ATE458485T1 - Ubiquitin-ligase-hemmer und verwandte verfahren - Google Patents
Ubiquitin-ligase-hemmer und verwandte verfahrenInfo
- Publication number
- ATE458485T1 ATE458485T1 AT04777768T AT04777768T ATE458485T1 AT E458485 T1 ATE458485 T1 AT E458485T1 AT 04777768 T AT04777768 T AT 04777768T AT 04777768 T AT04777768 T AT 04777768T AT E458485 T1 ATE458485 T1 AT E458485T1
- Authority
- AT
- Austria
- Prior art keywords
- ubiquitin ligase
- related methods
- compounds
- ligase inhibitors
- inhibitors
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/01—Hydrocarbons
- A61K31/015—Hydrocarbons carbocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/421—1,3-Oxazoles, e.g. pemoline, trimethadione
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
- A61K31/515—Barbituric acids; Derivatives thereof, e.g. sodium pentobarbital
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
Applications Claiming Priority (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US48673003P | 2003-07-11 | 2003-07-11 | |
US48979503P | 2003-07-24 | 2003-07-24 | |
PCT/US2003/035712 WO2004098492A2 (en) | 2002-11-11 | 2003-11-10 | Trans-golgi network-associated processes, methods and compositions related thereto |
US54989604P | 2004-03-02 | 2004-03-02 | |
PCT/US2004/006308 WO2004078130A2 (en) | 2003-03-03 | 2004-03-02 | Posh interacting proteins and related methods |
PCT/US2004/006619 WO2004099388A2 (en) | 2003-03-05 | 2004-03-05 | Cbl-b polypeptides, complexes and related methods |
PCT/US2004/010582 WO2004089302A2 (en) | 2003-04-03 | 2004-04-05 | Posh polypeptides, complexes and related methods |
PCT/US2004/016865 WO2005001485A2 (en) | 2003-05-30 | 2004-05-28 | Pem-3-like compositions and related methods thereof |
PCT/US2004/021900 WO2005007141A2 (en) | 2003-07-11 | 2004-07-09 | Ubiquitin ligase inhibitors and methods related thereto |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE458485T1 true ATE458485T1 (de) | 2010-03-15 |
Family
ID=41795377
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT04777768T ATE458485T1 (de) | 2003-07-11 | 2004-07-09 | Ubiquitin-ligase-hemmer und verwandte verfahren |
Country Status (5)
Country | Link |
---|---|
US (1) | US7659277B2 (de) |
EP (1) | EP1651226B1 (de) |
AT (1) | ATE458485T1 (de) |
DE (1) | DE602004025708D1 (de) |
WO (1) | WO2005007141A2 (de) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2526780A1 (en) * | 2003-05-30 | 2005-01-06 | Proteologics, Inc. | Pem-3-like compositions and related methods thereof |
JP2007522204A (ja) * | 2004-02-11 | 2007-08-09 | ペインセプター ファーマ コーポレーション | ニューロトロフィンが媒介する活性を調節する方法 |
FI20041129A0 (fi) * | 2004-08-30 | 2004-08-30 | Ctt Cancer Targeting Tech Oy | Tioksotiatsolidinoniyhdisteitä lääkkeinä käytettäviksi |
WO2006047162A2 (en) * | 2004-10-21 | 2006-05-04 | The Burnham Institute | Compositions and methods for treatment of disease caused by yersinia spp infection |
US20090263821A1 (en) * | 2004-12-01 | 2009-10-22 | Proteologics, Inc. | Ubiquitin Ligase Assays And Related Reagents |
ITMI20042475A1 (it) * | 2004-12-23 | 2005-03-23 | Cell Therapeutics Europe Srl | Uso di derivati tiazolidinonici come agenti terapeutici |
US8257931B2 (en) | 2005-01-21 | 2012-09-04 | President And Fellows Of Harvard College | Regulation of protein synthesis |
CA2608821A1 (en) * | 2005-06-15 | 2006-12-28 | Shibo Jiang | Anti-viral compositions comprising heterocyclic substituted phenyl furans and related compounds |
WO2007088531A2 (en) * | 2006-02-02 | 2007-08-09 | Proteologics Ltd. | Pem-3-like polypeptides, complexes, and related methods |
DE102006008321A1 (de) * | 2006-02-17 | 2007-08-30 | Virologik Gmbh | Mittel zur Behandlung von Infektionen mit Influenzaviren |
CA2667839C (en) * | 2006-10-30 | 2016-01-12 | Hybrigenics Sa | Novel tetracyclic inhibitors of cysteine proteases, the pharmaceutical compositions thereof and their therapeutic applications |
MX2009005478A (es) * | 2006-11-27 | 2009-08-12 | Lundbeck & Co As H | Derivados de heteroarilamida. |
WO2008094319A2 (en) * | 2007-02-01 | 2008-08-07 | The Board Of Regents Of The University Of Texas Sytem | Methods and compositions of trail-death receptor agonists/activators |
US20080221056A1 (en) * | 2007-02-12 | 2008-09-11 | Johns Hopkins University | Early Detection and Prognosis of Colon Cancers |
WO2008099022A1 (en) * | 2007-02-16 | 2008-08-21 | Tibotec Pharmaceuticals Ltd. | 10-sulfonyl-dibenzodiazepinones useful as hepatitis c virus inhibitors |
WO2009024980A2 (en) * | 2007-08-22 | 2009-02-26 | Proteologics Ltd | Pyrimidine and pyridine derivatives as posh and posh-ap inhibitors |
DE102007040336A1 (de) * | 2007-08-27 | 2009-03-05 | Johann Wolfgang Goethe-Universität Frankfurt am Main | Neue Inhibitoren der 5-Lipoxygenase und deren Verwendungen |
AT506041A1 (de) * | 2007-12-10 | 2009-05-15 | Univ Innsbruck | Verfahren zur erhöhung der immunreaktivität |
US9018238B2 (en) * | 2009-02-12 | 2015-04-28 | Pharmadesign, Inc. | Inhibitor of casein kinase 1δ and casein kinase 1ε |
JP2013512234A (ja) * | 2009-11-30 | 2013-04-11 | プロテオロジクス リミテッド | 小型ピリミジン誘導体およびその使用の方法 |
EP2555764A1 (de) * | 2010-04-09 | 2013-02-13 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Antimikrobielle verbindungen von 1,4-naphtochinonstruktur |
US9073941B2 (en) | 2010-06-28 | 2015-07-07 | Academia Sinica | Compounds and methods for treating tuberculosis infection |
JP6208122B2 (ja) * | 2011-05-12 | 2017-10-04 | プロテオステイシス セラピューティクス,インコーポレイテッド | プロテオスタシス調節因子 |
WO2014179785A1 (en) * | 2013-05-03 | 2014-11-06 | Inscent, Inc. | Improved honeybee repellents and uses thereof |
AR110456A1 (es) * | 2016-01-13 | 2019-04-03 | Bayer Cropscience Ag | Uso de sustancias activas para controlar infecciones por virus en plantas |
EP3577109A4 (de) * | 2017-01-31 | 2020-11-18 | Arvinas Operations, Inc. | Cereblonliganden und bifunktionale verbindungen damit |
JP2023507570A (ja) | 2019-12-19 | 2023-02-24 | アルビナス・オペレーションズ・インコーポレイテッド | アンドロゲン受容体の標的分解のための化合物および方法 |
CN114592006A (zh) * | 2022-04-29 | 2022-06-07 | 昆明理工大学 | Memo1基因的新用途 |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE590586A (de) * | 1959-05-07 | |||
JPS6253963A (ja) * | 1985-08-31 | 1987-03-09 | Taisho Pharmaceut Co Ltd | 肝疾患治療剤 |
IL141456A0 (en) * | 1998-08-21 | 2002-03-10 | Viropharma Inc | Rhodanine derivatives and pharmaceutical compositions containing the same |
CN1288667A (zh) * | 1999-09-21 | 2001-03-28 | 马越 | 乙霉威·多菌灵杀菌组合物 |
US20040009613A1 (en) * | 2001-02-16 | 2004-01-15 | Ming-Ming Zhou | Methods of identifying modulators of bromodomains |
WO2001077091A2 (en) * | 2000-04-05 | 2001-10-18 | Tularik Inc. | Ns5b hcv polymerase inhibitors |
AU2001240021A1 (en) * | 2000-04-13 | 2001-10-30 | Millennium Pharmaceuticals, Inc. | Diazafluorenone il-8 receptor antagonists |
GB0013655D0 (en) * | 2000-06-05 | 2000-07-26 | Prolifix Ltd | Therapeutic compounds |
WO2002062337A1 (en) * | 2000-12-18 | 2002-08-15 | Smithkline Beecham Corporation | Thiazolidinediones |
AU2002218897A1 (en) * | 2000-12-18 | 2002-07-01 | Boehringer Ingelheim (Canada) Ltd. | Inhibitors of papilloma virus |
GB2376943B (en) * | 2001-05-18 | 2005-03-16 | Pantherix Ltd | Compounds and their therapeutic use |
EP1310552B1 (de) | 2001-11-09 | 2007-06-13 | Proteologics, Inc. | Posh Nukleinsäure, Polypeptide und darauf bezogene Verfahren |
WO2004098492A2 (en) * | 2002-11-11 | 2004-11-18 | Proteologics, Inc. | Trans-golgi network-associated processes, methods and compositions related thereto |
FR2833949B1 (fr) * | 2001-12-21 | 2005-08-05 | Galderma Res & Dev | NOUVEAUX LIGANDS ACTIVATEURS DES RECEPTEURS PPARy, LEUR PROCEDE DE PREPARATION ET LEUR UTILISATION EN MEDECINE HUMAINE AINSI QU'EN COSMETIQUE |
WO2003074497A1 (en) * | 2002-03-01 | 2003-09-12 | Pintex Pharmaceutical, Inc. | Pin1-modulating compounds and methods of use thereof |
EP1556059A4 (de) * | 2002-06-06 | 2010-06-30 | Smithkline Beecham | Thrombopoietin-mimetika |
MXPA05000453A (es) * | 2002-07-10 | 2005-03-23 | Applied Research Systems | Derivados de benceno fusionados a azolidinona-vinilo. |
EP1389461A1 (de) * | 2002-08-14 | 2004-02-18 | Axxima Pharmaceuticals Aktiengesellschaft | Pyrimidone mit antiviralen Eigenschaften |
AU2004218430A1 (en) * | 2003-03-03 | 2004-09-16 | Proteologics, Inc. | Posh interacting proteins and related methods |
WO2004089302A2 (en) * | 2003-04-03 | 2004-10-21 | Proteologics, Inc. | Posh polypeptides, complexes and related methods |
-
2004
- 2004-07-09 DE DE602004025708T patent/DE602004025708D1/de active Active
- 2004-07-09 WO PCT/US2004/021900 patent/WO2005007141A2/en active Application Filing
- 2004-07-09 AT AT04777768T patent/ATE458485T1/de not_active IP Right Cessation
- 2004-07-09 EP EP04777768A patent/EP1651226B1/de not_active Not-in-force
-
2006
- 2006-01-11 US US11/330,500 patent/US7659277B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP1651226A2 (de) | 2006-05-03 |
WO2005007141A2 (en) | 2005-01-27 |
EP1651226B1 (de) | 2010-02-24 |
US7659277B2 (en) | 2010-02-09 |
WO2005007141A3 (en) | 2005-03-24 |
DE602004025708D1 (de) | 2010-04-08 |
US20070015768A1 (en) | 2007-01-18 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE458485T1 (de) | Ubiquitin-ligase-hemmer und verwandte verfahren | |
WO2006028958A3 (en) | Pyridyl inhibitors of hedgehog signalling | |
MX2007004276A (es) | 1,5-naftiridin-azolidinonas que tienen actividad antiproliferativa de cdk-1. | |
CY1116754T1 (el) | Παραγωγα νιτροκατεχολης ως αναστολεις της comt | |
ATE523196T1 (de) | Mitotische kinesinhemmer und verfahren zu ihrer verwendung | |
GEP20084420B (en) | Use of imidazole compounds for the treatment of neurodegenerative disorders | |
TW200700422A (en) | Compounds for inhibiting ksp kinesin activity | |
TW200510416A (en) | P38 inhibitors and methods of use thereof | |
ATE544748T1 (de) | Zusammensetzungen und verfahren für die behandlung von zellproliferationserkrankungen | |
ATE424388T1 (de) | Mitotische kinesinhemmer | |
ATE447577T1 (de) | Mitotische kinesin-hemmer | |
EA200970447A1 (ru) | Соединения и композиции в качестве ингибиторов протеинкиназы | |
HK1092467A1 (en) | N-alkyl-hydroxamic acid-isoindolyl compounds and their pharmaceutical uses n- | |
ATE437861T1 (de) | 2-(amino-substituierte)-4-arylpyramidine und verwandte verbindungen, die sich für die behandlung von entzündlichen krankheiten eignen | |
TW200700066A (en) | Compounds for inhibiting ksp kinesin activity | |
WO2004058148A3 (en) | Mitotic kinesin inhibitors | |
WO2007120333A3 (en) | Tetracyclic kinase inhibitors | |
WO2004058700A3 (en) | Mitotic kinesin inhibitors | |
TW200505443A (en) | Combination of SCR kinase inhibitors and chemotherapeutic agents for the treatment of proliferative diseases | |
BRPI0615141A2 (pt) | inibidores pentacìclicos de quinase | |
TW200716153A (en) | Mitotic kinesin inhibitors and methods of use thereof | |
IS7970A (is) | PDE4-hemlar til að meðhöndla eitlafrumuæxli | |
WO2002060375A3 (en) | Diphenyl ether derivatives and their uses as heparanase inhibitors | |
DE60329326D1 (de) | Tace inhibitoren | |
WO2004060878A3 (en) | Inhibitors of phosphatases |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |