ATE459653T1 - Monoklonale anti-cd71-antikörper und deren verwendung zur behandlung maligner tumorzellen - Google Patents
Monoklonale anti-cd71-antikörper und deren verwendung zur behandlung maligner tumorzellenInfo
- Publication number
- ATE459653T1 ATE459653T1 AT06795343T AT06795343T ATE459653T1 AT E459653 T1 ATE459653 T1 AT E459653T1 AT 06795343 T AT06795343 T AT 06795343T AT 06795343 T AT06795343 T AT 06795343T AT E459653 T1 ATE459653 T1 AT E459653T1
- Authority
- AT
- Austria
- Prior art keywords
- antibodies
- tumor cells
- monoclonal anti
- malignant tumor
- treating malignant
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1027—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against receptors, cell-surface antigens or cell-surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2881—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD71
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Optics & Photonics (AREA)
- Cell Biology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Transplantation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/154,262 US7736647B2 (en) | 2005-06-15 | 2005-06-15 | Anti-CD71 monoclonal antibodies and uses thereof for treating malignant tumor cells |
| PCT/IB2006/002331 WO2007000671A2 (en) | 2005-06-15 | 2006-06-14 | Anti-cd71 monoclonal antibodies and uses thereof for treating malignant tumour cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE459653T1 true ATE459653T1 (de) | 2010-03-15 |
Family
ID=37573538
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06795343T ATE459653T1 (de) | 2005-06-15 | 2006-06-14 | Monoklonale anti-cd71-antikörper und deren verwendung zur behandlung maligner tumorzellen |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US7736647B2 (de) |
| EP (1) | EP1896507B1 (de) |
| JP (1) | JP5185815B2 (de) |
| AT (1) | ATE459653T1 (de) |
| CA (1) | CA2612486A1 (de) |
| DE (1) | DE602006012672D1 (de) |
| DK (1) | DK1896507T3 (de) |
| ES (1) | ES2341625T3 (de) |
| PL (1) | PL1896507T3 (de) |
| WO (1) | WO2007000671A2 (de) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102203286B (zh) * | 2008-10-23 | 2013-07-17 | 弗·哈夫曼-拉罗切有限公司 | 免疫球蛋白编码核酸的测定 |
| IN2012DN00551A (de) * | 2009-07-22 | 2015-06-12 | Actinium Pharmaceuticals Inc | |
| US8734799B2 (en) | 2010-04-13 | 2014-05-27 | The Regents Of The University Of California | Unconjugated anti-TfR antibodies and compositions thereof for the treatment of cancer |
| FR2959416B1 (fr) * | 2010-05-03 | 2012-06-22 | Monoclonal Antibodies Therapeutics Mat Biopharma | Utilisation d'anticorps anti-cd71 pour la preparation d'un medicament |
| EA034333B1 (ru) | 2010-11-30 | 2020-01-29 | Дженентек, Инк. | Варианты антитела для переноса соединения через гематоэнцефалический барьер |
| US9623117B2 (en) * | 2011-04-04 | 2017-04-18 | Wisconsin Alumni Research Foundation | Method for selective targeting and entry of bacterial toxins to cells |
| AU2012245260B2 (en) | 2011-04-22 | 2016-09-08 | Aptevo Research And Development Llc | Prostate-specific membrane antigen binding proteins and related compositions and methods |
| US9696312B2 (en) | 2011-09-02 | 2017-07-04 | The Trustees Of Columbia University In The City Of New York | Diagnosis and treatment of cancer expressing ILT3 or ILT3 ligand |
| SG10201603411WA (en) | 2011-10-28 | 2016-07-28 | Teva Pharmaceuticals Australia Pty Ltd | Polypeptide constructs and uses thereof |
| KR102134088B1 (ko) | 2012-08-24 | 2020-07-14 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | Ror1 암을 치료하고 전이를 저해하는데 이용을 위한 항체와 백신 |
| US10179817B2 (en) | 2015-05-04 | 2019-01-15 | Cytomx Therapeutics, Inc. | Anti-CD71 antibodies, activatable anti-CD71 antibodies, and methods of use thereof |
| WO2016179335A1 (en) | 2015-05-04 | 2016-11-10 | Cytomx Therapeutics, Inc. | Anti-itga3 antibodies, activatable anti-itga3 antibodies, and methods of use thereof |
| WO2017015227A1 (en) | 2015-07-17 | 2017-01-26 | The Trustees Of Columbia University In The City Of New York | Methods of treating cd166-expressing cancer |
| UA126278C2 (uk) | 2015-09-21 | 2022-09-14 | Аптево Рісьорч Енд Девелопмент Ллс | Поліпептиди, які зв'язують cd3 |
| BR112018067458A2 (pt) | 2016-03-04 | 2019-01-02 | Abmuno Therapeutics Llc | anticorpos para tigit |
| MA45328A (fr) | 2016-04-01 | 2019-02-06 | Avidity Biosciences Llc | Compositions acide nucléique-polypeptide et utilisations de celles-ci |
| CN109310765A (zh) | 2016-06-20 | 2019-02-05 | 领先基因生物技术股份有限公司 | 抗体-药物偶联物 |
| US10688181B2 (en) | 2016-06-27 | 2020-06-23 | The Regents Of The University Of California | Cancer treatment combinations |
| EP3554535A4 (de) | 2016-12-14 | 2020-10-21 | Janssen Biotech, Inc. | Pd-l1-bindende fibronectin-typ iii-domänen |
| BR112019012154A2 (pt) | 2016-12-14 | 2019-11-12 | Janssen Biotech, Inc. | domínios do tipo iii da fibronectina de ligação a cd8a |
| EP3554561B1 (de) | 2016-12-14 | 2023-06-28 | Janssen Biotech, Inc. | Cd137-bindende fibronectin-typ-iii-domänen |
| SG10202107429WA (en) | 2017-01-06 | 2021-08-30 | Avidity Biosciences Inc | Nucleic acid-polypeptide compositions and methods of inducing exon skipping |
| CA3055574A1 (en) | 2017-03-09 | 2018-09-13 | Cytomx Therapeutics, Inc. | Cd147 antibodies, activatable cd147 antibodies, and methods of making and use thereof |
| GB201711809D0 (en) | 2017-07-21 | 2017-09-06 | Governors Of The Univ Of Alberta | Antisense oligonucleotide |
| EP3762420A1 (de) | 2018-03-09 | 2021-01-13 | CytomX Therapeutics, Inc. | Aktivierbare cd147-antikörper und verfahren zur herstellung und verwendung davon |
| US12097263B2 (en) * | 2018-08-02 | 2024-09-24 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating myotonic dystrophy |
| SG11202100934PA (en) | 2018-08-02 | 2021-02-25 | Dyne Therapeutics Inc | Muscle targeting complexes and uses thereof for treating dystrophinopathies |
| US12018087B2 (en) | 2018-08-02 | 2024-06-25 | Dyne Therapeutics, Inc. | Muscle-targeting complexes comprising an anti-transferrin receptor antibody linked to an oligonucleotide and methods of delivering oligonucleotide to a subject |
| KR102258015B1 (ko) * | 2019-05-15 | 2021-05-27 | 강원대학교 산학협력단 | 암 줄기세포 세포막 단백질에 특이적인 항체 및 그 응용 |
| KR102258014B1 (ko) * | 2019-05-15 | 2021-05-27 | 강원대학교 산학협력단 | 암 줄기세포 세포막 단백질에 특이적인 항체 및 그 응용 |
| TWI845724B (zh) * | 2019-07-19 | 2024-06-21 | 大陸商上海藥明合聯生物技術有限公司 | 用於偶聯的多肽複合物及其應用 |
| EP4017964A1 (de) * | 2019-08-19 | 2022-06-29 | Universität Basel | Zelltherapieverfahren |
| CN114650844A (zh) | 2019-09-23 | 2022-06-21 | 西托姆克斯治疗公司 | 抗cd47抗体、可活化抗cd47抗体及其使用方法 |
| US12491255B2 (en) | 2019-10-14 | 2025-12-09 | Aro Biotherapeutics Company | EPCAM binding fibronectin type III domains |
| EP4045061A4 (de) * | 2019-10-14 | 2024-04-17 | ARO Biotherapeutics Company | Cd71-bindende fibronectin-typ iii-domänen |
| US11781138B2 (en) | 2019-10-14 | 2023-10-10 | Aro Biotherapeutics Company | FN3 domain-siRNA conjugates and uses thereof |
| CR20220611A (es) | 2020-06-02 | 2023-06-07 | Arcus Biosciences Inc | Anticuerpos anti-tigit |
| AU2021414227A1 (en) | 2020-12-31 | 2023-07-06 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating myotonic dystrophy |
| CA3215367A1 (en) | 2021-04-14 | 2022-10-20 | Swapnil Kulkarni | Fn3 domain-sirna conjugates and uses thereof |
| EP4323409A4 (de) | 2021-04-14 | 2025-04-16 | ARO Biotherapeutics Company | Cd71-bindende fibronectin-typ-iii-domänen |
| US11969475B2 (en) | 2021-07-09 | 2024-04-30 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dystrophy |
| CA3230796A1 (en) | 2021-09-01 | 2023-03-09 | Biogen Ma Inc. | Anti-transferrin receptor antibodies and uses thereof |
| WO2025024334A1 (en) | 2023-07-21 | 2025-01-30 | Marrow Therapeutics, Inc. | Hematopoietic cell targeting conjugates and related methods |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5308626A (en) | 1985-06-28 | 1994-05-03 | Toni N. Mariani | Lymphokine activated effector cells for antibody-dependent cellular cytotoxicity (ADCC) treatment of cancer and other diseases |
| CA2081368A1 (en) | 1990-03-27 | 1991-09-28 | Ian S. Trowbridge | Method for inhibiting cell growth and compositions useful therefor |
| US5762932A (en) | 1990-04-26 | 1998-06-09 | University Of Iowa Research Foundation | Combined treatment of iron depletion and IgG antibody |
| US6107090A (en) * | 1996-05-06 | 2000-08-22 | Cornell Research Foundation, Inc. | Treatment and diagnosis of prostate cancer with antibodies to extracellur PSMA domains |
| AU2005252699B2 (en) | 2004-06-07 | 2010-12-23 | Macrogenics West, Inc. | Transferrin receptor antibodies |
-
2005
- 2005-06-15 US US11/154,262 patent/US7736647B2/en not_active Expired - Fee Related
-
2006
- 2006-06-14 EP EP06795343A patent/EP1896507B1/de not_active Not-in-force
- 2006-06-14 PL PL06795343T patent/PL1896507T3/pl unknown
- 2006-06-14 JP JP2008516448A patent/JP5185815B2/ja not_active Expired - Fee Related
- 2006-06-14 US US11/922,025 patent/US8409573B2/en not_active Expired - Fee Related
- 2006-06-14 WO PCT/IB2006/002331 patent/WO2007000671A2/en not_active Ceased
- 2006-06-14 CA CA002612486A patent/CA2612486A1/en not_active Abandoned
- 2006-06-14 ES ES06795343T patent/ES2341625T3/es active Active
- 2006-06-14 DE DE602006012672T patent/DE602006012672D1/de active Active
- 2006-06-14 DK DK06795343.0T patent/DK1896507T3/da active
- 2006-06-14 AT AT06795343T patent/ATE459653T1/de active
Also Published As
| Publication number | Publication date |
|---|---|
| JP2009509497A (ja) | 2009-03-12 |
| DE602006012672D1 (de) | 2010-04-15 |
| DK1896507T3 (da) | 2010-06-07 |
| PL1896507T3 (pl) | 2010-08-31 |
| US7736647B2 (en) | 2010-06-15 |
| US20060286030A1 (en) | 2006-12-21 |
| CA2612486A1 (en) | 2007-01-04 |
| US20110311544A1 (en) | 2011-12-22 |
| US8409573B2 (en) | 2013-04-02 |
| WO2007000671A3 (en) | 2007-04-26 |
| JP5185815B2 (ja) | 2013-04-17 |
| ES2341625T3 (es) | 2010-06-23 |
| WO2007000671A2 (en) | 2007-01-04 |
| EP1896507A2 (de) | 2008-03-12 |
| EP1896507B1 (de) | 2010-03-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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