ATE437961T1 - Verfahren zum testen von verbindungen, die die wirkung von poly(adp-ribose)-polymerase (parp) vermindern - Google Patents

Verfahren zum testen von verbindungen, die die wirkung von poly(adp-ribose)-polymerase (parp) vermindern

Info

Publication number
ATE437961T1
ATE437961T1 AT03779081T AT03779081T ATE437961T1 AT E437961 T1 ATE437961 T1 AT E437961T1 AT 03779081 T AT03779081 T AT 03779081T AT 03779081 T AT03779081 T AT 03779081T AT E437961 T1 ATE437961 T1 AT E437961T1
Authority
AT
Austria
Prior art keywords
parp
adp
ribose
polymerase
poly
Prior art date
Application number
AT03779081T
Other languages
English (en)
Inventor
Zhuyin Li
Shujaath Mehdi
Original Assignee
Aventis Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc
Priority claimed from PCT/US2003/029702 external-priority patent/WO2004026820A2/en
Application granted granted Critical
Publication of ATE437961T1 publication Critical patent/ATE437961T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/91—Transferases (2.)
    • G01N2333/91091—Glycosyltransferases (2.4)
    • G01N2333/91142—Pentosyltransferases (2.4.2)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Saccharide Compounds (AREA)
AT03779081T 2002-09-19 2003-09-18 Verfahren zum testen von verbindungen, die die wirkung von poly(adp-ribose)-polymerase (parp) vermindern ATE437961T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41213602P 2002-09-19 2002-09-19
GBGB0301628.4A GB0301628D0 (en) 2002-09-19 2003-01-24 Method for assaying compounds that decrease the activity of poly (ADP-ribose) - polymerase (PARP)
PCT/US2003/029702 WO2004026820A2 (en) 2002-09-19 2003-09-18 Method for assaying compounds that decrease the activity of poly(adp-ribose)-polymerase (parp)

Publications (1)

Publication Number Publication Date
ATE437961T1 true ATE437961T1 (de) 2009-08-15

Family

ID=23631742

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03779081T ATE437961T1 (de) 2002-09-19 2003-09-18 Verfahren zum testen von verbindungen, die die wirkung von poly(adp-ribose)-polymerase (parp) vermindern

Country Status (5)

Country Link
US (1) US20040115710A1 (de)
AT (1) ATE437961T1 (de)
DE (1) DE60328628D1 (de)
DK (1) DK1581486T3 (de)
GB (1) GB0301628D0 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8435961B2 (en) * 2009-06-26 2013-05-07 Massachusetts Institute Of Technology Methods and compositions for increasing the activity of inhibitory RNA
WO2010151664A2 (en) 2009-06-26 2010-12-29 Massachusetts Institute Of Technology Compositions and methods for treating cancer and modulating stress granule formation
US8268550B2 (en) * 2009-06-26 2012-09-18 Massachusetts Institute Of Technology Compositions and methods for identification of PARP function, inhibitors, and activators
BR112020022006A2 (pt) 2018-04-30 2021-01-26 Ribon Therapeutics Inc. piridazinonas como inibidores de parp7
WO2019212946A1 (en) * 2018-04-30 2019-11-07 Ribon Therapeutics Inc. Screening methods for parp modulators
CN114761086A (zh) 2019-10-30 2022-07-15 里邦医疗公司 作为parp7抑制剂的哒嗪酮
CN115951058B (zh) * 2022-12-20 2023-07-18 北京爱思益普生物科技股份有限公司 一种高通量筛选parg抑制剂的方法及其应用

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1722441A (en) * 1928-11-03 1929-07-30 Necker Frederick Theodore Display and decorating device
US2123745A (en) * 1935-07-16 1938-07-12 Rosenberg Goldie Drapery mounting
US2430959A (en) * 1945-01-22 1947-11-18 Cyrus G Soff Window drapery construction
US2522918A (en) * 1947-11-07 1950-09-19 Abrams Louis Support for curtains, draperies, and the like
US3007036A (en) * 1957-08-28 1961-10-31 Gen Electric Wall lighting unit
US3081819A (en) * 1961-07-25 1963-03-19 Eastern Prod Corp Pleater-and-hanger device for drapes or the like
US3185207A (en) * 1962-07-02 1965-05-25 David R Humble Decoration structure
US5092384A (en) * 1987-01-15 1992-03-03 Intrascapes, Ltd. Curtain system and method
US5010175A (en) * 1988-05-02 1991-04-23 The Regents Of The University Of California General method for producing and selecting peptides with specific properties
US5074348A (en) * 1989-09-25 1991-12-24 Phillips Roderick W Adjustable valence system for a window
US5117891A (en) * 1990-03-02 1992-06-02 Newell Opeating Co. Consumer sizable and installable fabric type window shade and method of manufacture thereof
JPH05104665A (ja) * 1991-10-16 1993-04-27 Ikeda Bussan Co Ltd 内装基材
US5240059A (en) * 1991-10-28 1993-08-31 Rosalee White Curtain tie member and method
US5219407A (en) * 1991-12-02 1993-06-15 Herring Lloyd W Curtains for irregular shaped windows
US5152331A (en) * 1991-12-16 1992-10-06 Barone Dana A No-sew window treatment
US5361821A (en) * 1993-09-07 1994-11-08 Dana Barone No-sew window treatment mounting assembly
US5345990A (en) * 1993-10-13 1994-09-13 Potts Kenneth J Decorative wall hanging article
US5503209A (en) * 1994-05-09 1996-04-02 Repcon International, Inc. Window valance kit
US5505245A (en) * 1994-07-18 1996-04-09 F & F Enterprises, Inc. Channeled, foam cornice window treatment
DE19708295A1 (de) * 1997-02-28 1998-09-10 Nath Guenther Flüssigkeitslichtleiter
US6173752B1 (en) * 1999-08-18 2001-01-16 Create It Decor'g Inc. Bay window cornice decorating joint

Also Published As

Publication number Publication date
DK1581486T3 (da) 2009-11-16
DE60328628D1 (de) 2009-09-10
US20040115710A1 (en) 2004-06-17
GB0301628D0 (en) 2003-02-26

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Legal Events

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