DE60330333D1 - Therapeutische zusammensetzungen enthaltend 1,2,3,6-tetrahydropyrimidin-2-one und entsprechende methoden - Google Patents

Therapeutische zusammensetzungen enthaltend 1,2,3,6-tetrahydropyrimidin-2-one und entsprechende methoden

Info

Publication number
DE60330333D1
DE60330333D1 DE2003630333 DE60330333A DE60330333D1 DE 60330333 D1 DE60330333 D1 DE 60330333D1 DE 2003630333 DE2003630333 DE 2003630333 DE 60330333 A DE60330333 A DE 60330333A DE 60330333 D1 DE60330333 D1 DE 60330333D1
Authority
DE
Germany
Prior art keywords
tetrahydropyrimidin
therapeutic compositions
compositions contain
corresponding methods
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE2003630333
Other languages
English (en)
Inventor
Edward T Wei
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CRAGMONT PHARMACEUTICALS LLC
Original Assignee
CRAGMONT PHARMACEUTICALS LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US10/139,193 priority Critical patent/US6919348B2/en
Priority to US10/191,481 priority patent/US20030207903A1/en
Priority to US10/233,126 priority patent/US20030206873A1/en
Priority to US10/232,798 priority patent/US6743801B2/en
Priority to US10/267,896 priority patent/US6933301B2/en
Priority to PCT/GB2003/001811 priority patent/WO2003092697A1/en
Application filed by CRAGMONT PHARMACEUTICALS LLC filed Critical CRAGMONT PHARMACEUTICALS LLC
Application granted granted Critical
Publication of DE60330333D1 publication Critical patent/DE60330333D1/de
Application status is Active legal-status Critical
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives, e.g. steroids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives, e.g. steroids
    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane, progesterone
    • A61K31/573Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane, progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0043Nose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/08Inhaling devices inserted into the nose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00Special media to be introduced, removed or treated
    • A61M2202/06Solids
    • A61M2202/064Powder
DE2003630333 2002-05-02 2003-04-28 Therapeutische zusammensetzungen enthaltend 1,2,3,6-tetrahydropyrimidin-2-one und entsprechende methoden Active DE60330333D1 (de)

Priority Applications (6)

Application Number Priority Date Filing Date Title
US10/139,193 US6919348B2 (en) 2002-05-02 2002-05-02 Therapeutic 1,2,3,6-tetrahydropyrimidine-2-one compositions and methods therewith
US10/191,481 US20030207903A1 (en) 2002-05-02 2002-07-08 1,2,3,6-tetrahydropyrimidine-2-one compositions and therapeutic methods therewith for sexual disfunction
US10/233,126 US20030206873A1 (en) 2002-05-02 2002-08-29 1,2,3,6-tetrahydropyrimidine-2-one compositions and therapeutic methods therewith for gastrointestinal dysfunction
US10/232,798 US6743801B2 (en) 2002-05-02 2002-08-29 1,2,3,6-tetrahydropyrimidine-2-one compositions and therapeutic methods therewith for pain and inflammation
US10/267,896 US6933301B2 (en) 2002-05-02 2002-10-08 1,2,3,6-tetrahydropyrimidine-2-one compositions, articles and therapeutic methods for upper airway breathing disorders
PCT/GB2003/001811 WO2003092697A1 (en) 2002-05-02 2003-04-28 Therapeutic 1,2,3,6-tetrahydropyrimidine-2-one compositions and methods therewith

Publications (1)

Publication Number Publication Date
DE60330333D1 true DE60330333D1 (de) 2010-01-14

Family

ID=29269528

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2003630333 Active DE60330333D1 (de) 2002-05-02 2003-04-28 Therapeutische zusammensetzungen enthaltend 1,2,3,6-tetrahydropyrimidin-2-one und entsprechende methoden

Country Status (4)

Country Link
US (5) US6919348B2 (de)
AT (1) AT450260T (de)
DE (1) DE60330333D1 (de)
ZA (1) ZA200408895B (de)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050281751A1 (en) * 1997-07-21 2005-12-22 Bruce Levin Directed intranasal administration of pharmaceutical agents
US6919348B2 (en) * 2002-05-02 2005-07-19 Edward T. Wei Therapeutic 1,2,3,6-tetrahydropyrimidine-2-one compositions and methods therewith
JP2004018470A (ja) * 2002-06-18 2004-01-22 Takasago Internatl Corp 抗菌香料組成物および口臭抑制香料組成物ならびにそれらを含有する口腔用組成物
GB0229811D0 (en) * 2002-12-20 2003-01-29 Unilever Plc Compound delivery systems
US7125497B1 (en) * 2003-05-22 2006-10-24 Sandia Corporation Reactive formulations for a neutralization of toxic industrial chemicals
US20060148781A1 (en) * 2003-11-10 2006-07-06 Lundeen James E Method and medicine for treating gastrointestinal disorder in a non-human mammal
US20070142367A1 (en) * 2003-11-10 2007-06-21 Lundeen James E Method and medicine for treating gastrointestinal disorder including fecal incontinence
US20050113365A1 (en) * 2003-11-10 2005-05-26 Sir Isaac Newton Enterprises Llc Method and medicine for treating gastrointestinal disorder including irritable bowel syndrome
US20060148783A1 (en) * 2003-11-10 2006-07-06 Lundeen James E Method and medicine for treating gastrointestinal disorder including fecal incontinence
US20060148782A1 (en) * 2003-11-10 2006-07-06 Lundeen James E Method and medicine for treating a mammal presenting urinary incontinence, urinary urgency, or both
US20050137166A1 (en) * 2003-12-19 2005-06-23 Alcon, Inc. Use of cooling agents to relieve mild ocular irritation and enhance comfort
US20050181057A1 (en) * 2004-02-13 2005-08-18 Rosenberg Paul K. Vaginal lubricant
US20070155755A1 (en) * 2004-02-23 2007-07-05 Wei Edward T N-arylshydroxyalkylidene-carboxamide compositions and methods
WO2006040103A1 (en) * 2004-10-13 2006-04-20 Bayer Healthcare Ag Use of cold menthol receptor modulators for the treatment of respiratory disorders
JP2014508740A (ja) 2011-01-18 2014-04-10 ウェイ,エドワード,タク 治療用冷却剤組成物における溶媒としての使用のための(r)−1,2−プロパンジオール
WO2006131203A1 (en) * 2005-06-10 2006-12-14 Unilever N.V. Oral care composition comprising a 1 , 2 , 3 , 6-tetrahydropyrimidine-2-one cooling agent
WO2006138691A1 (en) * 2005-06-17 2006-12-28 Wisconsin Alumni Research Foundation Topical vasoconstrictor preparations and methods for protecting cells during cancer chemotherapy and radiotherapy
WO2007021900A2 (en) * 2005-08-10 2007-02-22 Cutler Robert S Compositions and methods for treating wounds
US20070099237A1 (en) * 2005-10-31 2007-05-03 The Regents Of The University Of Michigan Reaction co-crystallization of molecular complexes or co-crystals
US20070110788A1 (en) * 2005-11-14 2007-05-17 Hissong James B Injectable formulation capable of forming a drug-releasing device
US7727516B2 (en) * 2006-02-28 2010-06-01 The Procter & Gamble Company Reduction of hair growth
US7976873B2 (en) * 2006-05-10 2011-07-12 Medtronic Xomed, Inc. Extracellular polysaccharide solvating system for treatment of bacterial ear conditions
US7993675B2 (en) * 2006-05-10 2011-08-09 Medtronic Xomed, Inc. Solvating system and sealant for medical use in the sinuses and nasal passages
US20070264296A1 (en) * 2006-05-10 2007-11-15 Myntti Matthew F Biofilm extracellular polysachharide solvating system
US7959943B2 (en) * 2006-05-10 2011-06-14 Medtronics Xomed, Inc. Solvating system and sealant for medical use in the middle or inner ear
US8088095B2 (en) 2007-02-08 2012-01-03 Medtronic Xomed, Inc. Polymeric sealant for medical use
WO2009044548A1 (ja) * 2007-10-02 2009-04-09 Shizuoka Prefectural Universities Corporation 抗下痢症組成物及びその含有物と下痢症予防方法
US20090110656A1 (en) * 2007-10-31 2009-04-30 Lemke Sarah A Skin cooling composition
US20090157153A1 (en) * 2007-12-13 2009-06-18 Sarah Anne Lemke Skin cooling system
WO2009146104A1 (en) * 2008-04-02 2009-12-03 Accentia Biopharmaceuticals, Inc. Formulations, devices and methods for treating and preventing mucositis
JP2011524367A (ja) 2008-06-12 2011-09-01 メドトロニック・ゾーメド・インコーポレーテッド 慢性の創傷を治療するための方法
EP2337773A4 (de) * 2008-08-13 2014-10-22 Algometron Pty Ltd Verfahren und vorrichtung zur bestimmung des schweregrades von schmerzen
ES2659421T3 (es) 2008-08-26 2018-03-15 Basf Se Detección y uso de moduladores de bajo peso molecular del receptor de mentol frío TRPM8
US20100086576A1 (en) * 2008-10-06 2010-04-08 Myntti Matthew F Antimicrobial composition and methods of making and using same
AU2010255540A1 (en) * 2009-06-05 2012-01-19 Edward Tak Wei Treatment of eye discomfort by topical administration of a cooling agent to the external surface of the eyelid
DE102010002558A1 (de) 2009-11-20 2011-06-01 Symrise Ag Verwendung physiologischer Kühlwirkstoffe und Mittel enthaltend solche Wirkstoffe
US9029415B2 (en) 2010-06-14 2015-05-12 Symrise Ag Cooling mixtures with an enhanced cooling effect of 5-methyl-2-(propane-2-yl)cyclohexyl-N-ethyloxamate
EP2394703B1 (de) 2010-06-14 2015-12-23 Symrise AG Kühlmischungen mit verstärkter Kühlwirkung von 5-Methyl-2-(propan-2-yl)cyclohexyl-N-ethyloxamat
WO2012018980A2 (en) * 2010-08-04 2012-02-09 Yun Michael Shim Compositions and methods for treating inflammatory diseases
ES2377785B2 (es) 2010-09-08 2012-09-26 Consejo Superior De Investigaciones Científicas Composición farmacéutica para el tratamiento del ojo seco.
US9532952B2 (en) 2011-01-28 2017-01-03 Physician's Seal, LLC Controlled-release compositions of melatonin combined with sedative and/or analgesic ingredients
WO2012103411A2 (en) 2011-01-28 2012-08-02 Zx Pharma, Llc Controlled-release melatonin composition and related methods
AU2015238807B2 (en) * 2011-02-11 2016-06-23 Zx Pharma, Llc Multiparticulate l-menthol formulations and related methods
US8808736B2 (en) 2011-02-11 2014-08-19 Zx Pharma, Llc Enteric coated multiparticulate controlled release peppermint oil composition and related methods
EP2672981B1 (de) * 2011-02-11 2018-03-28 Zx Pharma, Llc Multipartikuläre l-menthol-formulierung und entsprechende verfahren
US8911780B2 (en) 2011-02-11 2014-12-16 Zx Pharma, Llc Multiparticulate L-menthol formulations and related methods
DK2701681T3 (en) 2011-04-29 2017-01-09 Moberg Pharma Ab PHARMACEUTICAL COMPOSITIONS COMPRISING A LOCAL ANESTHETICS as bupivacaine for local administration to the mouth or throat
EP2758041A1 (de) 2011-09-20 2014-07-30 Basf Se Niedermolekulare modulatoren des kälte-menthol-rezeptors trpm8 und deren verwendung
CA2909591C (en) 2013-04-23 2017-03-28 Zx Pharma, Llc Enteric coated multiparticulate composition with proteinaceous subcoat
ITMI20132066A1 (it) * 2013-12-11 2015-06-12 Farmatron Ltd Sistemi terapeutici a rilascio modificato per la somministrazione orale di mentolo nel trattamento delle malattie intestinali
WO2019043164A1 (de) 2017-08-31 2019-03-07 Basf Se Verwendung physiologischer kühlwirkstoffe und mittel enthaltend solche wirkstoffe

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3821221A (en) * 1970-08-25 1974-06-28 Delmar Chem 1,2,3,6-tetrahydropyrimidine-2-one compounds and processes for makingthem
US3947439A (en) * 1973-03-30 1976-03-30 American Home Products Corporation 4-Hydroxy-4-phenyl-2,3-cycloalkylimino-2-thiazolidinealkylcarboxylic acid lactones
US5116868A (en) 1989-05-03 1992-05-26 The Johns Hopkins University Effective ophthalmic irrigation solution
US5192802A (en) 1991-09-25 1993-03-09 Mcneil-Ppc, Inc. Bioadhesive pharmaceutical carrier
US5215221A (en) 1992-05-07 1993-06-01 The Procter & Gamble Company Disposable unit dose dispenser for powdered medicants
IL108744A (en) 1994-02-22 1998-12-27 Trop Life Ltd Cooling cylindrical device for therapeutic treatment of hemorrhoids
US5582330A (en) 1994-12-28 1996-12-10 Allergan, Inc. Specific volume dispenser
US5889028A (en) 1996-02-09 1999-03-30 Mayo Foundation For Medical Education And Research Colonic delivery of nicotine to treat inflammatory bowel disease
WO1998029140A1 (en) 1996-12-31 1998-07-09 Inhale Therapeutic Systems Processes and compositions for spray drying hydrophobic drugs in organic solvent suspensions of hydrophilic excipients
US6245760B1 (en) * 1997-05-28 2001-06-12 Aventis Pharmaceuticals Products, Inc Quinoline and quinoxaline compounds which inhibit platelet-derived growth factor and/or p56lck tyrosine kinases
GB9810126D0 (de) 1998-05-13 1998-07-08 Glaxo Group Ltd
US5942545A (en) 1998-06-15 1999-08-24 Macrochem Corporation Composition and method for treating penile erectile dysfunction
US6436950B1 (en) 1998-08-14 2002-08-20 Nastech Pharmaceutical Company, Inc. Nasal delivery of apomorphine
US6319513B1 (en) 1998-08-24 2001-11-20 The Procter & Gamble Company Oral liquid mucoadhesive compounds
US6391869B1 (en) 1998-12-14 2002-05-21 Cellergy Pharmaceuticals, Inc. Compositions and methods for the treatment of anorectal disorders
US6443152B1 (en) 2001-01-12 2002-09-03 Becton Dickinson And Company Medicament respiratory delivery device
WO2002081466A1 (en) * 2001-04-09 2002-10-17 Sugen, Inc. Prodrugs of 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives
AU2003210663A1 (en) * 2002-01-25 2003-09-02 The Regents Of The University Of California Methods of modulating cold sensory perception
US6919348B2 (en) * 2002-05-02 2005-07-19 Edward T. Wei Therapeutic 1,2,3,6-tetrahydropyrimidine-2-one compositions and methods therewith

Also Published As

Publication number Publication date
ZA200408895B (en) 2006-01-25
US20030207903A1 (en) 2003-11-06
US20030207851A1 (en) 2003-11-06
US20030206873A1 (en) 2003-11-06
US20030206866A1 (en) 2003-11-06
US6919348B2 (en) 2005-07-19
US20030207904A1 (en) 2003-11-06
US6743801B2 (en) 2004-06-01
AT450260T (de) 2009-12-15
US6933301B2 (en) 2005-08-23

Similar Documents

Publication Publication Date Title
DE60325879D1 (de) Selbstverschliessende kanüle
DK1471915T3 (da) 2,4-pyrimidindiaminforbindelser og anvendelser heraf
DE60309856D1 (de) Substituierte phenylacetamide und deren verwendung als glucokinaseaktivatoren
DK1539231T3 (da) Iscom-præparation og anvendelse deraf
DE60330207D1 (de) le
DE60329856D1 (de) Orale zusammensetzungen und deren verwendung
DE60336213D1 (de) Chirurgisches klammergerät
DE50301944D1 (de) Kosmetisches wattepad
DE60326697D1 (de) Haarfestigende zusammensetzungen, polymere und methoden
DE60325048D1 (de) Immunmodulatorische verbindungen sowie deren verwendungsverfahren
DE60322020D1 (de) Alkali-quellbare assoziative polymere, methode und zusamensetzungen
DE60327940D1 (de) Hör-sprech-garnitur
FR2848115B1 (fr) Composition de bacteries et son utilisation
DE60330024D1 (de) Mikrointegrierter herzschrittmacher
DE60326611D1 (de) N und dergleichen
DE60313163D1 (de) Immunogene zusammensetzungen
DK1480955T3 (da) O-cyclopropyl-carboxanilider og deres anvendelse som fungicider
DE60324941D1 (de) Stuhl
DE60333537D1 (de) Herzschrittmacher
DE60315657D1 (de) Luminiszierende zusammensetzungen
DE60336320D1 (de) Implantat
DE60311853D1 (de) Neue 1,4-diazabicycloalkanderivate, deren herstellung und verwendung
DK1620437T3 (da) 5,7-diaminopyrazolo-4,3-d-pyrimidiner, der er anvendelige til behandling af hypertension
DE60227068D1 (de) Therapeutische verfahren unter verwendung von pflanzlichen zusammensetzungen
DE60306670D1 (de) 3,4-alkylendioxythiophen-verbindungen und ihre polymere

Legal Events

Date Code Title Description
8364 No opposition during term of opposition