JP5235879B2 - 両親媒性分子の二重層の形成 - Google Patents
両親媒性分子の二重層の形成 Download PDFInfo
- Publication number
- JP5235879B2 JP5235879B2 JP2009521345A JP2009521345A JP5235879B2 JP 5235879 B2 JP5235879 B2 JP 5235879B2 JP 2009521345 A JP2009521345 A JP 2009521345A JP 2009521345 A JP2009521345 A JP 2009521345A JP 5235879 B2 JP5235879 B2 JP 5235879B2
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- JP
- Japan
- Prior art keywords
- droplets
- droplet
- bilayer
- contact
- amphiphilic molecules
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads or physically stretching molecules
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
- B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
- B01L3/502792—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics for moving individual droplets on a plate, e.g. by locally altering surface tension
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/5432—Liposomes or microcapsules
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/16—Surface properties and coatings
- B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
- B01L2400/0427—Electrowetting
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
- G01N2333/305—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Micrococcaceae (F)
- G01N2333/31—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Micrococcaceae (F) from Staphylococcus (G)
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/12—Condition responsive control
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Dispersion Chemistry (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Clinical Laboratory Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Fluid Mechanics (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Medicinal Preparation (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0614835.7A GB0614835D0 (en) | 2006-07-26 | 2006-07-26 | Formation of bilayers of amphipathic molecules |
| GB0614835.7 | 2006-07-26 | ||
| PCT/GB2007/002856 WO2008012552A1 (en) | 2006-07-26 | 2007-07-26 | Formation of bilayers of amphipathic molecules |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010503517A JP2010503517A (ja) | 2010-02-04 |
| JP2010503517A5 JP2010503517A5 (https=) | 2011-08-18 |
| JP5235879B2 true JP5235879B2 (ja) | 2013-07-10 |
Family
ID=37006184
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009521345A Active JP5235879B2 (ja) | 2006-07-26 | 2007-07-26 | 両親媒性分子の二重層の形成 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US8268627B2 (https=) |
| EP (1) | EP2047266B1 (https=) |
| JP (1) | JP5235879B2 (https=) |
| AT (1) | ATE525653T1 (https=) |
| GB (1) | GB0614835D0 (https=) |
| WO (1) | WO2008012552A1 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2021507296A (ja) * | 2017-12-21 | 2021-02-22 | オックスフォード ナノポール テクノロジーズ リミテッド | エレクトロウェッティングデバイス内の液滴界面 |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2928387A1 (en) | 2004-05-03 | 2005-11-17 | Merrimack Pharmaceuticals, Inc. | Drug delivery liposomes containing anionic polyols or anionic sugars |
| WO2008102120A1 (en) | 2007-02-20 | 2008-08-28 | Oxford Nanopore Technologies Limited | Lipid bilayer sensor system |
| GB0716264D0 (en) * | 2007-08-21 | 2007-09-26 | Isis Innovation | Bilayers |
| GB0724736D0 (en) | 2007-12-19 | 2008-01-30 | Oxford Nanolabs Ltd | Formation of layers of amphiphilic molecules |
| US8772041B2 (en) * | 2008-05-22 | 2014-07-08 | The Regents Of The University Of California | Membrane precursors and membranes formed therefrom |
| DE102009053490A1 (de) * | 2009-11-16 | 2011-05-26 | Schaeffler Technologies Gmbh & Co. Kg | Turbolader einer Brennkraftmaschine mit einem elektrischen Energiefluss |
| GB201119032D0 (en) | 2011-11-03 | 2011-12-14 | Isis Innovation | Multisomes: encapsulated droplet networks |
| GB201202519D0 (en) | 2012-02-13 | 2012-03-28 | Oxford Nanopore Tech Ltd | Apparatus for supporting an array of layers of amphiphilic molecules and method of forming an array of layers of amphiphilic molecules |
| GB201219196D0 (en) | 2012-10-25 | 2012-12-12 | Isis Innovation | Droplet assembly method |
| GB201219201D0 (en) * | 2012-10-25 | 2012-12-12 | Isis Innovation | Hydrogel network |
| GB201313121D0 (en) | 2013-07-23 | 2013-09-04 | Oxford Nanopore Tech Ltd | Array of volumes of polar medium |
| EP2911771B1 (en) * | 2012-10-26 | 2017-01-18 | Oxford Nanopore Technologies Limited | Droplet interfaces |
| JP6078848B2 (ja) * | 2012-11-20 | 2017-02-15 | 公益財団法人神奈川科学技術アカデミー | 脂質二重膜の形成方法及びそのための器具 |
| EP2928610A2 (en) * | 2012-12-07 | 2015-10-14 | Isis Innovation Limited | Droplet assembly by 3d printing |
| GB201418512D0 (en) | 2014-10-17 | 2014-12-03 | Oxford Nanopore Tech Ltd | Electrical device with detachable components |
| WO2016081723A1 (en) * | 2014-11-21 | 2016-05-26 | Icahn School Of Medicine At Mount Sinai | Method of forming a lipid bilayer |
| US10641764B2 (en) | 2015-07-02 | 2020-05-05 | The University Of Massachusetts | Membrane and droplet-interface bilayer systems and methods |
| US10481120B1 (en) | 2015-08-06 | 2019-11-19 | University Of Tennessee Research Foundation | Droplet based measurement of specific capacitance and interfacial tensions |
| MX382522B (es) | 2015-10-16 | 2025-03-13 | Ipsen Biopharm Ltd | Composiciones farmaceuticas estabilizantes de camptotecina. |
| WO2017085189A1 (en) | 2015-11-17 | 2017-05-26 | Paris Sciences Et Lettres - Quartier Latin | A method for analyzing the activity of an ion channel |
| GB201611770D0 (en) | 2016-07-06 | 2016-08-17 | Oxford Nanopore Tech | Microfluidic device |
| GB201619930D0 (en) | 2016-11-24 | 2017-01-11 | Oxford Nanopore Tech | Apparatus and methods for controlling insertion of a membrane channel into a membrane |
| JP6877028B2 (ja) * | 2017-03-28 | 2021-05-26 | 国立大学法人福井大学 | 脂質二重膜形成装置、脂質二重膜形成方法、および評価システム |
| GB2568895B (en) | 2017-11-29 | 2021-10-27 | Oxford Nanopore Tech Ltd | Microfluidic device |
| GB2574048B (en) | 2018-05-24 | 2021-06-16 | Oxford Nanopore Tech Ltd | Nanopore sensor component with electrostatic discharge protection |
| WO2019227013A1 (en) | 2018-05-24 | 2019-11-28 | Oxford Nanopore Technologies Inc. | Droplet interfaces in electro-wetting devices |
| US11789006B2 (en) | 2019-03-12 | 2023-10-17 | Oxford Nanopore Technologies Plc | Nanopore sensing device, components and method of operation |
| EP3756761B1 (en) * | 2019-06-25 | 2025-08-06 | Sharp Life Science (EU) Limited | Microfluidic device and a method of manipulating droplets therein |
| EP3756762B1 (en) * | 2019-06-25 | 2025-08-06 | Sharp Life Science (EU) Limited | Method of manipulating droplets in a microfluidic device |
| WO2022013551A1 (en) | 2020-07-17 | 2022-01-20 | Oxford Nanopore Technologies Limited | Nanopore sensing device |
| CN116297721A (zh) * | 2021-12-21 | 2023-06-23 | 成都齐碳科技有限公司 | 成膜方法、包含膜的系统及应用 |
| GB202202716D0 (en) | 2022-02-28 | 2022-04-13 | Oxford Nanopore Tech Plc | Apparatus and methods for controlling insertion of a membrane channel into a membrane |
| CN114908358B8 (zh) * | 2022-04-14 | 2024-06-21 | 孔确(成都)科技有限公司 | 一种两亲性分子层的制备方法及装置 |
| CN117779058A (zh) * | 2022-04-14 | 2024-03-29 | 广州孔确基因科技有限公司 | 一种两亲性分子层的制备方法及装置 |
| GB202313035D0 (en) * | 2023-08-25 | 2023-10-11 | Univ Oxford Innovation Ltd | Power unit |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH03118832A (ja) * | 1989-09-29 | 1991-05-21 | Toshiba Corp | 二分子膜の形成方法 |
| JP3118832B2 (ja) | 1990-11-20 | 2000-12-18 | 松下電器産業株式会社 | アルカリ蓄電池 |
| US6962747B1 (en) * | 2001-10-23 | 2005-11-08 | Sandia Corporation | Self-assembled lipid bilayer materials |
| EP1712909B1 (en) | 2004-01-21 | 2012-09-19 | Japan Science and Technology Agency | Method of forming planar lipid double membrane for membrane protein analysis and apparatus therefor |
| JP4953044B2 (ja) * | 2005-05-09 | 2012-06-13 | 財団法人生産技術研究奨励会 | 脂質二重膜の形成方法およびその装置 |
| JP5114702B2 (ja) * | 2005-07-29 | 2013-01-09 | 国立大学法人 東京大学 | 両親媒性単分子膜の接触による二分子膜の形成方法およびその装置 |
| US7776927B2 (en) * | 2007-03-28 | 2010-08-17 | President And Fellows Of Harvard College | Emulsions and techniques for formation |
-
2006
- 2006-07-26 GB GBGB0614835.7A patent/GB0614835D0/en not_active Ceased
-
2007
- 2007-07-26 AT AT07789069T patent/ATE525653T1/de not_active IP Right Cessation
- 2007-07-26 US US12/375,103 patent/US8268627B2/en active Active
- 2007-07-26 JP JP2009521345A patent/JP5235879B2/ja active Active
- 2007-07-26 EP EP07789069A patent/EP2047266B1/en active Active
- 2007-07-26 WO PCT/GB2007/002856 patent/WO2008012552A1/en not_active Ceased
-
2012
- 2012-09-07 US US13/607,337 patent/US8691586B2/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2021507296A (ja) * | 2017-12-21 | 2021-02-22 | オックスフォード ナノポール テクノロジーズ リミテッド | エレクトロウェッティングデバイス内の液滴界面 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2047266B1 (en) | 2011-09-21 |
| EP2047266A1 (en) | 2009-04-15 |
| WO2008012552A1 (en) | 2008-01-31 |
| US20100032627A1 (en) | 2010-02-11 |
| US8268627B2 (en) | 2012-09-18 |
| JP2010503517A (ja) | 2010-02-04 |
| ATE525653T1 (de) | 2011-10-15 |
| US8691586B2 (en) | 2014-04-08 |
| US20130146815A1 (en) | 2013-06-13 |
| GB0614835D0 (en) | 2006-09-06 |
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