ATE490975T1 - 4-methylhexanoic kahalalide f verbindung - Google Patents
4-methylhexanoic kahalalide f verbindungInfo
- Publication number
- ATE490975T1 ATE490975T1 AT03779140T AT03779140T ATE490975T1 AT E490975 T1 ATE490975 T1 AT E490975T1 AT 03779140 T AT03779140 T AT 03779140T AT 03779140 T AT03779140 T AT 03779140T AT E490975 T1 ATE490975 T1 AT E490975T1
- Authority
- AT
- Austria
- Prior art keywords
- kahalalide
- methylhexanoic
- compound
- antitumoral
- antiviral
- Prior art date
Links
- -1 KAHALALIDE F COMPOUND Chemical class 0.000 title 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 2
- RCGXNDQKCXNWLO-WLEIXIPESA-N (2r)-n-[(2s)-5-amino-1-[[(2r,3r)-1-[[(3s,6z,9s,12r,15r,18r,19s)-9-benzyl-15-[(2r)-butan-2-yl]-6-ethylidene-19-methyl-2,5,8,11,14,17-hexaoxo-3,12-di(propan-2-yl)-1-oxa-4,7,10,13,16-pentazacyclononadec-18-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-1-oxopent Chemical class N([C@@H](CCCN)C(=O)N[C@H]([C@H](C)CC)C(=O)N[C@H]1C(N[C@@H](C(=O)N[C@@H](C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)NC(/C(=O)N[C@H](C(=O)O[C@H]1C)C(C)C)=C\C)C(C)C)[C@H](C)CC)=O)C(=O)[C@H]1CCCN1C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CCCC(C)C)C(C)C)[C@@H](C)O)C(C)C)C(C)C RCGXNDQKCXNWLO-WLEIXIPESA-N 0.000 abstract 1
- 201000004681 Psoriasis Diseases 0.000 abstract 1
- 230000000840 anti-viral effect Effects 0.000 abstract 1
- 229940121375 antifungal agent Drugs 0.000 abstract 1
- 239000003429 antifungal agent Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229930194861 kahalalide Natural products 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/GB2002/004735 WO2003033012A1 (en) | 2001-10-19 | 2002-10-18 | Kahalalide compounds for use in cancer therapy |
| GBGB0304367.6A GB0304367D0 (en) | 2003-02-26 | 2003-02-26 | Methods for treating psoriasis |
| GB0314725A GB0314725D0 (en) | 2003-06-24 | 2003-06-24 | New antitumoral compounds |
| PCT/US2003/033207 WO2004035613A2 (en) | 2002-10-18 | 2003-10-20 | 4-methylhexanoic kahalaide f compound |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE490975T1 true ATE490975T1 (de) | 2010-12-15 |
Family
ID=35276268
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03779140T ATE490975T1 (de) | 2002-10-18 | 2003-10-20 | 4-methylhexanoic kahalalide f verbindung |
Country Status (11)
| Country | Link |
|---|---|
| KR (2) | KR20110114690A (pl) |
| AT (1) | ATE490975T1 (pl) |
| AU (1) | AU2003285911B2 (pl) |
| CY (1) | CY1111319T1 (pl) |
| DE (1) | DE60335292D1 (pl) |
| DK (1) | DK1572726T3 (pl) |
| IL (1) | IL167724A (pl) |
| NO (1) | NO333448B1 (pl) |
| PL (1) | PL209129B1 (pl) |
| PT (1) | PT1572726E (pl) |
| SI (1) | SI1572726T1 (pl) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0321066D0 (en) * | 2003-09-09 | 2003-10-08 | Pharma Mar Sau | New antitumoral compounds |
| GB0408958D0 (en) * | 2004-04-22 | 2004-05-26 | Pharma Mar Sa | Convergent synthesis for kahalalide compounds |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9302046D0 (en) * | 1993-02-03 | 1993-03-24 | Pharma Mar Sa | Antiumoral compound-v |
| MXPA03003704A (es) * | 2000-10-31 | 2004-05-04 | Pharma Mar Sa | Formulacion de kahalalide f. |
| EP1435990A1 (en) * | 2001-10-19 | 2004-07-14 | Pharma Mar, S.A. | Kahalalide compounds for use in cancer therapy |
-
2003
- 2003-10-20 PL PL377056A patent/PL209129B1/pl unknown
- 2003-10-20 KR KR1020117020121A patent/KR20110114690A/ko not_active Ceased
- 2003-10-20 DE DE60335292T patent/DE60335292D1/de not_active Expired - Lifetime
- 2003-10-20 SI SI200331948T patent/SI1572726T1/sl unknown
- 2003-10-20 KR KR1020057006480A patent/KR101149095B1/ko not_active Expired - Fee Related
- 2003-10-20 DK DK03779140.7T patent/DK1572726T3/da active
- 2003-10-20 AT AT03779140T patent/ATE490975T1/de active
- 2003-10-20 AU AU2003285911A patent/AU2003285911B2/en not_active Ceased
- 2003-10-20 PT PT03779140T patent/PT1572726E/pt unknown
-
2005
- 2005-03-29 IL IL167724A patent/IL167724A/en not_active IP Right Cessation
- 2005-05-13 NO NO20052379A patent/NO333448B1/no not_active IP Right Cessation
-
2011
- 2011-03-08 CY CY20111100265T patent/CY1111319T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20110114690A (ko) | 2011-10-19 |
| DK1572726T3 (da) | 2011-03-28 |
| PL377056A1 (pl) | 2006-01-23 |
| CY1111319T1 (el) | 2015-08-05 |
| AU2003285911A1 (en) | 2004-05-04 |
| NO333448B1 (no) | 2013-06-10 |
| HK1082261A1 (en) | 2006-06-02 |
| NO20052379D0 (no) | 2005-05-13 |
| PT1572726E (pt) | 2011-02-14 |
| KR20050070056A (ko) | 2005-07-05 |
| SI1572726T1 (sl) | 2011-04-29 |
| KR101149095B1 (ko) | 2012-05-30 |
| DE60335292D1 (de) | 2011-01-20 |
| IL167724A (en) | 2012-01-31 |
| AU2003285911B2 (en) | 2009-11-19 |
| PL209129B1 (pl) | 2011-07-29 |
| NO20052379L (no) | 2005-07-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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