ATE513041T1 - Ghrelin bindende nukleinsäuren - Google Patents
Ghrelin bindende nukleinsäurenInfo
- Publication number
- ATE513041T1 ATE513041T1 AT03766390T AT03766390T ATE513041T1 AT E513041 T1 ATE513041 T1 AT E513041T1 AT 03766390 T AT03766390 T AT 03766390T AT 03766390 T AT03766390 T AT 03766390T AT E513041 T1 ATE513041 T1 AT E513041T1
- Authority
- AT
- Austria
- Prior art keywords
- nucleic acids
- binding nucleic
- ghrelin binding
- ghrelin
- nucleic acid
- Prior art date
Links
- 102000012004 Ghrelin Human genes 0.000 title abstract 2
- 101800001586 Ghrelin Proteins 0.000 title abstract 2
- GNKDKYIHGQKHHM-RJKLHVOGSA-N ghrelin Chemical compound C([C@H](NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)CN)COC(=O)CCCCCCC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1N=CNC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C1=CC=CC=C1 GNKDKYIHGQKHHM-RJKLHVOGSA-N 0.000 title abstract 2
- 150000007523 nucleic acids Chemical class 0.000 title abstract 2
- 102000039446 nucleic acids Human genes 0.000 title abstract 2
- 108020004707 nucleic acids Proteins 0.000 title abstract 2
- 239000005557 antagonist Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/16—Aptamers
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02017317A EP1386972A1 (de) | 2002-08-01 | 2002-08-01 | Verfahren und Vorrichtung zum Entwurf einer Nukleinsäure mit einer gewünschten Eigenschaft |
| EP02023637 | 2002-10-19 | ||
| EP03014111 | 2003-06-23 | ||
| PCT/EP2003/008542 WO2004013274A2 (en) | 2002-08-01 | 2003-08-01 | Ghrelin binding nucleic acids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE513041T1 true ATE513041T1 (de) | 2011-07-15 |
Family
ID=31498967
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03766390T ATE513041T1 (de) | 2002-08-01 | 2003-08-01 | Ghrelin bindende nukleinsäuren |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US7750140B2 (de) |
| EP (1) | EP1530635B1 (de) |
| JP (1) | JP4644599B2 (de) |
| AT (1) | ATE513041T1 (de) |
| AU (1) | AU2003251681A1 (de) |
| WO (1) | WO2004013274A2 (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20060125743A (ko) * | 2003-11-10 | 2006-12-06 | 녹손 파르마 아게 | 생체 활성형 그렐린에 특이적으로 결합하는 핵산 |
| US20090149512A1 (en) * | 2004-05-14 | 2009-06-11 | Novo Nordisk A/S | Use of Ghrelin Antagonists to the Treatment of Certain CNS Diseases |
| EP1817414B1 (de) * | 2004-11-29 | 2010-07-14 | Noxxon Pharma AG | Vasopressin bindende l-nukleinsäure |
| UY29460A1 (es) * | 2005-04-08 | 2006-11-30 | Noxxon Pharma Ag | Acidos nucleicos de union a ghrelin |
| CN103275984A (zh) * | 2006-02-14 | 2013-09-04 | 诺松制药股份公司 | 结合mcp-1的核酸 |
| US8367629B2 (en) * | 2006-02-14 | 2013-02-05 | Noxxon Pharma Ag | MCP-1 binding nucleic acids and use thereof |
| AU2008329070B2 (en) * | 2007-11-30 | 2014-11-20 | Noxxon Pharma Ag | MCP-I binding nucleic acids and use thereof |
| CN102869775A (zh) * | 2009-09-30 | 2013-01-09 | 哈佛大学校长及研究员协会 | 通过调节自噬抑制基因产物调节自噬的方法 |
| CN102812037A (zh) | 2009-10-30 | 2012-12-05 | 特兰齐姆制药公司 | 大环生长素释放肽受体拮抗剂和反向激动剂及其使用方法 |
| DE102012020496A1 (de) | 2012-10-18 | 2014-04-24 | Charité - Universitätsmedizin Berlin | Biomarker zur Diagnostik und Behandlung von Neurofibromatose Typ 1 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5614395A (en) * | 1988-03-08 | 1997-03-25 | Ciba-Geigy Corporation | Chemically regulatable and anti-pathogenic DNA sequences and uses thereof |
| ES2259800T3 (es) * | 1990-06-11 | 2006-10-16 | Gilead Sciences, Inc. | Procedimientos de uso de ligandos de acido nucleico. |
| JPH11505527A (ja) * | 1995-05-03 | 1999-05-21 | ホワイトヘッド インスティチュート フォー バイオメディカル リサーチ | 鏡像異性体リガンドの同定 |
| DE19808591C2 (de) * | 1998-02-28 | 2000-02-03 | Univ Leipzig | Standardisierter durchflußzytometrischer Vollblutassay |
| EP1286697A2 (de) * | 2000-05-17 | 2003-03-05 | Eli Lilly And Company | Methode zur selektiven hemmung der aktivität von ghrelin |
| US20030211967A1 (en) * | 2001-05-07 | 2003-11-13 | Bryant Henry Uhlman | Method for selectively inhibiting ghrelin action |
| EP1353683A4 (de) | 2000-05-30 | 2004-05-12 | Merck & Co Inc | Analoge von ghrelin |
| KR20060125743A (ko) * | 2003-11-10 | 2006-12-06 | 녹손 파르마 아게 | 생체 활성형 그렐린에 특이적으로 결합하는 핵산 |
| UY29460A1 (es) * | 2005-04-08 | 2006-11-30 | Noxxon Pharma Ag | Acidos nucleicos de union a ghrelin |
-
2003
- 2003-08-01 US US10/522,582 patent/US7750140B2/en not_active Expired - Fee Related
- 2003-08-01 JP JP2005506074A patent/JP4644599B2/ja not_active Expired - Fee Related
- 2003-08-01 AU AU2003251681A patent/AU2003251681A1/en not_active Abandoned
- 2003-08-01 EP EP03766390A patent/EP1530635B1/de not_active Expired - Lifetime
- 2003-08-01 AT AT03766390T patent/ATE513041T1/de not_active IP Right Cessation
- 2003-08-01 WO PCT/EP2003/008542 patent/WO2004013274A2/en active Application Filing
-
2010
- 2010-05-08 US US12/776,377 patent/US20120083520A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2003251681A1 (en) | 2004-02-23 |
| AU2003251681A8 (en) | 2004-02-23 |
| EP1530635B1 (de) | 2011-06-15 |
| US7750140B2 (en) | 2010-07-06 |
| WO2004013274A3 (en) | 2004-05-13 |
| US20120083520A1 (en) | 2012-04-05 |
| US20060257867A1 (en) | 2006-11-16 |
| EP1530635A2 (de) | 2005-05-18 |
| JP2006501864A (ja) | 2006-01-19 |
| WO2004013274A2 (en) | 2004-02-12 |
| JP4644599B2 (ja) | 2011-03-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |