ATE464392T1 - Verfahren zur identifizierung einzelner aktiver einheiten aus komplexen gemischen - Google Patents
Verfahren zur identifizierung einzelner aktiver einheiten aus komplexen gemischenInfo
- Publication number
- ATE464392T1 ATE464392T1 AT03739241T AT03739241T ATE464392T1 AT E464392 T1 ATE464392 T1 AT E464392T1 AT 03739241 T AT03739241 T AT 03739241T AT 03739241 T AT03739241 T AT 03739241T AT E464392 T1 ATE464392 T1 AT E464392T1
- Authority
- AT
- Austria
- Prior art keywords
- ligand
- entity
- support
- complex
- complex mixtures
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 title abstract 4
- 239000003446 ligand Substances 0.000 abstract 2
- 238000012216 screening Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B30/00—Methods of screening libraries
- C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- Organic Chemistry (AREA)
- Microbiology (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- Tropical Medicine & Parasitology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US39503802P | 2002-07-11 | 2002-07-11 | |
PCT/US2003/019584 WO2004007757A1 (en) | 2002-07-11 | 2003-06-20 | Method for identifying individual active entities from complex mixtures |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE464392T1 true ATE464392T1 (de) | 2010-04-15 |
Family
ID=30115803
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT03739241T ATE464392T1 (de) | 2002-07-11 | 2003-06-20 | Verfahren zur identifizierung einzelner aktiver einheiten aus komplexen gemischen |
Country Status (9)
Country | Link |
---|---|
US (1) | US20040101830A1 (de) |
EP (1) | EP1521841B1 (de) |
JP (1) | JP4486497B2 (de) |
CN (1) | CN1671859A (de) |
AT (1) | ATE464392T1 (de) |
AU (1) | AU2003245612A1 (de) |
CA (1) | CA2491969A1 (de) |
DE (1) | DE60332115D1 (de) |
WO (1) | WO2004007757A1 (de) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060275753A1 (en) * | 2002-04-15 | 2006-12-07 | Hammond David J | Recovery of analytes using combinatorial libraries |
EP1580559B1 (de) * | 2004-03-23 | 2013-12-25 | Bio-Rad Laboratories, Inc. | Methoden zur Verringerung der Varianz der Analytkonzentrationen von komplexen Probenmischungen |
US20090247421A1 (en) * | 2005-03-23 | 2009-10-01 | Egisto Boschetti | Diverse chemical libraries bound to small particles with paramagnetic properties |
US7754861B2 (en) * | 2005-03-23 | 2010-07-13 | Bio-Rad Laboratories, Inc. | Method for purifying proteins |
EP1734367A1 (de) * | 2005-06-14 | 2006-12-20 | Cellzome Ag | Verfahren zum Auffinden von neuen Verbindungen, die mit einem Enzym in Wechselwirkung treten |
DE102005047301B4 (de) * | 2005-09-30 | 2009-04-16 | Sartorius Stedim Biotech Gmbh | Verfahren zum Nachweis der Virenabreicherung für die Validierung von Filtern und Filtrationsprozessen |
WO2012129423A2 (en) | 2011-03-24 | 2012-09-27 | Opko Pharmaceuticals, Llc | Biomarker discovery in complex biological fluid using bead or particle based libraries and diagnostic kits and therapeutics |
JP5648613B2 (ja) * | 2011-09-12 | 2015-01-07 | コニカミノルタ株式会社 | 表面プラズモン励起増強蛍光分光法用センサチップおよびそれを用いた測定方法 |
US9220733B2 (en) | 2012-03-19 | 2015-12-29 | The Regents Of The University Of California | Solubilization of antigen components for removal from tissues |
US11899020B2 (en) | 2017-03-31 | 2024-02-13 | The Regents Of The University Of California | Shotgun proteomic antigen identification |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6034997A (ja) * | 1983-05-09 | 1985-02-22 | ジヨージ、ジヨセフ、トダロ | 生物学的活性ポリペプチド類 |
US5133866A (en) * | 1988-03-24 | 1992-07-28 | Terrapin Technologies, Inc. | Method to identify analyte-bending ligands |
US5010175A (en) * | 1988-05-02 | 1991-04-23 | The Regents Of The University Of California | General method for producing and selecting peptides with specific properties |
US5252743A (en) * | 1989-11-13 | 1993-10-12 | Affymax Technologies N.V. | Spatially-addressable immobilization of anti-ligands on surfaces |
US5498538A (en) * | 1990-02-15 | 1996-03-12 | The University Of North Carolina At Chapel Hill | Totally synthetic affinity reagents |
US5650489A (en) * | 1990-07-02 | 1997-07-22 | The Arizona Board Of Regents | Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof |
IL106106A0 (en) | 1993-06-22 | 1993-10-20 | Interpharm Lab Ltd | Library of polymeric molecules and its preparation |
US5723579A (en) * | 1996-02-02 | 1998-03-03 | Bayer Corporation | Fibrinogen binding peptides |
US5786458A (en) * | 1996-06-28 | 1998-07-28 | Bayer Corporation | Selective stabilization of protein during viral inactivation |
WO2001040265A2 (en) * | 1999-12-02 | 2001-06-07 | V.I. Technologies, Inc. | Ligands for a target molecule and a method for indentifying them |
AU2001268173A1 (en) * | 2000-06-05 | 2001-12-17 | Chiron Corporation | Microarrays for performing proteomic analyses |
WO2003088990A1 (en) * | 2002-04-15 | 2003-10-30 | American National Red Cross | Plasma protein-binding ligands |
-
2003
- 2003-06-20 AU AU2003245612A patent/AU2003245612A1/en not_active Abandoned
- 2003-06-20 JP JP2004521476A patent/JP4486497B2/ja not_active Expired - Fee Related
- 2003-06-20 CA CA002491969A patent/CA2491969A1/en not_active Abandoned
- 2003-06-20 DE DE60332115T patent/DE60332115D1/de not_active Expired - Lifetime
- 2003-06-20 US US10/601,032 patent/US20040101830A1/en not_active Abandoned
- 2003-06-20 AT AT03739241T patent/ATE464392T1/de not_active IP Right Cessation
- 2003-06-20 WO PCT/US2003/019584 patent/WO2004007757A1/en active Application Filing
- 2003-06-20 EP EP03739241A patent/EP1521841B1/de not_active Expired - Lifetime
- 2003-06-20 CN CN03816492.2A patent/CN1671859A/zh active Pending
Also Published As
Publication number | Publication date |
---|---|
EP1521841A4 (de) | 2006-09-20 |
EP1521841B1 (de) | 2010-04-14 |
AU2003245612A1 (en) | 2004-02-02 |
US20040101830A1 (en) | 2004-05-27 |
JP4486497B2 (ja) | 2010-06-23 |
WO2004007757A1 (en) | 2004-01-22 |
CN1671859A (zh) | 2005-09-21 |
DE60332115D1 (de) | 2010-05-27 |
EP1521841A1 (de) | 2005-04-13 |
JP2005532569A (ja) | 2005-10-27 |
CA2491969A1 (en) | 2004-01-22 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE455304T1 (de) | Verfahren zur selektiven zielen | |
ATE464392T1 (de) | Verfahren zur identifizierung einzelner aktiver einheiten aus komplexen gemischen | |
DE602004030472D1 (de) | Vorrichtung und verfahren zur quantifizierung von mrna aus vollblut mit hohem durchsatz | |
DE60328885D1 (de) | Verfahren zur Beurteilung eines Krankheitzustandes mittels Nachweis von partikel- und nicht partikelgebundenen Nukleinsäuren in Blutplasma und -serum | |
WO2005063817A3 (en) | Methods for identifying functional antibodies | |
CR10025A (es) | Formatos de anticuerpos de dominio competitivos que se enlazan con el receptor de interleucina-1 tipo-1 | |
DK1631318T3 (da) | Magnetiske nanopartikler bundet til en ligand | |
ATE417274T1 (de) | Verfahren zur identifizierung von mit zap-70 wechselwirkenden molekülen und zur zap-70- reinigung | |
WO2004062553A3 (en) | Affinity screening using “one-bead-one-compound” libraries | |
ATE414281T1 (de) | Verfahren zur identifizierung von molekülen die mit pi3k interagieren und verfahren zur reinigung von pi3k | |
IL183146A0 (en) | A nucleic acid which encodes a ligand binding fluorescent indicator and methods for detection and quantification of ligands utilizing the same | |
ATE469393T1 (de) | Verfahren zur bildung von prozessorenclusters und bestimmung von dienstpunkten in einem system | |
EP1129773A3 (de) | Verfahren zur in-situ Synthese einer kombinatorischen Bibliothek von getragenen Katalysatormaterialien | |
DE602004016009D1 (de) | Verfahren zur erfassung von mehreren analyten | |
DE50205750D1 (de) | Liganden für den nachweis von prionen | |
FR2849246B1 (fr) | Procede de determination du caractere vivant d'un element porteur d'une empreinte digitale | |
FR2849244B1 (fr) | Procede de determination du caractere vivant d'un element porteur d'une empreinte digitale | |
ATE377644T1 (de) | Systeme und verfahren zum nachweis der funktion nukleärer rezeptoren unter verwendung von reporterenzymmutanten komplementierungen | |
DE69731964D1 (de) | Map-kinase: polypeptide, polynukleotide und ihre verwendung | |
SE0301058D0 (sv) | Method and kit for cell analyte assay | |
ATE343785T1 (de) | Produkte und verfahren für einzelwert- und vielfachwert-phänotypisierung von zellen | |
WO2002057792A3 (en) | Affinity selection-based screening of hydrophobic proteins | |
WO2003093817A3 (en) | Method of identifying ligands for nuclear receptors | |
ATE412187T1 (de) | Screening test | |
DE60322717D1 (de) | Verfahren zum screening von antiligand-bibliotheken zur identifizierung von antiliganden, die spezifisch für unterschiedliche und selten experimierte liganden sind |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |