ATE411395T1 - Verfahren zur identifizierung und/oder validierung von rezeptortyrosinkinase-inhibitoren - Google Patents

Verfahren zur identifizierung und/oder validierung von rezeptortyrosinkinase-inhibitoren

Info

Publication number
ATE411395T1
ATE411395T1 AT03753198T AT03753198T ATE411395T1 AT E411395 T1 ATE411395 T1 AT E411395T1 AT 03753198 T AT03753198 T AT 03753198T AT 03753198 T AT03753198 T AT 03753198T AT E411395 T1 ATE411395 T1 AT E411395T1
Authority
AT
Austria
Prior art keywords
tyrosine kinase
validation
inhibitors
host cells
kinase activity
Prior art date
Application number
AT03753198T
Other languages
English (en)
Inventor
Tea Gunde
Catherine Berset
Alcide Barberis
Original Assignee
Oncalis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncalis Ag filed Critical Oncalis Ag
Application granted granted Critical
Publication of ATE411395T1 publication Critical patent/ATE411395T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT03753198T 2003-10-24 2003-10-24 Verfahren zur identifizierung und/oder validierung von rezeptortyrosinkinase-inhibitoren ATE411395T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CH2003/000694 WO2005040413A1 (en) 2003-10-24 2003-10-24 Method for the identification and/or validation of receptor tyrosine kinase inhibitors

Publications (1)

Publication Number Publication Date
ATE411395T1 true ATE411395T1 (de) 2008-10-15

Family

ID=34468779

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03753198T ATE411395T1 (de) 2003-10-24 2003-10-24 Verfahren zur identifizierung und/oder validierung von rezeptortyrosinkinase-inhibitoren

Country Status (11)

Country Link
US (1) US7566528B2 (de)
EP (1) EP1675961B1 (de)
JP (1) JP2007508801A (de)
AT (1) ATE411395T1 (de)
AU (1) AU2003271489B2 (de)
CA (1) CA2544074A1 (de)
DE (1) DE60324207D1 (de)
DK (1) DK1675961T3 (de)
IL (1) IL175097A0 (de)
NZ (1) NZ547398A (de)
WO (1) WO2005040413A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1675961B1 (de) 2003-10-24 2008-10-15 Oncalis AG Verfahren zur identifizierung und/oder validierung von rezeptortyrosinkinase-inhibitoren
EP1778858A4 (de) * 2004-01-15 2009-08-19 Univ Washington Unter verwendung von drosophila an pharmazeutika durchgeführtes screening mit hohem durchsatz
US20060156421A1 (en) * 2004-06-18 2006-07-13 Cagan Ross L High throughput screening methods for anti-metastatic compounds
EP1715059A1 (de) * 2005-04-21 2006-10-25 Esbatech AG Verfahren zur Erkennung von möglichen gesundheitsgefährdenden Rezeptortyrosinkinase-Mutationen und von Inhibitoren oder Medikamenten gegen RTK-Mutanten
WO2006111035A1 (en) * 2005-04-21 2006-10-26 Oncalis Ag Method for the identification of possibly harmful receptor tyrosine kinase (rtk) mutations and of inhibitors or medication directed against rtk mutantstitle
JP5554925B2 (ja) * 2006-01-20 2014-07-23 セル・シグナリング・テクノロジー・インコーポレイテツド ヒト非小細胞肺癌における転座及び変異体ｒｏｓキナーゼ
JP5392992B2 (ja) * 2007-03-30 2014-01-22 アズワン株式会社 自己リン酸化受容体のアゴニスト、アンタゴニストのスクリーニング方法、遺伝子組換え酵母
US20090226442A1 (en) * 2008-01-22 2009-09-10 Biogen Idec Ma Inc. RON antibodies and uses thereof
GB0900425D0 (en) * 2009-01-12 2009-02-11 Ucb Pharma Sa Biological products
KR101433057B1 (ko) 2012-03-07 2014-09-23 한국과학기술원 빛에 의해 ｒｔｋ 신호전달을 활성화하는 융합단백질 및 그의 용도
EP2789630A1 (de) 2013-04-09 2014-10-15 EngMab AG Bispezifische Antikörper gegen CD3e und ROR1
US10231965B2 (en) 2014-02-20 2019-03-19 Ignyta, Inc. Molecules for administration to ROS1 mutant cancer cells
PL3137114T3 (pl) 2014-04-30 2021-06-28 Pfizer Inc. Koniugaty przeciwciało anty-ptk7-lek
ES2850325T3 (es) 2014-10-09 2021-08-27 Engmab Sarl Anticuerpos biespecíficos contra CD3epsilon y ROR1
WO2016089760A1 (en) 2014-12-02 2016-06-09 Ignyta, Inc. Combinations for the treatment of neuroblastoma
CN107849113B (zh) * 2015-05-29 2022-03-22 亚尼塔公司 用于治疗具有rtk突变细胞的患者的组合物和方法
CA3008663A1 (en) 2015-12-18 2017-06-22 Ignyta, Inc. Combinations of a selective tyrosine kinase inhibitor (tki) with a mek or erk inhibitor for the treatment of cancer
BR112020000793A2 (pt) 2017-07-19 2020-07-14 Ignyta, Inc. composições farmacêuticas e formas de dosagem
WO2019077506A1 (en) 2017-10-17 2019-04-25 Ignyta, Inc. PHARMACEUTICAL COMPOSITIONS AND SOLID GALENIC FORMS

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0624192A1 (de) * 1992-01-22 1994-11-17 New England Deaconess Hospital Neue Protein Tyrosinkinasen
US6051397A (en) * 1993-11-16 2000-04-18 Max Planck Gesellschaft Zur Forderung Der Wissenschaften DNA encoding MCK-10, a novel receptor tyrosine kinase
US5573994A (en) * 1994-05-13 1996-11-12 University Of Cincinnati Superabsorbent foams, and method for producing the same
US5573944A (en) * 1994-07-22 1996-11-12 President And Fellows Of Harvard College Yeast cell expressing heterologous receptor kinase
US6433154B1 (en) * 1997-06-12 2002-08-13 Bristol-Myers Squibb Company Functional receptor/kinase chimera in yeast cells
AU2003218236B2 (en) * 2002-03-01 2007-12-06 Bristol-Myers Squibb Company Transgenic non-human mammals expressing constitutively activated tyrosine kinase receptors
EP1495329B1 (de) * 2002-04-18 2006-03-29 Esbatech AG Verfahren zum nachweis von modulatoren einer sekretaseaktivität
EP1675961B1 (de) 2003-10-24 2008-10-15 Oncalis AG Verfahren zur identifizierung und/oder validierung von rezeptortyrosinkinase-inhibitoren

Also Published As

Publication number Publication date
US20050239049A1 (en) 2005-10-27
EP1675961A1 (de) 2006-07-05
WO2005040413A1 (en) 2005-05-06
US7566528B2 (en) 2009-07-28
EP1675961B1 (de) 2008-10-15
AU2003271489A1 (en) 2005-05-11
JP2007508801A (ja) 2007-04-12
DE60324207D1 (de) 2008-11-27
CA2544074A1 (en) 2005-05-06
AU2003271489B2 (en) 2009-02-19
DK1675961T3 (da) 2009-02-23
NZ547398A (en) 2008-10-31
IL175097A0 (en) 2006-08-20

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