ATE48427T1 - Verfahren zur isolierung und reinigung von podophyllotoxin. - Google Patents
Verfahren zur isolierung und reinigung von podophyllotoxin.Info
- Publication number
- ATE48427T1 ATE48427T1 AT85306787T AT85306787T ATE48427T1 AT E48427 T1 ATE48427 T1 AT E48427T1 AT 85306787 T AT85306787 T AT 85306787T AT 85306787 T AT85306787 T AT 85306787T AT E48427 T1 ATE48427 T1 AT E48427T1
- Authority
- AT
- Austria
- Prior art keywords
- podophyllotoxin
- isolation
- purification
- procedure
- forming
- Prior art date
Links
- YJGVMLPVUAXIQN-UHFFFAOYSA-N epipodophyllotoxin Natural products COC1=C(OC)C(OC)=CC(C2C3=CC=4OCOC=4C=C3C(O)C3C2C(OC3)=O)=C1 YJGVMLPVUAXIQN-UHFFFAOYSA-N 0.000 title abstract 4
- YJGVMLPVUAXIQN-XVVDYKMHSA-N podophyllotoxin Chemical compound COC1=C(OC)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@H](O)[C@@H]3[C@@H]2C(OC3)=O)=C1 YJGVMLPVUAXIQN-XVVDYKMHSA-N 0.000 title abstract 4
- 229960001237 podophyllotoxin Drugs 0.000 title abstract 4
- YVCVYCSAAZQOJI-UHFFFAOYSA-N podophyllotoxin Natural products COC1=C(O)C(OC)=CC(C2C3=CC=4OCOC=4C=C3C(O)C3C2C(OC3)=O)=C1 YVCVYCSAAZQOJI-UHFFFAOYSA-N 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 2
- 238000002955 isolation Methods 0.000 title 1
- 238000000746 purification Methods 0.000 title 1
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 3
- 239000007787 solid Substances 0.000 abstract 2
- 239000007858 starting material Substances 0.000 abstract 2
- 150000001491 aromatic compounds Chemical class 0.000 abstract 1
- 150000002390 heteroarenes Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB848424269A GB8424269D0 (en) | 1984-09-26 | 1984-09-26 | Isolation and purification of podophyllotoxin |
| EP85306787A EP0197219B1 (de) | 1984-09-26 | 1985-09-24 | Verfahren zur Isolierung und Reinigung von Podophyllotoxin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE48427T1 true ATE48427T1 (de) | 1989-12-15 |
Family
ID=10567263
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT85306787T ATE48427T1 (de) | 1984-09-26 | 1985-09-24 | Verfahren zur isolierung und reinigung von podophyllotoxin. |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US4680399A (de) |
| EP (1) | EP0197219B1 (de) |
| AT (1) | ATE48427T1 (de) |
| CA (2) | CA1268709A (de) |
| DE (2) | DE3574595D1 (de) |
| DK (1) | DK169385B1 (de) |
| ES (2) | ES8702395A1 (de) |
| FI (1) | FI84557C (de) |
| GB (1) | GB8424269D0 (de) |
| IS (1) | IS3039A7 (de) |
| NO (1) | NO164658C (de) |
| PL (1) | PL147999B1 (de) |
| PT (1) | PT81190B (de) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU585936B2 (en) * | 1984-12-28 | 1989-06-29 | Conpharm A.B. | Pharmaceutically active podophyllotoxins |
| US5057616A (en) * | 1989-09-29 | 1991-10-15 | Oclassen Pharmaceuticals, Inc. | Podophyllotoxin purification process |
| US5315016A (en) * | 1992-10-13 | 1994-05-24 | Nycomed Dak A/S | Process for preparing pure podophyllotoxin |
| US5589106A (en) * | 1995-02-14 | 1996-12-31 | Nalco Chemical Company | Carbon steel corrosion inhibitors |
| US8414932B2 (en) | 1998-06-01 | 2013-04-09 | Albemarie Corporation | Active bromine containing biocidal compositions and their preparation |
| US6299909B1 (en) | 1998-06-01 | 2001-10-09 | Albemarle Corporation | Concentrated aqueous bromine solutions and their preparation |
| US6068861A (en) | 1998-06-01 | 2000-05-30 | Albemarle Corporation | Concentrated aqueous bromine solutions and their preparation |
| US8293795B1 (en) | 1998-06-01 | 2012-10-23 | Albemarle Corporation | Preparation of concentrated aqueous bromine solutions and biocidal applications thereof |
| US6352725B1 (en) | 1998-06-01 | 2002-03-05 | Albemarle Corporation | Continuous processes for preparing concentrated aqueous liquid biocidal composition |
| US6348219B1 (en) | 1998-06-01 | 2002-02-19 | Albemarle Corporation | Processes for preparing concentrated aqueous liquid biocidal compositions |
| US6511682B1 (en) | 1998-06-01 | 2003-01-28 | Albemarle Corporation | Concentrated aqueous bromine solutions and their preparation |
| US6652889B2 (en) | 1998-06-01 | 2003-11-25 | Albemarle Corporation | Concentrated aqueous bromine solutions and their preparation and use |
| US7087251B2 (en) | 1998-06-01 | 2006-08-08 | Albemarle Corporation | Control of biofilm |
| US6506418B1 (en) | 1999-09-24 | 2003-01-14 | Albemarle Corporation | Concentrated aqueous bromine solutions and their preparation |
| US6375991B1 (en) | 2000-09-08 | 2002-04-23 | Albemarle Corporation | Production of concentrated biocidal solutions |
| WO2003011033A1 (en) * | 2001-06-28 | 2003-02-13 | Solution Biosciences, Inc. | Microbiological control in animal processing |
| US6986910B2 (en) | 2001-06-28 | 2006-01-17 | Albemarle Corporation | Microbiological control in poultry processing |
| US6908636B2 (en) | 2001-06-28 | 2005-06-21 | Albermarle Corporation | Microbiological control in poultry processing |
| US7901276B2 (en) * | 2003-06-24 | 2011-03-08 | Albemarle Corporation | Microbiocidal control in the processing of meat-producing four-legged animals |
| US9005671B2 (en) * | 2004-09-07 | 2015-04-14 | Albemarle Corporation | Concentrated aqueous bromine solutions and their preparation |
| JP4688883B2 (ja) * | 2004-12-23 | 2011-05-25 | アルベマール・コーポレーシヨン | 肉生産用四つ足動物処理における殺微生物制御 |
| US7914365B2 (en) | 2005-12-01 | 2011-03-29 | Albemarle Corporation | Microbiocidal control in the processing of meat-producing four-legged animals |
| US20090130017A1 (en) * | 2007-11-19 | 2009-05-21 | Searete Llc | Targeted short-lived drug delivery |
| CN104098583B (zh) * | 2013-04-09 | 2018-02-02 | 中国医学科学院药物研究所 | 鬼臼毒素晶x型物质及制备方法和其药物组合物与用途 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2984674A (en) * | 1958-06-02 | 1961-05-16 | Sandoz Ag | Amides of podophyllic acid and picropodophyllic acid |
| US4122092A (en) * | 1977-08-25 | 1978-10-24 | University Of Rochester | Total synthesis of (±)-picropodophyllone and (±)-4'-demethylpicropodophyllone |
-
1984
- 1984-09-26 GB GB848424269A patent/GB8424269D0/en active Pending
-
1985
- 1985-09-09 US US06/773,929 patent/US4680399A/en not_active Expired - Lifetime
- 1985-09-10 IS IS3039A patent/IS3039A7/is unknown
- 1985-09-24 NO NO853743A patent/NO164658C/no not_active IP Right Cessation
- 1985-09-24 DE DE8585306787T patent/DE3574595D1/de not_active Expired - Fee Related
- 1985-09-24 AT AT85306787T patent/ATE48427T1/de not_active IP Right Cessation
- 1985-09-24 EP EP85306787A patent/EP0197219B1/de not_active Expired
- 1985-09-24 ES ES547248A patent/ES8702395A1/es not_active Expired
- 1985-09-24 DE DE8888120946T patent/DE3583043D1/de not_active Expired - Fee Related
- 1985-09-25 PT PT81190A patent/PT81190B/pt not_active IP Right Cessation
- 1985-09-25 FI FI853690A patent/FI84557C/fi not_active IP Right Cessation
- 1985-09-25 CA CA000491564A patent/CA1268709A/en not_active Expired - Lifetime
- 1985-09-25 DK DK434085A patent/DK169385B1/da not_active IP Right Cessation
- 1985-09-26 PL PL1985255527A patent/PL147999B1/pl unknown
-
1986
- 1986-05-16 ES ES555039A patent/ES8900110A1/es not_active Expired
-
1989
- 1989-02-22 CA CA000591830A patent/CA1276110C/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| PL147999B1 (en) | 1989-09-30 |
| FI853690A0 (fi) | 1985-09-25 |
| EP0197219B1 (de) | 1989-12-06 |
| ES8900110A1 (es) | 1988-12-16 |
| NO853743L (no) | 1986-04-01 |
| US4680399A (en) | 1987-07-14 |
| NO164658C (no) | 1990-10-31 |
| DE3583043D1 (de) | 1991-07-04 |
| CA1276110C (en) | 1990-11-13 |
| FI84557B (fi) | 1991-09-13 |
| DK434085D0 (da) | 1985-09-25 |
| CA1268709A (en) | 1990-05-08 |
| DK434085A (da) | 1986-03-27 |
| PT81190A (en) | 1985-10-01 |
| ES547248A0 (es) | 1987-01-01 |
| ES8702395A1 (es) | 1987-01-01 |
| PL255527A1 (en) | 1986-07-15 |
| NO164658B (no) | 1990-07-23 |
| IS3039A7 (is) | 1986-01-21 |
| GB8424269D0 (en) | 1984-10-31 |
| EP0197219A1 (de) | 1986-10-15 |
| ES555039A0 (es) | 1988-12-16 |
| DK169385B1 (da) | 1994-10-17 |
| FI84557C (fi) | 1991-12-27 |
| PT81190B (pt) | 1987-09-30 |
| FI853690L (fi) | 1986-03-27 |
| DE3574595D1 (de) | 1990-01-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE48427T1 (de) | Verfahren zur isolierung und reinigung von podophyllotoxin. | |
| DE69010857D1 (de) | Verfahren zur Herstellung dünner Schichten von hoher Reinheit. | |
| DE3788939D1 (de) | Verfahren zur Herstellung von Uretdionringen enthaltenden Polyurethanen. | |
| DE68913429D1 (de) | Verfahren zur Herstellung von Silicium-Einkristallen. | |
| DE3767835D1 (de) | Verfahren zur herstellung von fluor-halogen-aethern, ausgehend von fluoroxyverbindungen und halogenierten olefinen. | |
| ATE29500T1 (de) | Verfahren zur herstellung von nphosphonomethylglycin. | |
| DE68911810D1 (de) | Verfahren zur Herstellung von Graphitblöcken. | |
| DE3887434D1 (de) | Verfahren zur Gewinnung von Caprolactam aus Leichtsiedern oder Schwersiedern der Caprolactamdestillation oder Gemischen derselben. | |
| DE3851364D1 (de) | Verfahren zur Herstellung von supraleitendem Material. | |
| ATE38832T1 (de) | Verfahren zur herstellung von pyrrolidonderivaten. | |
| DE59008305D1 (de) | Verfahren zur gleichzeitigen Gewinnung von reinem Benzol und reinem Toluol. | |
| DE3889371D1 (de) | Verfahren zur Herstellung von supraleitenden Keramiken. | |
| DE3850151D1 (de) | Verfahren zur Herstellung von Mustern. | |
| NO171311C (no) | Fremgangsmaate for fremstilling av iodaromatiske forbindelser | |
| ATE49016T1 (de) | Verfahren zur herstellung von stabilen kohlewasser-gemischen. | |
| ATE51220T1 (de) | Verfahren zur abtrennung und reinigung der phydroxybenzoes|ure. | |
| ATE44949T1 (de) | Verfahren zur herstellung von benzolderivaten. | |
| DE3888392D1 (de) | Verfahren zur Reinigung von 2,4-Xylenol. | |
| ATE31406T1 (de) | Verfahren zur herstellung von hydroxylaminen. | |
| ATE46351T1 (de) | Verfahren zur herstellung von pulverfoermigen polymerisaten. | |
| ATE40901T1 (de) | Verfahren zur herstellung von chanoclavin. | |
| ATE32703T1 (de) | Verfahren zur herstellung von cycloalkadienen. | |
| ATE39916T1 (de) | Verfahren zur herstellung von 4biphenylylessigs|ure. | |
| ATE26931T1 (de) | Verfahren zur herstellung von mikrokapseln. | |
| ATE21688T1 (de) | Verfahren zur herstellung von phenylalkylaminoethylsalicylamid. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| EEIH | Change in the person of patent owner | ||
| REN | Ceased due to non-payment of the annual fee |