ATE468855T1 - Kombination von stickstoff-senf analogen und imatinib für die behandlung von chronischer lymphatischer leukämie - Google Patents

Kombination von stickstoff-senf analogen und imatinib für die behandlung von chronischer lymphatischer leukämie

Info

Publication number
ATE468855T1
ATE468855T1 AT03772561T AT03772561T ATE468855T1 AT E468855 T1 ATE468855 T1 AT E468855T1 AT 03772561 T AT03772561 T AT 03772561T AT 03772561 T AT03772561 T AT 03772561T AT E468855 T1 ATE468855 T1 AT E468855T1
Authority
AT
Austria
Prior art keywords
combination
nitrogen mustard
treatment
imatinib
lymphatic leukemia
Prior art date
Application number
AT03772561T
Other languages
English (en)
Inventor
Lawrence Panasci
Raquel Aloyz
Original Assignee
Jewish General Hospital
Panasci Lawrence Carl
Aloyz Raquel Silvia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jewish General Hospital, Panasci Lawrence Carl, Aloyz Raquel Silvia filed Critical Jewish General Hospital
Application granted granted Critical
Publication of ATE468855T1 publication Critical patent/ATE468855T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
AT03772561T 2002-11-12 2003-11-10 Kombination von stickstoff-senf analogen und imatinib für die behandlung von chronischer lymphatischer leukämie ATE468855T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42548102P 2002-11-12 2002-11-12
PCT/IB2003/005454 WO2004043466A1 (en) 2002-11-12 2003-11-10 Combination of a nitrogen mustard analogue and imatinib for the treatment of chronic lymphocytic leukemia

Publications (1)

Publication Number Publication Date
ATE468855T1 true ATE468855T1 (de) 2010-06-15

Family

ID=32312996

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03772561T ATE468855T1 (de) 2002-11-12 2003-11-10 Kombination von stickstoff-senf analogen und imatinib für die behandlung von chronischer lymphatischer leukämie

Country Status (11)

Country Link
US (2) US20060122186A1 (de)
EP (1) EP1578426B1 (de)
JP (1) JP4854198B2 (de)
CN (1) CN100475212C (de)
AT (1) ATE468855T1 (de)
AU (1) AU2003280191A1 (de)
BR (1) BR0316126A (de)
CA (1) CA2504665C (de)
DE (1) DE60332762D1 (de)
ES (1) ES2348140T3 (de)
WO (1) WO2004043466A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100386115C (zh) * 2004-10-14 2008-05-07 孔庆忠 一种抗癌药物组合物
US20110039943A1 (en) * 2005-03-14 2011-02-17 Robert Alonso Methods for treating skin disorders with topical nitrogen mustard compositions
US7872050B2 (en) * 2005-03-14 2011-01-18 Yaupon Therapeutics Inc. Stabilized compositions of volatile alkylating agents and methods of using thereof
US8501818B2 (en) * 2005-03-14 2013-08-06 Ceptaris Therapeutics, Inc. Stabilized compositions of alkylating agents and methods of using same
JP2011507880A (ja) * 2007-12-21 2011-03-10 ノバルティス アーゲー 慢性リンパ性白血病の処置のためのニロチニブとナイトロジェンマスタードの組み合わせ剤
ES2848841T3 (es) * 2008-03-27 2021-08-12 Helsinn Healthcare Sa Composiciones estabilizadas de agentes de alquilación y métodos de utilización de estas composiciones
EP2425830A1 (de) * 2010-09-03 2012-03-07 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Synergistische Arzneimittelkombination zur Behandlung von Krebs
JP2016519684A (ja) * 2013-04-08 2016-07-07 デニス エム ブラウン 準最適に投与された薬物療法の有効性を改善するための及び／又は副作用を低減するための方法および組成物
CN105997981A (zh) * 2016-06-13 2016-10-12 崔坤峰 苯丁酸氮芥的药物组合物及其抗抑郁的医药用途
JP7001529B2 (ja) 2018-04-13 2022-01-19 デンカ株式会社 治具及び製造方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5506257A (en) * 1992-03-26 1996-04-09 University Of British Columbia Aminocyclohexylamides for antiarrhythmic and anaesthetic uses
US20050261283A1 (en) * 2002-05-13 2005-11-24 Vikas Sukhatme Methods and compositions for the treatment of graft failure

Also Published As

Publication number Publication date
CA2504665C (en) 2012-12-18
BR0316126A (pt) 2005-09-27
ES2348140T3 (es) 2010-11-30
EP1578426A1 (de) 2005-09-28
CN1711090A (zh) 2005-12-21
US20060122186A1 (en) 2006-06-08
EP1578426B1 (de) 2010-05-26
DE60332762D1 (de) 2010-07-08
US8492383B2 (en) 2013-07-23
CN100475212C (zh) 2009-04-08
AU2003280191A1 (en) 2004-06-03
US20090312290A1 (en) 2009-12-17
JP4854198B2 (ja) 2012-01-18
WO2004043466A1 (en) 2004-05-27
CA2504665A1 (en) 2004-05-27
JP2006508118A (ja) 2006-03-09

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