ATE467635T1 - Halogenierte pyrazoloä1,5-aüpyrimidine, verfahren,anwendungen als gaba-a-rezeptorligand, zusammensetzungen und zwischenprodukte - Google Patents
Halogenierte pyrazoloä1,5-aüpyrimidine, verfahren,anwendungen als gaba-a-rezeptorligand, zusammensetzungen und zwischenprodukteInfo
- Publication number
- ATE467635T1 ATE467635T1 AT06763737T AT06763737T ATE467635T1 AT E467635 T1 ATE467635 T1 AT E467635T1 AT 06763737 T AT06763737 T AT 06763737T AT 06763737 T AT06763737 T AT 06763737T AT E467635 T1 ATE467635 T1 AT E467635T1
- Authority
- AT
- Austria
- Prior art keywords
- aüpyrimidines
- gaba
- halogenated
- compositions
- applications
- Prior art date
Links
- 102000004300 GABA-A Receptors Human genes 0.000 title 1
- 108090000839 GABA-A Receptors Proteins 0.000 title 1
- 239000013067 intermediate product Substances 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/30—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms
- C07C233/33—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
- C07C233/42—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
- C07C233/43—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
- C07C303/40—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reactions not involving the formation of sulfonamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69286605P | 2005-06-21 | 2005-06-21 | |
| EP05105478A EP1736475A1 (de) | 2005-06-21 | 2005-06-21 | Halogenierte Pyrazolo[1,5-a]pyrimidine, Verfahrene, Verwendung und Zwischenprodukte |
| PCT/EP2006/063243 WO2006136530A1 (en) | 2005-06-21 | 2006-06-15 | Halogenated pyrazolo [1,5-a]pyrimidines, processes, uses as gaba-a receptors ligand, compositions and intermediates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE467635T1 true ATE467635T1 (de) | 2010-05-15 |
Family
ID=35311853
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06763737T ATE467635T1 (de) | 2005-06-21 | 2006-06-15 | Halogenierte pyrazoloä1,5-aüpyrimidine, verfahren,anwendungen als gaba-a-rezeptorligand, zusammensetzungen und zwischenprodukte |
Country Status (24)
| Country | Link |
|---|---|
| US (3) | US8530482B2 (de) |
| EP (2) | EP1736475A1 (de) |
| JP (1) | JP5010591B2 (de) |
| KR (1) | KR101465802B1 (de) |
| CN (1) | CN101243089B (de) |
| AR (1) | AR054785A1 (de) |
| AT (1) | ATE467635T1 (de) |
| AU (1) | AU2006261025B2 (de) |
| BR (1) | BRPI0612075A2 (de) |
| CA (1) | CA2612726C (de) |
| CY (1) | CY1111452T1 (de) |
| DE (1) | DE602006014272D1 (de) |
| DK (1) | DK1899343T3 (de) |
| ES (1) | ES2345999T3 (de) |
| MX (1) | MX2007016340A (de) |
| NO (1) | NO339973B1 (de) |
| PE (1) | PE20070071A1 (de) |
| PL (1) | PL1899343T3 (de) |
| PT (1) | PT1899343E (de) |
| RU (1) | RU2478101C2 (de) |
| SI (1) | SI1899343T1 (de) |
| TW (1) | TWI382985B (de) |
| UY (1) | UY29618A1 (de) |
| WO (1) | WO2006136530A1 (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1736475A1 (de) | 2005-06-21 | 2006-12-27 | Ferrer Internacional, S.A. | Halogenierte Pyrazolo[1,5-a]pyrimidine, Verfahrene, Verwendung und Zwischenprodukte |
| AU2007227557A1 (en) * | 2006-03-17 | 2007-09-27 | Wyeth | Pyrazolo[1,5-a]pyrimidine derivatives and methods of use thereof |
| EP1884516A1 (de) * | 2006-08-04 | 2008-02-06 | Ferrer Internacional, S.A. | Pyrazolo[1,5-a]pyrimidine, diese enthaltende pharmazeutische Zubereitungen und ihre Verwendung |
| EP1918290A1 (de) * | 2006-10-11 | 2008-05-07 | Ferrer Internacional, S.A. | Polymprph B von N-{2-Fluor-5-[3-(thiophen-2-carbonyl)-pyrazolo[1,5-a]pyrimidin-7-yl]phenyl}-N-methyl-acetamid |
| EP1956021A1 (de) * | 2006-10-11 | 2008-08-13 | Ferrer Internacional, S.A. | Verfahren zur Herstellung von Crystallin pyrazol[1,5-a]pyrimidin Verbindung |
| EP1921079A1 (de) * | 2006-11-08 | 2008-05-14 | Ferrer Internacional, S.A. | Amorphen form von N-{2-Fluoro-5-[3-(thiophen-2-carbonyl)-pyrazolo[1,5-a] pyrimidin-7-yl]-phenyl}-N-methyl-acetamid |
| BRPI1006150A2 (pt) | 2009-01-13 | 2018-01-16 | Interquim Sa | Processo para preparação de n-[5-(3-dimetilamino- acriloil)-2fluorofenil]-n-metil-acetamida |
| WO2014163162A1 (ja) | 2013-04-04 | 2014-10-09 | 武田薬品工業株式会社 | 複素環化合物 |
| JP2018199623A (ja) * | 2015-10-22 | 2018-12-20 | 大正製薬株式会社 | 含窒素縮合複素環化合物 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4521422A (en) * | 1983-06-23 | 1985-06-04 | American Cyanamid Company | Aryl and heteroaryl[7-(aryl and heteroaryl)pyrazolo[1,5-a]pyrimidin-3-yl]methanones |
| US6399621B1 (en) * | 1999-08-10 | 2002-06-04 | American Cyanamid Company | N-methyl-N-(3-{3-[2-thienylcarbonyl]-pyrazol-[1, 5-α]-pyrimidin-7-yl}phenyl)acetamide and compositions and methods related thereto |
| ES2311920T3 (es) * | 2001-03-14 | 2009-02-16 | Grunenthal Gmbh | Tiazolopirimidinas sustituidas como analgesicos. |
| JP2005516955A (ja) * | 2001-12-21 | 2005-06-09 | バイエル・ヘルスケア・アクチェンゲゼルシャフト | アロイル・ピリジノン化合物 |
| ES2222813B1 (es) * | 2003-07-24 | 2005-12-16 | Ferrer Internacional, S.A. | N-(3-(3-sustituidas-pirazolo(1,5-a)pirimidin-7-il)-fenil)-sulfonamidas y composiciones y metodos relacionados. |
| WO2006033795A2 (en) * | 2004-09-17 | 2006-03-30 | Wyeth | Substituted pyrazolo [1, 5-a] pyrimidines for inhibiting abnormal cell growth |
| WO2006033796A1 (en) * | 2004-09-17 | 2006-03-30 | Wyeth | SUBSTITUTED PYRAZOLO [1,5-a] PYRIMIDINES AND PROCESS FOR MAKING SAME |
| CN100528875C (zh) | 2005-02-18 | 2009-08-19 | 美德（江西）生物科技有限公司 | 无结晶型态的印地普隆及其制备方法 |
| EP1736475A1 (de) * | 2005-06-21 | 2006-12-27 | Ferrer Internacional, S.A. | Halogenierte Pyrazolo[1,5-a]pyrimidine, Verfahrene, Verwendung und Zwischenprodukte |
-
2005
- 2005-06-21 EP EP05105478A patent/EP1736475A1/de not_active Withdrawn
-
2006
- 2006-06-15 BR BRPI0612075-0A patent/BRPI0612075A2/pt not_active Application Discontinuation
- 2006-06-15 MX MX2007016340A patent/MX2007016340A/es active IP Right Grant
- 2006-06-15 CA CA2612726A patent/CA2612726C/en not_active Expired - Fee Related
- 2006-06-15 ES ES06763737T patent/ES2345999T3/es active Active
- 2006-06-15 PT PT06763737T patent/PT1899343E/pt unknown
- 2006-06-15 US US11/922,602 patent/US8530482B2/en not_active Expired - Fee Related
- 2006-06-15 AT AT06763737T patent/ATE467635T1/de active
- 2006-06-15 DE DE602006014272T patent/DE602006014272D1/de active Active
- 2006-06-15 JP JP2008517470A patent/JP5010591B2/ja not_active Expired - Fee Related
- 2006-06-15 CN CN2006800303968A patent/CN101243089B/zh not_active Expired - Fee Related
- 2006-06-15 RU RU2008101371/04A patent/RU2478101C2/ru not_active IP Right Cessation
- 2006-06-15 PL PL06763737T patent/PL1899343T3/pl unknown
- 2006-06-15 SI SI200630735T patent/SI1899343T1/sl unknown
- 2006-06-15 KR KR1020087001565A patent/KR101465802B1/ko not_active Expired - Fee Related
- 2006-06-15 WO PCT/EP2006/063243 patent/WO2006136530A1/en not_active Ceased
- 2006-06-15 AU AU2006261025A patent/AU2006261025B2/en not_active Ceased
- 2006-06-15 DK DK06763737.1T patent/DK1899343T3/da active
- 2006-06-15 EP EP06763737A patent/EP1899343B1/de not_active Not-in-force
- 2006-06-19 PE PE2006000684A patent/PE20070071A1/es active IP Right Grant
- 2006-06-19 TW TW095121824A patent/TWI382985B/zh not_active IP Right Cessation
- 2006-06-20 AR ARP060102604A patent/AR054785A1/es active IP Right Grant
- 2006-06-21 UY UY29618A patent/UY29618A1/es active IP Right Grant
-
2008
- 2008-01-21 NO NO20080393A patent/NO339973B1/no not_active IP Right Cessation
-
2010
- 2010-08-11 CY CY20101100750T patent/CY1111452T1/el unknown
-
2013
- 2013-08-13 US US13/965,383 patent/US20130331610A1/en not_active Abandoned
- 2013-08-13 US US13/965,516 patent/US10072000B2/en not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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