ATE435289T1 - Safracin-biosynthesegencluster und verwendungen in der gentechnologie - Google Patents
Safracin-biosynthesegencluster und verwendungen in der gentechnologieInfo
- Publication number
- ATE435289T1 ATE435289T1 AT03782652T AT03782652T ATE435289T1 AT E435289 T1 ATE435289 T1 AT E435289T1 AT 03782652 T AT03782652 T AT 03782652T AT 03782652 T AT03782652 T AT 03782652T AT E435289 T1 ATE435289 T1 AT E435289T1
- Authority
- AT
- Austria
- Prior art keywords
- gene cluster
- biosynthesis gene
- safracin
- genetic technology
- sacc
- Prior art date
Links
- 229930183496 Safracin Natural products 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 108091008053 gene clusters Proteins 0.000 title abstract 2
- 230000002068 genetic effect Effects 0.000 title 1
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 2
- 150000007523 nucleic acids Chemical group 0.000 abstract 2
- 101150080136 sacC gene Proteins 0.000 abstract 2
- 101100437895 Alternaria brassicicola bsc3 gene Proteins 0.000 abstract 1
- 101100095205 Lactococcus lactis subsp. lactis scrB gene Proteins 0.000 abstract 1
- 101150073872 ORF3 gene Proteins 0.000 abstract 1
- 108700026244 Open Reading Frames Proteins 0.000 abstract 1
- 101100226891 Phomopsis amygdali PaP450-1 gene Proteins 0.000 abstract 1
- 101000870438 Streptococcus gordonii UDP-N-acetylglucosamine-peptide N-acetylglucosaminyltransferase stabilizing protein GtfB Proteins 0.000 abstract 1
- 101100309436 Streptococcus mutans serotype c (strain ATCC 700610 / UA159) ftf gene Proteins 0.000 abstract 1
- 101100038645 Streptomyces griseus rppA gene Proteins 0.000 abstract 1
- 101000645119 Vibrio campbellii (strain ATCC BAA-1116 / BB120) Nucleotide-binding protein VIBHAR_03667 Proteins 0.000 abstract 1
- -1 orf2 Proteins 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 101150082821 sacA gene Proteins 0.000 abstract 1
- 101150025220 sacB gene Proteins 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4995—Pyrazines or piperazines forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/21—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pseudomonadaceae (F)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/10—Nitrogen as only ring hetero atom
- C12P17/12—Nitrogen as only ring hetero atom containing a six-membered hetero ring
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/182—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Saccharide Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0229793.5A GB0229793D0 (en) | 2002-12-20 | 2002-12-20 | The gene cluster involved in safracin biosynthesis and its uses for genetic engineering |
| PCT/GB2003/005563 WO2004056998A1 (en) | 2002-12-20 | 2003-12-19 | The gene cluster involved in safracin biosynthesis and its uses for genetic engineering |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE435289T1 true ATE435289T1 (de) | 2009-07-15 |
Family
ID=9950143
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03782652T ATE435289T1 (de) | 2002-12-20 | 2003-12-19 | Safracin-biosynthesegencluster und verwendungen in der gentechnologie |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US7723068B2 (de) |
| EP (1) | EP1576159B9 (de) |
| JP (1) | JP2006510375A (de) |
| CN (1) | CN1753996A (de) |
| AT (1) | ATE435289T1 (de) |
| AU (1) | AU2003290288B8 (de) |
| CA (1) | CA2510069A1 (de) |
| DE (1) | DE60328222D1 (de) |
| ES (1) | ES2329358T3 (de) |
| GB (1) | GB0229793D0 (de) |
| MX (1) | MXPA05006769A (de) |
| RU (1) | RU2385935C2 (de) |
| WO (1) | WO2004056998A1 (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0117402D0 (en) * | 2001-07-17 | 2001-09-05 | Pharma Mar Sa | New antitumoral derivatives of et-743 |
| GB0522082D0 (en) | 2005-10-31 | 2005-12-07 | Pharma Mar Sa | Formulations |
| US7955326B2 (en) | 2006-12-29 | 2011-06-07 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Pressure-sensitive conductive composite electrode and method for ablation |
| NZ589270A (en) * | 2008-05-16 | 2011-12-22 | Pharma Mar Sa | Multiple myeloma treatments |
| KR20110025178A (ko) * | 2008-05-16 | 2011-03-09 | 파르마 마르 에스.에이. | Ｐｍ00104 및 다른 항종양제를 이용한 복합 치료법 |
| US9487763B2 (en) * | 2014-01-22 | 2016-11-08 | Regents Of The University Of Michigan | Nonribosomal peptide synthetases |
| US9994885B2 (en) * | 2014-01-22 | 2018-06-12 | Regents Of The University Of Michigan | Nonribosomal peptide synthetases |
| US11332480B2 (en) | 2017-04-27 | 2022-05-17 | Pharma Mar, S.A. | Antitumoral compounds |
| CN114317581B (zh) * | 2022-03-15 | 2022-06-24 | 中国科学院天津工业生物技术研究所 | 增强红色糖多孢菌的红霉素生产能力的方法及其获得的菌株 |
| EP4705450A1 (de) | 2023-06-08 | 2026-03-11 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Modulation globaler regulatorischer mechanismen und biosynthetischer gencluster zur vereinfachten herstellung von naturprodukten |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6020000B2 (ja) * | 1980-07-07 | 1985-05-18 | ウェルファイド株式会社 | 新抗生物質ｙ−１６４８２物質およびその製造法 |
| US6551795B1 (en) * | 1998-02-18 | 2003-04-22 | Genome Therapeutics Corporation | Nucleic acid and amino acid sequences relating to pseudomonas aeruginosa for diagnostics and therapeutics |
| AR035842A1 (es) | 1999-05-14 | 2004-07-21 | Pharma Mar Sa | Metodo de hemisintesis para la formacion de compuestos intermediarios y derivados y de estructuras relacionadas con la ecteinascidina y de tetrahidroisoquinolinfenoles y compuestos intermediarios de aplicacion en dicho metodo |
-
2002
- 2002-12-20 GB GBGB0229793.5A patent/GB0229793D0/en not_active Ceased
-
2003
- 2003-12-19 EP EP03782652A patent/EP1576159B9/de not_active Expired - Lifetime
- 2003-12-19 AU AU2003290288A patent/AU2003290288B8/en not_active Ceased
- 2003-12-19 CN CNA2003801098581A patent/CN1753996A/zh active Pending
- 2003-12-19 WO PCT/GB2003/005563 patent/WO2004056998A1/en not_active Ceased
- 2003-12-19 ES ES03782652T patent/ES2329358T3/es not_active Expired - Lifetime
- 2003-12-19 DE DE60328222T patent/DE60328222D1/de not_active Expired - Lifetime
- 2003-12-19 AT AT03782652T patent/ATE435289T1/de not_active IP Right Cessation
- 2003-12-19 JP JP2004561647A patent/JP2006510375A/ja not_active Ceased
- 2003-12-19 MX MXPA05006769A patent/MXPA05006769A/es active IP Right Grant
- 2003-12-19 RU RU2005122950/13A patent/RU2385935C2/ru not_active IP Right Cessation
- 2003-12-19 US US10/540,092 patent/US7723068B2/en not_active Expired - Fee Related
- 2003-12-19 CA CA002510069A patent/CA2510069A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004056998A1 (en) | 2004-07-08 |
| US7723068B2 (en) | 2010-05-25 |
| AU2003290288B2 (en) | 2009-07-02 |
| GB0229793D0 (en) | 2003-01-29 |
| DE60328222D1 (de) | 2009-08-13 |
| AU2003290288B8 (en) | 2009-08-27 |
| JP2006510375A (ja) | 2006-03-30 |
| US20080182302A2 (en) | 2008-07-31 |
| MXPA05006769A (es) | 2005-10-05 |
| RU2005122950A (ru) | 2006-01-27 |
| CA2510069A1 (en) | 2004-07-08 |
| ES2329358T3 (es) | 2009-11-25 |
| CN1753996A (zh) | 2006-03-29 |
| EP1576159B9 (de) | 2009-12-16 |
| EP1576159A1 (de) | 2005-09-21 |
| RU2385935C2 (ru) | 2010-04-10 |
| AU2003290288A1 (en) | 2004-07-14 |
| US20060134764A1 (en) | 2006-06-22 |
| EP1576159B1 (de) | 2009-07-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |