ATE429645T1 - Verwendung von eph-rezeptor-inhibitoren zur behandlung neurodegenerativer krankheiten - Google Patents
Verwendung von eph-rezeptor-inhibitoren zur behandlung neurodegenerativer krankheitenInfo
- Publication number
- ATE429645T1 ATE429645T1 AT05811604T AT05811604T ATE429645T1 AT E429645 T1 ATE429645 T1 AT E429645T1 AT 05811604 T AT05811604 T AT 05811604T AT 05811604 T AT05811604 T AT 05811604T AT E429645 T1 ATE429645 T1 AT E429645T1
- Authority
- AT
- Austria
- Prior art keywords
- neurodegenerative diseases
- eph receptor
- receptor inhibitors
- treat neurodegenerative
- inhibitors
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 3
- 108091008815 Eph receptors Proteins 0.000 title abstract 2
- 208000015122 neurodegenerative disease Diseases 0.000 title abstract 2
- VHNYOQKVZQVBLC-RTCGXNAVSA-N (4r,7e,9as)-7-[[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]methylidene]-4-(3,4,5-trifluorophenyl)-1,3,4,8,9,9a-hexahydropyrido[2,1-c][1,4]oxazin-6-one Chemical compound C1([C@@H]2COC[C@@H]3CC\C(C(N32)=O)=C/C=2C=C(C(=CC=2)N2C=C(C)N=C2)OC)=CC(F)=C(F)C(F)=C1 VHNYOQKVZQVBLC-RTCGXNAVSA-N 0.000 abstract 1
- 102000050554 Eph Family Receptors Human genes 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000004770 neurodegeneration Effects 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
- 229940124648 γ-Secretase Modulator Drugs 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/715—Assays involving receptors, cell surface antigens or cell surface determinants for cytokines; for lymphokines; for interferons
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
- G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
- G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2821—Alzheimer
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Physics & Mathematics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Psychiatry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Hospice & Palliative Care (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04028046A EP1662259A1 (de) | 2004-11-25 | 2004-11-25 | Verwendung von Eph Rezeptor-Inhibitoren zur Behandlung von neurodegenerativen Erkrankungen |
| US63059204P | 2004-11-26 | 2004-11-26 | |
| PCT/EP2005/012649 WO2006056467A1 (en) | 2004-11-25 | 2005-11-25 | Use of eph receptor inhibitors for the treatment of neurodegenerative diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE429645T1 true ATE429645T1 (de) | 2009-05-15 |
Family
ID=34927535
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05811604T ATE429645T1 (de) | 2004-11-25 | 2005-11-25 | Verwendung von eph-rezeptor-inhibitoren zur behandlung neurodegenerativer krankheiten |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20080213250A1 (de) |
| EP (2) | EP1662259A1 (de) |
| AT (1) | ATE429645T1 (de) |
| CA (1) | CA2589173A1 (de) |
| DE (1) | DE602005014134D1 (de) |
| WO (1) | WO2006056467A1 (de) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2610685A1 (en) * | 2005-06-03 | 2006-12-14 | Novartis Vaccines And Diagnostics, Inc. | Methods of treating, diagnosing or detecting cancer using an ephb3 modulator |
| EP2484782B1 (de) | 2006-01-05 | 2015-11-18 | The Ohio State University Research Foundation | Verfahren und Zusammensetzungen auf Mikro-RNA-Basis zur Diagnose und Behandlung von soliden Krebs |
| ES2446362T3 (es) | 2006-03-20 | 2014-03-07 | The Ohio State University Research Foundation | Huellas de microARN durante megacariocipoyesis humana |
| DE602006004196D1 (de) * | 2006-06-01 | 2009-01-22 | Cellzome Ag | Verfahren zur Identifizierung von mit ZAP-70 wechselwirkenden Molekülen und zur ZAP-70-Reinigung |
| GB0624689D0 (en) * | 2006-12-11 | 2007-01-17 | Glaxo Group Ltd | Novel fluorescent kinase ligands and methods employing the same |
| DK2134374T3 (en) | 2007-03-14 | 2014-02-24 | Bionsil S R L In Liquidazione | BTK-INHIBITORS FOR USE IN PROCESSING chemotherapeutic agent RESISTANT TUMORS Epithelial |
| EP2166110B1 (de) * | 2007-06-08 | 2012-02-22 | Eisai R&D Management Co., Ltd. | Screening-verfahren mit verwendung des neuen substrats epha4 für gamma-sekretase |
| EP2177623A4 (de) * | 2007-07-19 | 2010-12-29 | Eisai R&D Man Co Ltd | SCREENINGVERFAHREN MIT c-MET, EINEM NEUEN SUBSTRAT FÜR GAMMA-SEKRETASE |
| WO2009017234A1 (ja) * | 2007-08-01 | 2009-02-05 | Eisai R & D Management Co., Ltd. | γ-セクレターゼの新規基質c-Retを利用したスクリーニング方法 |
| EP2653561B1 (de) | 2007-08-03 | 2016-03-02 | The Ohio State University Research Foundation | Ultrakonservierte Bereiche zur Codierung von ncRNA |
| EP3028708A1 (de) * | 2007-08-22 | 2016-06-08 | The Ohio State University Research Foundation | Verfahren und zusammensetzungen zur induzierung von epha7-deregulierung und erk-phosphorlylierung bei humaner akuter leukämie |
| US8530181B2 (en) * | 2007-11-15 | 2013-09-10 | Eisai R&D Management Co., Ltd. | Method of screening for compounds which affect the cleavage of EphA7 byγ-secretase |
| US7892769B2 (en) * | 2007-11-30 | 2011-02-22 | Eisai R&D Management Co., Ltd. | Processing of EphA4 polypeptide by γ-secretase activity |
| US20100197688A1 (en) * | 2008-05-29 | 2010-08-05 | Nantermet Philippe G | Epha4 rtk inhibitors for treatment of neurological and neurodegenerative disorders and cancer |
| US20100113415A1 (en) * | 2008-05-29 | 2010-05-06 | Rajapakse Hemaka A | Epha4 rtk inhibitors for treatment of neurological and neurodegenerative disorders and cancer |
| EP2297580B1 (de) | 2008-06-09 | 2015-03-04 | Oxford Biotherapeutics Ltd. | Antikörper gegen Ephrin Typ-A-Rezeptor-7 zur Behandlung von Blasenkrebs |
| US20100256214A1 (en) * | 2009-04-02 | 2010-10-07 | Burnham Institute For Medical Research | Eph receptor ligands and methods of use |
| WO2010141974A1 (en) * | 2009-06-10 | 2010-12-16 | The University Of Melbourne | Therapeutic applications |
| US8159780B2 (en) | 2009-07-15 | 2012-04-17 | Seagate Technology Llc | Recording head heater systems with two electrical connections |
| CN102639700A (zh) | 2009-09-30 | 2012-08-15 | 哈佛大学校长及研究员协会 | 通过调节自噬增强基因产物调节自噬的方法 |
| WO2012065049A1 (en) | 2010-11-12 | 2012-05-18 | The Ohio State University Research Foundation | Materials and methods related to microrna-21, mismatch repair, and colorectal cancer |
| WO2012067839A2 (en) * | 2010-11-15 | 2012-05-24 | The J. David Gladstone Institutes | Methods of treating neurodegenerative disease |
| CA2817982C (en) | 2010-11-15 | 2020-06-30 | The Regents Of The University Of Michigan | Controlled release mucoadhesive systems |
| WO2012081502A1 (ja) | 2010-12-17 | 2012-06-21 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ゼラチナーゼによるEphA4の切断反応を指標としたスクリーニング方法 |
| US9784751B2 (en) | 2011-04-25 | 2017-10-10 | Eisai R&D Management Co., Ltd. | Method for detecting neurological disease associated with cognitive impairment by measuring EphA4 extracellular domain |
| CA2852066A1 (en) | 2011-10-14 | 2013-04-18 | The Ohio State University | Methods and materials related to ovarian cancer |
| EP2790735A4 (de) | 2011-12-13 | 2015-12-09 | Ohio State Innovation Foundation | Verfahren und zusammensetzungen im zusammenhang mit mir-21 und mir-29a, exosomerhemmung und krebsmetastasen |
| JP2015511121A (ja) | 2012-01-20 | 2015-04-16 | ジ・オハイオ・ステート・ユニバーシティ | 浸潤性および予後に関する乳がんバイオマーカーシグネチャー |
| PE20181051A1 (es) * | 2015-09-08 | 2018-07-03 | Eisai Randd Man Co Ltd | Anticuerpo anti-epha4 |
| EP3995582B1 (de) | 2019-07-01 | 2026-04-22 | Eisai R&D Management Co., Ltd. | Anti-epha4-antikörper |
| EP4436999A4 (de) * | 2021-11-22 | 2025-10-22 | Univ China Medical | Mono- oder multispezifischer antikörper gegen ephrin-typ-a-rezeptor 10, chimäre antigenrezeptor-t-zelle, die diesen exprimiert, und verwendungen davon |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2548699A (en) * | 1998-02-23 | 1999-09-06 | Rei Asakai | Cell death inhibitors |
| GB9828640D0 (en) * | 1998-12-23 | 1999-02-17 | Smithkline Beecham Plc | Novel method and compounds |
| EP1469810A4 (de) * | 2002-01-04 | 2009-01-14 | Univ Rockefeller | Zusammensetzungen und verfahren zur verhütung und behandlung von erkrankungen im zusammenhang mit amyloid-beta peptid |
| JP2005531609A (ja) * | 2002-06-05 | 2005-10-20 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | キナーゼ阻害剤としてのシスインドリル−マレイミド誘導体 |
| JP2006507256A (ja) * | 2002-09-24 | 2006-03-02 | ザ バーナム インスティチュート | Ｅｐｈ受容体活性を調節する新規薬剤 |
-
2004
- 2004-11-25 EP EP04028046A patent/EP1662259A1/de not_active Withdrawn
-
2005
- 2005-11-25 CA CA002589173A patent/CA2589173A1/en not_active Abandoned
- 2005-11-25 US US11/791,289 patent/US20080213250A1/en not_active Abandoned
- 2005-11-25 AT AT05811604T patent/ATE429645T1/de not_active IP Right Cessation
- 2005-11-25 EP EP05811604A patent/EP1815255B1/de not_active Expired - Lifetime
- 2005-11-25 DE DE602005014134T patent/DE602005014134D1/de not_active Expired - Fee Related
- 2005-11-25 WO PCT/EP2005/012649 patent/WO2006056467A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP1815255B1 (de) | 2009-04-22 |
| EP1662259A1 (de) | 2006-05-31 |
| EP1815255A1 (de) | 2007-08-08 |
| US20080213250A1 (en) | 2008-09-04 |
| DE602005014134D1 (de) | 2009-06-04 |
| WO2006056467A1 (en) | 2006-06-01 |
| CA2589173A1 (en) | 2006-06-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |