WO2009063462A3 - Pico liter well holding device and method of making the same - Google Patents

Pico liter well holding device and method of making the same Download PDF

Info

Publication number
WO2009063462A3
WO2009063462A3 PCT/IL2008/001492 IL2008001492W WO2009063462A3 WO 2009063462 A3 WO2009063462 A3 WO 2009063462A3 IL 2008001492 W IL2008001492 W IL 2008001492W WO 2009063462 A3 WO2009063462 A3 WO 2009063462A3
Authority
WO
WIPO (PCT)
Prior art keywords
pico liter
making
same
holding device
liter well
Prior art date
Application number
PCT/IL2008/001492
Other languages
French (fr)
Other versions
WO2009063462A2 (en
Inventor
Mordechai Deutsch
Assaf Deutsch
Original Assignee
Seng Enterprises Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/940,996 external-priority patent/US7888110B2/en
Application filed by Seng Enterprises Ltd. filed Critical Seng Enterprises Ltd.
Priority to US12/742,730 priority Critical patent/US8597597B2/en
Priority to US12/810,868 priority patent/US9975118B2/en
Priority to EP08865081A priority patent/EP2237887A2/en
Priority to PCT/IL2008/001678 priority patent/WO2009081409A2/en
Publication of WO2009063462A2 publication Critical patent/WO2009063462A2/en
Priority to US12/712,232 priority patent/US9145540B1/en
Publication of WO2009063462A3 publication Critical patent/WO2009063462A3/en
Priority to IL205769A priority patent/IL205769A0/en
Priority to IL206588A priority patent/IL206588A0/en
Priority to US14/840,065 priority patent/US9739699B2/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/12—Well or multiwell plates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/22—Transparent or translucent parts
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0668—Trapping microscopic beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0822—Slides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0893—Geometry, shape and general structure having a very large number of wells, microfabricated wells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/12—Specific details about materials
    • B01L2300/123—Flexible; Elastomeric
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T29/00—Metal working
    • Y10T29/49—Method of mechanical manufacture
    • Y10T29/49826—Assembling or joining

Abstract

Described herein are embossing methods for forming pico liter well arrays (and other structures), arrangements of such pico liter well arrays, for example, in arrays of pico liter well areas, and methods of forming templates for such embossing. Also described as wells with a refractive index similar to that of an aqueous medium used for supporting cells in the wells.
PCT/IL2008/001492 2003-06-26 2008-11-13 Pico liter well holding device and method of making the same WO2009063462A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
US12/742,730 US8597597B2 (en) 2003-06-26 2008-11-13 Picoliter well holding device and method of making the same
US12/810,868 US9975118B2 (en) 2007-11-15 2008-12-25 Device for the study of living cells
EP08865081A EP2237887A2 (en) 2007-12-26 2008-12-25 Device for the study of living cells
PCT/IL2008/001678 WO2009081409A2 (en) 2007-12-26 2008-12-25 Device for the study of living cells
US12/712,232 US9145540B1 (en) 2007-11-15 2010-02-25 Device for the study of living cells
IL205769A IL205769A0 (en) 2007-11-15 2010-05-13 Pico liter well holding device and method of making the same
IL206588A IL206588A0 (en) 2007-12-26 2010-06-23 Device for the study of living cells
US14/840,065 US9739699B2 (en) 2007-11-15 2015-08-31 Device for the study of living cells

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US11/940,996 2007-11-15
US11/940,996 US7888110B2 (en) 2003-06-26 2007-11-15 Pico liter well holding device and method of making the same
US613007P 2007-12-26 2007-12-26
US61/006,130 2007-12-26

Related Parent Applications (2)

Application Number Title Priority Date Filing Date
US11/940,996 Continuation-In-Part US7888110B2 (en) 2003-06-26 2007-11-15 Pico liter well holding device and method of making the same
US12/810,868 Continuation-In-Part US9975118B2 (en) 2007-11-15 2008-12-25 Device for the study of living cells

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US12/810,868 Continuation-In-Part US9975118B2 (en) 2007-11-15 2008-12-25 Device for the study of living cells
PCT/IL2008/001678 Continuation-In-Part WO2009081409A2 (en) 2007-11-15 2008-12-25 Device for the study of living cells

Publications (2)

Publication Number Publication Date
WO2009063462A2 WO2009063462A2 (en) 2009-05-22
WO2009063462A3 true WO2009063462A3 (en) 2010-03-11

Family

ID=63350279

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2008/001492 WO2009063462A2 (en) 2003-06-26 2008-11-13 Pico liter well holding device and method of making the same

Country Status (2)

Country Link
EP (1) EP2222832A4 (en)
WO (1) WO2009063462A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9200245B2 (en) 2003-06-26 2015-12-01 Seng Enterprises Ltd. Multiwell plate
US9145540B1 (en) 2007-11-15 2015-09-29 Seng Enterprises Ltd. Device for the study of living cells
EP2237887A2 (en) 2007-12-26 2010-10-13 Seng Enterprises Ltd. Device for the study of living cells
WO2012120514A2 (en) 2011-03-09 2012-09-13 Seng Enterprises Ltd. Arresting objects
US10078778B2 (en) 2015-01-15 2018-09-18 Massachusetts Institute Of Technology Systems, methods, and apparatus for in vitro single-cell identification and recovery
JP7361700B2 (en) 2017-09-25 2023-10-16 プレキシウム インコーポレイテッド Oligonucleotide-encoded chemical library
EP3536402A1 (en) * 2018-03-09 2019-09-11 Ibidi Gmbh Sample chamber
CN108636465B (en) * 2018-05-15 2020-08-14 中国科学院化学研究所 Patterned fluid array, and preparation method and application thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3558387A (en) * 1966-06-10 1971-01-26 Sun Chemical Corp Radiation-curable compositions
US4684538A (en) * 1986-02-21 1987-08-04 Loctite Corporation Polysiloxane urethane compounds and adhesive compositions, and method of making and using the same
WO2005007796A2 (en) * 2003-07-21 2005-01-27 Molecular Cytomics Ltd. Improved multiwell plate
US20050026299A1 (en) * 2003-07-31 2005-02-03 Arindam Bhattacharjee Chemical arrays on a common carrier
US20050277125A1 (en) * 2003-10-27 2005-12-15 Massachusetts Institute Of Technology High-density reaction chambers and methods of use

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6844184B2 (en) * 2000-11-08 2005-01-18 Surface Logix, Inc. Device for arraying biomolecules and for monitoring cell motility in real-time
FR2890975A1 (en) * 2005-09-22 2007-03-23 Ecole Norm Superieure Cachan Biochemical, biological/pharmacological test plate comprises wells subdivided into hollow section and microcavity discretes, for receiving culture cells and their products to test

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3558387A (en) * 1966-06-10 1971-01-26 Sun Chemical Corp Radiation-curable compositions
US4684538A (en) * 1986-02-21 1987-08-04 Loctite Corporation Polysiloxane urethane compounds and adhesive compositions, and method of making and using the same
WO2005007796A2 (en) * 2003-07-21 2005-01-27 Molecular Cytomics Ltd. Improved multiwell plate
US20050026299A1 (en) * 2003-07-31 2005-02-03 Arindam Bhattacharjee Chemical arrays on a common carrier
US20050277125A1 (en) * 2003-10-27 2005-12-15 Massachusetts Institute Of Technology High-density reaction chambers and methods of use

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP2222832A4 *

Also Published As

Publication number Publication date
WO2009063462A2 (en) 2009-05-22
EP2222832A2 (en) 2010-09-01
EP2222832A4 (en) 2012-08-29

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