ATE492295T1 - Radioaktiv markierte verbindungen und liposome und ihre herstellungs- und anwendungsverfahren - Google Patents

Radioaktiv markierte verbindungen und liposome und ihre herstellungs- und anwendungsverfahren

Info

Publication number
ATE492295T1
ATE492295T1 AT03731347T AT03731347T ATE492295T1 AT E492295 T1 ATE492295 T1 AT E492295T1 AT 03731347 T AT03731347 T AT 03731347T AT 03731347 T AT03731347 T AT 03731347T AT E492295 T1 ATE492295 T1 AT E492295T1
Authority
AT
Austria
Prior art keywords
liposomes
production
labeled compounds
radioactively labeled
use methods
Prior art date
Application number
AT03731347T
Other languages
English (en)
Inventor
Ande Bao
William Phillips
Beth Goins
Original Assignee
Univ Texas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Texas filed Critical Univ Texas
Application granted granted Critical
Publication of ATE492295T1 publication Critical patent/ATE492295T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1217—Dispersions, suspensions, colloids, emulsions, e.g. perfluorinated emulsion, sols
    • A61K51/1234—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • C07F13/005—Compounds without a metal-carbon linkage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
AT03731347T 2002-07-02 2003-05-22 Radioaktiv markierte verbindungen und liposome und ihre herstellungs- und anwendungsverfahren ATE492295T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39361902P 2002-07-02 2002-07-02
PCT/US2003/016363 WO2004004635A2 (en) 2002-07-02 2003-05-22 Radiolabeled compounds and liposomes and their methods of making and using the same

Publications (1)

Publication Number Publication Date
ATE492295T1 true ATE492295T1 (de) 2011-01-15

Family

ID=30115613

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03731347T ATE492295T1 (de) 2002-07-02 2003-05-22 Radioaktiv markierte verbindungen und liposome und ihre herstellungs- und anwendungsverfahren

Country Status (7)

Country Link
US (1) US7718160B2 (de)
EP (1) EP1536843B1 (de)
AT (1) ATE492295T1 (de)
AU (2) AU2003241598B2 (de)
CA (1) CA2490959C (de)
DE (1) DE60335469D1 (de)
WO (1) WO2004004635A2 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0423565D0 (en) * 2004-10-22 2004-11-24 Algeta As Formulation
WO2007115132A2 (en) * 2006-03-29 2007-10-11 Guilford F Timothy Radiopharmaceutical in self-forming liposomal formulation capable of multipath administration including other ingredients
US20080226546A1 (en) * 2007-03-18 2008-09-18 Te-Wei Lee Kit for preparation of nano-targeted liposome drug in combined radionuclide therapy and chemotherapy
LT2494993T (lt) * 2007-05-04 2018-12-27 Marina Biotech, Inc. Aminorūgščių lipidai ir jų panaudojimas
TW200922630A (en) * 2007-09-26 2009-06-01 Nat Health Research Institutes Liposome compositions useful for tumor imaging and treatment
EP2123258A1 (de) 2008-05-23 2009-11-25 Liplasome Pharma A/S Liposomen zur Arzneimittelverabreichung
US20120135064A1 (en) * 2009-05-27 2012-05-31 Northeastern University Conjugated nanodelivery vehicles
DK177532B1 (en) * 2009-09-17 2013-09-08 Bio Bedst Aps Medical use of sPLA2 hydrolysable liposomes
US20110158903A1 (en) * 2009-12-31 2011-06-30 Institute Of Nuclear Energy Research Atomic Energy Council, Executive Yuan One pot processes of preparing multifunctional liposome drug for imaging, delivery and targeting in cancer diagnosis and therapy
US20120310140A1 (en) 2010-12-01 2012-12-06 Spinal Modulation, Inc. Directed delivery of agents to neural anatomy
US9511155B2 (en) 2012-04-17 2016-12-06 Merrimack Pharmaceuticals, Inc. Compositions and methods for non-invasive imaging
TW201615229A (zh) 2014-10-23 2016-05-01 行政院原子能委員會核能研究所 製備放射標靶藥物的套件及放射標靶藥物之製造方法
AU2017258901A1 (en) 2016-12-30 2018-07-19 Allarity Therapeutics Europe ApS Methods for predicting drug responsiveness in cancer patients
JP2023524679A (ja) 2020-04-30 2023-06-13 フィジーン、エルエルシー 癌線維芽細胞を標的化するための免疫療法の方法および組成物
IL302964A (en) * 2020-11-18 2023-07-01 Plus Therapeutics Inc Radiolabeled liposomes and methods of use thereof
US20240148918A1 (en) * 2021-03-05 2024-05-09 Board Of Regents, The University Of Texas System Loading of Alginate Microspheres
MX2024009199A (es) * 2022-01-25 2024-09-23 Plus Therapeutics Inc Liposomas radiomarcados y metodos de uso para el tratamiento de metastasis leptomeningeas.

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4310505A (en) * 1979-11-08 1982-01-12 California Institute Of Technology Lipid vesicles bearing carbohydrate surfaces as lymphatic directed vehicles for therapeutic and diagnostic substances
US5059421A (en) * 1985-07-26 1991-10-22 The Liposome Company, Inc. Preparation of targeted liposome systems of a defined size distribution
JPS6295134A (ja) 1985-10-21 1987-05-01 Nippon Saafuakutanto Kogyo Kk リポソ−ムの製造法
US4776991A (en) * 1986-08-29 1988-10-11 The United States Of America As Represented By The Secretary Of The Navy Scaled-up production of liposome-encapsulated hemoglobin
US4911929A (en) * 1986-08-29 1990-03-27 The United States Of America As Represented By The Secretary Of The Navy Blood substitute comprising liposome-encapsulated hemoglobin
JPH0720857B2 (ja) 1988-08-11 1995-03-08 テルモ株式会社 リポソームおよびその製法
GB8824593D0 (en) 1988-10-20 1988-11-23 Royal Free Hosp School Med Liposomes
US5173426A (en) * 1989-10-06 1992-12-22 Yale University DNAs encoding genetically engineered low oxygen affinity mutants of human hemoglobin
US5013556A (en) * 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
JP3085963B2 (ja) 1990-04-24 2000-09-11 テルモ株式会社 人工血液
US5158760A (en) * 1990-05-30 1992-10-27 Board Of Regents, The University Of Texas System 99m TC labeled liposomes
US5143713A (en) * 1990-05-30 1992-09-01 Board Of Regents, The University Of Texas System 99m Tc labeled liposomes
US5306862A (en) * 1990-10-12 1994-04-26 Amoco Corporation Method and composition for increasing sterol accumulation in higher plants
JPH04300838A (ja) 1991-03-28 1992-10-23 Terumo Corp 人工赤血球および人工赤血球懸濁液
US5395619A (en) 1993-03-03 1995-03-07 Liposome Technology, Inc. Lipid-polymer conjugates and liposomes
EP0615747B1 (de) * 1993-03-18 1999-09-29 Terumo Kabushiki Kaisha Liposom mit eingekapseltem Hämoglobin sowie Verfahren zu dessen Herstellung
JPH09510433A (ja) * 1993-12-17 1997-10-21 マイクロパック インコーポレイテッド 生物学的に活性な物質を細胞に送達する方法
US5674528A (en) * 1994-06-15 1997-10-07 Terumo Kabushiki Kaisha Hemoglobin-encapsulated liposome
US5589189A (en) 1994-09-14 1996-12-31 Nexstar Pharmaceuticals, Inc. Liposome dispersion
US5534263A (en) * 1995-02-24 1996-07-09 Alza Corporation Active agent dosage form comprising a matrix and at least two insoluble bands
WO1996030054A1 (en) 1995-03-28 1996-10-03 Mallinckrodt Medical, Inc. 99mTc - LABELLED SEROTONIN RECEPTOR BINDING SUBSTANCES
US6241963B1 (en) * 1995-10-19 2001-06-05 The Trustees Of The University Of Pennsylvania Dopamine and serotonin transporter ligands and imaging agents
US6056973A (en) * 1996-10-11 2000-05-02 Sequus Pharmaceuticals, Inc. Therapeutic liposome composition and method of preparation
HUP0000522A3 (en) * 1996-10-15 2000-10-30 Transave Inc Monmouth Junction N-acyl phoshpatidylethanolamine-mediated liposomal drug delivery
US5814601A (en) * 1997-02-28 1998-09-29 The Regents Of The University Of California Methods and compositions for optimization of oxygen transport by cell-free systems
US6033708A (en) 1997-09-30 2000-03-07 The United States Of America As Represented By The Secretary Of The Navy Method for producing sterile filterable liposome dispersion
DE59712553D1 (de) 1997-11-28 2006-04-06 Zimmer Gmbh Winterthur Instrumentenbaukasten für Kniegelenkprothesen
US6320017B1 (en) * 1997-12-23 2001-11-20 Inex Pharmaceuticals Corp. Polyamide oligomers
CA2319433C (en) * 1998-02-09 2008-04-22 Bracco Suisse S.A. Targeted delivery of biologically active media
DE69922189T2 (de) * 1998-04-27 2005-11-10 Opperbas Holding B.V. Pharmazeutische zusammensetzungen enthaltend faktor viii und neutrale liposomen
JP4181290B2 (ja) * 2000-06-12 2008-11-12 学校法人早稲田大学 ヘモグロビン小胞体の光還元法
US6680068B2 (en) 2000-07-06 2004-01-20 The General Hospital Corporation Drug delivery formulations and targeting
TW474417U (en) * 2000-12-01 2002-01-21 Inventec Multimedia & Telecom Digital camera structure capable of rotating multi-angles for picking up image
US6984395B2 (en) 2001-04-11 2006-01-10 Qlt, Inc. Drug delivery system for hydrophobic drugs
JP4300838B2 (ja) 2003-03-25 2009-07-22 沖電気工業株式会社 分散計算装置及び分散計算システム

Also Published As

Publication number Publication date
DE60335469D1 (de) 2011-02-03
CA2490959C (en) 2013-04-16
CA2490959A1 (en) 2004-01-15
WO2004004635A2 (en) 2004-01-15
US20050222396A1 (en) 2005-10-06
EP1536843A4 (de) 2009-01-14
EP1536843B1 (de) 2010-12-22
EP1536843A2 (de) 2005-06-08
US7718160B2 (en) 2010-05-18
AU2003241598B2 (en) 2009-11-05
AU2003241598A1 (en) 2004-01-23
AU2009233821A1 (en) 2009-11-26
WO2004004635A3 (en) 2004-07-01

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