeric pure diels-alder adduct

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3662008A (en) * 1969-05-21 1972-05-09 Procter & Gamble Process for preparing beta-santalol from 3-methylnorcamphor
US4223167A (en) * 1978-02-14 1980-09-16 Fritzsche Dodge & Olcott Inc. Processes for preparing β-santalol, β-santalene dihydro-β-santalol and related compounds
DE2843838A1 (de) 1978-10-07 1980-04-24 Basf Ag Bicyclische verbindungen, verfahren zu deren herstellung und deren verwendung
JPS5738730A (en) * 1980-08-14 1982-03-03 Kuraray Co Ltd Cis-pentene derivative and its preparation
JPS5742659A (en) * 1980-08-28 1982-03-10 Kuraray Co Ltd Bicyclo 2 2 1 heptane derivative and its preparation
US4510319A (en) * 1982-07-01 1985-04-09 Fritzsche Dodge & Olcott Inc. Functionalization of terminal trisubstituted alkenes and derivatives thereof
FR2621912B1 (fr) * 1987-10-16 1990-03-02 Oreal Nouveaux derives du norbornane, leur procede de preparation et compositions cosmetique et medicamenteuse les contenant
JP2929943B2 (ja) * 1994-09-07 1999-08-03 ダイソー株式会社 カルシトリオール中間体及びその製法
WO2003002491A2 (en) 2001-06-29 2003-01-09 California Institute Of Technology ENANTIOSELECTIVE TRANSFORMATION OF α, β-UNSATURATED ALDEHYDES USING CHIRAL ORGANIC CATALYSTS
DE10348062A1 (de) * 2003-10-16 2005-05-19 Symrise Gmbh & Co. Kg Kurzkettige Enolester als Riechstoff-Prekursoren
US7112700B1 (en) * 2005-04-14 2006-09-26 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Efficient and economic asymmetric synthesis of nootkatone, tetrahydronootkatone, their precursors and derivatives
WO2008120175A1 (en) 2007-04-03 2008-10-09 Firmenich Sa 1,4-hydrogenation of dienes with ru complexes

Also Published As

Publication number Publication date
US8119826B2 (en) 2012-02-21
EP2386537A2 (en) 2011-11-16
JP5717893B2 (ja) 2015-05-13
ES2372911T3 (es) 2012-01-27
EP2282985A1 (en) 2011-02-16
IL226276A0 (en) 2013-06-27
US7902393B2 (en) 2011-03-08
US20110028750A1 (en) 2011-02-03
JP2011520950A (ja) 2011-07-21
WO2009141781A1 (en) 2009-11-26
JP5550637B2 (ja) 2014-07-16
IL209363A0 (en) 2011-01-31
CN102036941B (zh) 2013-07-31
EP2386537A3 (en) 2012-01-11
JP2014098019A (ja) 2014-05-29
EP2282985B1 (en) 2011-10-05
IL209363A (en) 2014-04-30
ES2401986T3 (es) 2013-04-26
CN102036941A (zh) 2011-04-27
US20110118497A1 (en) 2011-05-19
EP2386537B1 (en) 2013-01-16

Similar Documents

Publication Publication Date Title
IL226276A0 (en) Process for the preparation of beta-santanol and its derivatives
CY1110956T1 (el) Παραγωγα πυριδο-πυραζινης χρησιμα ως ζιζανιοκτονες ενωσεις
ATE507224T1 (de) Verfahren und zwischenverbindungen zur herstellung von n4-phenyl-quinazolin-4-amin derivaten
ATE542803T1 (de) Verfahren zur herstellung von dihydrochinazolinen
ATE556085T1 (de) Phosphoramiditverbindung und verfahren zur herstellung von oligo-rna
MX2009007075A (es) Metodos de uso para analogos de ciclopamina.
EA201000017A1 (ru) Предварительная композиция серного цемента и способ приготовления предварительной композиции серного цемента
ATE498669T1 (de) 2,6-naphthylreste enthaltende verbindungen
ATE501103T1 (de) Organische verbindungen
ATE548019T1 (de) Hautaufhellende mittel, zusammensetzungen und verfahren
ATE486857T1 (de) Verfahren zur herstellung von telmisartan
ATE354583T1 (de) Verfahren zur herstellung c-7 substituierter 5- androstene
CY1107101T1 (el) Μεθοδος συνθεσης παραγωγων της 1,3-διϋδρο-2h-3-βενζαζεπιν-2-ονης και εφαρμογη στη συνθεση της ιβαβραδινης και των αλατων προσθηκης με φαρμακευτικως αποδεκτο οξυ
DE602005014280D1 (de) Verfahren zur herstellung von ä1,4,5ü-oxadiazepinderivaten
ATE517079T1 (de) Adamantanderivate mit neuroprotektoren, antidepressoren und antiischaemischer wirkung, und verfahren zur ihrer herstellung
ATE554093T1 (de) Zwischenprodukt und verfahren zur herstellung von ecteinascidinen wie ecteinascidin 583 und 597 unter verwendung eines solchen zwischenprodukts
ATE424892T1 (de) Verfahren zur herstellung von derivaten des 4a,5, 9,10,11,12-hexahydrobenzofuro ä3a,3,2üä 2 ü- benzazepins
ATE447567T1 (de) Verfahren zur herstellung von tryptase- inhibitoren
DE502005007702D1 (de) Verfahren zur herstellung von terrylen-3,4:11,12-t
DE602006005349D1 (de) Verfahren zur herstellung von hydrazon-derivaten
DE602006008720D1 (de) Verfahren zur Herstellung von Dialkylcarbonaten
TW200728357A (en) Polycarbosilane, manufacture method of the same, silicon dioxide based composition for coatings and silicon dioxide film
ATE515502T1 (de) Verfahren zur herstellung von tetranorlabdanderivaten
ATE444323T1 (de) Neuartige epoxidverbindungen und verfahren zu ihrer herstellung
MXPA05009338A (es) 7-alquenilamino-triazolopirimidinas, procedimientos para su obtencion y el uso de las mismas para controlar hongos nocivos, asi como productos que los contienen.

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties