ATE458833T1 - Krankheitsnachweis mit digitalen proteinverkürzungsassays - Google Patents

Krankheitsnachweis mit digitalen proteinverkürzungsassays

Info

Publication number
ATE458833T1
ATE458833T1 AT02808038T AT02808038T ATE458833T1 AT E458833 T1 ATE458833 T1 AT E458833T1 AT 02808038 T AT02808038 T AT 02808038T AT 02808038 T AT02808038 T AT 02808038T AT E458833 T1 ATE458833 T1 AT E458833T1
Authority
AT
Austria
Prior art keywords
sensitivity
mutations
assay
signal generated
assays
Prior art date
Application number
AT02808038T
Other languages
English (en)
Inventor
C Traverso
Kenneth Kinzler
Bert Vogelstein
Original Assignee
Univ Johns Hopkins
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Johns Hopkins filed Critical Univ Johns Hopkins
Application granted granted Critical
Publication of ATE458833T1 publication Critical patent/ATE458833T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT02808038T 2001-12-06 2002-12-04 Krankheitsnachweis mit digitalen proteinverkürzungsassays ATE458833T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33617701P 2001-12-06 2001-12-06
PCT/US2002/036143 WO2004036171A2 (en) 2001-12-06 2002-12-04 Disease detection by digital protein truncation assays

Publications (1)

Publication Number Publication Date
ATE458833T1 true ATE458833T1 (de) 2010-03-15

Family

ID=32107735

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02808038T ATE458833T1 (de) 2001-12-06 2002-12-04 Krankheitsnachweis mit digitalen proteinverkürzungsassays

Country Status (8)

Country Link
US (3) US20030165940A1 (de)
EP (3) EP2192194B8 (de)
JP (1) JP2005531328A (de)
AT (1) ATE458833T1 (de)
AU (1) AU2002368209A1 (de)
CA (2) CA2836656C (de)
DE (1) DE60235504D1 (de)
WO (1) WO2004036171A2 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6306628B1 (en) * 1999-08-25 2001-10-23 Ambergen, Incorporated Methods for the detection, analysis and isolation of Nascent proteins
DE102006015001A1 (de) * 2006-03-31 2007-10-11 NMI Naturwissenschaftliches und Medizinisches Institut an der Universität Tübingen Verfahren zum Nachweis und/oder zur Anreicherung von Analytproteinen und/oder Analytpeptiden aus einer komplexen Proteinmischung
US20100041048A1 (en) * 2008-07-31 2010-02-18 The Johns Hopkins University Circulating Mutant DNA to Assess Tumor Dynamics
US20100042433A1 (en) * 2008-08-12 2010-02-18 Cerner Innovation, Inc. Cross continuum associated therapy reconciliation
US20100042432A1 (en) * 2008-08-12 2010-02-18 Cerner Innovation, Inc. Therapy discharge reconciliation
GB2467691A (en) 2008-09-05 2010-08-11 Aueon Inc Methods for stratifying and annotating cancer drug treatment options
WO2011004517A1 (ja) * 2009-07-06 2011-01-13 オリンパス株式会社 標的核酸の検出方法、及び大腸癌の検査方法
WO2012040387A1 (en) 2010-09-24 2012-03-29 The Board Of Trustees Of The Leland Stanford Junior University Direct capture, amplification and sequencing of target dna using immobilized primers
CN117649880B (zh) * 2024-01-30 2024-04-16 北京大学口腔医学院 用于口腔脱落细胞生物检测的数据匹配方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2210239T3 (es) 1992-04-01 2004-07-01 The Johns Hopkins University School Of Medicine Metodo para detectar acidos nucleicos de mamiferos aislados en heces y reactivos para el mismo.
US5709998A (en) * 1993-12-15 1998-01-20 The Johns Hopkins University Molecular diagnosis of familial adenomatous polyposis
US6191268B1 (en) 1993-12-17 2001-02-20 Dana-Farber Cancer Institute Compositions and methods relating to DNA mismatch repair genes
WO1998011249A1 (en) * 1996-09-13 1998-03-19 Garvin Alex M Mutation detection using peptide tagged in vitro synthesized proteins
US6440706B1 (en) * 1999-08-02 2002-08-27 Johns Hopkins University Digital amplification

Also Published As

Publication number Publication date
CA2836656C (en) 2017-06-13
US8669062B2 (en) 2014-03-11
DE60235504D1 (de) 2010-04-08
WO2004036171A3 (en) 2005-02-24
CA2468273C (en) 2014-04-01
WO2004036171A2 (en) 2004-04-29
EP2192194A2 (de) 2010-06-02
US7910300B2 (en) 2011-03-22
EP1523573A4 (de) 2006-03-08
JP2005531328A (ja) 2005-10-20
US20110195416A1 (en) 2011-08-11
CA2468273A1 (en) 2004-04-29
EP2960343A1 (de) 2015-12-30
CA2836656A1 (en) 2004-04-29
AU2002368209A1 (en) 2004-05-04
EP2192194B1 (de) 2015-05-20
EP2192194A3 (de) 2010-10-20
EP1523573B1 (de) 2010-02-24
EP1523573A2 (de) 2005-04-20
US20030165940A1 (en) 2003-09-04
EP2192194B8 (de) 2015-06-24
US20090117546A1 (en) 2009-05-07

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