ATE517090T1 - Piperidinsulfonamidderivate - Google Patents
PiperidinsulfonamidderivateInfo
- Publication number
- ATE517090T1 ATE517090T1 AT09711149T AT09711149T ATE517090T1 AT E517090 T1 ATE517090 T1 AT E517090T1 AT 09711149 T AT09711149 T AT 09711149T AT 09711149 T AT09711149 T AT 09711149T AT E517090 T1 ATE517090 T1 AT E517090T1
- Authority
- AT
- Austria
- Prior art keywords
- sulphonamide derivatives
- formula
- piperidine
- compounds
- piperidine sulphonamide
- Prior art date
Links
- FLKRMXAWABTWSH-UHFFFAOYSA-N piperidine-1-sulfonamide Chemical class NS(=O)(=O)N1CCCCC1 FLKRMXAWABTWSH-UHFFFAOYSA-N 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000001456 Jet Lag Syndrome Diseases 0.000 abstract 1
- 208000012902 Nervous system disease Diseases 0.000 abstract 1
- 208000025966 Neurological disease Diseases 0.000 abstract 1
- 229940123730 Orexin receptor antagonist Drugs 0.000 abstract 1
- 208000006199 Parasomnias Diseases 0.000 abstract 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000027288 circadian rhythm Effects 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 206010022437 insomnia Diseases 0.000 abstract 1
- 201000003631 narcolepsy Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 201000002859 sleep apnea Diseases 0.000 abstract 1
- 208000019116 sleep disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/96—Sulfur atom
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Addiction (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Psychology (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08151328 | 2008-02-12 | ||
| PCT/EP2009/051135 WO2009100994A1 (en) | 2008-02-12 | 2009-02-02 | Piperidine sulfonamide derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE517090T1 true ATE517090T1 (de) | 2011-08-15 |
Family
ID=40651273
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT09711149T ATE517090T1 (de) | 2008-02-12 | 2009-02-02 | Piperidinsulfonamidderivate |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US8202888B2 (de) |
| EP (1) | EP2252587B1 (de) |
| JP (1) | JP5346043B2 (de) |
| KR (1) | KR101229603B1 (de) |
| CN (1) | CN101918361B (de) |
| AT (1) | ATE517090T1 (de) |
| AU (1) | AU2009214244B2 (de) |
| BR (1) | BRPI0907627A2 (de) |
| CA (1) | CA2713713C (de) |
| ES (1) | ES2367341T3 (de) |
| IL (1) | IL206615A (de) |
| MX (1) | MX2010007968A (de) |
| WO (1) | WO2009100994A1 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101802726B1 (ko) * | 2010-08-24 | 2017-11-29 | 액테리온 파마슈티칼 리미티드 | 오렉신 수용체 안타고니스트로서의 프롤린 술폰아미드 유도체 |
| US9440982B2 (en) | 2012-02-07 | 2016-09-13 | Eolas Therapeutics, Inc. | Substituted prolines/piperidines as orexin receptor antagonists |
| RU2014136339A (ru) | 2012-02-07 | 2016-03-27 | Иолас Терапьютикс, Инк. | Замещенные пролины/пиперидины как антагонисты орексиновых рецепторов |
| EP3180332B1 (de) | 2014-08-13 | 2021-10-27 | Eolas Therapeutics Inc. | Difluorpyrrolidine als orexinrezeptormodulatoren |
| KR102738491B1 (ko) | 2016-02-12 | 2024-12-03 | 아스트라제네카 아베 | 오렉신 수용체 조정제로서의 할로-치환된 피페리딘 |
| US12187737B2 (en) | 2019-06-04 | 2025-01-07 | Hager Biosciences, Llc | Imidazolo derivatives, compositions and methods as orexin antagonists |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0115862D0 (en) * | 2001-06-28 | 2001-08-22 | Smithkline Beecham Plc | Compounds |
| CA2513921C (en) * | 2003-02-13 | 2009-07-21 | Guardian Industries Corp. | Coated articles with nitrided layer and methods of making same |
| EP1758882A4 (de) * | 2004-06-24 | 2008-01-23 | Incyte Corp | Amidverbindungen und ihre verwendung als arzneimittel |
| BRPI0609062A2 (pt) * | 2005-03-03 | 2010-02-17 | F. Hofmann-La Roche Ag | composição farmacêutica, compostos, método para o tratamento terapêutico e/ou profilático de enfermidades que são moduladas por inibidores de deidrogenase de hidroxiesteróide-11ß e utilização dos compostos |
| WO2006127550A1 (en) * | 2005-05-23 | 2006-11-30 | Merck & Co., Inc. | Proline bis-amide orexin receptor antagonists |
| ES2349160T3 (es) * | 2006-01-23 | 2010-12-28 | F. Hoffmann-La Roche Ag | Derivados de la ciclohexil sulfonamida con actividad frente a los receptores h3. |
| CN101432285A (zh) * | 2006-04-26 | 2009-05-13 | 埃科特莱茵药品有限公司 | 作为食欲素受体拮抗剂的吡唑并-四氢吡啶衍生物 |
| AU2007272795A1 (en) * | 2006-07-14 | 2008-01-17 | Merck & Co., Inc. | 2-substituted proline bis-amide orexin receptor antagonists |
-
2009
- 2009-02-02 AT AT09711149T patent/ATE517090T1/de active
- 2009-02-02 AU AU2009214244A patent/AU2009214244B2/en not_active Ceased
- 2009-02-02 BR BRPI0907627-1A patent/BRPI0907627A2/pt not_active Application Discontinuation
- 2009-02-02 CN CN200980102624.1A patent/CN101918361B/zh not_active Expired - Fee Related
- 2009-02-02 ES ES09711149T patent/ES2367341T3/es active Active
- 2009-02-02 EP EP09711149A patent/EP2252587B1/de not_active Not-in-force
- 2009-02-02 KR KR1020107017153A patent/KR101229603B1/ko not_active Expired - Fee Related
- 2009-02-02 JP JP2010546286A patent/JP5346043B2/ja not_active Expired - Fee Related
- 2009-02-02 CA CA2713713A patent/CA2713713C/en not_active Expired - Fee Related
- 2009-02-02 MX MX2010007968A patent/MX2010007968A/es active IP Right Grant
- 2009-02-02 WO PCT/EP2009/051135 patent/WO2009100994A1/en not_active Ceased
- 2009-02-05 US US12/365,911 patent/US8202888B2/en not_active Expired - Fee Related
-
2010
- 2010-06-24 IL IL206615A patent/IL206615A/en not_active IP Right Cessation
-
2012
- 2012-05-23 US US13/478,163 patent/US20120238602A1/en not_active Abandoned
-
2013
- 2013-04-02 US US13/855,470 patent/US8691846B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| IL206615A0 (en) | 2010-12-30 |
| US8691846B2 (en) | 2014-04-08 |
| CN101918361B (zh) | 2014-05-28 |
| KR20100111709A (ko) | 2010-10-15 |
| KR101229603B1 (ko) | 2013-02-04 |
| CN101918361A (zh) | 2010-12-15 |
| JP5346043B2 (ja) | 2013-11-20 |
| US20090203736A1 (en) | 2009-08-13 |
| AU2009214244B2 (en) | 2013-02-07 |
| CA2713713C (en) | 2016-05-24 |
| WO2009100994A1 (en) | 2009-08-20 |
| EP2252587B1 (de) | 2011-07-20 |
| EP2252587A1 (de) | 2010-11-24 |
| US20130217729A1 (en) | 2013-08-22 |
| MX2010007968A (es) | 2010-08-04 |
| BRPI0907627A2 (pt) | 2015-07-21 |
| US8202888B2 (en) | 2012-06-19 |
| ES2367341T3 (es) | 2011-11-02 |
| US20120238602A1 (en) | 2012-09-20 |
| JP2011511822A (ja) | 2011-04-14 |
| CA2713713A1 (en) | 2009-08-20 |
| IL206615A (en) | 2015-10-29 |
| AU2009214244A1 (en) | 2009-08-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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