ATE435656T1 - Nkg2d modulation - Google Patents
Nkg2d modulationInfo
- Publication number
- ATE435656T1 ATE435656T1 AT05761976T AT05761976T ATE435656T1 AT E435656 T1 ATE435656 T1 AT E435656T1 AT 05761976 T AT05761976 T AT 05761976T AT 05761976 T AT05761976 T AT 05761976T AT E435656 T1 ATE435656 T1 AT E435656T1
- Authority
- AT
- Austria
- Prior art keywords
- nkg2d
- cells
- present
- modulation
- nkg2d modulation
- Prior art date
Links
- 101001109501 Homo sapiens NKG2-D type II integral membrane protein Proteins 0.000 title abstract 2
- 102100022680 NKG2-D type II integral membrane protein Human genes 0.000 title abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 1
- 230000001363 autoimmune Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 210000000822 natural killer cell Anatomy 0.000 abstract 1
Classifications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2851—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5047—Cells of the immune system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurosurgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pulmonology (AREA)
- Endocrinology (AREA)
- Cell Biology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Dermatology (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Vascular Medicine (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55991904P | 2004-04-05 | 2004-04-05 | |
| US57624204P | 2004-06-01 | 2004-06-01 | |
| US65967805P | 2005-03-07 | 2005-03-07 | |
| PCT/US2005/011487 WO2005097160A2 (en) | 2004-04-05 | 2005-04-05 | Modulation of nkg2d |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE435656T1 true ATE435656T1 (de) | 2009-07-15 |
Family
ID=35125614
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05761976T ATE435656T1 (de) | 2004-04-05 | 2005-04-05 | Nkg2d modulation |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US20080260727A1 (de) |
| EP (3) | EP2248529B1 (de) |
| JP (2) | JP4667451B2 (de) |
| KR (3) | KR100919915B1 (de) |
| CN (2) | CN102988959B (de) |
| AT (1) | ATE435656T1 (de) |
| AU (2) | AU2005231478C1 (de) |
| BR (1) | BRPI0509620A (de) |
| CA (1) | CA2563313C (de) |
| DE (1) | DE602005015302D1 (de) |
| DK (1) | DK1732588T3 (de) |
| ES (2) | ES2328597T3 (de) |
| MX (1) | MXPA06011553A (de) |
| PL (1) | PL1732588T3 (de) |
| WO (1) | WO2005097160A2 (de) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7998481B2 (en) * | 2004-04-05 | 2011-08-16 | The Regents Of The University Of California | Modulation of NKG2D for treating or preventing solid organ allograft rejection |
| WO2005115517A2 (en) * | 2004-04-28 | 2005-12-08 | Joslin Diabetes Center, Inc. | Methods of treating diabetes |
| JP2009514528A (ja) * | 2005-11-03 | 2009-04-09 | フレッド ハッチンソン キャンサー リサーチ センター | Nkg2d陽性cd4+細胞による免疫応答の負の免疫調節法 |
| WO2008014035A2 (en) * | 2006-07-25 | 2008-01-31 | The Regents Of The University Of California | Modulation of nkg2d and method for treating or preventing solid organ allograft rejection |
| PL2222706T5 (pl) † | 2007-12-14 | 2017-09-29 | Novo Nordisk As | Przeciwciała przeciwko ludzkiemu NKG2D i ich zastosowania |
| ES2550384T3 (es) | 2008-12-18 | 2015-11-06 | Dana-Farber Cancer Institute, Inc. | NKG2D-Fc para la inmunoterapia |
| KR20120090931A (ko) * | 2009-08-17 | 2012-08-17 | 더 리전트 오브 더 유니버시티 오브 캘리포니아 | 심혈관 및 대사성 질환, 예컨대 제2형 당뇨병의 치료를 위한 nkg2d 억제제의 용도 |
| CN103153332A (zh) | 2010-09-28 | 2013-06-12 | 卡尔医疗有限公司 | 用于治疗血液恶性肿瘤的组合物和方法 |
| KR101240206B1 (ko) | 2010-10-05 | 2013-03-06 | 고려대학교 산학협력단 | 자연살상 세포-매개 면역반응 억제용 조성물 |
| WO2013032943A1 (en) * | 2011-08-26 | 2013-03-07 | The Regents Of The University Of California | Methods and compositions for the treatment of respiratory conditions via nkg2d inhibition |
| PE20142361A1 (es) * | 2011-09-30 | 2015-01-16 | Dana Farber Cancer Inst Inc | Peptidos terapeuticos |
| GB201218195D0 (en) * | 2012-10-10 | 2012-11-21 | Istituto Zooprofilattico Sperimentale Delle Venezie | Composition |
| KR102228828B1 (ko) * | 2014-03-11 | 2021-03-16 | 셀렉티스 | 동종이형 이식에 양립성인 t-세포들을 만들어내는 방법 |
| AU2016231061B2 (en) * | 2015-03-11 | 2020-11-26 | Cellectis | Methods for engineering allogeneic T cell to increase their persistence and/or engraftment into patients |
| KR20180086183A (ko) | 2015-09-03 | 2018-07-30 | 더 유에이비 리서치 파운데이션 | 유전자 조작 약물 내성 t 세포 및 이것의 사용 방법 |
| US10815290B2 (en) | 2015-11-10 | 2020-10-27 | Fred Hutchinson Cancer Research Center | NKG2D decoys |
| CN108367071B (zh) | 2015-11-13 | 2022-05-13 | 达纳-法伯癌症研究所有限公司 | 用于癌症免疫疗法的nkg2d-ig融合蛋白 |
| WO2017180587A2 (en) | 2016-04-11 | 2017-10-19 | Obsidian Therapeutics, Inc. | Regulated biocircuit systems |
| EP3601528A4 (de) * | 2017-03-20 | 2021-05-05 | Washington University | Zellen und verfahren zur verwendung und herstellung derselben |
| WO2019110667A1 (en) * | 2017-12-05 | 2019-06-13 | Celyad S.A. | Reducing fratricide of immune cells expressing nkg2d-based receptors |
| WO2019241315A1 (en) | 2018-06-12 | 2019-12-19 | Obsidian Therapeutics, Inc. | Pde5 derived regulatory constructs and methods of use in immunotherapy |
| CN110713977B (zh) * | 2018-07-12 | 2022-05-27 | 上海赛傲生物技术有限公司 | 一种cd8 t细胞的培养扩增方法 |
| CN113056484B (zh) | 2018-07-31 | 2025-01-14 | 库利南Mica公司 | 阻断mica/b脱落的抗mica/b抗体及其使用方法 |
| EP3894011B1 (de) | 2018-12-11 | 2025-09-17 | Obsidian Therapeutics, Inc. | Membrangebundene il12-zusammensetzungen und verfahren zur abstimmbaren regulierung |
| CN113966397A (zh) | 2019-03-08 | 2022-01-21 | 黑曜石疗法公司 | 人碳酸酐酶2组合物和用于可调调节的方法 |
| EP3983538A1 (de) | 2019-06-12 | 2022-04-20 | Obsidian Therapeutics, Inc. | Ca2-zusammensetzungen und verfahren zur abstimmbaren regulierung |
| WO2020252404A1 (en) | 2019-06-12 | 2020-12-17 | Obsidian Therapeutics, Inc. | Ca2 compositions and methods for tunable regulation |
| WO2021030588A1 (en) * | 2019-08-13 | 2021-02-18 | Courier Therapeutics, Inc. | Orthopoxvirus major histocompatibility complex (mhc) class-i like protein (omcp) for treatment of autoimmune disease |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA89189A (en) | 1904-03-10 | 1904-09-13 | Frederick Palm | Valve |
| CA95137A (en) | 1905-07-25 | 1905-09-19 | William E. Hingston | Envelope |
| DK26743C (da) | 1918-10-14 | 1920-10-04 | Fabrikanter Og Forhandlere Af | Symaskine. |
| DK63720C (da) | 1944-02-26 | 1945-07-23 | Jes Hansen Lauritzen | Anordning ved Maksimalafbrydere med en alt efter Overbelastningens Størrelse forsinket eller øjeblikkelig Afbrydelse af Forbrugsstrømmen. |
| US6541610B1 (en) * | 1989-09-05 | 2003-04-01 | Immunex Corporation | Fusion proteins comprising tumor necrosis factor receptor |
| WO1992017198A1 (en) | 1991-03-28 | 1992-10-15 | The Regents Of The University Of Minnesota | Dna and amino acid sequence specific for natural killer cells |
| US5635532A (en) | 1991-10-21 | 1997-06-03 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Compositions and methods for therapy and prevention of pathologies including cancer, AIDS and anemia |
| WO1995034671A1 (en) | 1994-06-10 | 1995-12-21 | Genvec, Inc. | Complementary adenoviral vector systems and cell lines |
| US5789244A (en) | 1996-01-08 | 1998-08-04 | Canji, Inc. | Compositions and methods for the treatment of cancer using recombinant viral vector delivery systems |
| WO1998019167A2 (en) | 1996-10-29 | 1998-05-07 | Fred Hutchinson Cancer Research Center, Inc. | Cell stress regulated human mhc class i gene |
| ATE279518T1 (de) | 1997-01-29 | 2004-10-15 | Cornell Res Foundation Inc | An verschiedenen orten verabreichung von adenoviren-vektor zur induzierung von angiogenese |
| EP1037991B1 (de) | 1997-12-17 | 2005-09-28 | Immunex Corporation | Zelloberflächenglycoproteinen zusammenhang mit menschlicher b zell lymphomen - ulbp, dns und polypeptiden |
| US6225289B1 (en) | 1998-12-10 | 2001-05-01 | Genvec, Inc. | Methods and compositions for preserving adenoviral vectors |
| US6414218B1 (en) | 2000-01-18 | 2002-07-02 | The General Hospital Corporation | Mouse model for rheumatoid arthritis |
| AU2001253255A1 (en) | 2000-04-07 | 2001-10-23 | Large Scale Biology Corporation | Compositions and methods for inhibiting gene expression |
| US20040031066A9 (en) | 2001-01-18 | 2004-02-12 | Faustman Denise L. | Mouse model for rheumatoid arthritis |
| US20040115198A1 (en) * | 2001-02-28 | 2004-06-17 | Fred Hutchinson Cancer Research Center | Activation of lymphocyte populations expressing NKG2D using anti-NKG2D antibodies and ligand derivatives |
| US20030095965A1 (en) * | 2001-05-02 | 2003-05-22 | Katrien Van Beneden | Antibodies to Ly49E and CD94/NKG2 receptors |
| US6821522B2 (en) * | 2001-05-31 | 2004-11-23 | The Regents Of The University Of California | Tumor Therapy |
| CN1555272A (zh) * | 2001-07-31 | 2004-12-15 | �ո��� | 调节免疫应答的组合物和方法 |
| US7771718B2 (en) * | 2002-04-22 | 2010-08-10 | Fred Hutchinson Cancer Research Center | Soluble MIC polypeptides as markers for diagnosis, prognosis and treatment of cancer and autoimmune diseases or conditions |
| US7666417B2 (en) * | 2003-04-22 | 2010-02-23 | Fred Hutchinson Cancer Research Center | Methods and compositions for treating autoimmune diseases or conditions |
| US7998481B2 (en) * | 2004-04-05 | 2011-08-16 | The Regents Of The University Of California | Modulation of NKG2D for treating or preventing solid organ allograft rejection |
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