ATE466095T1 - Stabile faltungszwischenverbindung von apolipoprotein e und verfahren zur verwendung davon - Google Patents

Stabile faltungszwischenverbindung von apolipoprotein e und verfahren zur verwendung davon

Info

Publication number
ATE466095T1
ATE466095T1 AT03784807T AT03784807T ATE466095T1 AT E466095 T1 ATE466095 T1 AT E466095T1 AT 03784807 T AT03784807 T AT 03784807T AT 03784807 T AT03784807 T AT 03784807T AT E466095 T1 ATE466095 T1 AT E466095T1
Authority
AT
Austria
Prior art keywords
stable folding
apoe
apolipoprotein
folding intermediate
activity
Prior art date
Application number
AT03784807T
Other languages
English (en)
Inventor
Karl Weisgraber
Julie Morrow
Original Assignee
David Gladstone Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by David Gladstone Inst filed Critical David Gladstone Inst
Application granted granted Critical
Publication of ATE466095T1 publication Critical patent/ATE466095T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/775—Apolipopeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Endocrinology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Toxicology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
AT03784807T 2002-08-09 2003-07-24 Stabile faltungszwischenverbindung von apolipoprotein e und verfahren zur verwendung davon ATE466095T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40247002P 2002-08-09 2002-08-09
PCT/US2003/023092 WO2004015135A1 (en) 2002-08-09 2003-07-24 Apolipoprotein e stable folding intermediate and methods of use thereof

Publications (1)

Publication Number Publication Date
ATE466095T1 true ATE466095T1 (de) 2010-05-15

Family

ID=31715861

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03784807T ATE466095T1 (de) 2002-08-09 2003-07-24 Stabile faltungszwischenverbindung von apolipoprotein e und verfahren zur verwendung davon

Country Status (6)

Country Link
US (2) US7432355B2 (de)
EP (1) EP1546362B1 (de)
AT (1) ATE466095T1 (de)
AU (1) AU2003261230A1 (de)
DE (1) DE60332366D1 (de)
WO (1) WO2004015135A1 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7785615B2 (en) * 2004-05-28 2010-08-31 Cordis Corporation Biodegradable medical implant with encapsulated buffering agent
US7803182B2 (en) * 2004-05-28 2010-09-28 Cordis Corporation Biodegradable vascular device with buffering agent

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69333461T2 (de) * 1992-10-13 2005-03-24 Duke University VERFAHREN ZUM nachweis der Alzheimer Krankheit
US6022683A (en) * 1996-12-16 2000-02-08 Nova Molecular Inc. Methods for assessing the prognosis of a patient with a neurodegenerative disease
US20020009439A1 (en) 1995-10-17 2002-01-24 Mahley Robert W. Compounds effecting neuron remodeling and assays for same
US6331296B1 (en) 1999-06-01 2001-12-18 Stanley B. Prusiner Food additives which affect conformationally altered proteins
US6322802B1 (en) 1999-06-01 2001-11-27 The Regents Of The University Of California Method of sterilizing
US6046381A (en) 1998-04-30 2000-04-04 The Regents Of The University Of California Apolipoprotein E transgenic mice and assay methods

Also Published As

Publication number Publication date
US20040228851A1 (en) 2004-11-18
US20090017558A1 (en) 2009-01-15
EP1546362A4 (de) 2006-10-11
DE60332366D1 (de) 2010-06-10
EP1546362B1 (de) 2010-04-28
EP1546362A1 (de) 2005-06-29
WO2004015135A1 (en) 2004-02-19
US7432355B2 (en) 2008-10-07
AU2003261230A1 (en) 2004-02-25

Similar Documents

Publication Publication Date Title
ATE429645T1 (de) Verwendung von eph-rezeptor-inhibitoren zur behandlung neurodegenerativer krankheiten
DE602004014117D1 (de) Thiazole zur verwendung als inhibitoren von protein-kinasen
DE602004023829D1 (de) Verfahren zur behandlung von sinuskopfschmerzen
DE69815090D1 (de) Verwendung von cholinesterasehemmer zur behandlung von konzentrationsstörungen
NO20052928L (no) Nye kjemiske forbindelser
DE602004017736D1 (de) Verwendung von rapamycin und dessen derivaten zur behandlung von knochenverlust
ATE507224T1 (de) Verfahren und zwischenverbindungen zur herstellung von n4-phenyl-quinazolin-4-amin derivaten
ATE360417T1 (de) Methode zur behandlung von zytokinvermittelten erkrankungen
ATE450530T1 (de) Zusammensetzungen zur verwendung als protein- kinase-inhibitoren
ATE409037T1 (de) Verfahren zur erhöhung der leptinspiegel unter verwendung von nikotinsäureverbindungen
ATE495243T1 (de) Verfahren zur herstellung von hochempfindlichen endonukleasen, neuartige zubereitungen von nukleasen und ihre verwendung
ATE471722T1 (de) Verfahren zur regulierung von angiogenese mit apelin-zusammensetzungen
ATE478661T1 (de) Verfahren zur reduzierung der angiogenese
DE60232956D1 (de) Verfahren zur behandlung von stressbedingten erkrankungen unter verwendung von glucocorticoid-rezepto-spezifischen antagonisten
ATE481101T1 (de) Verfahren zur behandlung von angstzuständen
DE602005021766D1 (de) Verfahren zur behandlung von atherosklerose
DE60314730D1 (de) Verwendung von 4-aminopyrimidinen zur antimikrobiellen behandlung von oberflächen
DE60325194D1 (de) Methoden zur verwendung von lamellaren körpern für therapeutische zwecke
ATE372114T1 (de) Verfahren zur erhöhung des testosteronspiegels
ATE466095T1 (de) Stabile faltungszwischenverbindung von apolipoprotein e und verfahren zur verwendung davon
DE60323533D1 (de) Methode zur stimulierung von haarwuchs auf der basis von benzopyranen
ATE333869T1 (de) Verwendung von mglur5 antagonisten zur behandlung von pruritischen zuständen
ATE361755T1 (de) Verwendung von thrombomodulinanaloga zur regenerierung von rückenmarkverletzungen
DE60212757D1 (de) Verfahren zur Verwendung von Pyrrolederivaten gegen Zwangsstörungen
ATE397085T1 (de) Verfahren zur reproduzierung von pleuromutilinen

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties