ATE377644T1 - Systeme und verfahren zum nachweis der funktion nukleärer rezeptoren unter verwendung von reporterenzymmutanten komplementierungen - Google Patents
Systeme und verfahren zum nachweis der funktion nukleärer rezeptoren unter verwendung von reporterenzymmutanten komplementierungenInfo
- Publication number
- ATE377644T1 ATE377644T1 AT03723800T AT03723800T ATE377644T1 AT E377644 T1 ATE377644 T1 AT E377644T1 AT 03723800 T AT03723800 T AT 03723800T AT 03723800 T AT03723800 T AT 03723800T AT E377644 T1 ATE377644 T1 AT E377644T1
- Authority
- AT
- Austria
- Prior art keywords
- methods
- systems
- nuclear receptor
- detecting
- function
- Prior art date
Links
- 108020005497 Nuclear hormone receptor Proteins 0.000 title abstract 6
- 238000000034 method Methods 0.000 title abstract 6
- 102000006255 nuclear receptors Human genes 0.000 title abstract 6
- 108020004017 nuclear receptors Proteins 0.000 title abstract 6
- 239000003446 ligand Substances 0.000 abstract 3
- 238000003556 assay Methods 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 102000004164 orphan nuclear receptors Human genes 0.000 abstract 2
- 108090000629 orphan nuclear receptors Proteins 0.000 abstract 2
- 238000012216 screening Methods 0.000 abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 230000000295 complement effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 239000002547 new drug Substances 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 230000007363 regulatory process Effects 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6875—Nucleoproteins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Monitoring And Testing Of Nuclear Reactors (AREA)
- Transmission And Conversion Of Sensor Element Output (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36652402P | 2002-03-25 | 2002-03-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE377644T1 true ATE377644T1 (de) | 2007-11-15 |
Family
ID=29270478
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03723800T ATE377644T1 (de) | 2002-03-25 | 2003-03-25 | Systeme und verfahren zum nachweis der funktion nukleärer rezeptoren unter verwendung von reporterenzymmutanten komplementierungen |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20040029187A1 (de) |
| EP (1) | EP1520010B1 (de) |
| JP (1) | JP2005521430A (de) |
| AT (1) | ATE377644T1 (de) |
| AU (1) | AU2003230710A1 (de) |
| DE (1) | DE60317330T2 (de) |
| WO (1) | WO2003090515A2 (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007512359A (ja) * | 2003-11-19 | 2007-05-17 | メタバシス・セラピューティクス・インコーポレイテッド | 新規なリン含有甲状腺ホルモン様物質 |
| RU2007148927A (ru) * | 2005-05-26 | 2009-07-10 | Метабэйзис Терапьютикс, Инк. (Us) | Новые тиреомиметики, содержащие фосфиновую кислоту |
| CA2606499C (en) | 2005-05-26 | 2017-06-13 | Metabasis Therapeutics, Inc. | Thyromimetics for the treatment of fatty liver diseases |
| JP2009512460A (ja) * | 2005-10-24 | 2009-03-26 | ディスカヴァーエックス インコーポレイテッド | 細胞内の酵素複合体の検出方法 |
| WO2014113585A1 (en) | 2013-01-16 | 2014-07-24 | Massachusetts Institute Of Technology | Split peroxidases and methods of use |
| HK1248811A1 (zh) * | 2015-03-30 | 2018-10-19 | 英特瑞克斯顿股份有限公司 | 配体诱导型多肽耦合器系统 |
| WO2018094265A2 (en) | 2016-11-21 | 2018-05-24 | Viking Therapeutics, Inc. | Method of treating glycogen storage disease |
| CN110996966A (zh) | 2017-06-05 | 2020-04-10 | 维京治疗公司 | 用于治疗纤维化的组合物 |
| KR20200138283A (ko) | 2018-03-22 | 2020-12-09 | 바이킹 테라퓨틱스 인코포레이티드 | 결정질 형태, 및 결정질 형태의 화합물을 제조하는 방법 |
| WO2020117962A1 (en) | 2018-12-05 | 2020-06-11 | Viking Therapeutics, Inc. | Compositions for the treatment of fibrosis and inflammation |
| CN110669794B (zh) * | 2019-09-30 | 2021-07-16 | 北京市农林科学院 | 以突变的筛选剂抗性基因为报告体系的c·t碱基替换的细胞富集技术及其应用 |
| CN110669775B (zh) * | 2019-09-30 | 2021-07-16 | 北京市农林科学院 | 差异代理技术在a·g碱基替换细胞富集中的应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5071773A (en) * | 1986-10-24 | 1991-12-10 | The Salk Institute For Biological Studies | Hormone receptor-related bioassays |
| CA2196496A1 (en) * | 1997-01-31 | 1998-07-31 | Stephen William Watson Michnick | Protein fragment complementation assay for the detection of protein-protein interactions |
| US6294330B1 (en) * | 1997-01-31 | 2001-09-25 | Odyssey Pharmaceuticals Inc. | Protein fragment complementation assays for the detection of biological or drug interactions |
| US6342345B1 (en) * | 1997-04-02 | 2002-01-29 | The Board Of Trustees Of The Leland Stanford Junior University | Detection of molecular interactions by reporter subunit complementation |
| US6117639A (en) * | 1998-08-31 | 2000-09-12 | Vertex Pharmaceuticals Incorporated | Fusion proteins, DNA molecules, vectors, and host cells useful for measuring protease activity |
| US6756213B1 (en) * | 2000-10-11 | 2004-06-29 | Applera Corporation | Nucleic acid encoding retinoic acid receptor |
-
2003
- 2003-03-25 AT AT03723800T patent/ATE377644T1/de not_active IP Right Cessation
- 2003-03-25 DE DE60317330T patent/DE60317330T2/de not_active Expired - Lifetime
- 2003-03-25 EP EP03723800A patent/EP1520010B1/de not_active Expired - Lifetime
- 2003-03-25 AU AU2003230710A patent/AU2003230710A1/en not_active Abandoned
- 2003-03-25 WO PCT/US2003/008767 patent/WO2003090515A2/en not_active Ceased
- 2003-03-25 US US10/395,142 patent/US20040029187A1/en not_active Abandoned
- 2003-03-25 JP JP2003587165A patent/JP2005521430A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| EP1520010A4 (de) | 2006-05-17 |
| EP1520010A2 (de) | 2005-04-06 |
| DE60317330T2 (de) | 2008-08-21 |
| AU2003230710A8 (en) | 2003-11-10 |
| AU2003230710A1 (en) | 2003-11-10 |
| WO2003090515A2 (en) | 2003-11-06 |
| JP2005521430A (ja) | 2005-07-21 |
| DE60317330D1 (de) | 2007-12-20 |
| WO2003090515A3 (en) | 2005-02-03 |
| US20040029187A1 (en) | 2004-02-12 |
| EP1520010B1 (de) | 2007-11-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |