ATE525653T1 - Bildung von doppelschichten amphipathischer moleküle - Google Patents

Bildung von doppelschichten amphipathischer moleküle

Info

Publication number
ATE525653T1
ATE525653T1 AT07789069T AT07789069T ATE525653T1 AT E525653 T1 ATE525653 T1 AT E525653T1 AT 07789069 T AT07789069 T AT 07789069T AT 07789069 T AT07789069 T AT 07789069T AT E525653 T1 ATE525653 T1 AT E525653T1
Authority
AT
Austria
Prior art keywords
droplets
amphipathic molecules
bilayers
formation
lipid
Prior art date
Application number
AT07789069T
Other languages
German (de)
English (en)
Inventor
John Hagan Pryce Bayley
Matthew Holden
Andrew John Heron
David Needham
Original Assignee
Isis Innovation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isis Innovation filed Critical Isis Innovation
Application granted granted Critical
Publication of ATE525653T1 publication Critical patent/ATE525653T1/de

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads or physically stretching molecules
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502784Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
    • B01L3/502792Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics for moving individual droplets on a plate, e.g. by locally altering surface tension
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/5432Liposomes or microcapsules
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0809Geometry, shape and general structure rectangular shaped
    • B01L2300/0816Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0861Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867Multiple inlets and one sample wells, e.g. mixing, dilution
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/16Surface properties and coatings
    • B01L2300/161Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0403Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0427Electrowetting
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/195Assays involving biological materials from specific organisms or of a specific nature from bacteria
    • G01N2333/305Assays involving biological materials from specific organisms or of a specific nature from bacteria from Micrococcaceae (F)
    • G01N2333/31Assays involving biological materials from specific organisms or of a specific nature from bacteria from Micrococcaceae (F) from Staphylococcus (G)
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/12Condition responsive control

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Clinical Laboratory Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Fluid Mechanics (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicinal Preparation (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
AT07789069T 2006-07-26 2007-07-26 Bildung von doppelschichten amphipathischer moleküle ATE525653T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0614835.7A GB0614835D0 (en) 2006-07-26 2006-07-26 Formation of bilayers of amphipathic molecules
PCT/GB2007/002856 WO2008012552A1 (en) 2006-07-26 2007-07-26 Formation of bilayers of amphipathic molecules

Publications (1)

Publication Number Publication Date
ATE525653T1 true ATE525653T1 (de) 2011-10-15

Family

ID=37006184

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07789069T ATE525653T1 (de) 2006-07-26 2007-07-26 Bildung von doppelschichten amphipathischer moleküle

Country Status (6)

Country Link
US (2) US8268627B2 (https=)
EP (1) EP2047266B1 (https=)
JP (1) JP5235879B2 (https=)
AT (1) ATE525653T1 (https=)
GB (1) GB0614835D0 (https=)
WO (1) WO2008012552A1 (https=)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2928387A1 (en) 2004-05-03 2005-11-17 Merrimack Pharmaceuticals, Inc. Drug delivery liposomes containing anionic polyols or anionic sugars
WO2008102120A1 (en) 2007-02-20 2008-08-28 Oxford Nanopore Technologies Limited Lipid bilayer sensor system
GB0716264D0 (en) * 2007-08-21 2007-09-26 Isis Innovation Bilayers
GB0724736D0 (en) 2007-12-19 2008-01-30 Oxford Nanolabs Ltd Formation of layers of amphiphilic molecules
US8772041B2 (en) * 2008-05-22 2014-07-08 The Regents Of The University Of California Membrane precursors and membranes formed therefrom
DE102009053490A1 (de) * 2009-11-16 2011-05-26 Schaeffler Technologies Gmbh & Co. Kg Turbolader einer Brennkraftmaschine mit einem elektrischen Energiefluss
GB201119032D0 (en) 2011-11-03 2011-12-14 Isis Innovation Multisomes: encapsulated droplet networks
GB201202519D0 (en) 2012-02-13 2012-03-28 Oxford Nanopore Tech Ltd Apparatus for supporting an array of layers of amphiphilic molecules and method of forming an array of layers of amphiphilic molecules
GB201219196D0 (en) 2012-10-25 2012-12-12 Isis Innovation Droplet assembly method
GB201219201D0 (en) * 2012-10-25 2012-12-12 Isis Innovation Hydrogel network
GB201313121D0 (en) 2013-07-23 2013-09-04 Oxford Nanopore Tech Ltd Array of volumes of polar medium
EP2911771B1 (en) * 2012-10-26 2017-01-18 Oxford Nanopore Technologies Limited Droplet interfaces
JP6078848B2 (ja) * 2012-11-20 2017-02-15 公益財団法人神奈川科学技術アカデミー 脂質二重膜の形成方法及びそのための器具
EP2928610A2 (en) * 2012-12-07 2015-10-14 Isis Innovation Limited Droplet assembly by 3d printing
GB201418512D0 (en) 2014-10-17 2014-12-03 Oxford Nanopore Tech Ltd Electrical device with detachable components
WO2016081723A1 (en) * 2014-11-21 2016-05-26 Icahn School Of Medicine At Mount Sinai Method of forming a lipid bilayer
US10641764B2 (en) 2015-07-02 2020-05-05 The University Of Massachusetts Membrane and droplet-interface bilayer systems and methods
US10481120B1 (en) 2015-08-06 2019-11-19 University Of Tennessee Research Foundation Droplet based measurement of specific capacitance and interfacial tensions
MX382522B (es) 2015-10-16 2025-03-13 Ipsen Biopharm Ltd Composiciones farmaceuticas estabilizantes de camptotecina.
WO2017085189A1 (en) 2015-11-17 2017-05-26 Paris Sciences Et Lettres - Quartier Latin A method for analyzing the activity of an ion channel
GB201611770D0 (en) 2016-07-06 2016-08-17 Oxford Nanopore Tech Microfluidic device
GB201619930D0 (en) 2016-11-24 2017-01-11 Oxford Nanopore Tech Apparatus and methods for controlling insertion of a membrane channel into a membrane
JP6877028B2 (ja) * 2017-03-28 2021-05-26 国立大学法人福井大学 脂質二重膜形成装置、脂質二重膜形成方法、および評価システム
GB2568895B (en) 2017-11-29 2021-10-27 Oxford Nanopore Tech Ltd Microfluidic device
GB2569630B (en) 2017-12-21 2022-10-12 Sharp Life Science Eu Ltd Droplet Interfaces in Electro-wetting Devices
GB2574048B (en) 2018-05-24 2021-06-16 Oxford Nanopore Tech Ltd Nanopore sensor component with electrostatic discharge protection
WO2019227013A1 (en) 2018-05-24 2019-11-28 Oxford Nanopore Technologies Inc. Droplet interfaces in electro-wetting devices
US11789006B2 (en) 2019-03-12 2023-10-17 Oxford Nanopore Technologies Plc Nanopore sensing device, components and method of operation
EP3756761B1 (en) * 2019-06-25 2025-08-06 Sharp Life Science (EU) Limited Microfluidic device and a method of manipulating droplets therein
EP3756762B1 (en) * 2019-06-25 2025-08-06 Sharp Life Science (EU) Limited Method of manipulating droplets in a microfluidic device
WO2022013551A1 (en) 2020-07-17 2022-01-20 Oxford Nanopore Technologies Limited Nanopore sensing device
CN116297721A (zh) * 2021-12-21 2023-06-23 成都齐碳科技有限公司 成膜方法、包含膜的系统及应用
GB202202716D0 (en) 2022-02-28 2022-04-13 Oxford Nanopore Tech Plc Apparatus and methods for controlling insertion of a membrane channel into a membrane
CN114908358B8 (zh) * 2022-04-14 2024-06-21 孔确(成都)科技有限公司 一种两亲性分子层的制备方法及装置
CN117779058A (zh) * 2022-04-14 2024-03-29 广州孔确基因科技有限公司 一种两亲性分子层的制备方法及装置
GB202313035D0 (en) * 2023-08-25 2023-10-11 Univ Oxford Innovation Ltd Power unit

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03118832A (ja) * 1989-09-29 1991-05-21 Toshiba Corp 二分子膜の形成方法
JP3118832B2 (ja) 1990-11-20 2000-12-18 松下電器産業株式会社 アルカリ蓄電池
US6962747B1 (en) * 2001-10-23 2005-11-08 Sandia Corporation Self-assembled lipid bilayer materials
EP1712909B1 (en) 2004-01-21 2012-09-19 Japan Science and Technology Agency Method of forming planar lipid double membrane for membrane protein analysis and apparatus therefor
JP4953044B2 (ja) * 2005-05-09 2012-06-13 財団法人生産技術研究奨励会 脂質二重膜の形成方法およびその装置
JP5114702B2 (ja) * 2005-07-29 2013-01-09 国立大学法人 東京大学 両親媒性単分子膜の接触による二分子膜の形成方法およびその装置
US7776927B2 (en) * 2007-03-28 2010-08-17 President And Fellows Of Harvard College Emulsions and techniques for formation

Also Published As

Publication number Publication date
EP2047266B1 (en) 2011-09-21
EP2047266A1 (en) 2009-04-15
WO2008012552A1 (en) 2008-01-31
US20100032627A1 (en) 2010-02-11
US8268627B2 (en) 2012-09-18
JP2010503517A (ja) 2010-02-04
US8691586B2 (en) 2014-04-08
US20130146815A1 (en) 2013-06-13
JP5235879B2 (ja) 2013-07-10
GB0614835D0 (en) 2006-09-06

Similar Documents

Publication Publication Date Title
ATE525653T1 (de) Bildung von doppelschichten amphipathischer moleküle
EA200600345A1 (ru) Способ культивирования клеток
AR075258A1 (es) Microencapsulacion
WO2009121944A3 (fr) Procede pour assembler deux surfaces ou une surface avec une molecule d'interet
WO2013006312A3 (en) Reagent storage on a droplet actuator
WO2008016990A3 (en) High performance ultracapacitors with carbon nanomaterials and ionic liquids
ATE528811T1 (de) Nanodraht-strukturen mit kohlenstoff
BRPI1013974A2 (pt) processo para recuperação de óleo a partir de uma formação contendo petróleo, composição para uso na recuperação de óleo a partir de uma formação contendo petróleo e derivados sulfonado de uma ou mais olefinas internas.
CL2011000905A1 (es) Un revestimiento que comprende una serie de microobjetos, en donde una primera y una segunda imagenes compuestas parecen flotar para el ojo sin ayuda, en donde la segunda imagen es alineada con la primera; un metodo de formacion de dos imagenes compuestas en un revestimiento
CU20140067A7 (es) Panel de construcción y metodo de fabricación
ATE544183T1 (de) Verfahren zur herstellung einer verbundglas- /polyolefinfolienstruktur
DK2302376T3 (da) Elektrokemisk sensor til bestemmelse af en analytkoncentration
WO2008119770A9 (de) Verfahren zur modifizierung der struktur eines cellulosematerials durch behandeln mit einer ionischen flüssigkeit
CL2007002527A1 (es) Compuesto con superficie de contacto termica que comprende mezcla de matriz polimera y relleno de conduccion termica, la matriz incluye organopolisiloxano, organohidrogenpolisiloxano y catalizador de hidrosililacion compuesto por metal de transicion;
BR112013003460A2 (pt) revestimento óptico compreendendo nanopartículas de sílica porosas
MX360544B (es) Película de barrera de capas múltiples, laminados y procesos de los mismos.
MX347413B (es) Medio de impresion.
CL2007002989A1 (es) Anticuerpos anti-notch3; acido nucleico que los codifica; vector y celula que lo comprende; metodo de produccion; y su uso para el diagnostico de enfermedades relacionadas con notch3.
WO2012048032A3 (en) Chemical systems and methods for operating an electrochemical cell with an acidic anolyte
WO2017009710A3 (en) Dynamic formation of nanochannels for single-molecule dna analysis
WO2008117533A1 (ja) 2次元フォトニック結晶
GB2492232B (en) Illuminated panel and method of fabrication thereof
BR112016014305A2 (pt) Lenço com gel e método para fabricar um lenço com gel
ATE371705T1 (de) Wässrige bitumenemulsion
WO2009063462A3 (en) Pico liter well holding device and method of making the same

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties