ATE429645T1 - Verwendung von eph-rezeptor-inhibitoren zur behandlung neurodegenerativer krankheiten - Google Patents
Verwendung von eph-rezeptor-inhibitoren zur behandlung neurodegenerativer krankheitenInfo
- Publication number
- ATE429645T1 ATE429645T1 AT05811604T AT05811604T ATE429645T1 AT E429645 T1 ATE429645 T1 AT E429645T1 AT 05811604 T AT05811604 T AT 05811604T AT 05811604 T AT05811604 T AT 05811604T AT E429645 T1 ATE429645 T1 AT E429645T1
- Authority
- AT
- Austria
- Prior art keywords
- neurodegenerative diseases
- eph receptor
- receptor inhibitors
- treat neurodegenerative
- inhibitors
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 3
- 108091008815 Eph receptors Proteins 0.000 title abstract 2
- 208000015122 neurodegenerative disease Diseases 0.000 title abstract 2
- VHNYOQKVZQVBLC-RTCGXNAVSA-N (4r,7e,9as)-7-[[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]methylidene]-4-(3,4,5-trifluorophenyl)-1,3,4,8,9,9a-hexahydropyrido[2,1-c][1,4]oxazin-6-one Chemical compound C1([C@@H]2COC[C@@H]3CC\C(C(N32)=O)=C/C=2C=C(C(=CC=2)N2C=C(C)N=C2)OC)=CC(F)=C(F)C(F)=C1 VHNYOQKVZQVBLC-RTCGXNAVSA-N 0.000 abstract 1
- 102000050554 Eph Family Receptors Human genes 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000004770 neurodegeneration Effects 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
- 229940124648 γ-Secretase Modulator Drugs 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/715—Assays involving receptors, cell surface antigens or cell surface determinants for cytokines; for lymphokines; for interferons
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
- G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
- G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2821—Alzheimer
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pathology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Neurosurgery (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Neurology (AREA)
- General Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04028046A EP1662259A1 (de) | 2004-11-25 | 2004-11-25 | Verwendung von Eph Rezeptor-Inhibitoren zur Behandlung von neurodegenerativen Erkrankungen |
| US63059204P | 2004-11-26 | 2004-11-26 | |
| PCT/EP2005/012649 WO2006056467A1 (en) | 2004-11-25 | 2005-11-25 | Use of eph receptor inhibitors for the treatment of neurodegenerative diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE429645T1 true ATE429645T1 (de) | 2009-05-15 |
Family
ID=34927535
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05811604T ATE429645T1 (de) | 2004-11-25 | 2005-11-25 | Verwendung von eph-rezeptor-inhibitoren zur behandlung neurodegenerativer krankheiten |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20080213250A1 (de) |
| EP (2) | EP1662259A1 (de) |
| AT (1) | ATE429645T1 (de) |
| CA (1) | CA2589173A1 (de) |
| DE (1) | DE602005014134D1 (de) |
| WO (1) | WO2006056467A1 (de) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2610685A1 (en) * | 2005-06-03 | 2006-12-14 | Novartis Vaccines And Diagnostics, Inc. | Methods of treating, diagnosing or detecting cancer using an ephb3 modulator |
| CN103642900B (zh) | 2006-01-05 | 2016-04-13 | 俄亥俄州立大学研究基金会 | 用于诊断和治疗实体癌的基于微小rna的方法和组合物 |
| CN101448958A (zh) | 2006-03-20 | 2009-06-03 | 俄亥俄州立大学研究基金会 | 人巨核细胞生成期间的微小rna指纹 |
| DE602006004196D1 (de) * | 2006-06-01 | 2009-01-22 | Cellzome Ag | Verfahren zur Identifizierung von mit ZAP-70 wechselwirkenden Molekülen und zur ZAP-70-Reinigung |
| GB0624689D0 (en) * | 2006-12-11 | 2007-01-17 | Glaxo Group Ltd | Novel fluorescent kinase ligands and methods employing the same |
| WO2008110624A2 (en) | 2007-03-14 | 2008-09-18 | Universita' Degli Studi Di Milano-Bicocca | Sirna-mediated silencing of genes for treating chemotherapeutic drug-resistant epithelial tumors |
| ATE546543T1 (de) * | 2007-06-08 | 2012-03-15 | Eisai R&D Man Co Ltd | Screening-verfahren mit verwendung des neuen substrats epha4 für gamma-sekretase |
| EP2177623A4 (de) * | 2007-07-19 | 2010-12-29 | Eisai R&D Man Co Ltd | SCREENINGVERFAHREN MIT c-MET, EINEM NEUEN SUBSTRAT FÜR GAMMA-SEKRETASE |
| WO2009017234A1 (ja) * | 2007-08-01 | 2009-02-05 | Eisai R & D Management Co., Ltd. | γ-セクレターゼの新規基質c-Retを利用したスクリーニング方法 |
| ES2627059T3 (es) | 2007-08-03 | 2017-07-26 | The Ohio State University Research Foundation | Regiones ultraconservadas que codifican ARNnc |
| ES2562078T3 (es) * | 2007-08-22 | 2016-03-02 | The Ohio State University Research Foundation | Métodos y composiciones para inducir la desregulación de la fosforilación de EphA7 y ERK en leucemias agudas humanas |
| JP5580598B2 (ja) * | 2007-11-15 | 2014-08-27 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | γ−セクレターゼの新規基質ＥｐｈＡ７を利用したスクリーニング方法 |
| US7892769B2 (en) * | 2007-11-30 | 2011-02-22 | Eisai R&D Management Co., Ltd. | Processing of EphA4 polypeptide by γ-secretase activity |
| US20100113415A1 (en) * | 2008-05-29 | 2010-05-06 | Rajapakse Hemaka A | Epha4 rtk inhibitors for treatment of neurological and neurodegenerative disorders and cancer |
| US20100197688A1 (en) * | 2008-05-29 | 2010-08-05 | Nantermet Philippe G | Epha4 rtk inhibitors for treatment of neurological and neurodegenerative disorders and cancer |
| WO2009150513A2 (en) * | 2008-06-09 | 2009-12-17 | Oxford Biotherapeutics Ltd. | Protein |
| US20100256214A1 (en) * | 2009-04-02 | 2010-10-07 | Burnham Institute For Medical Research | Eph receptor ligands and methods of use |
| WO2010141974A1 (en) * | 2009-06-10 | 2010-12-16 | The University Of Melbourne | Therapeutic applications |
| US8159780B2 (en) | 2009-07-15 | 2012-04-17 | Seagate Technology Llc | Recording head heater systems with two electrical connections |
| JP2013506686A (ja) | 2009-09-30 | 2013-02-28 | プレジデント アンド フェロウズ オブ ハーバード カレッジ | オートファジー阻害遺伝子産物の変調によりオートファジーを変調する方法 |
| WO2012065049A1 (en) | 2010-11-12 | 2012-05-18 | The Ohio State University Research Foundation | Materials and methods related to microrna-21, mismatch repair, and colorectal cancer |
| AU2011329066B2 (en) | 2010-11-15 | 2017-03-09 | The Ohio State University Research Foundation | Controlled release mucoadhesive systems |
| US9101644B2 (en) | 2010-11-15 | 2015-08-11 | The J. David Gladstone Institutes | Methods of treating neurodegenerative disease |
| EP2653552B1 (de) | 2010-12-17 | 2016-10-19 | Eisai R&D Management Co., Ltd. | Screeningverfahren als index mit epha4-spaltungsreaktion durch gelatinase |
| EP2703814B1 (de) | 2011-04-25 | 2017-11-01 | Eisai R&D Management Co., Ltd. | Verfahren zum nachweis von neurologischen krankheiten im zusammenhang mit kognitiver dysfunktion durch messung der extrazellulären domäne von epha4 |
| AU2012323924A1 (en) | 2011-10-14 | 2014-05-29 | The Ohio State University | Methods and materials related to ovarian cancer |
| AU2012352265B2 (en) | 2011-12-13 | 2017-02-16 | Ohio State Innovation Foundation | Methods and compositions related to miR-21 and miR-29a, exosome inhibition, and cancer metastasis |
| EP2804960A4 (de) | 2012-01-20 | 2015-08-19 | Univ Ohio State | Brustkrebsbiomarkersignaturen für invasivität und prognose |
| EP3381941B1 (de) * | 2015-09-08 | 2020-11-11 | Eisai R&D Management Co., Ltd. | Anti-epha4-antikörper |
| NZ783106A (en) | 2019-07-01 | 2025-08-29 | Eisai R&D Man Co Ltd | Anti-epha4 antibody |
| TWI853348B (zh) * | 2021-11-22 | 2024-08-21 | 中國醫藥大學 | Ephrin a型受體10特異性抗體、表現其之嵌合抗原受體t細胞及其應用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1057484A4 (de) * | 1998-02-23 | 2002-11-20 | Sagami Chem Res | Inhibitoren des zelltodes |
| GB9828640D0 (en) * | 1998-12-23 | 1999-02-17 | Smithkline Beecham Plc | Novel method and compounds |
| IL162838A0 (en) * | 2002-01-04 | 2005-11-20 | Univ Rockefeller | Compositions and methods for prevention and treatment peptide-of amyloid- related disorders |
| WO2003104222A1 (en) * | 2002-06-05 | 2003-12-18 | Janssen Pharmaceutica N.V. | Bisindolyl-maleimid derivatives as kinase inhibitors |
| WO2004028551A1 (en) * | 2002-09-24 | 2004-04-08 | The Burnham Institute | Novel agents that modulate eph receptor activity |
-
2004
- 2004-11-25 EP EP04028046A patent/EP1662259A1/de not_active Withdrawn
-
2005
- 2005-11-25 US US11/791,289 patent/US20080213250A1/en not_active Abandoned
- 2005-11-25 AT AT05811604T patent/ATE429645T1/de not_active IP Right Cessation
- 2005-11-25 CA CA002589173A patent/CA2589173A1/en not_active Abandoned
- 2005-11-25 WO PCT/EP2005/012649 patent/WO2006056467A1/en not_active Ceased
- 2005-11-25 EP EP05811604A patent/EP1815255B1/de not_active Expired - Lifetime
- 2005-11-25 DE DE602005014134T patent/DE602005014134D1/de not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2589173A1 (en) | 2006-06-01 |
| DE602005014134D1 (de) | 2009-06-04 |
| US20080213250A1 (en) | 2008-09-04 |
| EP1815255B1 (de) | 2009-04-22 |
| WO2006056467A1 (en) | 2006-06-01 |
| EP1815255A1 (de) | 2007-08-08 |
| EP1662259A1 (de) | 2006-05-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE429645T1 (de) | Verwendung von eph-rezeptor-inhibitoren zur behandlung neurodegenerativer krankheiten | |
| MX2010002674A (es) | Moduladores de gamma secretasa. | |
| EA200970403A1 (ru) | Бициклические триазолы в качестве модуляторов протеинкиназы | |
| ATE399155T1 (de) | Imidazolverbindungen zur behandlung von neurodegenerativen erkrankungen | |
| MX2010006379A (es) | Moduladores de la secretasa gamma. | |
| MX2010005028A (es) | Moduladores de gamma secretasa. | |
| DE602006019560D1 (de) | 2-cyanobenzolsulfonamidverbindungen zur behandlung von samen | |
| EP1881823A4 (de) | Zusammensetzungen und verfahren zur behandlung von augenleiden | |
| ATE414089T1 (de) | Verwendung von rapamycin und dessen derivaten zur behandlung von knochenverlust | |
| EA200900802A1 (ru) | Способы и композиции для лечения амилоидных заболеваний | |
| TNSN07027A1 (en) | Pyrrolo-pyridine kinase modulators | |
| EA200600078A1 (ru) | Способы и композиции для лечения амилоидных заболеваний | |
| DK1836169T3 (da) | Sammensætninger og fremgangsmåder til behandling af celleproliferationslidelser | |
| ATE512948T1 (de) | Biphenyl-sulfonyl- und phenyl-heteroaryl-sulfonyl-modulatoren des histamin-h3-rezeptors zur behandlung von damit verbundenen erkrankungen | |
| EP1732484A4 (de) | Ophthalmisches implantat zur behandlung von glaukom | |
| EA202091559A1 (ru) | Способ получения модуляторов соматостатина | |
| ATE542536T1 (de) | 3-ä4-(dibenzoäb,füä1,4üoxazepin-11-yl)-piperazi - 1-ylü-2,2-dimethyl propansäure zur verwendung in der behandlung von schlafstörungen | |
| DE502005010499D1 (de) | Implantat zur Behandlung von Fettsucht | |
| ATE421501T1 (de) | 2,7-substituierte 5-amino-4-hydroxy-8-(1h-indol-5-yl)-octanamid derivate als renin inhibitoren zur behandlung von bluthochdruck | |
| NO20073369L (no) | Modulatorer av muskarinreseptorer | |
| DE602004022035D1 (de) | Verwendung von pthalide derivativen zur behandlung | |
| ATE423110T1 (de) | Verbindungen, zusammensetzungen und verfahren zur behandlung von zellulären proliferativen erkrankungen | |
| EP4149464A4 (de) | Thiolhaltige verbindungen zur verwendung bei der behandlung von coronavirus | |
| WO2010147969A3 (en) | Gamma secretase modulators | |
| MX2010001501A (es) | Moduladores de gamma secretasa. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |