ATE49751T1 - Verfahren und zwischenprodukte zur herstellung trans-4-substituierter s-proline. - Google Patents
Verfahren und zwischenprodukte zur herstellung trans-4-substituierter s-proline.Info
- Publication number
- ATE49751T1 ATE49751T1 AT85307748T AT85307748T ATE49751T1 AT E49751 T1 ATE49751 T1 AT E49751T1 AT 85307748 T AT85307748 T AT 85307748T AT 85307748 T AT85307748 T AT 85307748T AT E49751 T1 ATE49751 T1 AT E49751T1
- Authority
- AT
- Austria
- Prior art keywords
- compound
- sub
- substituted
- arylalkyl
- aryl
- Prior art date
Links
- 239000013067 intermediate product Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 8
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 4
- 125000003118 aryl group Chemical group 0.000 abstract 4
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 3
- -1 4-Substituted proline Chemical class 0.000 abstract 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 abstract 1
- 230000002152 alkylating effect Effects 0.000 abstract 1
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 230000001590 oxidative effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyrrole Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/672,989 US4588819A (en) | 1984-11-19 | 1984-11-19 | Process and intermediates for preparing trans-4-substituted-s-prolines |
| EP85307748A EP0183390B1 (de) | 1984-11-19 | 1985-10-25 | Verfahren und Zwischenprodukte zur Herstellung trans-4-substituierter S-Proline |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE49751T1 true ATE49751T1 (de) | 1990-02-15 |
Family
ID=24700865
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT85307748T ATE49751T1 (de) | 1984-11-19 | 1985-10-25 | Verfahren und zwischenprodukte zur herstellung trans-4-substituierter s-proline. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US4588819A (de) |
| EP (1) | EP0183390B1 (de) |
| JP (3) | JPH0637461B2 (de) |
| AT (1) | ATE49751T1 (de) |
| CA (3) | CA1265525C (de) |
| DE (1) | DE3575555D1 (de) |
| FI (1) | FI82034C (de) |
| HU (1) | HU196056B (de) |
| IE (1) | IE58763B1 (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4851514A (en) * | 1987-05-01 | 1989-07-25 | E. R. Squibb & Sons, Inc. | Process for preparing a compound useful in preparing ace inhibitors and intermediate produced thereby |
| US4734508A (en) * | 1987-05-01 | 1988-03-29 | E. R. Squibb & Sons, Inc. | Process and intermediates for preparing 4-substituted proline derivatives |
| US4912231A (en) * | 1987-06-15 | 1990-03-27 | E. R. Squibb & Sons, Inc. | Process for preparing (trans)-4-phenyl-L-proline derivatives |
| CA1333807C (en) * | 1987-06-15 | 1995-01-03 | David R. Kronenthal | Process for preparing (trans)-4-phenyl-l-proline derivatives |
| US4937355A (en) * | 1989-01-17 | 1990-06-26 | E. R. Squibb & Sons, Inc. | Process for preparing (trans)-4-substituted-dl-proline derivatives |
| CN101462996B (zh) * | 2007-12-21 | 2011-04-20 | 上海医药工业研究院 | 4-环己基脯氨酸衍生物的制备方法 |
| CN101445475B (zh) * | 2008-12-30 | 2010-12-22 | 浙江工业大学 | 一种(反)-4-环己基-l-脯氨酸的制备方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1199273B (de) * | 1959-06-22 | 1965-08-26 | Mead Johnson & Co | Verfahren zur Herstellung von 3-Oxymethyl-pyrrolidinen |
| CH435287A (de) * | 1964-02-11 | 1967-05-15 | Geigy Ag J R | Verfahren zur Herstellung von neuen, kondensierten heterocyclischen Verbindungen |
| US3544590A (en) * | 1967-04-28 | 1970-12-01 | Exxon Research Engineering Co | Cyclic amines and the process for their formation |
| US3636043A (en) * | 1969-02-04 | 1972-01-18 | Upjohn Co | Method for the preparation of 4-alkylprolines and compounds produced thereby |
| JPS5821622B2 (ja) * | 1973-02-28 | 1983-05-02 | ウェルファイド株式会社 | ピロリジンメタノ−ル ノ セイゾウホウ |
| US4105776A (en) * | 1976-06-21 | 1978-08-08 | E. R. Squibb & Sons, Inc. | Proline derivatives and related compounds |
| US4168267A (en) * | 1978-10-23 | 1979-09-18 | E. R. Squibb & Sons, Inc. | Phosphinylalkanoyl prolines |
| US4337201A (en) * | 1980-12-04 | 1982-06-29 | E. R. Squibb & Sons, Inc. | Phosphinylalkanoyl substituted prolines |
| FR2520360A1 (fr) * | 1982-01-26 | 1983-07-29 | Nicoud Jean | Nouveaux derives de la paranitroaniline utilisables en optique non lineaire et en electro-optique et leur procede de preparation |
| DE3306199A1 (de) * | 1983-02-23 | 1984-08-23 | Bayer Ag, 5090 Leverkusen | 7-oxo-3-oxa-1-azabicyclo(3.2.0)heptan-2-carbonsaeuren und deren derivate |
-
1984
- 1984-11-19 US US06/672,989 patent/US4588819A/en not_active Expired - Lifetime
-
1985
- 1985-10-25 DE DE8585307748T patent/DE3575555D1/de not_active Expired - Lifetime
- 1985-10-25 AT AT85307748T patent/ATE49751T1/de not_active IP Right Cessation
- 1985-10-25 EP EP85307748A patent/EP0183390B1/de not_active Expired - Lifetime
- 1985-10-29 CA CA494153A patent/CA1265525C/en not_active Expired
- 1985-11-04 IE IE272985A patent/IE58763B1/en not_active IP Right Cessation
- 1985-11-18 FI FI854528A patent/FI82034C/fi not_active IP Right Cessation
- 1985-11-18 HU HU854383A patent/HU196056B/hu unknown
- 1985-11-18 JP JP60259667A patent/JPH0637461B2/ja not_active Expired - Lifetime
-
1989
- 1989-10-11 CA CA000615519A patent/CA1278298C/en not_active Expired - Lifetime
- 1989-10-11 CA CA000615518A patent/CA1278296C/en not_active Expired - Lifetime
-
1993
- 1993-11-10 JP JP5281058A patent/JPH0747591B2/ja not_active Expired - Lifetime
- 1993-11-10 JP JP5281061A patent/JPH0723357B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| FI82034C (fi) | 1991-01-10 |
| CA1278296C (en) | 1990-12-27 |
| JPH0747591B2 (ja) | 1995-05-24 |
| CA1265525A (en) | 1990-02-06 |
| JPS61122264A (ja) | 1986-06-10 |
| FI854528A7 (fi) | 1986-05-20 |
| JPH06293731A (ja) | 1994-10-21 |
| JPH06293773A (ja) | 1994-10-21 |
| JPH0723357B2 (ja) | 1995-03-15 |
| IE852729L (en) | 1986-05-19 |
| CA1278298C (en) | 1990-12-27 |
| IE58763B1 (en) | 1993-11-03 |
| HUT40408A (en) | 1986-12-28 |
| FI82034B (fi) | 1990-09-28 |
| HU196056B (en) | 1988-09-28 |
| EP0183390A1 (de) | 1986-06-04 |
| US4588819A (en) | 1986-05-13 |
| FI854528A0 (fi) | 1985-11-18 |
| EP0183390B1 (de) | 1990-01-24 |
| CA1265525C (en) | 1990-02-06 |
| JPH0637461B2 (ja) | 1994-05-18 |
| DE3575555D1 (de) | 1990-03-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| EELA | Cancelled due to lapse of time |