ATE470863T1 - Diagnostischer assay mit makrophagenhemmendem zytokin-1 (mic-1) - Google Patents

Diagnostischer assay mit makrophagenhemmendem zytokin-1 (mic-1)

Info

Publication number
ATE470863T1
ATE470863T1 AT07023699T AT07023699T ATE470863T1 AT E470863 T1 ATE470863 T1 AT E470863T1 AT 07023699 T AT07023699 T AT 07023699T AT 07023699 T AT07023699 T AT 07023699T AT E470863 T1 ATE470863 T1 AT E470863T1
Authority
AT
Austria
Prior art keywords
mic
macrophage
methods
diagnostic assay
cancer
Prior art date
Application number
AT07023699T
Other languages
German (de)
English (en)
Inventor
Samuel Norbert Breit
David Alexander Brown
Original Assignee
St Vincents Hosp Sydney
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AUPQ7037A external-priority patent/AUPQ703700A0/en
Priority claimed from AUPQ7465A external-priority patent/AUPQ746500A0/en
Application filed by St Vincents Hosp Sydney filed Critical St Vincents Hosp Sydney
Application granted granted Critical
Publication of ATE470863T1 publication Critical patent/ATE470863T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/195—Chemokines, e.g. RANTES
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/10—Musculoskeletal or connective tissue disorders
    • G01N2800/101—Diffuse connective tissue disease, e.g. Sjögren, Wegener's granulomatosis
    • G01N2800/102—Arthritis; Rheumatoid arthritis, i.e. inflammation of peripheral joints

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Gynecology & Obstetrics (AREA)
AT07023699T 2000-04-20 2001-04-20 Diagnostischer assay mit makrophagenhemmendem zytokin-1 (mic-1) ATE470863T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AUPQ7037A AUPQ703700A0 (en) 2000-04-20 2000-04-20 Diagnostic assay and method of treatment
AUPQ7465A AUPQ746500A0 (en) 2000-05-11 2000-05-11 Diagnostic assay

Publications (1)

Publication Number Publication Date
ATE470863T1 true ATE470863T1 (de) 2010-06-15

Family

ID=25646308

Family Applications (2)

Application Number Title Priority Date Filing Date
AT07023699T ATE470863T1 (de) 2000-04-20 2001-04-20 Diagnostischer assay mit makrophagenhemmendem zytokin-1 (mic-1)
AT01923411T ATE384265T1 (de) 2000-04-20 2001-04-20 Diagnostischer assay mit dem makrophagen- inhibitorischen-zytokin-1 (mic-1)

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT01923411T ATE384265T1 (de) 2000-04-20 2001-04-20 Diagnostischer assay mit dem makrophagen- inhibitorischen-zytokin-1 (mic-1)

Country Status (9)

Country Link
US (2) US7514221B2 (fr)
EP (2) EP1279039B1 (fr)
JP (1) JP4920851B2 (fr)
AT (2) ATE470863T1 (fr)
AU (2) AU2001250182B2 (fr)
CA (1) CA2405680C (fr)
DE (2) DE60142372D1 (fr)
ES (2) ES2300325T3 (fr)
WO (1) WO2001081928A1 (fr)

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KR100475642B1 (ko) * 2001-12-29 2005-03-10 한국생명공학연구원 암 발생 및 전이에 관여하는 단백질의 당쇄 변화를측정하여 암을 진단하는 방법 및 이를 이용한 진단킷트
US7157235B2 (en) 2002-06-17 2007-01-02 St. Vincent's Hospital Sydney Limited Methods of diagnosis, prognosis and treatment of cardiovascular disease
US7919084B2 (en) 2002-06-17 2011-04-05 St. Vincent's Hospital Sydney Limited Methods of diagnosis, prognosis and treatment of cardiovascular disease
AU2003295424A1 (en) * 2002-11-08 2004-06-03 Barnes-Jewish Hospital Methods and compositions for prostate epithelial cell differentiation
WO2005017192A2 (fr) * 2003-08-14 2005-02-24 The General Hospital Corporation Criblage a la recherche de troubles gestationnels
KR100679666B1 (ko) * 2004-01-20 2007-02-07 한국생명공학연구원 인간 대식세포 억제 사이토카인-1 특이적 단일클론항체,이를 분비하는 하이브리도마 및 이를 포함하는 위암 진단키트
AU2005232335B2 (en) * 2004-04-13 2009-09-03 St Vincent's Hospital Sydney Limited Method for modulating appetite
PT2441466E (pt) * 2004-04-13 2014-09-09 St Vincents Hosp Sydney Agente de inibição de mic-1
US20070237713A1 (en) 2006-04-04 2007-10-11 Fan Rong A PCan065 Antibody Compositions and Methods of Use
CA2660691C (fr) 2006-08-04 2020-01-14 Medizinische Hochschule Hannover Moyens et procedes d'evaluation du risque d'interventions cardiaques a partir du gene gdf-15
AU2008307643B9 (en) 2007-09-28 2014-04-17 Intrexon Corporation Therapeutic gene-switch constructs and bioreactors for the expression of biotherapeutic molecules, and uses thereof
JP5272011B2 (ja) * 2007-10-22 2013-08-28 セントビンセンツ ホスピタル シドニー リミテッド 予後判定の方法
EP2350669B9 (fr) 2008-10-31 2014-06-11 St Vincent's Hospital Sydney Limited Procédés de pronostic d'une affection rénale chronique
GB0902737D0 (en) 2009-02-19 2009-04-01 Univ Gent GDF15 as a differential marker for spondyloarthropathy
GB0902793D0 (en) 2009-02-20 2009-04-08 Univ Gent GDF15 as molecular tool to monitor and enhance phenotypic stability of articular chondrocytes
US9212221B2 (en) * 2010-03-03 2015-12-15 Detroit R & D, Inc. Form-specific antibodies for NAG-1 (MIC-1, GDF-15), H6D and other TGF-β subfamily and heart disease and cancer diagnoses
EP2545376A4 (fr) 2010-03-11 2013-08-28 Univ Louisville Res Found Méthodes permettant de prédire et de diminuer le risque de fausse couche
AU2011280936A1 (en) * 2010-07-23 2013-02-28 President And Fellows Of Harvard College Methods of detecting prenatal or pregnancy-related diseases or conditions
WO2013148117A1 (fr) * 2012-03-27 2013-10-03 Ngm Biopharmaceuticals, Inc. Compositions et méthodes d'utilisation pour le traitement de troubles métaboliques
CA2896076C (fr) 2012-12-21 2022-12-06 Aveo Pharmaceuticals, Inc. Anticorps anti-gdf15
US9161966B2 (en) 2013-01-30 2015-10-20 Ngm Biopharmaceuticals, Inc. GDF15 mutein polypeptides
RU2704285C2 (ru) 2013-01-30 2019-10-25 Нгм Байофармасьютикалз, Инк. Композиции и способы применения для лечения метаболических расстройств
US10588980B2 (en) 2014-06-23 2020-03-17 Novartis Ag Fatty acids and their use in conjugation to biomolecules
CR20170027A (es) 2014-07-30 2017-05-09 Ngm Biopharmaceuticals Inc Composiciones y métodos de uso para tratar trastornos metabólicos
TWI703161B (zh) 2014-10-31 2020-09-01 美商Ｎｇｍ生物製藥公司 用於治療代謝病症之組合物及方法
WO2017150314A1 (fr) 2016-02-29 2017-09-08 公立大学法人横浜市立大学 Procédé de détection d'un cancer de la prostate résistant à la castration et réactif de détection
KR102370762B1 (ko) 2016-03-31 2022-03-04 엔지엠 바이오파마슈티컬스, 아이엔씨. 결합 단백질 및 이의 사용 방법
WO2018187767A1 (fr) * 2017-04-06 2018-10-11 The Regents Of The University Of California Prédiction, diagnostic et traitement de nausées et de vomissements liés à la grossesse
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EP1074620A1 (fr) * 1999-08-06 2001-02-07 HyGene AG Protéine monomère de la famille TGF-beta
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Also Published As

Publication number Publication date
EP1914554A3 (fr) 2008-08-06
AU2001250182B2 (en) 2006-06-08
DE60132442D1 (de) 2008-03-06
US7968303B2 (en) 2011-06-28
CA2405680A1 (fr) 2001-11-01
JP2003532079A (ja) 2003-10-28
ES2300325T3 (es) 2008-06-16
EP1279039A1 (fr) 2003-01-29
EP1914554A2 (fr) 2008-04-23
AU5018201A (en) 2001-11-07
US20090291889A1 (en) 2009-11-26
WO2001081928A1 (fr) 2001-11-01
JP4920851B2 (ja) 2012-04-18
CA2405680C (fr) 2018-02-13
EP1279039B1 (fr) 2008-01-16
US20040053325A1 (en) 2004-03-18
ATE384265T1 (de) 2008-02-15
US7514221B2 (en) 2009-04-07
EP1279039A4 (fr) 2005-05-25
ES2346918T3 (es) 2010-10-21
DE60132442T2 (de) 2009-01-22
EP1914554B1 (fr) 2010-06-09
DE60142372D1 (de) 2010-07-22

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