ATE428786T1 - Antisense-oligonukleotid mit antikrebsaktivität - Google Patents
Antisense-oligonukleotid mit antikrebsaktivitätInfo
- Publication number
- ATE428786T1 ATE428786T1 AT04793044T AT04793044T ATE428786T1 AT E428786 T1 ATE428786 T1 AT E428786T1 AT 04793044 T AT04793044 T AT 04793044T AT 04793044 T AT04793044 T AT 04793044T AT E428786 T1 ATE428786 T1 AT E428786T1
- Authority
- AT
- Austria
- Prior art keywords
- antisense oligonucleotide
- cancer
- therapeutic
- cancer activity
- inhibitor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Biotechnology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2004014883 | 2004-01-22 | ||
PCT/JP2004/015932 WO2005071082A1 (ja) | 2004-01-22 | 2004-10-27 | 抗癌作用を有するアンチセンスオリゴヌクレオチド |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE428786T1 true ATE428786T1 (de) | 2009-05-15 |
Family
ID=34805433
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT04793044T ATE428786T1 (de) | 2004-01-22 | 2004-10-27 | Antisense-oligonukleotid mit antikrebsaktivität |
Country Status (7)
Country | Link |
---|---|
US (1) | US7393951B2 (de) |
EP (1) | EP1707630B1 (de) |
JP (1) | JP4226006B2 (de) |
CN (1) | CN1816626B (de) |
AT (1) | ATE428786T1 (de) |
DE (1) | DE602004020677D1 (de) |
WO (1) | WO2005071082A1 (de) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007035962A2 (en) * | 2005-09-23 | 2007-03-29 | California Institute Of Technology | Gene blocking method |
CN109517894B (zh) * | 2018-08-31 | 2020-01-21 | 清华大学 | 一种与肝癌相关的非编码rna生物标志物及其应用 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994008003A1 (en) | 1991-06-14 | 1994-04-14 | Isis Pharmaceuticals, Inc. | ANTISENSE OLIGONUCLEOTIDE INHIBITION OF THE ras GENE |
US5985558A (en) * | 1997-04-14 | 1999-11-16 | Isis Pharmaceuticals Inc. | Antisense oligonucleotide compositions and methods for the inibition of c-Jun and c-Fos |
EP0914326A1 (de) * | 1996-03-22 | 1999-05-12 | South Alabama Medical Science Foundation | Molekul und verfahren um dns in einen kern einzufuhren |
US6130207A (en) * | 1997-11-05 | 2000-10-10 | South Alabama Medical Science Foundation | Cell-specific molecule and method for importing DNA into a nucleus |
KR20010040448A (ko) * | 1998-01-30 | 2001-05-15 | 진센스 테크놀로지즈 인코포레이티드 | 티오레독신 또는 티오레독신 환원효소의 유전자와상보적인 올리고뉴클레오 타이드 서열 및 이들을 사용하는세포성장 조절 방법 |
WO2002044332A2 (en) | 2000-12-01 | 2002-06-06 | Origene Technologies Inc | Prostate polynucleotides and uses |
US20030232443A1 (en) * | 2002-06-18 | 2003-12-18 | Isis Pharmaceuticals Inc. | Antisense modulation of centromere protein B expression |
-
2004
- 2004-10-27 WO PCT/JP2004/015932 patent/WO2005071082A1/ja active Application Filing
- 2004-10-27 DE DE602004020677T patent/DE602004020677D1/de active Active
- 2004-10-27 AT AT04793044T patent/ATE428786T1/de not_active IP Right Cessation
- 2004-10-27 US US10/558,265 patent/US7393951B2/en active Active
- 2004-10-27 JP JP2005517190A patent/JP4226006B2/ja active Active
- 2004-10-27 CN CN2004800187313A patent/CN1816626B/zh not_active Expired - Fee Related
- 2004-10-27 EP EP04793044A patent/EP1707630B1/de active Active
Also Published As
Publication number | Publication date |
---|---|
CN1816626A (zh) | 2006-08-09 |
JPWO2005071082A1 (ja) | 2007-12-27 |
EP1707630A4 (de) | 2007-01-24 |
DE602004020677D1 (de) | 2009-05-28 |
EP1707630A1 (de) | 2006-10-04 |
US7393951B2 (en) | 2008-07-01 |
EP1707630B1 (de) | 2009-04-15 |
US20070129318A1 (en) | 2007-06-07 |
CN1816626B (zh) | 2010-05-26 |
WO2005071082A1 (ja) | 2005-08-04 |
JP4226006B2 (ja) | 2009-02-18 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP1490489A4 (de) | Verfahren und mittel zur überwachung und modulation des gen-silencing | |
WO2007005645A3 (en) | Materials and methods for the generation of fully 2'-modified nucleic acid transcripts | |
WO2006018836A3 (en) | Nucleic acid constructs and cells, and methods utilizing same for modifying the electrophysiological function of excitable tissues | |
WO2010048552A3 (en) | Methods of using oligomeric compounds comprising 2'-substituted nucleosides | |
DK2092065T4 (da) | Antisense-forbindelser | |
WO2007076423A3 (en) | INHIBITORS OF Akt ACTIVITY | |
EP1931806A4 (de) | Pkr-aktivierung mittels hybridisierungskettenreaktion | |
EP2527444A3 (de) | Antisense-Oligonukleotid-Modulation einer STAT3-Expression | |
WO2003097794A3 (en) | Universal-tagged oligonucleotide primers and methods of use | |
EP1445312A4 (de) | Verfahren zur hemmung der genexpression | |
WO2005089287A3 (en) | Methods and compositions for the specific inhibition of gene expression by double-stranded rna | |
DE69403642D1 (de) | 7-deazapurin modifizierte oligonukleotide | |
WO2005105829A3 (en) | Caspase-2 inhibitors and their biological applications | |
WO2004080418A3 (en) | Nucleic acid compounds for inhibiting angiogenesis and tumor growth | |
TW200716110A (en) | Inhibitors of AKT activity | |
AU2005273867A1 (en) | Benzothienopyridines for use as inhibitors of Eg5 kinesin | |
HK1106171A1 (en) | Tetrahydropyridothiophenes | |
WO2006029161A3 (en) | Cell specific gene silencing using cell-specific promoters in vitro and in vivo | |
WO2005118592A8 (en) | Tetrahydropyridothiophenes for use in the treatment of cancer | |
EP2157182A3 (de) | Modifizierte kurz interferierende RNA | |
WO2005001039A3 (en) | Ribozyme-regulated small inhibitory rna (sirna) production and methods of use thereof | |
WO2004027056A3 (en) | Methods of use for thermostable rna ligases | |
WO2005000320A3 (en) | Use of double-stranded ribonucleic acid for inducing cell lysis | |
EP1546180A4 (de) | Verwendung von antisens-oligonukleotiden zur inhibierung der expression von akt-1 | |
BRPI0308119A2 (pt) | microorganismo como portadores de seqüências de nucleotídeos codificando para antígenos de células para o tratamento de tumores. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |