ATE445638T1 - Tuberkulose diagnose test - Google Patents
Tuberkulose diagnose testInfo
- Publication number
- ATE445638T1 ATE445638T1 AT99952697T AT99952697T ATE445638T1 AT E445638 T1 ATE445638 T1 AT E445638T1 AT 99952697 T AT99952697 T AT 99952697T AT 99952697 T AT99952697 T AT 99952697T AT E445638 T1 ATE445638 T1 AT E445638T1
- Authority
- AT
- Austria
- Prior art keywords
- peptides
- diagnosis test
- cells
- tuberculosis diagnosis
- analogues
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/35—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56911—Bacteria
- G01N33/5695—Mycobacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/975—Kit
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Organic Chemistry (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biophysics (AREA)
- Virology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10700498P | 1998-11-04 | 1998-11-04 | |
GBGB9824213.4A GB9824213D0 (en) | 1998-11-04 | 1998-11-04 | Diagnostic test |
PCT/GB1999/003635 WO2000026248A2 (en) | 1998-11-04 | 1999-11-03 | Tuberculosis diagnostic test |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE445638T1 true ATE445638T1 (de) | 2009-10-15 |
Family
ID=26314614
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT99952697T ATE445638T1 (de) | 1998-11-04 | 1999-11-03 | Tuberkulose diagnose test |
Country Status (14)
Country | Link |
---|---|
US (5) | US7632646B1 (de) |
EP (1) | EP1144447B1 (de) |
JP (1) | JP4633931B2 (de) |
CN (1) | CN1350546A (de) |
AT (1) | ATE445638T1 (de) |
AU (1) | AU6480999A (de) |
BR (1) | BR9915055A (de) |
CA (1) | CA2348475A1 (de) |
DE (1) | DE69941545D1 (de) |
DK (1) | DK1144447T3 (de) |
ES (1) | ES2333073T3 (de) |
ID (1) | ID29858A (de) |
MX (1) | MXPA01004469A (de) |
WO (1) | WO2000026248A2 (de) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9624456D0 (en) * | 1996-11-25 | 1997-01-15 | Isis Innovation | Assay method |
WO2000026248A2 (en) | 1998-11-04 | 2000-05-11 | Isis Innovation Limited | Tuberculosis diagnostic test |
AU2002219338B2 (en) | 2001-01-08 | 2006-12-14 | Oxford Immunotec Limited | Assay to determine efficacy of treatment for mycobacterial infection |
GB0215710D0 (en) * | 2002-07-05 | 2002-08-14 | Isis Innovation | Diagnostic method |
ITRM20040091A1 (it) | 2004-02-19 | 2004-05-19 | Istituto Naz Per Le Malattie | Test immunologico rapido per la diagnosi ed il monitoraggio dell'infezione tubercolare. |
EP1716417B1 (de) * | 2004-02-19 | 2008-03-05 | Department Of Biotechnology, Ministery Of Science And Technology, Government Of India | Diagnostischer kit zum nachweis pulmonaler und extrapulmonaler tb |
CN1305900C (zh) * | 2004-03-16 | 2007-03-21 | 中国药品生物制品检定所 | Esat-6蛋白在诊断结核病中的用途 |
GB0406271D0 (en) * | 2004-03-19 | 2004-04-21 | Isis Innovation | Diagnostic test |
FR2872579B1 (fr) * | 2004-06-30 | 2006-11-24 | Pasteur Institut | Detection de la tuberculose et de l'infection par mycobacterium tuberculosis a l'aide de hbha |
ES2534428T3 (es) * | 2005-07-26 | 2015-04-22 | Rutgers, The State University Of New Jersey | Perfiles de anticuerpos específicos de un estado tuberculoso |
CN101294964B (zh) * | 2007-11-27 | 2012-06-27 | 复旦大学附属华山医院 | 一种检测活动性结核病和结核潜伏感染的试剂和方法 |
CN102297968B (zh) * | 2010-06-28 | 2013-10-30 | 程小星 | 辅助诊断结核病的试剂盒 |
ITRM20100411A1 (it) * | 2010-07-23 | 2012-01-24 | Massimo Amicosante | Uso di sequenze amminoacidiche da mycobacterium tuberculosis o dei loro corrispondenti acidi nucleici per la diagnosi e la prevenzione di infezione tubercolare, relativo kit diagnostico e vaccino. |
CN101985473B (zh) * | 2010-10-12 | 2011-11-09 | 浙江大学 | 抗结核杆菌esat-6单克隆抗体tbef3及应用 |
CN101987872B (zh) * | 2010-10-12 | 2011-11-09 | 浙江大学 | 抗结核杆菌esat-6单克隆抗体tbea8及应用 |
IT1403092B1 (it) | 2010-12-01 | 2013-10-04 | Univ Degli Studi Modena E Reggio Emilia | Metodo per la diagnosi e/o il monitoraggio della mucormicosi. |
CN102305855A (zh) * | 2011-05-19 | 2012-01-04 | 中山大学 | 体外检测结核分枝杆菌感染的试剂和方法 |
MX347154B (es) | 2012-02-24 | 2017-02-21 | Centro De Investigación Científica Y De Educación Superior De Ensenada Baja California (Cicese) | Prueba de diagnóstico para enfermedades infecciosas en ganado bovino. |
RU2571713C2 (ru) * | 2014-05-12 | 2015-12-20 | Федеральное Государственное Бюджетное Учреждение "Новосибирский научно-исследовательский институт туберкулеза" Минздрава России (ФГБУ "ННИИТ" Минздрава России) | Способ диагностики латентного туберкулеза внелегочных локализаций |
CN105954521B (zh) * | 2016-07-08 | 2017-04-12 | 广州华弘生物科技有限公司 | 一种结核分枝杆菌感染诊断试剂盒 |
US10245320B2 (en) | 2016-09-30 | 2019-04-02 | Enzo Biochem, Inc. | Immunomodulatory pharmaceutical compositions and methods of use thereof |
ES2950436T3 (es) | 2016-12-14 | 2023-10-10 | Becton Dickinson Co | Métodos y composiciones para obtener una valoración de tuberculosis en un sujeto |
EP3619533B1 (de) | 2017-05-05 | 2022-09-28 | bioMérieux | Erkennungsverfahren einer zellulären immunantwort |
EP3399312A1 (de) * | 2017-05-05 | 2018-11-07 | Biomérieux | Erkennungsverfahren einer zellulären immunantwort |
WO2019018607A1 (en) | 2017-07-20 | 2019-01-24 | Enzo Biochem, Inc. | IMMUNOMODULATORY COMPOSITIONS AND METHODS OF USE THEREOF |
WO2022076428A1 (en) | 2020-10-06 | 2022-04-14 | Cepheid | Methods of diagnosing tuberculosis and differentiating between active and latent tuberculosis |
Family Cites Families (59)
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US6641814B1 (en) * | 1997-04-02 | 2003-11-04 | Statens Serum Institut | Nucleic acids fragments and polypeptide fragments derived from M. tuberculosis |
US5955077A (en) * | 1993-07-02 | 1999-09-21 | Statens Seruminstitut | Tuberculosis vaccine |
US6991797B2 (en) * | 1993-07-02 | 2006-01-31 | Statens Serum Institut | M. tuberculosis antigens |
DK79893D0 (da) | 1993-07-02 | 1993-07-02 | Statens Seruminstitut | New vaccine |
US5736524A (en) * | 1994-11-14 | 1998-04-07 | Merck & Co.,. Inc. | Polynucleotide tuberculosis vaccine |
US5775870A (en) * | 1995-08-03 | 1998-07-07 | Hogan; Sherman David | Vehicle side tilting apparatus |
US6338852B1 (en) * | 1995-09-01 | 2002-01-15 | Corixa Corporation | Compounds and methods for diagnosis of tuberculosis |
DE69637879D1 (de) * | 1995-09-01 | 2009-04-30 | Corixa Corp | Verbindungen und Verfahren zur Immuntherapie und Diagnose von Tuberkulose |
US6290969B1 (en) * | 1995-09-01 | 2001-09-18 | Corixa Corporation | Compounds and methods for immunotherapy and diagnosis of tuberculosis |
US6592877B1 (en) * | 1995-09-01 | 2003-07-15 | Corixa Corporation | Compounds and methods for immunotherapy and diagnosis of tuberculosis |
US6458366B1 (en) * | 1995-09-01 | 2002-10-01 | Corixa Corporation | Compounds and methods for diagnosis of tuberculosis |
US6087163A (en) * | 1997-02-06 | 2000-07-11 | The Public Health Research Institute Of The City Of New York, Inc. | Mycobacterium tuberculosis specific proteins and genes, mixtures of anitgens and uses thereof |
GB9624456D0 (en) * | 1996-11-25 | 1997-01-15 | Isis Innovation | Assay method |
US6245331B1 (en) * | 1997-01-02 | 2001-06-12 | New York Univ. Medical Center | Early detection of mycobacterial disease |
US6350456B1 (en) * | 1997-03-13 | 2002-02-26 | Corixa Corporation | Compositions and methods for the prevention and treatment of M. tuberculosis infection |
US6982085B2 (en) * | 1997-04-02 | 2006-01-03 | Statens Serum Institut | TB diagnostic based on antigens from M. tuberculosis |
US7037510B2 (en) * | 1997-04-18 | 2006-05-02 | Statens Serum Institut | Hybrids of M. tuberculosis antigens |
US6613881B1 (en) * | 1997-05-20 | 2003-09-02 | Corixa Corporation | Compounds for immunotherapy and diagnosis of tuberculosis and methods of their use |
EP0902086A1 (de) * | 1997-08-22 | 1999-03-17 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Tuberkolose Impfstoff |
NZ507278A (en) * | 1998-03-06 | 2003-10-31 | Statens Seruminstitut | Production of mycobacterial polypeptides by lactic acid bacteria |
TR200002938T2 (tr) * | 1998-04-07 | 2001-02-21 | Corixa Corporation | Mikrobakteri tüberküloz antijenlerinin füzyon proteinleri ve bunların kullanımı |
US20030044431A1 (en) * | 1998-06-19 | 2003-03-06 | Gerhardt Schurig | Over-expressing homologous antigen vaccine and a method of making the same |
WO2000026248A2 (en) * | 1998-11-04 | 2000-05-11 | Isis Innovation Limited | Tuberculosis diagnostic test |
US20020131976A1 (en) * | 1998-12-23 | 2002-09-19 | Ajit Lalvani | Tuberculosis vaccine |
US6649170B1 (en) * | 1999-05-12 | 2003-11-18 | Statens Serum Institut | Adjuvant combinations for immunization composition and vaccines |
JP5010079B2 (ja) * | 1999-07-13 | 2012-08-29 | スタテンズ セーラム インスティテュート | マイコバクテリウム・ツベルクローシスesat−6遺伝子ファミリーベースの結核ワクチン及び診断法 |
US6537552B1 (en) * | 1999-10-19 | 2003-03-25 | Iowa State University Research Foundation | Vaccine adjuvant |
US6776993B2 (en) * | 2000-02-22 | 2004-08-17 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Tuberculosis vaccine |
AU2001241738A1 (en) * | 2000-02-25 | 2001-09-03 | Corixa Corporation | Compounds and methods for diagnosis and immunotherapy of tuberculosis |
WO2002015407A2 (en) | 2000-08-11 | 2002-02-21 | Koninklijke Philips Electronics N.V. | Method and arrangement for synchronizing a σδ-modulator |
AU2002219338B2 (en) * | 2001-01-08 | 2006-12-14 | Oxford Immunotec Limited | Assay to determine efficacy of treatment for mycobacterial infection |
WO2003000721A2 (en) * | 2001-06-22 | 2003-01-03 | Health Protection Agency | Mycobacterial antigens expressed under low oxygen tension |
FR2828934B1 (fr) * | 2001-08-27 | 2004-08-13 | Inst Nat Sante Rech Med | Test de l'immunite cellulaire par des peptides fixes sur support solide |
GB0125535D0 (en) * | 2001-10-24 | 2001-12-12 | Microbiological Res Authority | Mycobacterial genes down-regulated during latency |
GB0215710D0 (en) * | 2002-07-05 | 2002-08-14 | Isis Innovation | Diagnostic method |
WO2004099771A1 (en) * | 2003-05-08 | 2004-11-18 | Statens Serum Institut | A new specific epitope based immunological diagnosis of tuberculosis |
WO2005054851A1 (en) * | 2003-11-21 | 2005-06-16 | Institut Pasteur | Recombinant adenylate cyclase of bordetella sp. for diagnostic and immunomonitoring uses, method of diagnosing or immunomonitoring using said recombinant adenylate cyclase, and kit for diagnosing or immunomonitoring comprising said recombinant adenylate cyclase |
ITRM20040091A1 (it) * | 2004-02-19 | 2004-05-19 | Istituto Naz Per Le Malattie | Test immunologico rapido per la diagnosi ed il monitoraggio dell'infezione tubercolare. |
GB0406271D0 (en) * | 2004-03-19 | 2004-04-21 | Isis Innovation | Diagnostic test |
US7820142B2 (en) * | 2004-09-30 | 2010-10-26 | Institut Pasteur | Immunogenic glycopeptides, screening, preparation and uses |
GB0500102D0 (en) * | 2005-01-05 | 2005-02-09 | Isis Innovation | Method for generating a memory t cell response |
US20080124738A1 (en) * | 2005-03-01 | 2008-05-29 | Pritest, Inc | Compositions and methods of testing for tuberculosis and mycobacterium infection |
EA013016B1 (ru) * | 2005-03-31 | 2010-02-26 | Лейден Юниверсити Медикал Сентер | Способы и средства диагностики, профилактики и лечения инфекций mycobacterium и заболевания туберкулезом |
US7968694B2 (en) * | 2005-07-01 | 2011-06-28 | Forsyth Dental Infirmary For Children | Tuberculosis antigen detection assays and vaccines |
ES2534428T3 (es) * | 2005-07-26 | 2015-04-22 | Rutgers, The State University Of New Jersey | Perfiles de anticuerpos específicos de un estado tuberculoso |
GB0605474D0 (en) * | 2006-03-17 | 2006-04-26 | Isis Innovation | Clinical correlates |
EP2402023A1 (de) * | 2006-06-28 | 2012-01-04 | Statens Serum Institut | Ausweitung des T-Zell-Repertoires zum Einbeziehen subdominanter Epitope durch Impfung mit als Proteinfragmente oder Peptid-Cocktails abgegebenen Antigenen |
GB0618127D0 (en) * | 2006-09-14 | 2006-10-25 | Isis Innovation | Biomarker |
US8304372B2 (en) * | 2007-01-31 | 2012-11-06 | Council Of Scientific And Industrial Research | Process for joining oxide superconducting tubes with a superconducting joint |
GB0708874D0 (en) * | 2007-05-08 | 2007-06-13 | Univ The Of Birmingham | Assay for detecting mycrobacterial infection |
EP2185195A2 (de) * | 2007-08-16 | 2010-05-19 | Tripep Ab | Immunogen-plattform |
US10611818B2 (en) * | 2007-09-27 | 2020-04-07 | Agilent Technologies, Inc. | MHC multimers in tuberculosis diagnostics, vaccine and therapeutics |
GB0722105D0 (en) * | 2007-11-10 | 2007-12-19 | Sec Dep For Environment Food A | Antigens |
US7670609B2 (en) * | 2007-11-27 | 2010-03-02 | Aeras Global Tb Vaccine Foundation | Recombinant BCG tuberculosis vaccine designed to elicit immune responses to Mycobacterium tuberculosis in all physiological stages of infection and disease |
JP5873332B2 (ja) * | 2008-07-25 | 2016-03-01 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 新規化合物および方法 |
WO2010034007A2 (en) * | 2008-09-22 | 2010-03-25 | Oregon Health & Science University | Methods for detecting a mycobacterium tuberculosis infection |
US20100159485A1 (en) * | 2008-12-19 | 2010-06-24 | Centre For Dna Fingerprinting And Diagnostics | Detection of mycobacterium tuberculosis |
GB0906215D0 (en) * | 2009-04-09 | 2009-05-20 | Lalvani Ajit | Diagnostic test |
US9173930B2 (en) * | 2009-11-20 | 2015-11-03 | Oregon Health & Science University | Methods for detecting a mycobacterium tuberculosis infection |
-
1999
- 1999-11-03 WO PCT/GB1999/003635 patent/WO2000026248A2/en active Application Filing
- 1999-11-03 DE DE69941545T patent/DE69941545D1/de not_active Expired - Lifetime
- 1999-11-03 US US09/830,839 patent/US7632646B1/en not_active Expired - Fee Related
- 1999-11-03 JP JP2000579635A patent/JP4633931B2/ja not_active Expired - Lifetime
- 1999-11-03 CN CN99813005.2A patent/CN1350546A/zh active Pending
- 1999-11-03 AU AU64809/99A patent/AU6480999A/en not_active Abandoned
- 1999-11-03 EP EP99952697A patent/EP1144447B1/de not_active Expired - Lifetime
- 1999-11-03 CA CA002348475A patent/CA2348475A1/en not_active Abandoned
- 1999-11-03 MX MXPA01004469A patent/MXPA01004469A/es unknown
- 1999-11-03 ES ES99952697T patent/ES2333073T3/es not_active Expired - Lifetime
- 1999-11-03 AT AT99952697T patent/ATE445638T1/de active
- 1999-11-03 ID IDW00200100974A patent/ID29858A/id unknown
- 1999-11-03 DK DK99952697.3T patent/DK1144447T3/da active
- 1999-11-03 BR BR9915055-7A patent/BR9915055A/pt not_active IP Right Cessation
-
2009
- 2009-10-14 US US12/579,019 patent/US7901898B2/en not_active Expired - Lifetime
-
2011
- 2011-01-25 US US13/013,466 patent/US8216795B2/en not_active Expired - Fee Related
-
2012
- 2012-06-06 US US13/489,621 patent/US8507211B2/en not_active Expired - Fee Related
-
2013
- 2013-07-12 US US13/940,758 patent/US9005902B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US20100041075A1 (en) | 2010-02-18 |
DK1144447T3 (da) | 2010-02-08 |
US20120264141A1 (en) | 2012-10-18 |
CA2348475A1 (en) | 2000-05-11 |
BR9915055A (pt) | 2001-08-07 |
US20130310271A1 (en) | 2013-11-21 |
US9005902B2 (en) | 2015-04-14 |
EP1144447A2 (de) | 2001-10-17 |
WO2000026248A2 (en) | 2000-05-11 |
WO2000026248A3 (en) | 2001-10-11 |
US8216795B2 (en) | 2012-07-10 |
JP2002532064A (ja) | 2002-10-02 |
ES2333073T3 (es) | 2010-02-16 |
ID29858A (id) | 2001-10-18 |
US7901898B2 (en) | 2011-03-08 |
MXPA01004469A (es) | 2002-08-30 |
EP1144447B1 (de) | 2009-10-14 |
JP4633931B2 (ja) | 2011-02-16 |
AU6480999A (en) | 2000-05-22 |
DE69941545D1 (de) | 2009-11-26 |
US7632646B1 (en) | 2009-12-15 |
CN1350546A (zh) | 2002-05-22 |
US20110201044A1 (en) | 2011-08-18 |
US8507211B2 (en) | 2013-08-13 |
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