ATE482182T1 - Asymmetrische hydrierung zur herstellung von diphenylalaninderivaten - Google Patents
Asymmetrische hydrierung zur herstellung von diphenylalaninderivatenInfo
- Publication number
- ATE482182T1 ATE482182T1 AT06770147T AT06770147T ATE482182T1 AT E482182 T1 ATE482182 T1 AT E482182T1 AT 06770147 T AT06770147 T AT 06770147T AT 06770147 T AT06770147 T AT 06770147T AT E482182 T1 ATE482182 T1 AT E482182T1
- Authority
- AT
- Austria
- Prior art keywords
- diphenylalanine
- derivatives
- production
- asymmetric hydrogenation
- hydrogenation
- Prior art date
Links
- PECGVEGMRUZOML-AWEZNQCLSA-N (2s)-2-amino-3,3-diphenylpropanoic acid Chemical class C=1C=CC=CC=1C([C@H](N)C(O)=O)C1=CC=CC=C1 PECGVEGMRUZOML-AWEZNQCLSA-N 0.000 title abstract 2
- 238000009876 asymmetric hydrogenation reaction Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000003054 catalyst Substances 0.000 abstract 1
- 238000005984 hydrogenation reaction Methods 0.000 abstract 1
- 229910052703 rhodium Inorganic materials 0.000 abstract 1
- 239000010948 rhodium Substances 0.000 abstract 1
- MHOVAHRLVXNVSD-UHFFFAOYSA-N rhodium atom Chemical compound [Rh] MHOVAHRLVXNVSD-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/16—Preparation of optical isomers
- C07C231/18—Preparation of optical isomers by stereospecific synthesis
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68315005P | 2005-05-20 | 2005-05-20 | |
| PCT/US2006/017978 WO2006127273A2 (en) | 2005-05-20 | 2006-05-09 | Asymmetric hydrogenation for the preparation of diphenylalanine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE482182T1 true ATE482182T1 (de) | 2010-10-15 |
Family
ID=37027602
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06770147T ATE482182T1 (de) | 2005-05-20 | 2006-05-09 | Asymmetrische hydrierung zur herstellung von diphenylalaninderivaten |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP1885688B1 (enExample) |
| JP (1) | JP5001263B2 (enExample) |
| CN (1) | CN101175715B (enExample) |
| AT (1) | ATE482182T1 (enExample) |
| DE (1) | DE602006017064D1 (enExample) |
| WO (1) | WO2006127273A2 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8680278B2 (en) * | 2007-10-30 | 2014-03-25 | Janssen Pharmaceutica Nv | Enantioselective process for preparing a substituted alkanoic acid |
| JP2023535595A (ja) * | 2020-07-28 | 2023-08-18 | ジャズ ファーマシューティカルズ アイルランド リミテッド | 縮合二環式ｒａｆ阻害剤のキラル合成 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5198548A (en) * | 1992-01-30 | 1993-03-30 | Warner-Lambert Company | Process for the preparation of D(-) and L(+)-3,3-diphenylalanine and D(-) and L(+)-substituted 3,3-diphenylalanines and derivatives thereof |
| US5874629A (en) * | 1996-06-12 | 1999-02-23 | Merck & Co., Inc. | Chiral bisphosphines |
| WO2002057278A1 (en) * | 2001-01-19 | 2002-07-25 | Chirotech Technology Limited | Ligands and their use |
| JP2007537256A (ja) * | 2004-05-11 | 2007-12-20 | メルク エンド カムパニー インコーポレーテッド | Ｎ−スルホン化アミノ酸誘導体調製のためのプロセス |
-
2006
- 2006-05-09 EP EP06770147A patent/EP1885688B1/en not_active Not-in-force
- 2006-05-09 AT AT06770147T patent/ATE482182T1/de not_active IP Right Cessation
- 2006-05-09 WO PCT/US2006/017978 patent/WO2006127273A2/en not_active Ceased
- 2006-05-09 DE DE602006017064T patent/DE602006017064D1/de active Active
- 2006-05-09 CN CN2006800170720A patent/CN101175715B/zh not_active Expired - Fee Related
- 2006-05-09 JP JP2008512351A patent/JP5001263B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP2008540650A (ja) | 2008-11-20 |
| CN101175715B (zh) | 2011-04-13 |
| WO2006127273A3 (en) | 2007-03-22 |
| DE602006017064D1 (de) | 2010-11-04 |
| EP1885688A2 (en) | 2008-02-13 |
| JP5001263B2 (ja) | 2012-08-15 |
| EP1885688B1 (en) | 2010-09-22 |
| WO2006127273A2 (en) | 2006-11-30 |
| CN101175715A (zh) | 2008-05-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |