ATE424224T1 - Dezellularisierung von gewebematrixen - Google Patents

Dezellularisierung von gewebematrixen

Info

Publication number
ATE424224T1
ATE424224T1 AT02735577T AT02735577T ATE424224T1 AT E424224 T1 ATE424224 T1 AT E424224T1 AT 02735577 T AT02735577 T AT 02735577T AT 02735577 T AT02735577 T AT 02735577T AT E424224 T1 ATE424224 T1 AT E424224T1
Authority
AT
Austria
Prior art keywords
decellularization
tissue
implantation
matrices
matrixes
Prior art date
Application number
AT02735577T
Other languages
English (en)
Inventor
John Fisher
Catherine Booth
Eileen Ingham
Original Assignee
Univ Leeds
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Leeds filed Critical Univ Leeds
Application granted granted Critical
Publication of ATE424224T1 publication Critical patent/ATE424224T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A61L27/3687—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by the use of chemical agents in the treatment, e.g. specific enzymes, detergents, capping agents, crosslinkers, anticalcification agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3633—Extracellular matrix [ECM]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Botany (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Detergent Compositions (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)
  • Magnetic Ceramics (AREA)
  • Inorganic Insulating Materials (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
AT02735577T 2001-05-24 2002-05-20 Dezellularisierung von gewebematrixen ATE424224T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB0112586A GB2375771A (en) 2001-05-24 2001-05-24 Decellularisation of tissue implant material

Publications (1)

Publication Number Publication Date
ATE424224T1 true ATE424224T1 (de) 2009-03-15

Family

ID=9915172

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02735577T ATE424224T1 (de) 2001-05-24 2002-05-20 Dezellularisierung von gewebematrixen

Country Status (9)

Country Link
US (1) US7354749B2 (de)
EP (1) EP1392372B1 (de)
AT (1) ATE424224T1 (de)
AU (1) AU2002310589B2 (de)
CA (1) CA2447847C (de)
DE (1) DE60231395D1 (de)
ES (1) ES2322891T3 (de)
GB (1) GB2375771A (de)
WO (1) WO2002096476A1 (de)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6214054B1 (en) * 1998-09-21 2001-04-10 Edwards Lifesciences Corporation Method for fixation of biological tissues having mitigated propensity for post-implantation calcification and thrombosis and bioprosthetic devices prepared thereby
US6878168B2 (en) 2002-01-03 2005-04-12 Edwards Lifesciences Corporation Treatment of bioprosthetic tissues to mitigate post implantation calcification
US20050013870A1 (en) * 2003-07-17 2005-01-20 Toby Freyman Decellularized extracellular matrix of conditioned body tissues and uses thereof
DE102004047247B3 (de) * 2004-09-22 2006-03-16 Auto Tissue Gmbh Sterilisationsverfahren zur Herstellung von implantierbarem oder transplantierbarem biologischem Material
JP2009505752A (ja) 2005-08-26 2009-02-12 リージェンツ オブ ザ ユニバーシティ オブ ミネソタ 臓器および組織の脱細胞化および再細胞化
US20100093066A1 (en) * 2005-08-26 2010-04-15 Regents Of The University Of Minnesota Decellularization and recellularization apparatuses and systems containing the same
GB0606231D0 (en) 2006-03-29 2006-05-10 Univ Leeds Improvements relating to decellurisation of tissue matrices for bladder implantation
EP2606723B1 (de) 2006-10-27 2014-06-18 Edwards Lifesciences Corporation Biologisches Gewebe für chirurgische Implantation
CA2701175C (en) * 2006-11-16 2015-03-31 University Of Leeds Preparation of tissue for meniscal implantation
US9101691B2 (en) * 2007-06-11 2015-08-11 Edwards Lifesciences Corporation Methods for pre-stressing and capping bioprosthetic tissue
JP2009050297A (ja) * 2007-08-23 2009-03-12 Tokyo Medical & Dental Univ 脱細胞処理液、脱細胞化組織の調製方法、移植片、及び培養部材
US8357387B2 (en) 2007-12-21 2013-01-22 Edwards Lifesciences Corporation Capping bioprosthetic tissue to reduce calcification
FR2951549B1 (fr) 2009-10-15 2013-08-23 Olivier Schussler Procede d'obtention de bioprotheses medicales implantables
US20110165676A1 (en) * 2009-11-06 2011-07-07 The Children's Mercy Hospital Method for decellularization
EP2538988B1 (de) 2010-02-26 2019-01-30 DeCell Technologies Inc. Verfahren zur gewebe-entzellularisierung
EP2656863B1 (de) 2010-03-23 2019-09-18 Edwards Lifesciences Corporation Verfahren zur bearbeitung eines scheibenförmigen bioprothese-gewebes
CA2794135C (en) * 2010-06-17 2018-01-02 Edwards Lifesciences Corporation Methods for stabilizing a bioprosthetic tissue by chemical modification of antigenic carbohydrates
US8906601B2 (en) 2010-06-17 2014-12-09 Edwardss Lifesciences Corporation Methods for stabilizing a bioprosthetic tissue by chemical modification of antigenic carbohydrates
US8435305B2 (en) 2010-08-31 2013-05-07 Zimmer, Inc. Osteochondral graft delivery device and uses thereof
EP2611472B1 (de) 2010-09-01 2016-02-10 Regents of the University of Minnesota Verfahren zur rezellularisierung eines gewebes oder organs für verbesserte tranplantationsfähigkeit
CA2808478C (en) 2010-09-27 2015-10-06 University Of Leeds Acellular vascular products
US9351829B2 (en) 2010-11-17 2016-05-31 Edwards Lifesciences Corporation Double cross-linkage process to enhance post-implantation bioprosthetic tissue durability
US9290738B2 (en) 2012-06-13 2016-03-22 Miromatrix Medical Inc. Methods of decellularizing bone
RU2499611C1 (ru) * 2012-09-28 2013-11-27 Федеральное государственное бюджетное учреждение науки Институт теоретической и экспериментальной биофизики Российской академии наук (ИТЭБ РАН) Способ повышения биосовместимости трансплантатов клапанов сердца и сосудов
US10238771B2 (en) 2012-11-08 2019-03-26 Edwards Lifesciences Corporation Methods for treating bioprosthetic tissue using a nucleophile/electrophile in a catalytic system
JP2016513465A (ja) 2013-03-15 2016-05-16 ミロマトリックス メディカル インコーポレイティド 膵島細胞の再細胞化のための灌流型脱細胞化肝臓の使用
WO2015017500A1 (en) 2013-07-30 2015-02-05 Musculoskeletal Transplant Foundation Acellular soft tissue-derived matrices and methods for preparing same
US9615922B2 (en) 2013-09-30 2017-04-11 Edwards Lifesciences Corporation Method and apparatus for preparing a contoured biological tissue
US10959839B2 (en) 2013-10-08 2021-03-30 Edwards Lifesciences Corporation Method for directing cellular migration patterns on a biological tissue
US10307510B2 (en) 2013-11-04 2019-06-04 Lifecell Corporation Methods of removing alpha-galactose
RU2586952C1 (ru) * 2015-07-20 2016-06-10 Федеральное государственное бюджетное учреждение "Федеральный научный центр трансплантологии и искусственных органов имени академика В.И. Шумакова" Министерства здравоохранения Российской Федерации Способ лечения печеночной недостаточности
US10912864B2 (en) 2015-07-24 2021-02-09 Musculoskeletal Transplant Foundation Acellular soft tissue-derived matrices and methods for preparing same
US11052175B2 (en) 2015-08-19 2021-07-06 Musculoskeletal Transplant Foundation Cartilage-derived implants and methods of making and using same
CN105709276B (zh) * 2016-01-28 2018-08-10 成都清科生物科技有限公司 一种绒毛膜脱细胞液以及脱细胞方法
EP3509651B1 (de) 2016-09-06 2022-12-28 Miromatrix Medical Inc. Verwendung von reseziertem leberserum zum engineering der ganzen leber
CN107596446B (zh) * 2017-09-16 2020-07-28 温州医科大学 一种维持组织超微结构和营养微环境的脱细胞试剂盒
RU2678966C1 (ru) * 2018-04-03 2019-02-05 ООО "БиоИн-М" Способ повышения биосовместимости перикардиальных биоматериалов для реконструктивной хирургии
CN109260517B (zh) * 2018-09-19 2020-10-30 杭州启明医疗器械股份有限公司 一种可预装干燥生物心脏瓣膜及其制备方法
WO2020092205A1 (en) 2018-11-01 2020-05-07 Edwards Lifesciences Corporation Transcatheter pulmonic regenerative valve
GB202003210D0 (en) 2020-03-05 2020-04-22 Tissue Regenix Ltd A method for producing a decellularized tissue scaffold
US11998662B1 (en) 2021-06-09 2024-06-04 Reprise Biomedical, Inc. Biologic matrix for a wound site and related methods
CN113368313B (zh) * 2021-06-10 2022-06-03 吾奇生物医疗科技(江苏)有限公司 一种生物膜的制备方法及其产品和应用
CN115006594B (zh) * 2022-06-26 2023-07-11 中国海洋大学 机械增强型脱细胞猪角膜后板层载体支架制备方法及应用
CN115453021B (zh) * 2022-08-15 2023-11-14 首都医科大学附属北京友谊医院 一种sds脱细胞溶液及其在脱细胞处理或细胞外基质不可溶组分鉴定中的应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN157379B (de) * 1981-04-30 1986-03-15 Extracorporeal Med Spec
US4323358A (en) 1981-04-30 1982-04-06 Vascor, Inc. Method for inhibiting mineralization of natural tissue during implantation
US6100064A (en) * 1984-04-06 2000-08-08 Chiron Corporation Secreted viral proteins useful for vaccines and diagnostics
GB8618374D0 (en) * 1986-07-28 1986-09-03 Hsc Res Dev Corp Biological vascular prostheses
US5336616A (en) * 1990-09-12 1994-08-09 Lifecell Corporation Method for processing and preserving collagen-based tissues for transplantation
EP0871414B1 (de) * 1994-03-14 2004-04-28 Cryolife, Inc Herstellungsverfahren von gewebe zur implantation
WO1996003093A1 (en) * 1994-07-28 1996-02-08 Ivan Vesely Bioprosthetic implants and method of making and using same
US5986054A (en) 1995-04-28 1999-11-16 The Hospital For Sick Children, Hsc Research And Development Limited Partnership Genetic sequences and proteins related to alzheimer's disease
US6147080A (en) * 1996-12-18 2000-11-14 Vertex Pharmaceuticals Incorporated Inhibitors of p38
WO1999041981A1 (en) * 1998-02-20 1999-08-26 Lifecell Corporation Method of processing and preserving collagen based tissues
AU2001284968B2 (en) * 2000-08-16 2006-12-21 Duke University Decellularized tissue engineered constructs and tissues

Also Published As

Publication number Publication date
GB0112586D0 (en) 2001-07-18
WO2002096476A1 (en) 2002-12-05
US7354749B2 (en) 2008-04-08
ES2322891T3 (es) 2009-07-01
GB2375771A (en) 2002-11-27
CA2447847A1 (en) 2002-12-05
US20040157206A1 (en) 2004-08-12
EP1392372A1 (de) 2004-03-03
AU2002310589B2 (en) 2007-01-25
CA2447847C (en) 2011-11-22
DE60231395D1 (de) 2009-04-16
EP1392372B1 (de) 2009-03-04

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