ATE508183T1 - Sekretierte proteine für zelldifferenzierungsmarker - Google Patents

Sekretierte proteine für zelldifferenzierungsmarker

Info

Publication number
ATE508183T1
ATE508183T1 AT04740821T AT04740821T ATE508183T1 AT E508183 T1 ATE508183 T1 AT E508183T1 AT 04740821 T AT04740821 T AT 04740821T AT 04740821 T AT04740821 T AT 04740821T AT E508183 T1 ATE508183 T1 AT E508183T1
Authority
AT
Austria
Prior art keywords
cells
cell differentiation
secreted proteins
differentiation
differentiation markers
Prior art date
Application number
AT04740821T
Other languages
English (en)
Inventor
Andreas Ehlich
Heribert Bohlen
Silke Schwengberg
Original Assignee
Axiogenesis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Axiogenesis Ag filed Critical Axiogenesis Ag
Application granted granted Critical
Publication of ATE508183T1 publication Critical patent/ATE508183T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0393—Animal model comprising a reporter system for screening tests
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT04740821T 2003-07-08 2004-07-08 Sekretierte proteine für zelldifferenzierungsmarker ATE508183T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US48546203P 2003-07-08 2003-07-08
EP03015400 2003-07-08
PCT/EP2004/007529 WO2005005662A2 (en) 2003-07-08 2004-07-08 Secreted proteins as markers for cell differentiation

Publications (1)

Publication Number Publication Date
ATE508183T1 true ATE508183T1 (de) 2011-05-15

Family

ID=34923783

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04740821T ATE508183T1 (de) 2003-07-08 2004-07-08 Sekretierte proteine für zelldifferenzierungsmarker

Country Status (9)

Country Link
US (1) US20090328243A1 (de)
EP (1) EP1644485B9 (de)
JP (1) JP2009513106A (de)
AT (1) ATE508183T1 (de)
AU (1) AU2004256208B2 (de)
CA (1) CA2559791A1 (de)
DK (1) DK1644485T3 (de)
ES (1) ES2365786T3 (de)
WO (1) WO2005005662A2 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2560334A1 (en) 2004-04-07 2005-10-20 Axiogenesis Ag Non-invasive, in vitro functional tissue assay systems
CA2565858C (en) 2004-05-11 2021-06-22 Axiogenesis Ag Assay for drug discovery based on in vitro differentiated cells
JP5421767B2 (ja) * 2006-04-10 2014-02-19 ウィスコンシン・アルムニ・リサーチ・ファウンデーション ヒト胚性幹細胞を使用して薬学的化合物および他の化学物質の毒性を評価するための試薬および方法
JP5428527B2 (ja) * 2008-06-03 2014-02-26 住友化学株式会社 化学物質が有する発生毒性の予測方法
JP6083559B2 (ja) * 2009-07-31 2017-02-22 クロモセル コーポレーション 細胞運命の修飾因子を同定および検証するための方法および組成物
HUE039900T2 (hu) 2010-03-22 2019-02-28 Stemina Biomarker Discovery Inc Gyógyszerek humán fejlõdésre gyakorolt toxicitásának elõrejelzése humán õssejtszerû sejtek és metabolomika alkalmazásával
GB201007197D0 (en) * 2010-04-30 2010-06-16 Ge Healthcare Uk Ltd Methods and kits for determining the toxicity of an agent
WO2021015611A1 (en) * 2019-07-19 2021-01-28 Toxys B.V. Methods to determine the effect of an agent on mammalian embryonic development.

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06189770A (ja) * 1992-06-01 1994-07-12 Takeda Chem Ind Ltd 発現用プロモーターおよびその用途
US5602301A (en) * 1993-11-16 1997-02-11 Indiana University Foundation Non-human mammal having a graft and methods of delivering protein to myocardial tissue
EP0776335A4 (de) * 1994-08-18 1999-09-15 Ariad Gene Therapeutics Inc Regulierbare elimination der genexpression, genproduktfunktion und gentechnologisch hergestellte wirtszellen
CA2203613C (en) * 1997-04-24 2008-01-15 Navneet K. Ahluwalia Secreted .alpha.-amylase as a reporter gene
GB9708526D0 (en) 1997-04-25 1997-06-18 Royal Free Hosp School Med Eukaryotic gene expression cassette and uses thereof
DE19727962A1 (de) * 1997-07-02 1999-01-14 Juergen Hescheler Fluoreszierende Proteine als zelltypspezifische Reporter
WO1999009152A1 (en) 1997-08-12 1999-02-25 Human Genome Sciences, Inc. Human frezzled-like protein
US5968829A (en) 1997-09-05 1999-10-19 Cytotherapeutics, Inc. Human CNS neural stem cells
WO2000063221A2 (en) 1999-04-21 2000-10-26 Human Genome Sciences, Inc. Galectin 11
US20020168711A1 (en) * 2000-01-31 2002-11-14 Rosen Craig A. Nucleic acids, proteins, and antibodies
JP2002051782A (ja) 2000-08-09 2002-02-19 Sankyo Co Ltd 骨粗鬆症もしくは関節リウマチの治療または予防剤の試験方法
JP4159358B2 (ja) * 2000-12-27 2008-10-01 アクシオジェネシス アーゲー 分化中の胚幹細胞、成体幹細胞および胚生殖系細胞を細胞特異的および成長特異的に選択するためのシステム
WO2002086073A2 (en) 2001-04-20 2002-10-31 Memorial Sloan-Kettering Cancer Center Generation of differentiated tissue from nuclear transfer embryonic stem cells and methods of use
EP1444326A4 (de) 2001-08-24 2006-06-28 Advanced Cell Tech Inc Screening-assays zur identifizierung differenzierung induzierender stoffe und herstellung differenzierter zellen zur zelltherapie
WO2003048345A1 (en) * 2001-12-07 2003-06-12 Toolgen, Inc. Phenotypic screen of chimeric proteins
JP4904153B2 (ja) * 2003-06-20 2012-03-28 アキシオジェネシス エージー 胚性幹（ｅｓ）細胞系での組織モデリング
CA2558946C (en) * 2003-07-08 2013-05-21 Axiogenesis Ag Novel method for the preparation of embryoid bodies (ebs) and uses thereof

Also Published As

Publication number Publication date
JP2009513106A (ja) 2009-04-02
CA2559791A1 (en) 2005-01-20
EP1644485A2 (de) 2006-04-12
EP1644485B1 (de) 2011-05-04
DK1644485T3 (da) 2011-08-15
ES2365786T3 (es) 2011-10-11
WO2005005662A3 (en) 2005-05-12
AU2004256208B2 (en) 2010-05-20
EP1644485B9 (de) 2012-01-04
AU2004256208A1 (en) 2005-01-20
ES2365786T9 (es) 2012-02-20
WO2005005662A2 (en) 2005-01-20
US20090328243A1 (en) 2009-12-31

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