ATE450611T1 - Feedback-resistente acetohydroxysäure-synthetase- mutanten - Google Patents

Feedback-resistente acetohydroxysäure-synthetase- mutanten

Info

Publication number
ATE450611T1
ATE450611T1 AT04739686T AT04739686T ATE450611T1 AT E450611 T1 ATE450611 T1 AT E450611T1 AT 04739686 T AT04739686 T AT 04739686T AT 04739686 T AT04739686 T AT 04739686T AT E450611 T1 ATE450611 T1 AT E450611T1
Authority
AT
Austria
Prior art keywords
nucleic acid
polypeptide
sequence
acid sequences
cited above
Prior art date
Application number
AT04739686T
Other languages
English (en)
Inventor
Miroslav Patek
Veronika Elisakova
Original Assignee
Evonik Degussa Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Evonik Degussa Gmbh filed Critical Evonik Degussa Gmbh
Application granted granted Critical
Publication of ATE450611T1 publication Critical patent/ATE450611T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1022—Transferases (2.) transferring aldehyde or ketonic groups (2.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/06—Alanine; Leucine; Isoleucine; Serine; Homoserine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
AT04739686T 2003-06-26 2004-06-08 Feedback-resistente acetohydroxysäure-synthetase- mutanten ATE450611T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP20030014640 EP1491634A1 (de) 2003-06-26 2003-06-26 Feedback resistente Acetohydroxysäure-Synthetase Mutanten
PCT/EP2004/006157 WO2005003357A1 (en) 2003-06-26 2004-06-08 Feedback resistant acetohydroxy acid synthethase mutants

Publications (1)

Publication Number Publication Date
ATE450611T1 true ATE450611T1 (de) 2009-12-15

Family

ID=33395884

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04739686T ATE450611T1 (de) 2003-06-26 2004-06-08 Feedback-resistente acetohydroxysäure-synthetase- mutanten

Country Status (11)

Country Link
US (2) US7585959B2 (de)
EP (2) EP1491634A1 (de)
JP (1) JP2007506407A (de)
KR (1) KR20060024437A (de)
CN (1) CN100523197C (de)
AT (1) ATE450611T1 (de)
BR (1) BRPI0411975A (de)
DE (1) DE602004024394D1 (de)
RU (1) RU2325439C2 (de)
WO (1) WO2005003357A1 (de)
ZA (1) ZA200510448B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2355763C2 (ru) 2006-09-13 2009-05-20 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) Мутантная ацетолактатсинтаза и способ продукции разветвленных l-аминокислот
WO2012014228A1 (en) 2010-07-28 2012-02-02 Abhishek Narain Singh A method to by-pass allosteric domain activity of an enzyme so as to alter its feedback or feed-forward inhibition or activation
DE102011118019A1 (de) 2011-06-28 2013-01-03 Evonik Degussa Gmbh Varianten des Promotors des für die Glyzerinaldehyd-3-phosphat-Dehydrogenase kodierenden gap-Gens
ES2623161T3 (es) 2013-06-03 2017-07-10 Evonik Degussa Gmbh Procedimiento para la preparación de L-valina utilizando corinebacterias recombinantes que contienen el operón ilvBN inducible por propionato
KR101720836B1 (ko) 2014-08-05 2017-04-03 씨제이제일제당 (주) 피드백 저항성 아세토하이드록시산 신타아제 변이체 및 이를 이용한 l-발린의 생산방법
CN105886431B (zh) * 2016-04-27 2019-05-10 天津科技大学 一株谷氨酸棒状杆菌及其高产异亮氨酸的方法
WO2017194696A1 (en) 2016-05-12 2017-11-16 Danmarks Tekniske Universitet Bacterial cells with improved tolerance to isobutyric acid
KR101996129B1 (ko) 2017-07-11 2019-07-04 씨제이제일제당 (주) 아세토하이드록시산 신타아제 변이체, 이를 포함하는 미생물 또는 이를 이용하는 l-분지쇄 아미노산 생산 방법
US11021697B2 (en) 2017-07-11 2021-06-01 Cj Cheiljedang Corporation Acetohydroxy acid synthase variant, microorganism comprising the same, and method of producing L-branched-chain amino acid using the same
JP6604584B1 (ja) * 2018-12-12 2019-11-13 株式会社Ｃｏ２資源化研究所 バリン生成能が向上したヒドロゲノフィラス属細菌遺伝子組換え体
CN110229797B (zh) * 2019-06-05 2020-08-28 天津科技大学 一种乙酰羟酸合成酶及其应用
KR102147381B1 (ko) * 2019-11-22 2020-08-24 씨제이제일제당 주식회사 아세토하이드록시산 신타제 신규 변이체 및 이를 포함하는 미생물
KR102673796B1 (ko) * 2021-09-29 2024-06-10 씨제이제일제당 주식회사 신규한 아세토하이드록시산 신테아제 변이체 및 이를 이용한 l-이소류신 생산방법
KR20230045990A (ko) * 2021-09-29 2023-04-05 씨제이제일제당 (주) 신규한 아세토하이드록시산 신테아제 변이체 및 이를 이용한 l-이소류신 생산방법

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2748418B2 (ja) * 1988-08-03 1998-05-06 味の素株式会社 組換えｄｎａ、該組換えｄｎａを有する微生物
DE3942947A1 (de) * 1989-12-23 1991-06-27 Forschungszentrum Juelich Gmbh Verfahren zur herstellung von l-isoleucin und dafuer geeignete mikroorganismen und rekombinante dna
JP4623825B2 (ja) * 1999-12-16 2011-02-02 協和発酵バイオ株式会社 新規ポリヌクレオチド
RU2209246C2 (ru) * 2000-01-26 2003-07-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" Малая субъединица изозима iii и изозим iii синтетазы ацетогидроксикислот из escherichia coli, фрагмент днк (варианты), штамм бактерии escherichia coli - продуцент l-валина (варианты) и способ получения l-валина
ATE286135T1 (de) * 2000-10-13 2005-01-15 Archer Daniels Midland Co Rückkopplungfestes pyruvatcarboxylase gen aus corynebacterium

Also Published As

Publication number Publication date
WO2005003357A1 (en) 2005-01-13
BRPI0411975A (pt) 2006-08-29
US7585959B2 (en) 2009-09-08
EP1491634A1 (de) 2004-12-29
CN1813065A (zh) 2006-08-02
US20100086966A1 (en) 2010-04-08
JP2007506407A (ja) 2007-03-22
RU2325439C2 (ru) 2008-05-27
CN100523197C (zh) 2009-08-05
KR20060024437A (ko) 2006-03-16
EP1636366A1 (de) 2006-03-22
ZA200510448B (en) 2006-12-27
DE602004024394D1 (en) 2010-01-14
EP1636366B1 (de) 2009-12-02
RU2006102024A (ru) 2006-09-10
US20070292914A1 (en) 2007-12-20

Similar Documents

Publication Publication Date Title
ZA200510448B (en) Feedback resistant acetohydroxy acid synthetase mutants
Peters-Wendisch et al. Pyruvate carboxylase from Corynebacterium glutamicum: characterization, expression and inactivation of the pyc gene
Mootz et al. The tyrocidine biosynthesis operon of Bacillus brevis: complete nucleotide sequence and biochemical characterization of functional internal adenylation domains
Stein et al. Two different lantibiotic-like peptides originate from the ericin gene cluster of Bacillus subtilis A1/3
Kuen et al. Molecular characterization of the Bacillus stearothermophilus PV72 S-layer gene sbsB induced by oxidative stress
Fernández et al. Molecular and functional analyses of the metC gene of Lactococcus lactis, encoding cystathionine β-lyase
RU2504584C2 (ru) СПОСОБ ПОЛУЧЕНИЯ ПИРРОЛОХИНОЛИНОХИНОНА (PQQ) С ИСПОЛЬЗОВАНИЕМ БАКТЕРИИ РОДА Methylobacterium ИЛИ Hyphomicrobium
Faraldo et al. Sequence of the S-layer gene of Thermus thermophilus HB8 and functionality of its promoter in Escherichia coli
DK2041276T3 (da) Fremgangsmåde til fremstilling af l-aminosyrer ved hjælp af mutanter af glta-genet kodende for citrat synthase
KR100762315B1 (ko) 푸자리시딘 생합성 효소 및 이를 코딩하는 유전자
DK2267007T3 (en) New gene products that form or degrade polyaminoacids, of Bacillus licheniformis and end supporting improved biotechnological production methods
Vesanto et al. Characterization and expression of the Lactobacillus helveticus pepC gene encoding a general aminopeptidase
RU2012136449A (ru) Способ получения пирипиропена
AU2001279674A1 (en) New nucleotide sequences which code for the mdha gene
Treuner-Lange et al. The kdp system of Clostridium acetobutylicum: cloning, sequencing, and transcriptional regulation in response to potassium concentration
ZA200007221B (en) Novel nucleotide sequences coding for the genes sdhA, sdhB and sdhC.
JP2004537296A (ja) 環状ｌ−アミノ酸の立体選択的製造
DK1085094T3 (da) Nucleotidsekvenser, som koder for dapF-genet
Halgasova et al. Cloning and transcriptional characterization of two sigma factor genes, sigA and sigB, from Brevibacterium flavum
AU2001273977A1 (en) Novel nucleotide sequences coding for the glbo gene
WO2002010384A1 (fr) Genes codant des proteines capables de regenerer la luciferine, adn recombine et methode de production de proteines capables de regenerer la luciferine
Hudspeth et al. spoVG sequence of Bacillus megaterium and Bacillus subtilis
KR101165247B1 (ko) 트리데캅틴 생합성 효소 및 이를 코딩하는 유전자
KR101250604B1 (ko) 푸자리시딘 유도체 ｌｉ－ｆ０７의 생산량이 증가된 패니바실러스 폴리믹사 디비비１７０９의 변이균주와 이의 제조방법
EP3312286A2 (de) Verfahren zur umwandlung von dinitrilen in dicarbonsäuren

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties