ATE506368T1 - Pyridin-boronsäure-quencher zur verwendung in analytsensoren - Google Patents

Pyridin-boronsäure-quencher zur verwendung in analytsensoren

Info

Publication number
ATE506368T1
ATE506368T1 AT08769266T AT08769266T ATE506368T1 AT E506368 T1 ATE506368 T1 AT E506368T1 AT 08769266 T AT08769266 T AT 08769266T AT 08769266 T AT08769266 T AT 08769266T AT E506368 T1 ATE506368 T1 AT E506368T1
Authority
AT
Austria
Prior art keywords
boronic acid
pyridine boronic
acid quencher
analytical sensors
analytical
Prior art date
Application number
AT08769266T
Other languages
German (de)
English (en)
Inventor
Soya Gamsey
Ritchie Wessling
Original Assignee
Glumetrics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glumetrics Inc filed Critical Glumetrics Inc
Application granted granted Critical
Publication of ATE506368T1 publication Critical patent/ATE506368T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
    • G01N33/521—Single-layer analytical elements
    • G01N33/523—Single-layer analytical elements the element being adapted for a specific analyte
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y10T436/104998—Glucose, ketone, nitrate standard or control
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]
    • Y10T436/144444—Glucose
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/145555—Hetero-N

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
AT08769266T 2007-05-01 2008-05-01 Pyridin-boronsäure-quencher zur verwendung in analytsensoren ATE506368T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US91537207P 2007-05-01 2007-05-01
PCT/US2008/062303 WO2008137604A1 (en) 2007-05-01 2008-05-01 Pyridinium boronic acid quenchers for use in analyte sensors

Publications (1)

Publication Number Publication Date
ATE506368T1 true ATE506368T1 (de) 2011-05-15

Family

ID=39639212

Family Applications (1)

Application Number Title Priority Date Filing Date
AT08769266T ATE506368T1 (de) 2007-05-01 2008-05-01 Pyridin-boronsäure-quencher zur verwendung in analytsensoren

Country Status (7)

Country Link
US (3) US7939664B2 (enExample)
EP (1) EP2147003B1 (enExample)
JP (1) JP5706686B2 (enExample)
AT (1) ATE506368T1 (enExample)
CA (1) CA2684511A1 (enExample)
DE (1) DE602008006382D1 (enExample)
WO (1) WO2008137604A1 (enExample)

Families Citing this family (97)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7899511B2 (en) 2004-07-13 2011-03-01 Dexcom, Inc. Low oxygen in vivo analyte sensor
US7192450B2 (en) 2003-05-21 2007-03-20 Dexcom, Inc. Porous membranes for use with implantable devices
US8527026B2 (en) 1997-03-04 2013-09-03 Dexcom, Inc. Device and method for determining analyte levels
US9155496B2 (en) 1997-03-04 2015-10-13 Dexcom, Inc. Low oxygen in vivo analyte sensor
US6001067A (en) * 1997-03-04 1999-12-14 Shults; Mark C. Device and method for determining analyte levels
US6862465B2 (en) 1997-03-04 2005-03-01 Dexcom, Inc. Device and method for determining analyte levels
US6949816B2 (en) 2003-04-21 2005-09-27 Motorola, Inc. Semiconductor component having first surface area for electrically coupling to a semiconductor chip and second surface area for electrically coupling to a substrate, and method of manufacturing same
US8974386B2 (en) 1998-04-30 2015-03-10 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8346337B2 (en) 1998-04-30 2013-01-01 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8480580B2 (en) 1998-04-30 2013-07-09 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US9066695B2 (en) 1998-04-30 2015-06-30 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8465425B2 (en) 1998-04-30 2013-06-18 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8688188B2 (en) 1998-04-30 2014-04-01 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US6175752B1 (en) 1998-04-30 2001-01-16 Therasense, Inc. Analyte monitoring device and methods of use
US7470420B2 (en) * 2000-12-05 2008-12-30 The Regents Of The University Of California Optical determination of glucose utilizing boronic acid adducts
US6560471B1 (en) 2001-01-02 2003-05-06 Therasense, Inc. Analyte monitoring device and methods of use
US6702857B2 (en) 2001-07-27 2004-03-09 Dexcom, Inc. Membrane for use with implantable devices
US20030032874A1 (en) 2001-07-27 2003-02-13 Dexcom, Inc. Sensor head for use with implantable devices
US7828728B2 (en) 2003-07-25 2010-11-09 Dexcom, Inc. Analyte sensor
US8010174B2 (en) 2003-08-22 2011-08-30 Dexcom, Inc. Systems and methods for replacing signal artifacts in a glucose sensor data stream
US9282925B2 (en) 2002-02-12 2016-03-15 Dexcom, Inc. Systems and methods for replacing signal artifacts in a glucose sensor data stream
US8260393B2 (en) 2003-07-25 2012-09-04 Dexcom, Inc. Systems and methods for replacing signal data artifacts in a glucose sensor data stream
US9247901B2 (en) 2003-08-22 2016-02-02 Dexcom, Inc. Systems and methods for replacing signal artifacts in a glucose sensor data stream
US7134999B2 (en) 2003-04-04 2006-11-14 Dexcom, Inc. Optimized sensor geometry for an implantable glucose sensor
US8423113B2 (en) 2003-07-25 2013-04-16 Dexcom, Inc. Systems and methods for processing sensor data
JP4708342B2 (ja) 2003-07-25 2011-06-22 デックスコム・インコーポレーテッド 埋設可能な装置に用いる酸素増大膜システム
US7494465B2 (en) 2004-07-13 2009-02-24 Dexcom, Inc. Transcutaneous analyte sensor
US8761856B2 (en) 2003-08-01 2014-06-24 Dexcom, Inc. System and methods for processing analyte sensor data
US20100168542A1 (en) 2003-08-01 2010-07-01 Dexcom, Inc. System and methods for processing analyte sensor data
US7774145B2 (en) 2003-08-01 2010-08-10 Dexcom, Inc. Transcutaneous analyte sensor
US8886273B2 (en) 2003-08-01 2014-11-11 Dexcom, Inc. Analyte sensor
US7778680B2 (en) 2003-08-01 2010-08-17 Dexcom, Inc. System and methods for processing analyte sensor data
US8369919B2 (en) 2003-08-01 2013-02-05 Dexcom, Inc. Systems and methods for processing sensor data
US7591801B2 (en) 2004-02-26 2009-09-22 Dexcom, Inc. Integrated delivery device for continuous glucose sensor
US7519408B2 (en) 2003-11-19 2009-04-14 Dexcom, Inc. Integrated receiver for continuous analyte sensor
US20190357827A1 (en) 2003-08-01 2019-11-28 Dexcom, Inc. Analyte sensor
US7920906B2 (en) 2005-03-10 2011-04-05 Dexcom, Inc. System and methods for processing analyte sensor data for sensor calibration
US8233959B2 (en) 2003-08-22 2012-07-31 Dexcom, Inc. Systems and methods for processing analyte sensor data
US20140121989A1 (en) 2003-08-22 2014-05-01 Dexcom, Inc. Systems and methods for processing analyte sensor data
US9247900B2 (en) 2004-07-13 2016-02-02 Dexcom, Inc. Analyte sensor
US11633133B2 (en) 2003-12-05 2023-04-25 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US8364231B2 (en) 2006-10-04 2013-01-29 Dexcom, Inc. Analyte sensor
EP2239567B1 (en) 2003-12-05 2015-09-02 DexCom, Inc. Calibration techniques for a continuous analyte sensor
US8423114B2 (en) 2006-10-04 2013-04-16 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US8774886B2 (en) 2006-10-04 2014-07-08 Dexcom, Inc. Analyte sensor
US8287453B2 (en) 2003-12-05 2012-10-16 Dexcom, Inc. Analyte sensor
EP2316331B1 (en) 2003-12-09 2016-06-29 Dexcom, Inc. Signal processing for continuous analyte sensor
US8808228B2 (en) 2004-02-26 2014-08-19 Dexcom, Inc. Integrated medicament delivery device for use with continuous analyte sensor
US8792955B2 (en) 2004-05-03 2014-07-29 Dexcom, Inc. Transcutaneous analyte sensor
US8277713B2 (en) 2004-05-03 2012-10-02 Dexcom, Inc. Implantable analyte sensor
US7783333B2 (en) 2004-07-13 2010-08-24 Dexcom, Inc. Transcutaneous medical device with variable stiffness
US8989833B2 (en) 2004-07-13 2015-03-24 Dexcom, Inc. Transcutaneous analyte sensor
US8565848B2 (en) 2004-07-13 2013-10-22 Dexcom, Inc. Transcutaneous analyte sensor
US7857760B2 (en) 2004-07-13 2010-12-28 Dexcom, Inc. Analyte sensor
WO2006127694A2 (en) 2004-07-13 2006-11-30 Dexcom, Inc. Analyte sensor
US8452368B2 (en) 2004-07-13 2013-05-28 Dexcom, Inc. Transcutaneous analyte sensor
US8133178B2 (en) 2006-02-22 2012-03-13 Dexcom, Inc. Analyte sensor
US8744546B2 (en) 2005-05-05 2014-06-03 Dexcom, Inc. Cellulosic-based resistance domain for an analyte sensor
US8060174B2 (en) 2005-04-15 2011-11-15 Dexcom, Inc. Analyte sensing biointerface
US9757061B2 (en) 2006-01-17 2017-09-12 Dexcom, Inc. Low oxygen in vivo analyte sensor
US7831287B2 (en) 2006-10-04 2010-11-09 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US7751863B2 (en) 2007-02-06 2010-07-06 Glumetrics, Inc. Optical determination of ph and glucose
AU2008213677A1 (en) 2007-02-06 2008-08-14 Glumetrics, Inc. Optical systems and methods for rationmetric measurement of blood glucose concentration
JP5517919B2 (ja) * 2007-05-10 2014-06-11 グルメトリクス、 インク． 即時血管内グルコース測定のための平衡非消費蛍光センサー
EP2150814A2 (en) * 2007-05-10 2010-02-10 Glumetrics, Inc. Device and methods for calibrating analyte sensors
US20080306434A1 (en) 2007-06-08 2008-12-11 Dexcom, Inc. Integrated medicament delivery device for use with continuous analyte sensor
JP5675350B2 (ja) 2007-07-11 2015-02-25 メドトロニック ミニメド インコーポレイテッド ポリビオロゲン化合物、該化合物の合成方法、グルコースセンサー、およびグルコース測定用組成物
EP2227132B1 (en) 2007-10-09 2023-03-08 DexCom, Inc. Integrated insulin delivery system with continuous glucose sensor
US8417312B2 (en) 2007-10-25 2013-04-09 Dexcom, Inc. Systems and methods for processing sensor data
WO2009067626A1 (en) 2007-11-21 2009-05-28 Glumetrics, Inc. Use of an equilibrium intravascular sensor to achieve tight glycemic control
US11730407B2 (en) 2008-03-28 2023-08-22 Dexcom, Inc. Polymer membranes for continuous analyte sensors
US8682408B2 (en) 2008-03-28 2014-03-25 Dexcom, Inc. Polymer membranes for continuous analyte sensors
US8583204B2 (en) 2008-03-28 2013-11-12 Dexcom, Inc. Polymer membranes for continuous analyte sensors
WO2009129186A2 (en) 2008-04-17 2009-10-22 Glumetrics, Inc. Sensor for percutaneous intravascular deployment without an indwelling cannula
US7858512B2 (en) * 2008-06-26 2010-12-28 Wafer-Level Packaging Portfolio Llc Semiconductor with bottom-side wrap-around flange contact
EP4227675B1 (en) 2008-09-19 2024-12-11 DexCom, Inc. Particle-containing membrane and particulate electrode for analyte sensors
US9446194B2 (en) 2009-03-27 2016-09-20 Dexcom, Inc. Methods and systems for promoting glucose management
EP2483679A4 (en) 2009-09-30 2013-04-24 Glumetrics Inc SENSORS WITH THROMORETIC COATINGS
US8467843B2 (en) 2009-11-04 2013-06-18 Glumetrics, Inc. Optical sensor configuration for ratiometric correction of blood glucose measurement
JP2013519101A (ja) 2010-02-08 2013-05-23 グルメトリクス， インコーポレイテッド 化学センサーの抗酸化剤保護
EP2545373B1 (en) * 2010-03-11 2022-08-24 Medtronic Minimed, Inc. Measuring analyte concentration incorporating temperature and ph correction
US9848809B2 (en) 2011-04-15 2017-12-26 Dexcom, Inc. Advanced analyte sensor calibration and error detection
GB201113435D0 (en) 2011-08-03 2011-09-21 Glysure Ltd Sensor calibration
DK2769226T3 (en) * 2011-07-15 2017-09-11 Medtronic Minimed Inc COMBINATIONS OF FLUORPHORES AND PYRIDINIUM BORIC ACID QUENCHERS FOR USE IN ANALYTICAL SENSORS
EP2760432B1 (en) 2011-09-27 2019-03-20 Medtronic Minimed, Inc. Method for functionalizing a porous membrane covering of an optical sensor to facilitate coupling of an antithrombogenic agent
US9017622B2 (en) 2012-04-10 2015-04-28 Lightship Medical Limited Calibrator for a sensor
US20130344619A1 (en) 2012-06-21 2013-12-26 Lightship Medical Limited Glucose sensor
WO2014074621A1 (en) * 2012-11-07 2014-05-15 Glumetrics, Inc. Dry insertion and one-point in vivo calibration of an optical analyte sensor
US8834401B2 (en) 2012-11-26 2014-09-16 Becton, Dickinson And Company Glucose management and dialysis method and apparatus
JP2017512118A (ja) * 2014-03-12 2017-05-18 グルコベーション, インコーポレーテッドGlucovation, Inc. ウエアラブル電気化学センサーおよび方法
JP2017513017A (ja) * 2014-03-12 2017-05-25 グルコベーション, インコーポレーテッドGlucovation, Inc. 電気化学センシングシステム
CN106232606A (zh) 2014-04-23 2016-12-14 血糖测试仪股份有限公司 用于测定分析物的非酶电化学传感器
WO2015188144A2 (en) * 2014-06-05 2015-12-10 The Regents Of The University Of California Fluorescence method for sensing chlorinated disaccharides
US11331022B2 (en) 2017-10-24 2022-05-17 Dexcom, Inc. Pre-connected analyte sensors
EP3928687B1 (en) 2017-10-24 2024-06-26 Dexcom, Inc. Wearable device with pre-connected analyte sensor
WO2019160854A1 (en) * 2018-02-13 2019-08-22 The Board Of Trustees Of The Leland Stanford Junior University Boronic acid appended naphthyl-pyridinium fluorescent saccharide sensors for early detection of gastrointestinal diseases
JP7455366B2 (ja) * 2020-03-11 2024-03-26 学校法人東京電機大学 化合物、それを含んでなるアンモニア検出材料及びその製造方法、並びにそれを用いたアンモニアの検出方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6627177B2 (en) 2000-12-05 2003-09-30 The Regents Of The University Of California Polyhydroxyl-substituted organic molecule sensing optical in vivo method utilizing a boronic acid adduct and the device thereof
US7470420B2 (en) * 2000-12-05 2008-12-30 The Regents Of The University Of California Optical determination of glucose utilizing boronic acid adducts
ATE514755T1 (de) * 2006-07-25 2011-07-15 Glumetrics Inc Fluoreszenzfarbstoffe zur verwendung bei der glukoseerfassung
JP5675350B2 (ja) * 2007-07-11 2015-02-25 メドトロニック ミニメド インコーポレイテッド ポリビオロゲン化合物、該化合物の合成方法、グルコースセンサー、およびグルコース測定用組成物

Also Published As

Publication number Publication date
EP2147003A1 (en) 2010-01-27
JP2010526094A (ja) 2010-07-29
US20120208286A1 (en) 2012-08-16
US8658795B2 (en) 2014-02-25
CA2684511A1 (en) 2008-11-13
US20080305009A1 (en) 2008-12-11
WO2008137604A1 (en) 2008-11-13
JP5706686B2 (ja) 2015-04-22
US20110171742A1 (en) 2011-07-14
US7939664B2 (en) 2011-05-10
EP2147003B1 (en) 2011-04-20
DE602008006382D1 (de) 2011-06-01
US8178676B2 (en) 2012-05-15

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