WO2002060375A3 - Diphenyl ether derivatives and their uses as heparanase inhibitors - Google Patents

Diphenyl ether derivatives and their uses as heparanase inhibitors Download PDF

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Publication number
WO2002060375A3
WO2002060375A3 PCT/IL2002/000082 IL0200082W WO02060375A3 WO 2002060375 A3 WO2002060375 A3 WO 2002060375A3 IL 0200082 W IL0200082 W IL 0200082W WO 02060375 A3 WO02060375 A3 WO 02060375A3
Authority
WO
WIPO (PCT)
Prior art keywords
diphenyl ether
ether derivatives
heparanase inhibitors
heparanase
diseases
Prior art date
Application number
PCT/IL2002/000082
Other languages
French (fr)
Other versions
WO2002060375A2 (en
Inventor
Maty Ayal-Hershkovitz
Daphna Miron
Avi Koller
Neta Ilan
Ofra Levy
Original Assignee
Insight Strategy And Marketing
Maty Ayal-Hershkovitz
Daphna Miron
Avi Koller
Neta Ilan
Ofra Levy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Insight Strategy And Marketing, Maty Ayal-Hershkovitz, Daphna Miron, Avi Koller, Neta Ilan, Ofra Levy filed Critical Insight Strategy And Marketing
Priority to AU2002230057A priority Critical patent/AU2002230057A1/en
Publication of WO2002060375A2 publication Critical patent/WO2002060375A2/en
Publication of WO2002060375A3 publication Critical patent/WO2002060375A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention provides diphenyl ether compounds as heparanase inhibitors suitable for treatment of diseases and disorders caused by or associated with heparanase catalytic activity such as cancer, inflammatory disorders and autoimmune diseases.
PCT/IL2002/000082 2001-01-29 2002-01-29 Diphenyl ether derivatives and their uses as heparanase inhibitors WO2002060375A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002230057A AU2002230057A1 (en) 2001-01-29 2002-01-29 Diphenyl ether derivatives and their uses as heparanase inhibitors

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26430501P 2001-01-29 2001-01-29
US60/264,305 2001-01-29

Publications (2)

Publication Number Publication Date
WO2002060375A2 WO2002060375A2 (en) 2002-08-08
WO2002060375A3 true WO2002060375A3 (en) 2003-10-09

Family

ID=23005449

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2002/000082 WO2002060375A2 (en) 2001-01-29 2002-01-29 Diphenyl ether derivatives and their uses as heparanase inhibitors

Country Status (2)

Country Link
AU (1) AU2002230057A1 (en)
WO (1) WO2002060375A2 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7465766B2 (en) 2004-01-08 2008-12-16 The Cleveland Clinic Foundation Hydroxyphenyl cross-linked macromolecular network and applications thereof
US8138265B2 (en) 2003-01-10 2012-03-20 The Cleveland Clinic Foundation Hydroxyphenyl cross-linked macromolecular network and applications thereof
US6982298B2 (en) 2003-01-10 2006-01-03 The Cleveland Clinic Foundation Hydroxyphenyl cross-linked macromolecular network and applications thereof
US8137688B2 (en) 2003-01-10 2012-03-20 The Cleveland Clinic Foundation Hydroxyphenyl cross-linked macromolecular network and applications thereof
US7321065B2 (en) 2003-04-18 2008-01-22 The Regents Of The University Of California Thyronamine derivatives and analogs and methods of use thereof
US6979750B1 (en) 2003-04-18 2005-12-27 The Regents Of The University Of California Thyronamine derivatives and analogs and methods of use thereof
EP1675814A1 (en) * 2003-10-14 2006-07-05 Eli Lilly And Company Phenoxyether derivatives as ppar modulators
JP2007525494A (en) * 2004-02-06 2007-09-06 インサイト バイオファーマシューティカルズ リミテッド Heparanase inhibitors and uses thereof
WO2008046162A1 (en) * 2006-10-20 2008-04-24 The Australian National University Inhibition of degradation of extracellular matrix
BRPI0810621A2 (en) 2007-04-13 2017-06-06 Southern Res Inst methods of inhibiting or reducing angiogenesis, tumor-dependent tumor growth or metastasis, and treating angiogenesis-associated disease or disorder.
US8080260B2 (en) 2008-02-13 2011-12-20 The Cleveland Clinic Foundation Molecular enhancement of extracellular matrix and methods of use
WO2009135029A2 (en) 2008-04-30 2009-11-05 The Cleveland Clinic Foundation Compositions and methods to treat urinary incontinence
KR20190093214A (en) 2016-12-13 2019-08-08 베타 테라퓨틱스 피티와이 리미티드 Heparanase inhibitors and uses thereof
US11787783B2 (en) 2016-12-13 2023-10-17 Beta Therapeutics Pty Ltd Heparanase inhibitors and use thereof
EP3381906A1 (en) * 2017-03-27 2018-10-03 Leadiant Biosciences SA Compounds for use as heparanase inhibitors

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999064044A1 (en) * 1998-06-08 1999-12-16 Advanced Medicine, Inc. Novel therapeutic agents that modulate 5-ht receptors

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999064044A1 (en) * 1998-06-08 1999-12-16 Advanced Medicine, Inc. Novel therapeutic agents that modulate 5-ht receptors

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE CAPLUS [online] SHEVELEV ET AL.: "Phenol substitution of nitro groups in 1,3,5-trinitrobenzene-method of preparation of 5-nitroresorcinol diaryl ethers and 3,5-dinitrophenyl aryl ethers", XP002966629, accession no. STN Database accession no. 1995:656708 *
IZVESTIYA AKADEMII NAUK, SERIYA KHIMICHESKAY, vol. 2, 1995, pages 393 - 394 *

Also Published As

Publication number Publication date
WO2002060375A2 (en) 2002-08-08
AU2002230057A1 (en) 2002-08-12

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