ATE494897T1 - Biokompatible multifunktionsbeschichtungen für intravaskuläre vorrichtungen - Google Patents

Biokompatible multifunktionsbeschichtungen für intravaskuläre vorrichtungen

Info

Publication number
ATE494897T1
ATE494897T1 AT05809787T AT05809787T ATE494897T1 AT E494897 T1 ATE494897 T1 AT E494897T1 AT 05809787 T AT05809787 T AT 05809787T AT 05809787 T AT05809787 T AT 05809787T AT E494897 T1 ATE494897 T1 AT E494897T1
Authority
AT
Austria
Prior art keywords
polymeric
nitric oxide
layer
intravascular devices
multifunctional coatings
Prior art date
Application number
AT05809787T
Other languages
English (en)
Inventor
Zhengrong Zhou
Mark Meyerhoff
Melissa Reynolds
Original Assignee
Univ Michigan
Michigan Critical Care Consultants Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Michigan, Michigan Critical Care Consultants Inc filed Critical Univ Michigan
Application granted granted Critical
Publication of ATE494897T1 publication Critical patent/ATE494897T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/655—Azo (—N=N—), diazo (=N2), azoxy (>N—O—N< or N(=O)—N<), azido (—N3) or diazoamino (—N=N—N<) compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/114—Nitric oxide, i.e. NO
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/42—Anti-thrombotic agents, anticoagulants, anti-platelet agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/606—Coatings
    • A61L2300/608—Coatings having two or more layers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2420/00—Materials or methods for coatings medical devices
    • A61L2420/08—Coatings comprising two or more layers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Vascular Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)
AT05809787T 2004-08-23 2005-08-18 Biokompatible multifunktionsbeschichtungen für intravaskuläre vorrichtungen ATE494897T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/924,102 US20060039950A1 (en) 2004-08-23 2004-08-23 Multi-functional biocompatible coatings for intravascular devices
PCT/US2005/029490 WO2006023693A2 (en) 2004-08-23 2005-08-18 Multi-functional biocompatible coatings for intravascular devices

Publications (1)

Publication Number Publication Date
ATE494897T1 true ATE494897T1 (de) 2011-01-15

Family

ID=35909876

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05809787T ATE494897T1 (de) 2004-08-23 2005-08-18 Biokompatible multifunktionsbeschichtungen für intravaskuläre vorrichtungen

Country Status (8)

Country Link
US (2) US20060039950A1 (de)
EP (1) EP1788980B1 (de)
JP (1) JP2008510569A (de)
CN (1) CN101065079A (de)
AT (1) ATE494897T1 (de)
CA (1) CA2577780A1 (de)
DE (1) DE602005025894D1 (de)
WO (1) WO2006023693A2 (de)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8388677B2 (en) 2004-10-29 2013-03-05 Boston Scientific Scimed, Inc. Anti-thrombogenic and anti-restenotic vascular medical devices
WO2006128121A2 (en) 2005-05-27 2006-11-30 The University Of North Carolina At Chapel Hill Nitric oxide-releasing particles for nitric oxide therapeutics and biomedical applications
JP2009500083A (ja) * 2005-06-30 2009-01-08 エムシー３， インコーポレイテッド 検体センサーおよびその中で使用するための組成物
JP2008544820A (ja) * 2005-06-30 2008-12-11 エムシー３， インコーポレイテッド 医療デバイスのための一酸化窒素コーティング
ATE485849T1 (de) * 2005-12-02 2010-11-15 Univ Michigan Polymerzusammensetzungen, überzüge und vorrichtungen und herstellungs- und anwendungsverfahren damit
US20070196428A1 (en) 2006-02-17 2007-08-23 Thierry Glauser Nitric oxide generating medical devices
US8133553B2 (en) 2007-06-18 2012-03-13 Zimmer, Inc. Process for forming a ceramic layer
US8309521B2 (en) 2007-06-19 2012-11-13 Zimmer, Inc. Spacer with a coating thereon for use with an implant device
US8608049B2 (en) * 2007-10-10 2013-12-17 Zimmer, Inc. Method for bonding a tantalum structure to a cobalt-alloy substrate
US20110230973A1 (en) * 2007-10-10 2011-09-22 Zimmer, Inc. Method for bonding a tantalum structure to a cobalt-alloy substrate
WO2009067626A1 (en) 2007-11-21 2009-05-28 Glumetrics, Inc. Use of an equilibrium intravascular sensor to achieve tight glycemic control
WO2009073643A2 (en) * 2007-12-03 2009-06-11 Cleveland State University Nitric oxide release coatings incorporating nitric oxide synthase enzyme
US7974702B1 (en) 2008-01-10 2011-07-05 Pacesetter, Inc. Communication device, communication system and communication method for an implantable medical device
US20090187256A1 (en) * 2008-01-21 2009-07-23 Zimmer, Inc. Method for forming an integral porous region in a cast implant
US8283384B2 (en) 2008-01-24 2012-10-09 University Of Utah Research Foundation Adhesive complex coacervates and methods of making and using thereof
EP2599508B1 (de) * 2008-01-24 2016-05-25 University of Utah Research Foundation Haftkomplex-Koazervate sowie Verfahren zu ihrer Herstellung und Verwendung
US20090198286A1 (en) * 2008-02-05 2009-08-06 Zimmer, Inc. Bone fracture fixation system
US20090222088A1 (en) * 2008-02-29 2009-09-03 Medtronic Vascular, Inc. Secondary Amine Containing Nitric Oxide Releasing Polymer Composition
EP2300603A4 (de) * 2008-06-24 2011-08-03 Micropharma Ltd Stickoxidvorrichtung und verfahren zur wundheilung, behandlung von hauterkrankungen und mikrobiellen infektionen
WO2010022132A2 (en) * 2008-08-19 2010-02-25 The Regents Of The University Of Michigan Biocompatible coatings, and methods of making and using the same
WO2010044875A2 (en) * 2008-10-16 2010-04-22 Novan, Inc. Nitric oxide releasing particles for oral care applications
WO2010090767A2 (en) * 2009-02-09 2010-08-12 St. Jude Medical, Inc. Enhancing biocompatibility of a medical device
EP2467173B8 (de) 2009-08-21 2019-06-19 Novan, Inc. Wundverbände, verfahren zu ihrer anwendung und verfahren zu ihrer herstellung
ES2958410T3 (es) 2009-08-21 2024-02-08 Novan Inc Geles tópicos
JP2013506503A (ja) 2009-09-30 2013-02-28 グルメトリクス， インコーポレイテッド 抗血栓性コーティングを備えたセンサー
US8467843B2 (en) 2009-11-04 2013-06-18 Glumetrics, Inc. Optical sensor configuration for ratiometric correction of blood glucose measurement
CA2799818A1 (en) 2010-05-24 2011-12-01 University Of Utah Research Foundation Reinforced adhesive complex coacervates and methods of making and using thereof
US9173971B2 (en) 2010-11-12 2015-11-03 University Of Utah Research Foundation Simple adhesive coacervates and methods of making and using thereof
US8591876B2 (en) 2010-12-15 2013-11-26 Novan, Inc. Methods of decreasing sebum production in the skin
WO2012118829A2 (en) 2011-02-28 2012-09-07 Novan, Inc. Tertiary s-nitrosothiol-modified nitricoxide-releasing xerogels and methods of using the same
EP2760432B1 (de) * 2011-09-27 2019-03-20 Medtronic Minimed, Inc. Verfahren zur funktionalisierung einer porösen membran als abdeckung eines optischen sensors zur ermöglichung der kopplung eines antithrombotikums
CN102961783A (zh) * 2012-04-20 2013-03-13 南开大学 抗凝血性人工血管支架材料的构建方法
US9566372B2 (en) 2012-09-28 2017-02-14 The Regents Of The University Of Michigan Sustained nitric oxide release coating using diazeniumdiolate-doped polymer matrix with ester capped poly(lactic-co-glycolic acid) additive
EP2953992B1 (de) 2013-02-06 2021-11-24 3M Innovative Properties Company Polymere sowie herstellung und verwendung davon
CA2899477C (en) 2013-02-07 2019-09-17 The Regents Of The University Of Michigan Thromboresistant/bactericidal s-nitroso-n-acetylpenicillamine (snap)-doped nitric oxide release polymers with enhanced stability
US20140272232A1 (en) * 2013-03-15 2014-09-18 Bard Access Systems, Inc. Antithrombic coatings and uses thereof
EP3169374B1 (de) 2014-07-14 2022-01-05 University of Utah Research Foundation In-situ-verfestigende komplexe koazervate sowie verfahren zur herstellung und verwendung davon
CN108261559B (zh) * 2016-12-30 2021-07-30 元心科技(深圳)有限公司 可吸收铁基器械
WO2018136845A1 (en) 2017-01-21 2018-07-26 Biocrede Inc. Medical products and methods configured for controlled release of nitrous oxide
CN111601626B (zh) * 2017-09-02 2022-05-06 生物克瑞德公司 具有集成的生物传感器的医疗装置
EP3743120A4 (de) 2018-01-26 2021-10-13 Fluidx Medical Technology, LLC Vorrichtung und verfahren zur verwendung von in situ verfestigenden komplexen koazervaten für gefässverschluss
CN109627778A (zh) * 2018-11-27 2019-04-16 东莞市朗晟硅材料有限公司 一种低硬度挤出的电线用硅橡胶及其制备方法
CN113855864A (zh) * 2021-09-26 2021-12-31 苏州纽创医疗科技有限公司 一种具有抗凝血涂层的支架的制备方法及支架

Family Cites Families (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2847441A1 (de) * 1978-11-02 1980-05-22 Basf Ag Imidazol-kupferkomplexverbindungen
US4959135A (en) * 1987-02-25 1990-09-25 Aquanautics Corporation Polyalkylamine complexes for ligand extraction and generation
US4952289A (en) * 1988-05-09 1990-08-28 Aquanautics Corporation Macrocyclic amine complexes for ligand extraction and generation
JPH0337073A (ja) * 1989-07-05 1991-02-18 Terumo Corp 抗血栓性医療材料およびその製法
US5386012A (en) * 1990-02-06 1995-01-31 Strid; Lars Growth factor in connection with artificial implants
US5155137A (en) * 1990-09-20 1992-10-13 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Complexes of nitric oxide with polyamines
US5389675A (en) * 1992-03-27 1995-02-14 The United States Of America As Represented By The Department Of Health And Human Services Mixed ligand metal complexes of nitric oxide-nucleophile adducts useful as cardiovascular agents
US5814666A (en) * 1992-04-13 1998-09-29 The United States As Represented By The Department Of Health And Human Services Encapsulated and non-encapsulated nitric oxide generators used as antimicrobial agents
US5405919A (en) * 1992-08-24 1995-04-11 The United States Of America As Represented By The Secretary Of Health And Human Services Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions and methods of treating biological disorders
US5632981A (en) * 1992-08-24 1997-05-27 The United States Of America As Represented By The Department Of Health And Human Services Biopolymer-bound nitric oxide-releasing compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same
US5650447A (en) * 1992-08-24 1997-07-22 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Nitric oxide-releasing polymers to treat restenosis and related disorders
US5525357A (en) * 1992-08-24 1996-06-11 The United States Of America As Represented By The Department Of Health And Human Services Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same
US5350800A (en) * 1993-01-19 1994-09-27 Medtronic, Inc. Method for improving the biocompatibility of solid surfaces
US6284752B1 (en) * 1993-08-25 2001-09-04 Anormed Inc. Pharmaceutical compositions comprising metal complexes
GB9317686D0 (en) * 1993-08-25 1993-10-13 Johnson Matthey Plc Pharmaceutical compositions
US6087479A (en) * 1993-09-17 2000-07-11 Nitromed, Inc. Localized use of nitric oxide-adducts to prevent internal tissue damage
EP0722320B1 (de) * 1993-10-08 2000-07-19 THE UNITED STATES OF AMERICA, as represented by the Secretary of the Department of Health and Human Services Verwendung von stickstoffoxid freisetzenden verbindungen als arzneimittel zur strahlungssensibilisation fur hypoxische zellen
US5840759A (en) * 1993-10-08 1998-11-24 The United States Of America As Represented By The Department Of Health And Human Services Use of nitric oxide releasing compounds to protect noncancerous cells from chemotherapeutic agents
US5482925A (en) * 1994-03-17 1996-01-09 Comedicus Incorporated Complexes of nitric oxide with cardiovascular amines as dual acting cardiovascular agents
US6747062B2 (en) * 1994-09-26 2004-06-08 New York Society For The Ruptured And Crippled Maintaining The Hospital For Special Surgery Regulation of wound healing by nitric oxide
US5714511A (en) * 1995-07-31 1998-02-03 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Selective prevention of organ injury in sepsis and shock using selection release of nitric oxide in vulnerable organs
US6232434B1 (en) * 1996-08-02 2001-05-15 Duke University Medical Center Polymers for delivering nitric oxide in vivo
US5797887A (en) * 1996-08-27 1998-08-25 Novovasc Llc Medical device with a surface adapted for exposure to a blood stream which is coated with a polymer containing a nitrosyl-containing organo-metallic compound which releases nitric oxide from the coating to mediate platelet aggregation
US5855618A (en) * 1996-09-13 1999-01-05 Meadox Medicals, Inc. Polyurethanes grafted with polyethylene oxide chains containing covalently bonded heparin
US5972338A (en) * 1997-09-19 1999-10-26 Genentech, Inc. Tie ligands homologues
US5994444A (en) * 1997-10-16 1999-11-30 Medtronic, Inc. Polymeric material that releases nitric oxide
US6119028A (en) * 1997-10-20 2000-09-12 Alfred E. Mann Foundation Implantable enzyme-based monitoring systems having improved longevity due to improved exterior surfaces
US6335029B1 (en) * 1998-08-28 2002-01-01 Scimed Life Systems, Inc. Polymeric coatings for controlled delivery of active agents
US6299980B1 (en) * 1998-09-29 2001-10-09 Medtronic Ave, Inc. One step lubricious coating
US6379691B1 (en) * 1998-09-29 2002-04-30 Medtronic/Ave, Inc. Uses for medical devices having a lubricious, nitric oxide-releasing coating
US6636652B1 (en) * 1999-08-02 2003-10-21 The Regents Of The University Of Michigan Optical sensors for the detection of nitric oxide
US6270779B1 (en) * 2000-05-10 2001-08-07 United States Of America Nitric oxide-releasing metallic medical devices
CA2410632A1 (en) * 2000-06-22 2001-12-27 David S. Garvey Nitrosated and nitrosylated taxanes, compositions and methods of use
US6403788B1 (en) * 2000-07-11 2002-06-11 Eukarion, Inc. Non-genotoxic metalloporphyrins as synthetic catalytic scavengers of reactive oxygen species
US20020051730A1 (en) * 2000-09-29 2002-05-02 Stanko Bodnar Coated medical devices and sterilization thereof
US6746773B2 (en) * 2000-09-29 2004-06-08 Ethicon, Inc. Coatings for medical devices
DE60129578T2 (de) * 2000-10-31 2008-04-03 Med Institute, Inc., West Lafayette Beschichtete, implantierbare medizinische geräte
US6780849B2 (en) * 2000-12-21 2004-08-24 Scimed Life Systems, Inc. Lipid-based nitric oxide donors
US7128904B2 (en) * 2001-01-16 2006-10-31 The Regents Of The University Of Michigan Material containing metal ion ligand complex producing nitric oxide in contact with blood
US7335383B2 (en) * 2001-01-16 2008-02-26 The Regents Of The University Of Michigan Generation of nitric oxide in vivo from nitrite, nitrate or nitrosothiols endogenous in blood
US6706274B2 (en) * 2001-01-18 2004-03-16 Scimed Life Systems, Inc. Differential delivery of nitric oxide
US7048939B2 (en) * 2001-04-20 2006-05-23 The Board Of Trustees Of The Leland Stanford Junior University Methods for the inhibition of neointima formation
US6660034B1 (en) * 2001-04-30 2003-12-09 Advanced Cardiovascular Systems, Inc. Stent for increasing blood flow to ischemic tissues and a method of using the same
IL160031A0 (en) * 2001-07-23 2004-06-20 Novovascular Inc Nitric oxide releasing eptfe coated medical device sandwich
US6977138B2 (en) * 2001-07-24 2005-12-20 Massachusetts Institute Of Technology Reactive polymer coatings
SE523216C2 (sv) * 2001-07-27 2004-04-06 Zoucas Kirurgkonsult Ab Heparinstent
US6841166B1 (en) * 2001-08-21 2005-01-11 The Regents Of The University Of Michigan Nitric oxide-releasing polymers incorporating diazeniumdiolated silane derivatives
US7135189B2 (en) * 2001-08-23 2006-11-14 Boston Scientific Scimed, Inc. Compositions and techniques for localized therapy
US20030065377A1 (en) * 2001-09-28 2003-04-03 Davila Luis A. Coated medical devices
US6703046B2 (en) * 2001-10-04 2004-03-09 Medtronic Ave Inc. Highly cross-linked, extremely hydrophobic nitric oxide-releasing polymers and methods for their manufacture and use
CA2480832A1 (en) * 2002-04-05 2003-10-23 Nitromed, Inc. Nitric oxide donors, compositions and methods of use
US7105175B2 (en) * 2002-06-19 2006-09-12 Boston Scientific Scimed, Inc. Implantable or insertable medical devices for controlled delivery of a therapeutic agent
US20050008676A1 (en) * 2002-12-19 2005-01-13 Yongxing Qiu Medical devices having antimicrobial coatings thereon
US20040215313A1 (en) * 2003-04-22 2004-10-28 Peiwen Cheng Stent with sandwich type coating
PL1638624T3 (pl) * 2003-06-19 2014-06-30 Vascular Therapies Llc Wyrób do zamykania naczyń krwionośnych
US20050033417A1 (en) * 2003-07-31 2005-02-10 John Borges Coating for controlled release of a therapeutic agent
US20050033263A1 (en) * 2003-08-07 2005-02-10 Medtronic-Minimed, Inc. System and method for restenosis mitigation
US20060008529A1 (en) * 2004-07-12 2006-01-12 Meyerhoff Mark E Use of additive sites to control nitric oxide release from nitric oxide donors contained within polymers
US8217166B2 (en) * 2005-05-05 2012-07-10 Galera Therapeutics, Llc Polyethylene glycolated superoxide dismutase mimetics
JP2009500083A (ja) * 2005-06-30 2009-01-08 エムシー３， インコーポレイテッド 検体センサーおよびその中で使用するための組成物
US20070196428A1 (en) * 2006-02-17 2007-08-23 Thierry Glauser Nitric oxide generating medical devices

Also Published As

Publication number Publication date
US20120070483A1 (en) 2012-03-22
DE602005025894D1 (de) 2011-02-24
EP1788980A4 (de) 2009-06-17
JP2008510569A (ja) 2008-04-10
WO2006023693A3 (en) 2007-03-15
WO2006023693A2 (en) 2006-03-02
CA2577780A1 (en) 2006-03-02
CN101065079A (zh) 2007-10-31
EP1788980A2 (de) 2007-05-30
US20060039950A1 (en) 2006-02-23
EP1788980B1 (de) 2011-01-12

Similar Documents

Publication Publication Date Title
ATE494897T1 (de) Biokompatible multifunktionsbeschichtungen für intravaskuläre vorrichtungen
WO2006014969A3 (en) Medical device having a coating layer with structural elements therein and method of making the same
HK1101341A1 (en) Dressing for a wound
WO2007084361A3 (en) Coated medical devices and methods of making the same
ATE476397T1 (de) Substrat, wie glassubstrat, mit hydrophober oberfläche und verbesserter dauerhaftigkeit hydrophober eigenschaften
WO2008108987A3 (en) Medical device with a porous surface for delivery of a therapeutic agent
DK1937328T3 (da) Polymercoating til medicinske indretninger
DE60020337D1 (de) Wundauflage
WO2007143089A3 (en) Foam layer cohesive articles and wound care bandages and methods of making and using same
WO2004030678A8 (en) Polymer compositions containing bioactive agents and methods for their use
ATE374050T1 (de) Sperrschicht für wirkstoffhaltige polymere beschichtungen
WO2006058234A3 (en) Medical devices with highly flexible coated hypotube
WO2007126768A3 (en) Medical devices comprising a porous metal oxide or metal material and a polymer coating for delivering therapeutic agents
ATE494914T1 (de) Mehrschichtige, absorbierende wundauflage mit einer hydrophilen wundkontaktschicht
GB2396109B (en) Absorbent multilayer hydrogel wound dressings
WO2008014438A3 (en) Vascular access device non-adhering surfaces
ATE422909T1 (de) Therapeutische beschichtung für ein intravaskuläres implantat
WO2007078304A3 (en) Medical device applications of nanostructured surfaces
WO2006058322A3 (en) Implantable devices with reduced needle puncture site leakage
DK1871316T3 (da) Kompressionsbandagesystem
FR2844707B1 (fr) Lingette et ses utilisations sans le domaine cosmetique
WO2005089480A3 (en) Activation method
ATE519510T1 (de) Antithrombogene und antirestenotische vaskuläre medizinprodukte
WO2007076413A3 (en) Antimicrobial durable medical equipment
WO2009039429A3 (en) Therapeutic agent-eluting medical devices having textured polymeric surfaces

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties