ATE450260T1 - Therapeutische zusammensetzungen enthaltend 1,2,3,6-tetrahydropyrimidin-2-one und entsprechende methoden - Google Patents
Therapeutische zusammensetzungen enthaltend 1,2,3,6-tetrahydropyrimidin-2-one und entsprechende methodenInfo
- Publication number
- ATE450260T1 ATE450260T1 AT03718956T AT03718956T ATE450260T1 AT E450260 T1 ATE450260 T1 AT E450260T1 AT 03718956 T AT03718956 T AT 03718956T AT 03718956 T AT03718956 T AT 03718956T AT E450260 T1 ATE450260 T1 AT E450260T1
- Authority
- AT
- Austria
- Prior art keywords
- tetrahydropyrimidine
- phenyl
- therapeutic compositions
- compositions containing
- trifluoromethyl
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/08—Inhaling devices inserted into the nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/06—Solids
- A61M2202/064—Powder
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/139,193 US6919348B2 (en) | 2002-05-02 | 2002-05-02 | Therapeutic 1,2,3,6-tetrahydropyrimidine-2-one compositions and methods therewith |
US10/191,481 US20030207903A1 (en) | 2002-05-02 | 2002-07-08 | 1,2,3,6-tetrahydropyrimidine-2-one compositions and therapeutic methods therewith for sexual disfunction |
US10/233,126 US20030206873A1 (en) | 2002-05-02 | 2002-08-29 | 1,2,3,6-tetrahydropyrimidine-2-one compositions and therapeutic methods therewith for gastrointestinal dysfunction |
US10/232,798 US6743801B2 (en) | 2002-05-02 | 2002-08-29 | 1,2,3,6-tetrahydropyrimidine-2-one compositions and therapeutic methods therewith for pain and inflammation |
US10/267,896 US6933301B2 (en) | 2002-05-02 | 2002-10-08 | 1,2,3,6-tetrahydropyrimidine-2-one compositions, articles and therapeutic methods for upper airway breathing disorders |
PCT/GB2003/001811 WO2003092697A1 (en) | 2002-05-02 | 2003-04-28 | Therapeutic 1,2,3,6-tetrahydropyrimidine-2-one compositions and methods therewith |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE450260T1 true ATE450260T1 (de) | 2009-12-15 |
Family
ID=29269528
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT03718956T ATE450260T1 (de) | 2002-05-02 | 2003-04-28 | Therapeutische zusammensetzungen enthaltend 1,2,3,6-tetrahydropyrimidin-2-one und entsprechende methoden |
Country Status (4)
Country | Link |
---|---|
US (5) | US6919348B2 (de) |
AT (1) | ATE450260T1 (de) |
DE (1) | DE60330333D1 (de) |
ZA (1) | ZA200408895B (de) |
Families Citing this family (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050281751A1 (en) * | 1997-07-21 | 2005-12-22 | Bruce Levin | Directed intranasal administration of pharmaceutical agents |
US6919348B2 (en) * | 2002-05-02 | 2005-07-19 | Edward T. Wei | Therapeutic 1,2,3,6-tetrahydropyrimidine-2-one compositions and methods therewith |
JP2004018470A (ja) * | 2002-06-18 | 2004-01-22 | Takasago Internatl Corp | 抗菌香料組成物および口臭抑制香料組成物ならびにそれらを含有する口腔用組成物 |
GB0229811D0 (en) * | 2002-12-20 | 2003-01-29 | Unilever Plc | Compound delivery systems |
US7125497B1 (en) * | 2003-05-22 | 2006-10-24 | Sandia Corporation | Reactive formulations for a neutralization of toxic industrial chemicals |
US20050113365A1 (en) * | 2003-11-10 | 2005-05-26 | Sir Isaac Newton Enterprises Llc | Method and medicine for treating gastrointestinal disorder including irritable bowel syndrome |
US20060148783A1 (en) * | 2003-11-10 | 2006-07-06 | Lundeen James E | Method and medicine for treating gastrointestinal disorder including fecal incontinence |
US20060148781A1 (en) * | 2003-11-10 | 2006-07-06 | Lundeen James E | Method and medicine for treating gastrointestinal disorder in a non-human mammal |
US20060148782A1 (en) * | 2003-11-10 | 2006-07-06 | Lundeen James E | Method and medicine for treating a mammal presenting urinary incontinence, urinary urgency, or both |
US20070142367A1 (en) * | 2003-11-10 | 2007-06-21 | Lundeen James E | Method and medicine for treating gastrointestinal disorder including fecal incontinence |
US20050137166A1 (en) * | 2003-12-19 | 2005-06-23 | Alcon, Inc. | Use of cooling agents to relieve mild ocular irritation and enhance comfort |
US20050181057A1 (en) * | 2004-02-13 | 2005-08-18 | Rosenberg Paul K. | Vaginal lubricant |
US20070155755A1 (en) * | 2004-02-23 | 2007-07-05 | Wei Edward T | N-arylshydroxyalkylidene-carboxamide compositions and methods |
WO2006040103A1 (en) * | 2004-10-13 | 2006-04-20 | Bayer Healthcare Ag | Use of cold menthol receptor modulators for the treatment of respiratory disorders |
WO2006131203A1 (en) * | 2005-06-10 | 2006-12-14 | Unilever N.V. | Oral care composition comprising a 1 , 2 , 3 , 6-tetrahydropyrimidine-2-one cooling agent |
WO2006138691A1 (en) * | 2005-06-17 | 2006-12-28 | Wisconsin Alumni Research Foundation | Topical vasoconstrictor preparations and methods for protecting cells during cancer chemotherapy and radiotherapy |
WO2007021900A2 (en) * | 2005-08-10 | 2007-02-22 | Cutler Robert S | Compositions and methods for treating wounds |
US20070099237A1 (en) * | 2005-10-31 | 2007-05-03 | The Regents Of The University Of Michigan | Reaction co-crystallization of molecular complexes or co-crystals |
US20070110788A1 (en) * | 2005-11-14 | 2007-05-17 | Hissong James B | Injectable formulation capable of forming a drug-releasing device |
US7727516B2 (en) * | 2006-02-28 | 2010-06-01 | The Procter & Gamble Company | Reduction of hair growth |
US7993675B2 (en) * | 2006-05-10 | 2011-08-09 | Medtronic Xomed, Inc. | Solvating system and sealant for medical use in the sinuses and nasal passages |
US7959943B2 (en) * | 2006-05-10 | 2011-06-14 | Medtronics Xomed, Inc. | Solvating system and sealant for medical use in the middle or inner ear |
US20070264296A1 (en) * | 2006-05-10 | 2007-11-15 | Myntti Matthew F | Biofilm extracellular polysachharide solvating system |
US7976873B2 (en) * | 2006-05-10 | 2011-07-12 | Medtronic Xomed, Inc. | Extracellular polysaccharide solvating system for treatment of bacterial ear conditions |
US8088095B2 (en) * | 2007-02-08 | 2012-01-03 | Medtronic Xomed, Inc. | Polymeric sealant for medical use |
US20100216876A1 (en) * | 2007-10-02 | 2010-08-26 | Yuichi Suzuki | Antidiarrhetic composition, product containing the same and method of preventing diahhrea |
US20090110656A1 (en) * | 2007-10-31 | 2009-04-30 | Lemke Sarah A | Skin cooling composition |
US20090157153A1 (en) * | 2007-12-13 | 2009-06-18 | Sarah Anne Lemke | Skin cooling system |
WO2009146104A1 (en) * | 2008-04-02 | 2009-12-03 | Accentia Biopharmaceuticals, Inc. | Formulations, devices and methods for treating and preventing mucositis |
WO2009152374A2 (en) | 2008-06-12 | 2009-12-17 | Medtronic Xomed, Inc. | Method for treating chronic wounds |
US20110158912A1 (en) * | 2008-08-13 | 2011-06-30 | Tony Wright | Method and device for determining the severity of a pain disorder |
CA2937195C (en) * | 2008-08-26 | 2019-07-09 | Basf Se | Detection and use of compounds containing a benzodioxol group as modulators of the cold-menthol receptor |
US20100086576A1 (en) * | 2008-10-06 | 2010-04-08 | Myntti Matthew F | Antimicrobial composition and methods of making and using same |
AU2010255540A1 (en) * | 2009-06-05 | 2012-01-19 | Edward Tak Wei | Treatment of eye discomfort by topical administration of a cooling agent to the external surface of the eyelid |
DE102010002558A1 (de) | 2009-11-20 | 2011-06-01 | Symrise Ag | Verwendung physiologischer Kühlwirkstoffe und Mittel enthaltend solche Wirkstoffe |
EP2394703B1 (de) | 2010-06-14 | 2015-12-23 | Symrise AG | Kühlmischungen mit verstärkter Kühlwirkung von 5-Methyl-2-(propan-2-yl)cyclohexyl-N-ethyloxamat |
US9029415B2 (en) | 2010-06-14 | 2015-05-12 | Symrise Ag | Cooling mixtures with an enhanced cooling effect of 5-methyl-2-(propane-2-yl)cyclohexyl-N-ethyloxamate |
WO2012018980A2 (en) * | 2010-08-04 | 2012-02-09 | Yun Michael Shim | Compositions and methods for treating inflammatory diseases |
ES2377785B2 (es) * | 2010-09-08 | 2012-09-26 | Universidad Miguel Hernández De Elche | Composición farmacéutica para el tratamiento del ojo seco. |
CN103458928B (zh) | 2011-01-18 | 2015-09-30 | 魏德烽 | (r)-1,2-丙二醇用作治疗性冷却剂组合物中的溶剂 |
US9532952B2 (en) | 2011-01-28 | 2017-01-03 | Physician's Seal, LLC | Controlled-release compositions of melatonin combined with sedative and/or analgesic ingredients |
US8691275B2 (en) | 2011-01-28 | 2014-04-08 | Zx Pharma, Llc | Controlled-release melatonin compositions and related methods |
AU2012214553B2 (en) | 2011-02-11 | 2015-07-09 | Sociétés des Produits Nestlé S.A. | Multiparticulate L-menthol formulations and related methods |
AU2015238807B2 (en) * | 2011-02-11 | 2016-06-23 | Sociétés des Produits Nestlé S.A. | Multiparticulate l-menthol formulations and related methods |
US8911780B2 (en) | 2011-02-11 | 2014-12-16 | Zx Pharma, Llc | Multiparticulate L-menthol formulations and related methods |
US8808736B2 (en) | 2011-02-11 | 2014-08-19 | Zx Pharma, Llc | Enteric coated multiparticulate controlled release peppermint oil composition and related methods |
HUE030921T2 (en) | 2011-04-29 | 2017-06-28 | Moberg Pharma Ab | Pharmaceutical preparations containing a local anesthetic such as bupivacaine for topical administration to the mouth or throat |
US10653133B2 (en) | 2011-05-10 | 2020-05-19 | Next Science IP Holdings Pty Ltd | Antimicrobial solid and methods of making and using same |
WO2013041621A1 (de) | 2011-09-20 | 2013-03-28 | Basf Se | Niedermolekulare modulatoren des kälte-menthol-rezeptors trpm8 und deren verwendung |
PT2872123T (pt) | 2013-04-23 | 2017-03-15 | Zx Pharma Llc | Composição multiparticulada com revestimento entérico de libertação controlada de óleo de hortelã-pimenta e métodos relacionados |
ITMI20132066A1 (it) * | 2013-12-11 | 2015-06-12 | Farmatron Ltd | Sistemi terapeutici a rilascio modificato per la somministrazione orale di mentolo nel trattamento delle malattie intestinali |
CN111343963B (zh) | 2017-08-31 | 2023-09-12 | 巴斯夫欧洲公司 | 生理清凉活性成分的用途以及包含此类活性成分的组合物 |
WO2022207944A2 (en) | 2022-07-11 | 2022-10-06 | Symrise Ag | Novel mixtures and uses of (2e)-3-(1,3-benzodioxol-5-yl)-n-phenyl-n-(tetrahydro-3-furanyl)-2-propenamide |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3821221A (en) * | 1970-08-25 | 1974-06-28 | Delmar Chem | 1,2,3,6-tetrahydropyrimidine-2-one compounds and processes for makingthem |
US3947439A (en) * | 1973-03-30 | 1976-03-30 | American Home Products Corporation | 4-Hydroxy-4-phenyl-2,3-cycloalkylimino-2-thiazolidinealkylcarboxylic acid lactones |
US5116868A (en) | 1989-05-03 | 1992-05-26 | The Johns Hopkins University | Effective ophthalmic irrigation solution |
US5192802A (en) | 1991-09-25 | 1993-03-09 | Mcneil-Ppc, Inc. | Bioadhesive pharmaceutical carrier |
US5215221A (en) | 1992-05-07 | 1993-06-01 | The Procter & Gamble Company | Disposable unit dose dispenser for powdered medicants |
IL108744A (en) | 1994-02-22 | 1998-12-27 | Trop Life Ltd | Cylindrical cooling device for medical treatment of hemorrhoids |
US5582330A (en) | 1994-12-28 | 1996-12-10 | Allergan, Inc. | Specific volume dispenser |
US5889028A (en) | 1996-02-09 | 1999-03-30 | Mayo Foundation For Medical Education And Research | Colonic delivery of nicotine to treat inflammatory bowel disease |
WO1998029140A1 (en) | 1996-12-31 | 1998-07-09 | Inhale Therapeutic Systems | Processes and compositions for spray drying hydrophobic drugs in organic solvent suspensions of hydrophilic excipients |
US6245760B1 (en) * | 1997-05-28 | 2001-06-12 | Aventis Pharmaceuticals Products, Inc | Quinoline and quinoxaline compounds which inhibit platelet-derived growth factor and/or p56lck tyrosine kinases |
GB9810126D0 (de) | 1998-05-13 | 1998-07-08 | Glaxo Group Ltd | |
US5942545A (en) | 1998-06-15 | 1999-08-24 | Macrochem Corporation | Composition and method for treating penile erectile dysfunction |
US6436950B1 (en) | 1998-08-14 | 2002-08-20 | Nastech Pharmaceutical Company, Inc. | Nasal delivery of apomorphine |
US6319513B1 (en) | 1998-08-24 | 2001-11-20 | The Procter & Gamble Company | Oral liquid mucoadhesive compounds |
US6391869B1 (en) | 1998-12-14 | 2002-05-21 | Cellergy Pharmaceuticals, Inc. | Compositions and methods for the treatment of anorectal disorders |
US6443152B1 (en) | 2001-01-12 | 2002-09-03 | Becton Dickinson And Company | Medicament respiratory delivery device |
US6797725B2 (en) * | 2001-04-09 | 2004-09-28 | Sugen, Inc. | Prodrugs of a 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives |
US7371841B2 (en) * | 2002-01-25 | 2008-05-13 | Regents Of The University Of California | Methods of modulating cold sensory perception |
US6919348B2 (en) * | 2002-05-02 | 2005-07-19 | Edward T. Wei | Therapeutic 1,2,3,6-tetrahydropyrimidine-2-one compositions and methods therewith |
-
2002
- 2002-05-02 US US10/139,193 patent/US6919348B2/en not_active Expired - Fee Related
- 2002-07-08 US US10/191,481 patent/US20030207903A1/en not_active Abandoned
- 2002-08-29 US US10/232,798 patent/US6743801B2/en not_active Expired - Fee Related
- 2002-08-29 US US10/233,126 patent/US20030206873A1/en not_active Abandoned
- 2002-10-08 US US10/267,896 patent/US6933301B2/en not_active Expired - Fee Related
-
2003
- 2003-04-28 ZA ZA200408895A patent/ZA200408895B/en unknown
- 2003-04-28 DE DE60330333T patent/DE60330333D1/de not_active Expired - Lifetime
- 2003-04-28 AT AT03718956T patent/ATE450260T1/de not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
US6919348B2 (en) | 2005-07-19 |
US6743801B2 (en) | 2004-06-01 |
US20030207851A1 (en) | 2003-11-06 |
US6933301B2 (en) | 2005-08-23 |
US20030206873A1 (en) | 2003-11-06 |
DE60330333D1 (de) | 2010-01-14 |
US20030207903A1 (en) | 2003-11-06 |
ZA200408895B (en) | 2006-01-25 |
US20030207904A1 (en) | 2003-11-06 |
US20030206866A1 (en) | 2003-11-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |